Clinical trials: Controlled Diabetes
Diabetic Foot
Removable Walker for Neuropathic Ulcers
1. Objective: To evaluate the efficacy of removable cast walker compared to non-removable fiberglass off-bearing cast in the treatment of diabetic plantar foot ulcer 2.
- Trial name
- NCT01005264
- Testing
- non-removable fiberglass, Stabil-D®
- Where
- Italy
- Volunteers
- 48 people
- Sponsor
- IRCCS Multimedica
Mental Health Issue, Depression
Development and Validation of Psycho-Social Program (PSP)
The study aims to determine the effectiveness of a structured psycho-social program (PSP) in improving mental health outcomes among patients with Type 2 diabetes mellitus (T2DM).
- Conditions
- Mental Health Issue, Depression, Diabetes Distress, Quality of Life
- Trial name
- PSP-T2DM (NCT07456410)
- Testing
- Psycho-Social Program
- Where
- Pakistan
- Volunteers
- 80 people
- Sponsor
- Government College University Faisalabad
Primary Mitochondrial Disease
Efficacy of KL1333 in Adult Patients With Primary Mitochondrial Disease
The primary objective of the FALCON study is to evaluate the efficacy of KL1333 on selected disease manifestations of primary mitochondrial disease (PMD) following 48 weeks of treatment.
- Trial name
- FALCON (NCT05650229)
- Testing
- KL1333
- Where
- 55 sites in United States, Australia and 9 more
- Volunteers
- 180 people
- Sponsor
- Pharming Technologies B.V.
Urinary Tract Infection, Kidney Failure
Healthy.io Method Comparison & User Performance Study
The objectives of the Healthy.io Method Comparison and User Performance Study are: 1. To evaluate the performance of Dip.io Device in comparison to the ACON U500 Mission® U500 Urine Analyzer. 2.
- Conditions
- Urinary Tract Infection, Kidney Failure, Diabetes
- Trial name
- NCT02785445
- Testing
- Dip.io Home Based Dipstick Analyzer, ACON U500 Mission® U500 Urine Analyzer
- Where
- 2 sites in United States
- Volunteers
- 425 people, healthy volunteers welcome
- Sponsor
- Healthy.io Ltd.
Type 2 Diabetes Mellitus
Pharmacist Counseling on the Health-related Quality of Life of Patients With Type 2 Diabetes Mellitus
The quality of life (QoL) of patients with type 2 diabetes mellitus (T2DM) is a measure of the successful outcomes of therapy. The program of management of chronic diseases "Program Pengelolaan Penyakit Kronis" (Prolanis) among…
- Trial name
- NCT04313829
- Testing
- Pharmacist Counseling Intervention
- Where
- 4 sites in Indonesia
- Volunteers
- 220 people
- Sponsor
- Universitas Padjadjaran
Diabetes Mellitus, Type 2
A Safety and Efficacy Study of Canagliflozin in Older Patients (55 to 80 Years of Age) With Type 2 Diabetes Mellitus
The purpose of this study is to evaluate the efficacy and safety of 2 different doses of canagliflozin compared with placebo in older patients (55 to 80 years of age) with type 2 diabetes mellitus (T2DM) with inadequate control…
- Trial name
- NCT01106651
- Testing
- Canagliflozin 100 mg, Canagliflozin 300 mg, Antihyperglycemic agent(s)
- Where
- 86 sites in United States, Australia and 15 more
- Volunteers
- 716 people
- Sponsor
- Janssen Research & Development, LLC
Pre-diabetes
Anti-hyperglycemic Effect of Short-term Arginyl-fructose Supplementation in Subjects With Pre-diabetes and Newly Diagnosed Type 2 Diabetes: Randomized, Double-blinded, Placebo-controlled Trial.
In this double-blind, placebo-controlled study, subjects with prediabetes and type 2 diabetes were randomly assigned to the placebo control group or the test (Arginyl-fructose: AF) group.
- Trial name
- NCT02285231
- Testing
- Arginyl-fructose
- Volunteers
- 60 people
- Sponsor
- Yonsei University
Gestatiaonl Diabetes Mellitus
The Role of Progesterone Membrane Receptors in the Development of Gestational Diabetes Mellitus
The aim of this study is to investigate the potential roles of PGRMC1, PGRMC2, and PAQR family membrane progesterone receptors in the pathophysiology of gestational diabetes mellitus by comparing their expression levels in…
- Trial name
- NCT07750431
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Samsun University
Type 2 Diabetes
The Effects of Specialty Coffee on Cognitive Function in People With Type 2 Diabetes
Coffee has been found to have beneficial effects on cognitive function and blood sugar control. Benefits include reduced risk of cognitive decline and improved performance on cognitive tests, as well as reduced risk of diabetes…
- Trial name
- NCT05709847
- Testing
- Coffee
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- University of Reading
Diabetes Mellitus, Type 1
Randomized Trial of Supplemental Synchronous and Asynchronous Telehealth to Improve Glycemic Control for Pediatric Patients With Type 1 Diabetes
This study will test the hypothesis that supplemental synchronous video visits and supplemental asynchronous remote monitoring can each significantly improve glycemic control for pediatric patients with uncontrolled type 1…
- Trial name
- NCT04428658
- Testing
- Supplemental video visits, Standard of Care, Supplemental remote monitoring
- Where
- United States
- Volunteers
- 82 people
- Sponsor
- University of California, Davis
Diabetic Foot Ulcer, Diabetes
Hyperbaric Oxygen Therapy in Diabetics With Chronic Foot Ulcers and Improvement of Quality of Life
This study evaluated the effect of hyperbaric oxygen therapy (HBOT) on wound healing, inflammation index, glycemic control, amputation rate, survival rate of tissue, bacterial wound cultures, and quality of life (QOL) in diabetic…
- Trial name
- NCT02328508
- Testing
- Hyperbaric oxygen therapy
- Volunteers
- 38 people
- Sponsor
- Chen-Yu Chen
Diabetic Polyneuropathy, Weight Loss
Evaluating the Effect of Diabetes Control Through Intensive Lifestyle Modifications on Diabetic Peripheral Neuropathy
The purpose of this study is to find out the impact of improving diabetes control through weight reduction and lifestyle changes on a common diabetes complication called peripheral neuropathy.
