Clinical trials: Controlled Diabetes
Diabetes Mellitus, Type 2
Efficacy and Safety of Toujeo® Versus Tresiba® in Insulin-Naive Patients With Type 2 Diabetes Mellitus Inadequately Controlled With Oral Antihyperglycemic Drug(s) ± GLP-1 Receptor Agonist
Primary Objective: To demonstrate the noninferiority in the efficacy of Toujeo® to Tresiba® in glycated hemoglobin (HbA1c) change from Baseline to Week 24.
- Trial name
- BRIGHT (NCT02738151)
- Testing
- Insulin glargine, 300U/mL, Insulin degludec, 100 U/mL, Non-insulin anti-diabetic treatment
- Where
- 158 sites in United States, Bulgaria and 14 more
- Volunteers
- 929 people
- Sponsor
- Sanofi
Prediabetic State
Effect of Resistance Training on Metabolic Control and Outcome in Prediabetes (NMR-based Metabonomics)
This study evaluates the efficacy of a 12-month resistance training on metabolic control and reducing the risk of diabetes.
- Trial name
- NCT02561377
- Testing
- resistance training, aerobic training
- Where
- 2 sites in China
- Volunteers
- 276 people
- Sponsor
- Nanjing University of Traditional Chinese Medicine
Type 2 Diabetes Mellitus, Cardiovascular Risk Factors
Effectiveness of Nursing Care Plans Based in Nursing Diagnoses in Metabolic Control of Type 2 Diabetes Mellitus
Background: Nurses in clinical practice implement care to patients with Type 2 diabetes mellitus (DM2) in order to maintain normal blood glucose readings, promote weight loss and provide nutrition counseling to improve metabolic…
- Trial name
- NCT01482481
- Where
- Spain
- Volunteers
- 23,488 people
- Sponsor
- Hospital Carlos III, Madrid
Diabetes Mellitus, Type 2, Telerehabilitation
The Effect of a Supervised Home-based Tele-rehabilitation Program on Patients With Type 2 Diabetes
Tele-rehabilitation (TR) which carries health services distant through using electronic communication systems is an important treatment option.
- Trial name
- NCT05145465
- Testing
- Telerehabilitation group
- Where
- Greece
- Volunteers
- 24 people
- Sponsor
- University of Thessaly
Type 2 Diabetes
Clinical Trial of Pioglitazone Treatment in Patients With Type 2 Diabetes Mellitus and Covid-19
The treatment with pioglitazone added to the standard treatment of patients with DM2 hospitalized for COVID-19 may produce a decrease in the number of patients who progress to a second phase of severe systemic inflammation.
- Trial name
- NCT04535700
- Testing
- Pioglitazone 30 mg, standard of care
- Where
- Spain
- Volunteers
- 8 people
- Sponsor
- Fundacion para la Investigacion Biomedica del Hospital Universitario Ramon y Cajal
Non Alcoholic Steatohepatitis
A One-Year, Randomized, Double-Blind, Placebo-Controlled Trial of Rosiglitazone in Non-Alcoholic Steatohepatitis
This study is intended to find out whether treatment with rosiglitazone improves the state of the liver and related blood markers in patients with nonalcoholic steatohepatitis (NASH).
- Trial name
- FLIRT (NCT00492700)
- Testing
- rosiglitazone
- Where
- France
- Volunteers
- 63 people
- Sponsor
- Association pour la Recherche sur les Maladies Hépatiques Virales
Type 2 Diabetes Mellitus
Comparison of Pioglitazone Versus Glimepiride in Type 2 Diabetes Inadequately Controlled With Metformin Plus Alogliptin
The purpose of this study is to compare the treatment effect at week 26 between the two groups, sulfonylurea (SU, glimepiride) administration and thiazolidinedione (TZD, Pioglitazone) administration, as the third-order drug among…
- Trial name
- NCT02426294
- Testing
- Pioglitazone, Glimepiride
- Where
- South Korea
- Volunteers
- 154 people
- Sponsor
- Pusan National University Hospital
Impaired Glucose Tolerance, Diabetes
Effect of Ginseng on Glycemic Control
Ginseng (American ginseng, Asian ginseng, Korean ginseng etc) is expected to show positive hypoglycemic effects, including improvements in glycated blood proteins[HbA1c], fasting glucose, fasting insulin, and the homeostasis…
- Trial name
- NCT01841229
- Where
- Canada
- Volunteers
- 770 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Type2 Diabetes, NASH - Nonalcoholic Steatohepatitis
A Study of MSDC-0602K to Assess Glycemic Control and Cardiovascular Outcomes in Patients With Pre-T2D or T2D and NAFLD/NASH
This is a randomized, double-blind study of MSDC-0602K or placebo in subjects with pre-T2D or T2D and evidence of NAFLD/NASH.
- Conditions
- Type2 Diabetes, NASH - Nonalcoholic Steatohepatitis, Nonalcoholic Steatohepatitis, Non-Alcoholic Fatty Liver Disease
- Trial name
- NCT03970031
- Testing
- MSDC-0602K
- Volunteers
- 1,800 people
- Sponsor
- Cirius Therapeutics, Inc.
Type 2 Diabetes
BioDulse II: The Effect of an Irish Seaweed Protein Extract on Glucose Control in Adults With Type 2 Diabetes
Co-ingesting protein with carbohydrate is an effective way to improve postprandial glucose handling. The investigators have isolated and identified a bioactive protein extracted from seaweed.
