Clinical trials: Controlled Diabetes
Taurine, Cognitive Decline
Taurine Supplementation on Cognitive Function in Patients With Diabetes
Diabetes has become important risk factors for threatening human life and health. Studies have shown that chronic hyperglycemia lead to microvascular brain injury. The more common types of dementia are Alzheimer's disease (AD).
- Conditions
- Taurine, Cognitive Decline, Diabetes Mellitus
- Trial name
- NCT03410173
- Testing
- Taurine
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Third Military Medical University
Type 2 Diabetes
Comparison of Two Titration Programs of Adding Insulin Detemir to OADs in Poorly Controlled Type 2 Diabetes
This study compared the effectiveness and safety of two treatment algorithms for insulin detemir initiation and titration: active titration algorithm (performed by investigator weekly) versus usual titration algorithm (performed…
- Trial name
- NCT01281605
- Testing
- Active titration algorithm, Usual titration algorithm
- Where
- 3 sites in Taiwan
- Volunteers
- 181 people
- Sponsor
- Mackay Memorial Hospital
Diabetes Mellitus, Insulin Resistance
Insulin Infusion and Infectious Diabetic Foot Ulcers (IIIFU)
Normoglycemia is important for the outcome of surgical and medical conditions. Insulin infusions have been studied to achieve normoglycemia during these circumstances and have proved to be useful.
- Conditions
- Diabetes Mellitus, Insulin Resistance, Hyperglycemia, Infection
- Trial name
- NCT00700362
- Testing
- Insulin infusion (aspart), Standard care
- Where
- Sweden
- Sponsor
- Karolinska Institutet
Diabetic Neuropathies, Diabetes Mellitus, Type 2
A Study To Evaluate The Effect Of Topiramate On Clinical And Electrophysiological Parameters In Subjects With Diabetic Peripheral Polyneuropathy
The purpose of the study is to evaluate the effect of topiramate on clinical and electrophysiological parameters in patients with diabetic peripheral polyneuropathy.
- Conditions
- Diabetic Neuropathies, Diabetes Mellitus, Type 2, Polyneuropathies
- Trial name
- NCT00231673
- Testing
- Topiramate
- Volunteers
- 72 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Diabetes
Self-care Behaviour Treatment in Patients With Diabetes - a Randomised Controlled Trial
Diabetes is a common condition associated with increased morbidity and mortality. Non-pharmacological intervention strategies focusing on factors to improve self-management skills are considered an important part of the treatment…
- Trial name
- NCT00555854
- Testing
- An individual motivational intervention program to promote and maintain self-care behaviour
- Where
- Denmark
- Volunteers
- 349 people
- Sponsor
- Odense University Hospital
Peripheral Arterial Disease (PAD), Diabete Type 2
Electromagnetic Therapy, Peripheral Vascular Diseases, Diabetes
The goal of this clinical trial was to investigate the efficacy of Low frequency pulsed electromagnetic therapy (LFPEMT) in improving vascular-related quality of life (VQ) and spatiotemporal gait parameters in individuals with…
- Conditions
- Peripheral Arterial Disease (PAD), Diabete Type 2, Gait Abnormality, Quality of Life
- Trial name
- NCT07864805
- Testing
- Low-frequency pulsed electromagnetic therapy plus interval exercise training program
- Where
- Saudi Arabia
- Volunteers
- 60 people
- Sponsor
- Ashraf Abdelaal
Painful Diabetic Neuropathy
Efficacy and Safety of Eslicarbazepine Acetate as Therapy for Patients With Painful Diabetic Neuropathy
The primary objective of the study is to assess the efficacy of eslicarbazepine acetate (ESL) as therapy for patients with painful diabetic neuropathy.
- Trial name
- NCT00980746
- Testing
- Eslicarbazepine acetate
- Volunteers
- 557 people
- Sponsor
- Bial - Portela C S.A.
Diabetes Mellitus, Type 1, Albuminuria
Effect of Butyrate on Inflammation and Albuminuria in Patients With Albuminuria, Type 1 Diabetes and Intestinal Inflammation
The objective is to assess the impact of 12 weeks supplement of sodium-butyrate twice daily or placebo on intestinal inflammation and albuminuria.
- Trial name
- NCT04073927
- Testing
- Sodium butyrate
- Where
- 2 sites in Denmark, Finland
- Volunteers
- 48 people
- Sponsor
- Steno Diabetes Center Copenhagen
Vitamin D, Gestational Diabetes
Vitamin D Supplementation for the Prevention of GDM
This study was a double-blind multicenter randomized controlled study.
- Trial name
- NCT05208827
- Testing
- Vitamin D3
- Where
- China
- Volunteers
- 1,600 people, healthy volunteers welcome
- Sponsor
- Women's Hospital School Of Medicine Zhejiang University
Diabetes Mellitus Type 2
A Study of The Effect of Aleglitazar on Insulin Sensitivity in Patients With Type 2 Diabetes Mellitus Who Are Inadequately Controlled With Metformin
This single-center, randomized, double-blind, placebo-controlled study will evaluate the effect of aleglitazar on insulin sensitivity in patients with type 2 diabetes mellitus who are inadequately controlled on metformin…
- Trial name
- NCT01729403
- Testing
- aleglitazar, metformin
- Where
- Germany
- Volunteers
- 57 people
- Sponsor
- Hoffmann-La Roche
Diabetes Mellitus
Effects of a Patient Portal Intervention to Address Diabetes Care Gaps
The purpose of this study is to evaluate the effect of a novel patient portal intervention on the number of patients with diabetes care gaps (e.g., no diabetes eye exam i the last 12 months).
