Clinical trials: Controlled Diabetes
Diabetes, Obesity
Effects of Antioxidants and B Vitamins Supplements on Inflammation in Obese Diabetic Patients
Substantial evidence shows that diets incorporating antioxidants and B-group vitamins can offer significant protection against infections and cardiovascular disease (CVD) especially in diabetic patients.
- Trial name
- NCT01691365
- Testing
- vitamins
- Volunteers
- 100 people
- Sponsor
- United Arab Emirates University
Osteomyelitis, Diabetic Foot Osteomyelitis
Bacteriophage Therapy in Patients With Diabetic Foot Osteomyelitis
This is a phase 2b randomized trial designed to evaluate bacteriophage therapy in subjects with diabetic foot osteomyelitis.
- Trial name
- DANCE (NCT05177107)
- Testing
- Bacteriophage Therapy
- Where
- 15 sites in United States
- Volunteers
- 41 people
- Sponsor
- Adaptive Phage Therapeutics, Inc.
Pressure Ulcer, Leg Ulcer
Evaluation Of An Advanced Borderless Dressing
This study will gather preliminary clinical, health economic, and safety data on the treatment of chronic wounds with the ALLEVYN Life Non-Bordered dressing compared to standard of care treatment when used on a wound.
- Conditions
- Pressure Ulcer, Leg Ulcer, Diabetic Foot Ulcer
- Trial name
- NCT03146845
- Testing
- ALLEVYN Life Non-Bordered, Standard Care
- Where
- 6 sites in United States
- Volunteers
- 40 people
- Sponsor
- Smith & Nephew, Inc.
Diabetes Mellitus, Type 2
A Sub-study to LMF237A2302 to Assess the Effect of 24 Weeks Treatment With Initial Combination of Vildagliptin Plus Metformin
This study will evaluate the effects of treatment with vildagliptin and metformin as initial combination in newly diagnosed patients with type 2 diabetes who have very high levels of HbA1c and/or fasting plasma glucose.
- Trial name
- NCT00468039
- Testing
- vildagliptin + metformin
- Where
- United States
- Volunteers
- 94 people
- Sponsor
- Novartis
Diabetes Mellitus, Type 2, Atherosclerosis
Safety & Effectiveness on Vascular Structure and Function of ACZ885 in Atherosclerosis and Either T2DM or IGT Patients
This study will evaluate the effect of ACZ885 on vascular function in patients with documented atherosclerotic disease and T2DM or IGT.
- Conditions
- Diabetes Mellitus, Type 2, Atherosclerosis, Prediabetic State
- Trial name
- NCT00995930
- Testing
- ACZ885
- Where
- 9 sites in United States, Canada and 3 more
- Volunteers
- 189 people
- Sponsor
- Novartis Pharmaceuticals
Type2 Diabetes
Effect of Alirocumab on Postprandial Hyperlipemia in Patients With Type 2 Diabetes
Proprotein convertase subtilisin/kexin type 9 (PCSK9) has emerged over the past decade as a post-transcriptional regulator of the LDL receptor (LDL-R). PCSK9 acts as an endogenous natural inhibitor of the LDL-R pathway.
- Trial name
- EUTERPE (NCT03344692)
- Testing
- Alirocumab
- Where
- France
- Volunteers
- 22 people
- Sponsor
- Nantes University Hospital
Type2 Diabetes, Obesity
The vBlocT2D Study
Overall aim: To demonstrate that weight loss through vBloc Therapy in combination with usual care will achieve better glycemic control for patients with obesity and type 2 diabetes than usual care alone.
- Trial name
- NCT03355092
- Testing
- vBloc Therapy
- Where
- United States
- Sponsor
- Kaiser Permanente
Heart Failure, Diabetes Mellitus
Studies of Empagliflozin and Its Cardiovascular, Renal and Metabolic Effects
The investigators hypothesise that empagliflozin 10mg daily will have haemodynamic, cardiac, and renal benefits compared to placebo over 36 weeks in heart failure patients with type 2 diabetes (or pre-diabetes), leading to…
- Trial name
- SUGAR-DM-HF (NCT03485092)
- Testing
- Empagliflozin 10 MG
- Where
- United Kingdom
- Volunteers
- 105 people
- Sponsor
- NHS Greater Glasgow and Clyde
Type 2 Diabetes, Hypertension
A Randomized, Double-blind, Multi-center, Active-controlled, Phase 3 Clinical Trial to Evaluate the Efficacy and Safety of Combination Therapy of THP-00101, THP-00102, and THP-00103 in Subjects With T2DM and Essential Hypertension
[Primary Objective] To demonstrate the superiority of the change in mean sitting systolic blood pressure (MSSBP) and hemoglobin A1c (HbA1c)on week 12 of the combination therapy of THP-00101 (dapagliflozin 10 mg) and THP-00102…
- Trial name
- THP-001-031 (NCT06647745)
- Testing
- THP-00101, THP-00102, THP-00103
- Where
- 2 sites in South Korea, Thailand
- Volunteers
- 221 people
- Sponsor
- THPharm Corp.
Type 1 Diabetes
A Study to Assess the Effects of CT-868 Treatment on Glucose Homeostasis in Participants with Type 1 Diabetes
This study will be conducted primarily to evaluate the effects of CT-868 on glucose homeostasis in participants with Type 1 Diabetes Mellitus.
- Trial name
- NCT05794581
- Testing
- CT-868, Victoza
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Carmot Therapeutics, Inc.
Type2 Diabetes, Overweight and Obesity
Virtual Weight Control Program Tailored for Adults With Type 2 Diabetes (VITAL)
The purpose of the study is to evaluate the effect of the WW program on people with Type 2 diabetes and the effect on glycemic control.
