Clinical trials: Controlled Diabetes
Type 2 Diabetes
A Study of Prusogliptin Tablets Combined With Dapagliflozin Tablets and Metformin Hydrochloride Extended Release Tablets in Type 2 Diabetes
This study is a multicenter, randomized, double-blind, parallel-controlled, phase III clinical trial to evaluate efficacy and safety of the triple combination therapy of prusogliptin, dapagliflozin and metformin in subjects with…
- Trial name
- NCT07026968
- Where
- China
- Volunteers
- 815 people
- Sponsor
- CSPC Ouyi Pharmaceutical Co., Ltd.
Type 2 Diabetes Mellitus
Efficacy and Safety of Sotagliflozin Versus Placebo in Patients With Type 2 Diabetes Mellitus on Background of Metformin
Primary Objective: To demonstrate the superiority of Sotagliflozin versus placebo on hemoglobin A1c (HbA1c) reduction in participants with type 2 diabetes (T2D) who have inadequate glycemic control with metformin.
- Trial name
- NCT02926950
- Testing
- Sotagliflozin (SAR439954), Metformin
- Where
- 93 sites in United States, Canada and 2 more
- Volunteers
- 518 people
- Sponsor
- Lexicon Pharmaceuticals
Type 1 Diabetes
Effect of the InsuPatch on Automated Closed-loop Glucose Control in Type 1 Diabetes
This research study designed to look at how well adolescents' and young adults' blood sugars can be controlled with a "closed loop artificial pancreas" using a continuous glucose sensor, an insulin pump, and a computer program…
- Trial name
- IPCL (NCT01787318)
- Testing
- ePID closed loop system, InsuPatch
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Yale University
Pain, Infant, Newborn
Using Sugar Water to Relieve Pain in Infants
This study will examine the safety and effectiveness of sugar water to relieve pain in newborn infants during painful blood tests and injections.
- Conditions
- Pain, Infant, Newborn, Diabetes
- Trial name
- NCT00213213
- Testing
- Sucrose
- Where
- Canada
- Volunteers
- 240 people
- Sponsor
- The Hospital for Sick Children
Diabetes Mellitus, Type 2
A Study to Determine the Safety and Efficacy of Albiglutide Administered in Combination With Insulin Glargine
This study will examine the safety and efficacy of albiglutide in combination with insulin glargine as compared with the combination of insulin glargine and preprandial lispro insulin in subjects with type 2 diabetes.
- Trial name
- NCT00976391
- Testing
- albiglutide + insulin glargine, insulin glargine + preprandial lispro insulin
- Where
- 209 sites in United States, Brazil and 12 more
- Volunteers
- 586 people
- Sponsor
- GlaxoSmithKline
Diabetes Mellitus, Type 2
Single-Dose Study Of PF-04603629 In Type 2 Diabetic Subjects
PF 04603629 is a long acting exendin proposed for the treatment of Type 2 diabetes mellitus. The purpose of this study is to characterize the safety, tolerability, pharmacokinetics and glucose lowering capabilities following a…
- Trial name
- NCT00638313
- Testing
- PF-04603629
- Where
- 2 sites in United States
- Volunteers
- 71 people
- Sponsor
- Pfizer
Type 1 Diabetes Mellitis
Evaluation of Insulin Glulisine (GP40321) Compared to Insulin Glulisine (Apidra® SoloStar®) in Type 1 Diabetes Mellitus Patients
The goal of this clinical trial is to demonstrate the non-inferior immunogenicity of GP40321 compared to Apidra® SoloStar® at a concentration of 100 U/mL in type 1 diabetes mellitus patients.
- Trial name
- NCT07070752
- Testing
- GP40321, Apidra® SoloStar®, RinGlar®
- Where
- 17 sites in Russia
- Volunteers
- 224 people
- Sponsor
- Geropharm
Prediabetes, Overweight
FRESH Study (Fitness, Relaxation and Eating to Stay Healthy)
To examine whether a lifestyle program results in weight loss and thereby delays or prevents progression of pre-diabetes to diabetes, we propose a pilot randomized controlled trial of 6 weeks duration with 30 participants held at…
- Trial name
- FRESH (NCT01636258)
- Testing
- Stress Management, Diet, Exercise
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- The Cleveland Clinic
Diabetes, Metabolic Syndrome
Cardiac CT's Role in Asymptomatic Patients With Diabetes and Metabolic Syndrome
This study looked at the role of cardiac CT in improving risk factor control in those with diabetes.
- Trial name
- CTRAD (NCT01564485)
- Testing
- Cardiac CT, Usual medical care
- Where
- United States
- Volunteers
- 193 people, healthy volunteers welcome
- Sponsor
- University of California, Irvine
Type 2 Diabetes Mellitus
Feasibility Of Individualized Dietary Plan (Idp) On Glycemic Control And Total Cholestrol In Diabetic Patients At Diabetes Hospital And Research Centre Peshawar
This study aims to test whether a personalized meal plan (Individualized Dietary Plan, IDP) is practical and helpful for adults with type 2 diabetes in Peshawar, Pakistan.