- Trial name
- NCT04894903
- Testing
- Diabetes Care Gaps Patient Portal Intervention
- Where
- United States
- Volunteers
- 440 people
- Sponsor
- Vanderbilt University Medical Center
Diabetes
Study of BMS-477118 as Monotherapy With Titration in Subjects With Type 2 Diabetes Who Are Not Controlled With Diet and Exercise
The purpose of this trial is to understand if saxagliptin is more effective than placebo as a treatment for type 2 diabetic subjects who are not controlled with diet and exercise
- Trial name
- NCT00316082
- Testing
- Saxagliptin, metformin
- Where
- 74 sites in United States, India and 2 more
- Volunteers
- 365 people
- Sponsor
- AstraZeneca
Diabetic Foot Disease, Diabetic Foot Ulcer (DFU)
Implementation of a Diabetic Foot Prevention Strategy in Primary Care (iMplanta Study)
The goal of this two-arm cluster randomised controlled trial (RCT) is to evaluate the effectiveness of a new implementation strategy based on the ImM model for the Protocol of assistance to the person with diabetic foot (PAPDF)…
- Trial name
- iMplanta (NCT07004179)
- Testing
- Implementation strategy developed using the Implementation Mapping model to enhance the effective integration of the Protocol for Assistance to People with Diabetic Foot
- Where
- Spain
- Volunteers
- 1,520 people
- Sponsor
- University of the Balearic Islands
Angina Pectoris, Coronary Artery Disease
A Study on the Effects of Ranolazine on Exercise Duration in Subjects With Chronic Stable Angina and Coronary Artery Disease (CAD) With Type 2 Diabetes Mellitus (T2DM)
This study will evaluate the efficacy of ranolazine compared to placebo on duration of exercise assessed by exercise tolerance testing (ETT) at anticipated peak ranolazine plasma concentration after 12 weeks of treatment in…
- Conditions
- Angina Pectoris, Coronary Artery Disease, Type 2 Diabetes Mellitus
- Trial name
- NCT01334203
- Testing
- Ranolazine
- Sponsor
- Gilead Sciences
Diabetic Retinopathy
A Study to Investigate the Efficacy and Safety of RG7774 in Patients With Diabetes Mellitus Type 1 or Type 2 With Treatment-Naive Diabetic Retinopathy
The study's main purpose is to asses the safety, tolerability, and effect of oral administration of RG7774 on the severity of diabetic retinopathy (DR) in participants with moderately severe to severe non-proliferative diabetic…
- Trial name
- CANBERRA (NCT04265261)
- Testing
- RG7774
- Where
- 68 sites in United States, Australia and 5 more
- Volunteers
- 139 people
- Sponsor
- Hoffmann-La Roche
Diabetic Foot Ulcer
A Dose Finding Study of Topically Applied I-020201 as an Adjunct to Good Standard-of-care in Patients With Chronic Diabetic Foot Ulcers
Although major improvements in the management and treatment of diabetic foot ulcers have been made, the clinical and financial burden of such long-term wounds is still high and is likely to increase as the general population…
- Trial name
- DFU (NCT00915486)
- Testing
- Good Standard of Care (GSoC), Vehicle, I-020201
- Where
- 34 sites in Czechia, Germany and 4 more
- Volunteers
- 211 people
- Sponsor
- Kuros Biosurgery AG
Smoking Cessation, Diabetes Type 2
Diabetes and Smoking Cessation: a Gender-Oriented Study
People with diabetes still smoke at equivalent rates as non-diabetics. There is lack of evidence regarding interventions for smoking cessation among individuals with diabetes.
- Trial name
- DiSCGO (NCT03426423)
- Testing
- Behavioral smoking cessation intervention, Control
- Where
- Switzerland
- Volunteers
- 48 people
- Sponsor
- Carole Clair
Type 2 Diabetes Mellitus, Hyperglycemia Due to Type 2 Diabetes Mellitus
NMES, Exercise, and Glycemic Control in Older Adults With Type 2 Diabetes
Adults aged 60 years and older with type 2 diabetes living in nursing homes may experience difficulty participating in conventional exercise programs because of frailty, mobility limitations, or chronic health conditions.
- Conditions
- Type 2 Diabetes Mellitus, Hyperglycemia Due to Type 2 Diabetes Mellitus, Aging
- Trial name
- NMES4GlyCon (NCT06856720)
- Testing
- Neuromuscular Electrical Stimulation, Combined Aerobic and Resistance Exercise, Health Literacy Education
- Where
- Portugal
- Volunteers
- 75 people
- Sponsor
- University of Salamanca
Diabetic Neuropathy
A Trial to Assess the Efficacy and Safety of SPM 927 (Lacosamide) in Subjects With Painful Distal Diabetic Neuropathy
This trial was conducted at about 50 sites in Europe and has been clinically completed. Patients had symptoms of painful diabetic neuropathy for 6 months up to 5 years with an optimized diabetic control and at least moderate…
- Trial name
- NCT00238524
- Testing
- SPM 927
- Where
- Germany
- Volunteers
- 357 people
- Sponsor
- UCB Pharma
Type 2 Diabetes Mellitus
A Study to Evaluate the Effect of Ranolazine on Postprandial Glucagon in Subjects With Type 2 Diabetes.
To explore the mechanism of action of ranolazine as a potential treatment for type 2 diabetes mellitus (T2DM).
- Trial name
- NCT01843127
- Testing
- Ranolazine, Exenatide
- Where
- 3 sites in United States
- Volunteers
- 24 people
- Sponsor
- Gilead Sciences
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