- Trial name
- NCT05986253
- Testing
- Seaweed protein, Maltodextrin
- Where
- Ireland
- Volunteers
- 10 people
- Sponsor
- University of Limerick
Obesity, Overweight
A Safety and Efficacy Study Comparing Naltrexone SR/Bupropion SR and Placebo in Obese Subjects With Type 2 Diabetes
The purpose of this study is determine whether the combination of naltrexone SR and bupropion SR is safe and effective in treating obesity in subjects with type 2 diabetes.
- Conditions
- Obesity, Overweight, Diabetes Mellitus, Type 2
- Trial name
- NCT00474630
- Testing
- Naltrexone SR 32 mg/bupropion SR 360 mg/ day, Ancillary therapy
- Where
- 53 sites in United States
- Volunteers
- 505 people
- Sponsor
- Orexigen Therapeutics, Inc
Diabetic Foot Ulcers
Effectiveness of Buerger Allen Exercise Among Type 2 Diabetes Mellitus Patients With Foot Ulcer
This study was conducted to determine the effect of Buerger Allen exercises on lower extremity perfusion and wound healing in patients with foot ulcer type 2 diabetes.
- Trial name
- NCT05747872
- Testing
- Buerger Allen Exercises
- Where
- Turkey (Türkiye)
- Volunteers
- 72 people
- Sponsor
- Gazi University
Diabetic Neuropathy Peripheral
Effects of BFRT on Glycemic Control, Nerve Conduction, Functional Outcomes and QOL in Individuals With Type 2 Diabetes
Diabetic peripheral neuropathy is one of the most prevalent complications of Type 2 Diabetes Mellitus. Peripheral neuropathy is caused by unavailability of glucose in cells and low metabolism.
- Trial name
- NCT07763795
- Testing
- BFR with low resistance high repetition exercises, low resistance high repetition exercises
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- Superior University
Diabetes Mellitus, Type 2
The CANTATA-D Trial (CANagliflozin Treatment and Trial Analysis - DPP-4 Inhibitor Comparator Trial)
The purpose of this study is to evaluate the efficacy and safety of canagliflozin compared with sitagliptin and placebo in patients with type 2 diabetes mellitus who are receiving treatment with metformin monotherapy (i.e.…
- Trial name
- NCT01106677
- Testing
- Canagliflozin, Sitagliptin, Metformin immediate release
- Where
- 125 sites in United States, Argentina and 20 more
- Volunteers
- 1,284 people
- Sponsor
- Janssen Research & Development, LLC
PreDiabetes, Overweight and Obesity
Zein Nanoparticles for Glycemic Control
The use of zein nanoparticles as vehicles for drug delivery is under study, but of the effects observed in empty nanoparticles, in laboratory animals, the reduction of glucose levels was something worth studying.
- Conditions
- PreDiabetes, Overweight and Obesity, Adult ALL
- Trial name
- GLUCOCAPS (NCT05560412)
- Testing
- Zein nanocapsules, control
- Where
- Spain
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- Clinica Universidad de Navarra, Universidad de Navarra
Diabetic Foot Ulcer Neuropathic, Diabetic Foot Ulcer
Evaluating the Effectiveness of Piscean Derived Collagen Dressing on Neuropathic Diabetic Foot Ulcer in T2DM Patients
Diabetic foot ulcers (DFU) are challenging to treat with complicated healing processes and require advanced wound care. Piscean collagen has the potential to promote the regenerative process while remaining cost-effective and…
- Trial name
- NCT05324930
- Testing
- Piscean collagen dressing, Saline infused dressing
- Where
- Pakistan
- Volunteers
- 180 people
- Sponsor
- Corporacion Parc Tauli
Diabete Type 1
Eating Disturbances in Patients With Type 1 Diabetes Initiating Insulin Therapy
The prevalence of eating disorders is particularly high among people with type 1 diabetes (T1D). These abnormalities, such as "diabulimia," are frequently responsible for poor insulin therapy management and, consequently, chronic…
- Trial name
- CALI-BF (NCT07151924)
- Testing
- Questionnaires answers, Biological assessment
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Toulouse
Type 2 Diabetes Mellitus
Efficacy and Safety of Hebenrun in Patients With Type 2 Diabetes
This study aims to evaluate the efficacy and safety of Hebenrun (a functional food based on natural grain bran) combined with metformin in patients with type 2 diabetes mellitus (T2DM).
- Trial name
- NCT07768280
- Testing
- Metformin, Hebenrun
- Where
- China
- Volunteers
- 110 people
- Sponsor
- Jiangxi University of Traditional Chinese Medicine
Type 2 Diabetes Mellitus With Complication
Efficacy and Safety of Bifidobacterium Quadruple Live Tablets in Patients With T2DM and Constipation
Constipation is one of the common complication of diabetes mellitus, whose pathogenesis was previously recognized as decreased gastrointestinal motility caused by diabetic autonomic neuropathy.
- Trial name
- NCT04982380
- Testing
- Bifidobacterium, Lactobacillus, Enterococcus and Bacillus Cereus Tablets, Live, Siliankang simulating tablets
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Peking Union Medical College Hospital
Type 1 Diabetes
The International Diabetes Closed Loop (iDCL) Trial: Protocol 4
The investigators aim to compare the efficacy and safety of an AID system using an adaptive MPC algorithm versus SAP (which may or may not include PLGS; to be referred to as SAP) in people with type 1 diabetes.
- Trial name
- DCLP4 (NCT04436796)
- Testing
- interoperable Artificial Pancreas System (iAPS), Sensor-Augmented Pump (SAP)/Predictive Low Glucose Suspend (PLGS)
- Where
- 5 sites in United States
- Volunteers
- 35 people
- Sponsor
- Sansum Diabetes Research Institute
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