- Trial name
- NCT01565317
- Testing
- Weight Achievement and Intensive Treatment (Why WAIT)
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Joslin Diabetes Center
Type 2 Diabetes
Efficacy and Safety of HRS-7535 Tablets in T2DM Subjects Poorly Controlled With Metformin and SGLT2i.
2 weeks screening period, 3 weeks run-in period, 16 weeks double-blind treatment period, to evaluate the Safety and Efficacy of HRS-7535 in Subjects with Type 2 Diabetes who have Inadequate Glycemic Control on Metformin and…
- Trial name
- NCT06393348
- Testing
- HRS-7535
- Where
- China
- Volunteers
- 155 people
- Sponsor
- Shandong Suncadia Medicine Co., Ltd.
Type 2 Diabetes Mellitus
A Study of the Efficacy and Safety of Ertugliflozin in Participants With Type 2 Diabetes Mellitus With Stage 3 Chronic Kidney Disease Who Have Inadequate Glycemic Control on Antihyperglycemic Therapy (MK-8835-001)
This study will evaluate the efficacy and safety of ertugliflozin (MK-8835/PF-04971729) in participants with Type 2 diabetes mellitus with Stage 3 Chronic Kidney Disease (CKD) who have inadequate glycemic control on background…
- Trial name
- NCT01986855
- Testing
- Ertugliflozin 5 mg, Ertugliflozin 10 mg
- Volunteers
- 468 people
- Sponsor
- Merck Sharp & Dohme LLC
Type 2 Diabetes
Study to Assess the Efficacy and Safety of iNCDSS in Type 2 Diabetes Mellitus Patients
This is a multi-center, single-blind, parallel group, randomized controlled trial to access the effect and safety of the Artificial Intelligence Assisted Insulin Titration System (iNCDSS) in patients with Type 2 Diabetes Mellitus.
- Trial name
- iNCDSS-3 (NCT04642378)
- Testing
- iNCDSS based insulin regime, routine insulin treatment regime
- Where
- China
- Volunteers
- 149 people
- Sponsor
- Shanghai Zhongshan Hospital
Type 2 Diabetes Mellitus
Safety and Efficacy of XOMA 052 in Subjects With Type 2 Diabetes Mellitus on Stable Metformin Monotherapy
The study hypothesis is that XOMA 052 improves glycemic control in subjects with Type 2 Diabetes. Study X052078 is designed to establish efficacious dose(s) for future studies based on improvement in HbA1c.
- Trial name
- NCT01066715
- Testing
- XOMA 052
- Where
- 67 sites in United States
- Volunteers
- 421 people
- Sponsor
- XOMA (US) LLC
Diabetes Mellitus, Type 2
A Randomized Trial of Diabetes Prevention Through Lifestyle Change in India
People from the Indian subcontinent are more likely to get diabetes, even at younger ages. The Diabetes Community Lifestyle Improvement Program (D-CLIP) will test in a randomized trial if a culturally specific, community-based…
- Trial name
- D-CLIP (NCT01283308)
- Testing
- Lifestyle Intervention, Standard of Care
- Where
- India
- Volunteers
- 599 people, healthy volunteers welcome
- Sponsor
- Emory University
Hammer Toe Syndrome, Foot Ulcer, Diabetic
Flexor Tenotomy and Ulcer Recurrence
The main purpose of this study is to assess the efficacy of flexor tenotomy on the prevention of recurrence of toe ulcers in people with diabetes and a history of toe ulceration.
- Trial name
- NCT05228340
- Testing
- Flexor tenotomy
- Where
- Netherlands
- Volunteers
- 66 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Type 2 Diabetes
Liraglutide Hospital Discharge Trial
High blood glucose levels in hospitalized patients with diabetes are associated with increased risk of medical complications and death.
- Trial name
- NCT01919489
- Testing
- Liraglutide + OADs, Glargine + OADs
- Where
- 5 sites in United States
- Volunteers
- 273 people
- Sponsor
- Emory University
Type 2 Diabetes
A Study on Switching From Daily DPP-4 Inhibitor to HSK7653 in Type 2 Diabetes Patients
To assess the effectiveness of HSK7653 tablets following the substitution of daily DPP-4 inhibitor (DPP-4i) over a 24-week treatment period.
- Trial name
- NCT06703268
- Testing
- HSK7653 10 mg, Daily DPP-4 inhibitor
- Where
- China
- Volunteers
- 64 people
- Sponsor
- Haisco Pharmaceutical Group Co., Ltd.
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