- Trial name
- NCT07030543
- Testing
- Individualized Dietary Plan (IDP) for Type 2 Diabetes, Usual care
- Where
- Pakistan
- Volunteers
- 122 people
- Sponsor
- Khyber Medical University Peshawar
Smoking Cessation, Diabetes
Efficacy And Safety Of Smoking Cessation With Varenicline Tartrate In Diabetic Smokers: (DIASMOKE)
Objectives This protocol is intended to provide information regarding the efficacy and safety of the nicotine partial agonist varenicline tartrate, at a dose of 1 mg twice daily, for smoking cessation in diabetic subjects who…
- Trial name
- DIASMOKE (NCT01387425)
- Testing
- varenicline
- Where
- 2 sites in Italy
- Volunteers
- 300 people
- Sponsor
- University of Catania
Nonalcoholic Fatty Liver, Nonalcoholic Steatohepatitis
Prevalence of NAFLD and Advanced Fibrosis in Patients With Type 1 Diabetes
The aim of this study is to assess the prevalence of nonalcoholic fatty liver disease (NAFLD) in patients with type 1 diabetes receiving care at Joslin clinic using noninvasive imaging and serum-based methods with the goal of…
- Conditions
- Nonalcoholic Fatty Liver, Nonalcoholic Steatohepatitis, Fibrosis, Liver, Type 1 Diabetes
- Trial name
- NCT04595474
- Testing
- Transient Elastography
- Where
- United States
- Volunteers
- 533 people
- Sponsor
- Joslin Diabetes Center
PreDiabetes
Effect of Melatonin and Metformin on Glycemic Control Genotoxicity and Cytotoxicity Markers in Patients With Prediabetes
Melatonin is a hormone that regulates the circadian cycle in addition to having an antioxidant effect. Patients with prediabetes state, has a deregulation of glucose metabolism and an overproduction of reactive oxygen species…
- Trial name
- NCT03848533
- Testing
- melatonin, metformin
- Where
- Mexico
- Volunteers
- 42 people
- Sponsor
- University of Guadalajara
Prediabetes
Effect of Coadministration of Ume Paste (Prunus Mume) and Ginger Powder
This study is designed to evaluate the effect of ume paste and ginger powder on glucose metabolism in prediabetic subjects.
- Trial name
- NCT02213549
- Testing
- Ume paste and ginger powder
- Where
- Japan
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Hiroshima University
Diabetes Mellitus
Measurement Algorithm Control, Optimization, and Performance Evaluation of the Vital USA GlucoseDetect
Measurement Algorithm Control and Optimization with Subsequent Performance Evaluation of the Vital USA GlucoseDetect™ During a Standardized Meal Test in Patients with Diabetes mellitus Type 1 and Type 2
- Trial name
- NCT04340648
- Testing
- Vital GlucoseDetect
- Where
- Germany
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Sciema UG
Depression, Diabetes
Effectiveness of a mHealth Intervention for the Treatment of Depression in People With Diabetes or Hypertension in Peru
Background: Depression is a common comorbidity of physical chronic diseases such as diabetes and/or hypertension and constitutes an important public health problem.
- Conditions
- Depression, Diabetes, Hypertension
- Trial name
- LATIN-MHPeru (NCT03026426)
- Testing
- CONEMO
- Where
- 8 sites in Peru
- Volunteers
- 432 people
- Sponsor
- Universidad Peruana Cayetano Heredia
Prediabetic State, Dysglycemia
Clinical Trial to Evaluate the Efficacy and Safety of the Probiotic Strains Limosilactocillus Reuteri DSM 32910 and Lacticaseibacillus Paracasei DSM 32851 on Glucose Homeostatis in Prediabetic Adults
The aim of this international, randomized, parallel arms, double-blind, placebo-controlled clinical trial is to investigate the safety and efficacy of a combination of the two Lactobacillus strains (NZ-GHMH-01) on glucose and…
- Trial name
- NOVOGLUCOSE (NCT04767789)
- Testing
- NZ-GHMH-01
- Where
- 8 sites in France, Romania and 1 more
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Novozymes A/S
Type 2 Diabetes Mellitus
Phase 4: Investigational Study to Evaluate Metformin XR Monotherapy Versus Metformin IR Monotherapy in Subjects With Type 2 Diabetes
The purpose of this study is determine if Metformin XR monotherapy in subjects with type 2 diabetes is non-inferior to Metformin IR monotherapy
- Trial name
- NCT01864174
- Testing
- Metformin XR, Metformin IR
- Where
- 156 sites in United States, Canada and 8 more
- Volunteers
- 1,736 people
- Sponsor
- Bristol-Myers Squibb
Diabetic Kidney Disease, IgA Nephropathy
A Study to Evaluate the Efficacy and Safety of SC0062 in the Treatment of Chronic Kidney Disease
This is a phase II study to investigate the safety, preliminary efficacy and pharmacokinetics of SC0062 capsule in patients with chronic kidney disease (diabetic kidney disease and IgA nephropathy)with albuminuria compared to…
- Trial name
- NCT05687890
- Testing
- SC0062 low dose, SC0062 medium dose, SC0062 high dose
- Where
- China
- Volunteers
- 255 people
- Sponsor
- Biocity Biopharmaceutics Co., Ltd.
Diabetes Mellitus, Type 1
An Outpatient Study of Automated Blood Glucose Control With an Insulin-Only Bionic Pancreas
This is an open-label, non-randomized, pilot study to determine the safety and feasibility of the insulin-only bionic pancreas.
- Trial name
- NCT02536950
- Testing
- Fixed set point, Variable set point
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Bruce A. Buckingham
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