- Trial name
- VITAL (NCT04804774)
- Testing
- WW program modified for people with Type 2 diabetes
- Where
- 3 sites in United States
- Volunteers
- 136 people
- Sponsor
- Pennington Biomedical Research Center
Type 2 Diabetes Treated With Insulin, Pregnancy, High Risk
Continuous Glucose Monitor Use in Pregnancy
The purpose of this study is to perform a randomized controlled trial among 180 pregnant women with type 2 diabetes mellitus (T2DM) comparing continuous glucose monitor (CGM) use to the standard of care of multiple daily…
- Trial name
- NCT05317585
- Testing
- Continuous Glucose Monitor, Routine Capillary Blood Glucose Monitoring (Fingerstick Glucose)
- Where
- United States
- Volunteers
- 180 people
- Sponsor
- University of Massachusetts, Worcester
Diabetes Mellitus, Type 2
Linagliptin as Add on Therapy to Empagliflozin 10 mg or 25 mg With Japanese Patients With Type 2 Diabetes Mellitus
Two independent study parts (i.e. Part A and Part B) are included in this trial. Part A will evaluate empagliflozin 10 mg + linagliptin and Part B will evaluate empagliflozin 25 mg + linagliptin.
- Trial name
- NCT02489968
- Testing
- empagliflozin 10 mg + linagliptin 5 mg, empagliflozin 10 mg, empagliflozin 25 mg + linagliptin 5 mg
- Where
- 83 sites in Japan
- Volunteers
- 880 people
- Sponsor
- Boehringer Ingelheim
Type2 Diabetes
Efficacy and Safety of CKD-501 Added to D150 Plus D745 25mg Therapy in Patients With Type 2 Diabetes
The purpose of this study is to prove that the group treated with CKD-501 in combination added that the reduction of glycated hemoglobin superior to placebo treated group added in combination.
- Trial name
- NCT03627182
- Testing
- CKD-501 0.5mg
- Where
- South Korea
- Volunteers
- 240 people
- Sponsor
- Chong Kun Dang Pharmaceutical
Diabetes Mellitus, Type 1
SAFE-AP: Automatic Control of Blood Glucose Under Announced and Unannounced Exercise
Achieving near-normoglycemia has been established as the main objective for most patients with diabetes. Despite growing evidence about the health benefits of regular exercise in diabetes, exercise-associated glycemic imbalance…
- Trial name
- SAFE-AP3 (NCT03577158)
- Testing
- Closed-loop controller with exercise mitigation module, Closed-loop controller without exercise mitigation module, Open-loop insulin infusion system
- Where
- Spain
- Volunteers
- 10 people
- Sponsor
- Hospital Clinic of Barcelona
Diabete Mellitus
Impact of Therapeutic Education for Type 2 Diabetic Patients During Ramadan.
This randomized controlled trial evaluates the impact of therapeutic education, with or without personalized coaching, on clinical and biological outcomes in patients with type 2 diabetes during Ramadan fasting.
- Trial name
- NCT07112625
- Testing
- education and coaching, education
- Where
- Tunisia
- Volunteers
- 85 people
- Sponsor
- University of Monastir
Type 1 Diabetes Mellitus (T1DM), Motivational Interviewing
Motivational Interviewing and WhatsApp-Based Monitoring for Metabolic Control and Self-Efficacy in Adolescents With T1DM
This clinical study aims to determine the effects of motivational interviewing and social media-based patient monitoring on metabolic control and self-efficacy in adolescents with Type 1 diabetes.
- Conditions
- Type 1 Diabetes Mellitus (T1DM), Motivational Interviewing, Metabolic Control
- Trial name
- NCT06635460
- Testing
- Motivational interviewing, Social media-based patient monitoring
- Where
- Turkey (Türkiye)
- Volunteers
- 56 people
- Sponsor
- Istanbul Medeniyet University
Heart Diseases, Stroke
The HARMONY Study: A Intervention to Reduce Cardiometabolic Risk in African American Women
This study will test whether a culturally-tailored nutrition and exercise intervention designed for African-American women will lead to sustained improvements in exercise and healthy eating through improvements in self-management…
- Conditions
- Heart Diseases, Stroke, Pre-diabetes, Hypertension
- Trial name
- NCT04705779
- Testing
- HARMONY, Nutrition and Exercise Education (NEEW)
- Where
- United States
- Volunteers
- 175 people
- Sponsor
- University of North Carolina, Chapel Hill
type1diabetes, Adolescent Behavior
Disease Management in Adolescents With Type 1 Diabetes
Adolescence period; It is a transition period of rapid growth, development and maturation in biochemical, physical, social and spiritual terms, which lasts from the beginning of puberty to young adulthood.
- Conditions
- type1diabetes, Adolescent Behavior, Self Efficacy
- Trial name
- NCT06246279
- Testing
- Adaptation to Adolescence and Type 1 Diabetes Management Training Program
- Where
- Turkey (Türkiye)
- Volunteers
- 58 people
- Sponsor
- Akdeniz University
Type 2 Diabetes Mellitus
Value-based Emotion-focused Educational Programme to Reduce Diabetes-related Distress
The purpose of the clinical trial is to evaluate the effectiveness of a relatively simple and short value-based emotion-focused educational programme in adults with type 2 diabetes (VEMOFIT) on diabetes-related distress…
- Trial name
- VEMOFIT (NCT02730078)
- Testing
- VEMOFIT, Attention-meetings (AG)
- Volunteers
- 124 people
- Sponsor
- Universiti Putra Malaysia
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