Clinical trials: Convulsion, Non-Epileptic
Convulsion, Non-Epileptic, Conversion Disorder
Treatments for Psychogenic Nonepileptic Seizures (NES)
The investigators propose that treatment of the comorbid disorders (depression, anxiety, and impulsivity) with sertraline in patients with lone psychogenic nonepileptic seizures (NES), will result in a decreased number of NES.
- Conditions
- Convulsion, Non-Epileptic, Conversion Disorder, Depression, Stress Disorders, Post-Traumatic
- Trial name
- NES (NCT00159965)
- Testing
- sertraline
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- Rhode Island Hospital
Epilepsy
Activating Effects of Sleep Deprivation on Synchronized MEG-EEG Recordings of Epilepsy Patients With Non-Diagnostic EEG
This study will evaluate how the state of being completely deprived of sleep has an effect on recordings of magnetoencephalography (MEG) and electroencephalography (EEG), in relation to how alert someone is and how sleepy someone…
- Trial name
- NCT00071370
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Psychogenic Nonepileptic Seizures, Dissociative Seizures
ADIE-FS - Aligning Dimensions of Interoceptive Experience in Patients With Functional Seizures
Functional seizures are common and harmful. They look like epileptic seizures but are not caused by the excess electrical discharges in the brain that arise in epilepsy.
- Conditions
- Psychogenic Nonepileptic Seizures, Dissociative Seizures, Psychogenic Pseudoseizure, Functional Neurological Disorder
- Trial name
- ADIE-FS (NCT06105996)
- Testing
- Interoceptive training
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- University College, London
Functional Neurological Disorder, Dissociative Seizures
The Feasibility and Acceptability of an Online Yoga Program for People With Functional Neurological Disorders
This is a feasibility study to see if it is acceptable and helpful for people living with a functional neurological disorder to receive online group yoga sessions to improve their wellbeing
- Conditions
- Functional Neurological Disorder, Dissociative Seizures, Psychogenic Seizure, Non-Epileptic Seizure
- Trial name
- YOGA-FUND (NCT07077603)
- Testing
- A12 week, twice weekly, small group, online yoga program
- Volunteers
- 30 people
- Sponsor
- Nottingham University Hospitals NHS Trust
STXBP1 Encephalopathy with Epilepsy
Natural History Study in Pediatric Patients with STXBP1 Encephalopathy with Epilepsy
This is a prospective, non-interventional, longitudinal study designed to characterize the natural history of STXBP1 related encephalopathy with epilepsy, in participants ≤ <5 years of age.
- Trial name
- NCT05462054
- Sponsor
- Capsida Biotherapeutics, Inc.
Psychogenic Non Epileptic Seizure
Evaluation of a Telephone Follow-up Procedure on the Quality of Life in Psychogenic Non-epileptic Seizures
The goal of this study is to evaluate effectiveness of the phone follow-up method compared to the conventional filler taken one.
- Trial name
- EDUQ-CPNE (NCT02311829)
- Testing
- Telephone follow-up device
- Where
- 4 sites in France
- Volunteers
- 136 people
- Sponsor
- Central Hospital, Nancy, France
Localization-Related (Focal) (Partial) Idiopathic Epilepsy and Epileptic Syndromes With Seizures of Localized Onset, TRAIL: Tumor Necrosis Factor Related Apoptosis Inducing Ligand MCP-2
Inflammatory Biomarkers in Psychogenic Non-epileptic Seizure
1. Evaluation of the role of TRAIL and MCP-2 in differentiation between epileptic seizure and psychogenic non-epileptic seizure. 2. Possible role to predict the prognosis of patients with epileptic seizure.
- Conditions
- Localization-Related (Focal) (Partial) Idiopathic Epilepsy and Epileptic Syndromes With Seizures of Localized Onset, TRAIL: Tumor Necrosis Factor Related Apoptosis Inducing Ligand MCP-2, MCP-2: Monocyte Chemo-attractant Protein-2
- Trial name
- seizure (NCT05571371)
- Testing
- Measuring inflammatory serum biomarkers
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Esraa Mostafa Ahmed Abdel Aal
Convulsion, Non-Epileptic
Automated Identification of Psychogenic Nonepileptic Seizures
A retrospective validation study of a post-processing method intended to identify psychogenic nonepileptic seizures
- Trial name
- NCT03013348
- Testing
- Brain Sentinel's sEMG Post-processing algorithm
- Volunteers
- 104 people
- Sponsor
- Brain Sentinel
Convulsion, Non-Epileptic
Auricular Acupuncture For The Treatment Of Non-Epileptic Seizures
This feasibility study will determine the tolerability of auricular acupuncture, compliance with self-reported seizure tracking, and the quality of a proposed sham acupuncture protocol to inform the design of a large…
- Trial name
- NCT01919307
- Testing
- Auricular acupuncture
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- Denver Health and Hospital Authority
Psychogenic Non-Epileptic Seizure, Depression
Project UPLIFT for Psychogenic Non-Epileptic Seizures
Developed by researchers from the Centers for Disease Control and Prevention (CDC), Project UPLIFT (Using Practice and Learning to Increase Favorable Thoughts) is a group telephone program designed to improve depression for…
- Conditions
- Psychogenic Non-Epileptic Seizure, Depression, Non-Epileptic Seizure, Psychogenic Seizure
- Trial name
- PNES (NCT03329703)
- Testing
- Project UPLIFT
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Convulsion, Non-Epileptic
Retraining and Control Therapy (ReACT) R33 Phase
The purpose of this study is to assess sense of control and catastrophic symptom expectations as targets for Retraining and Control Therapy (ReACT- an intervention focused on changing behaviors and thoughts) for treatment of…
- Trial name
- ReACT (NCT06007053)
- Testing
- ReACT, Supportive Therapy
- Where
- United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Biomarkers in Seizures
Inflammatory Biomarkers in Seizure
1. Evaluation of the role of TRAIL and MCP-2 in differentiation between epileptic seizure and psychogenic non-epileptic seizure. 2. Possible role to predict the prognosis of patients with epileptic seizure
- Trial name
- seizure (NCT05556109)
- Testing
- Inflammatory serum biomarkers
- Volunteers
- 90 people
- Sponsor
- Assiut University
Psychogenic Non-epileptic Seizures
Emotional Lived in Patients Suffering From Psychogenic Nonepileptic Seizures : Study by Functional Magnetic Resonance Imaging
Currently, hypothetical models of understanding Psychogenic Non-epileptic Seizures (PNES) involve emotional dysregulation. The hypothesis of a disorder of emotional experience is mainly based on behavioral data and disturbance of…
- Trial name
- EMOCRISES (NCT02976545)
- Testing
- fMRI (functional Magnetic Resonance Imaging), psychiatric evaluation
- Where
- France
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Central Hospital, Nancy, France
Movement Disorders
Neurobiology of Functional Movement Disorder and Non-Epileptic Seizures
This study is part of a series of studies that will explore how the mind and the brain work to cause episodes of uncontrollable shaking in people who have no known underlying brain or medical disorder.
- Trial name
- NCT00500994
- Testing
- MRI
- Where
- 2 sites in United States
- Volunteers
- 254 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Psychogenic Non-Epileptic Seizure
TMS vs Conventional Therapy for the Treatment of Functional Neurological Non Epileptic Seizure Disorder
The aim of the study is to compare the effect of Transcranial Magnetic Stimulation (TMS) versus treatment with selective serotonin reuptake inhibitors (SSRIs), in patients with diagnosis of Functional Neurological Non Epileptic…
- Trial name
- NCT05241366
- Testing
- Transcranial Magnetic Stimulation
- Where
- Mexico
- Volunteers
- 28 people
- Sponsor
- El Instituto Nacional de Neurologia y Neurocirugia Manuel Velasco Suarez
Epilepsy With Partial Onset Seizures With or Without Secondary Generalization
Lacosamid-i.v.-Register
Lacosamide is a new antiepileptic drug (AED) marketed as Vimpat with three different formulations, tablets, oral syrup and a solution for intravenous infusion.
- Trial name
- LCM (NCT01620840)
- Testing
- Lacosamide 10mg/ml
- Where
- Germany
- Volunteers
- 130 people
- Sponsor
- University Hospital Schleswig-Holstein
Epilepsy
A Dose-ranging Study With Brivaracetam in Patients From 16 to 65 Years With Refractory Partial Onset Seizures.
This trial will evaluate the efficacy and safety of brivaracetam (at doses of 5, 20 and 50 mg/day in twice a day administration) as add-on therapy in subjects with focal epilepsy.
- Trial name
- NCT00175825
- Testing
- Brivaracetam
- Where
- 42 sites in United States, Brazil and 2 more
- Volunteers
- 210 people
- Sponsor
- UCB Pharma
Idiopathic Generalized Epilepsy, Partial Onset Seizures
A Study to Investigate Dosage, Effectiveness, and Safety of Perampanel When Used as First Add-on Therapy in Participants >=12 Years With Partial Onset Seizures With or Without Secondary Generalization or With Primary Generalized Tonic-Clonic Seizures Associated With Idiopathic Generalized Epilepsy
The primary purpose of this study is to assess the retention rate of perampanel as a reliable proxy for overall effectiveness and tolerability in participants aged at least 12 years who are prescribed perampanel (for partial…
- Conditions
- Idiopathic Generalized Epilepsy, Partial Onset Seizures, Generalised Tonic-Clonic Seizures
- Trial name
- NCT04252846
- Testing
- Perampanel
- Where
- 36 sites in Denmark, France and 5 more
- Volunteers
- 191 people
- Sponsor
- Eisai Limited
Somatoform Disorders, Irritable Bowel Syndrome
Neurovegetative Decoupling in Somatoform Disorders : Biofeedback Interest
Evaluation of the physiological and clinical effects of the biofeedback training with patients suffering from somatoform disorders, depending on their neurovegetative profile related to a visceral-brain decoupling.
- Conditions
- Somatoform Disorders, Irritable Bowel Syndrome, Psychogenic Non-Epileptic Seizure
- Trial name
- BIOFEESOMATO (NCT04807933)
- Testing
- Heart rate variability Biofeedback [HRV-BFB]
- Where
- France
- Volunteers
- 46 people
- Sponsor
- University Hospital, Grenoble
Neuralgia, Epilepsy
Clinical Study With Lyrica In Patients Suffering From Epilepsy
Clinical study with Lyrica (pregabalin) in patients suffering from epilepsy. This drug is used as adjunctive therapy with one or more antiepileptics. Lyrica has potential to reduce seizure frequency.
- Trial name
- NCT00922987
- Testing
- Lyrica (pregabalin)
- Where
- 61 sites in Slovakia
- Volunteers
- 286 people
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.