Clinical trials: Coordination Impairment
Hereditary Ataxia, Spinocerebellar Degenerations
Telerehabilitation, Core Stability Exercises and Hereditary Ataxia (TRCore-ataxia)
Hereditary ataxias (HA) are a heterogeneous group of degenerative diseases of the cerebellum, brain stem and spinal cord. People who suffer from AH, among other symptoms, present deficiencies in the stability of the trunk, which…
- Conditions
- Hereditary Ataxia, Spinocerebellar Degenerations, Cerebellar Ataxia
- Trial name
- TRCore-ataxia (NCT06152133)
- Testing
- Therapeutic core stability exercises
- Where
- Spain
- Volunteers
- 12 people
- Sponsor
- Universitat de Lleida
Friedreich Ataxia
Study of the Efficacy and Safety of Nicotinamide in Patients With Friedreich Ataxia
Friedreich ataxia is the most frequent early-onset autosomal recessive hereditary ataxia. It is caused by a pathological expansion of a GAA repeat in the first intron of the frataxin gene (FXN) and results in decreased levels of…
- Trial name
- NICOFA (NCT03761511)
- Testing
- Nicotinamide
- Where
- 7 sites in Austria, France and 4 more
- Sponsor
- RWTH Aachen University
Friedreich Ataxia
Characterization of the Interruptions of the GAA Expansion and Study of Their Influence on the Severity of Friedreich's Ataxia
Friedreich's ataxia (FA) is the most frequent recessive genetic ataxia with an estimated prevalence of 1/50 000. The first symptoms appear around the age of 10 years with a progressive course and the need for an armchair 10- 15…
- Trial name
- INTREP-AF (NCT04346238)
- Testing
- Reuse of existing data from patients' medical records
- Where
- France
- Volunteers
- 120 people
- Sponsor
- University Hospital, Montpellier
Friedreich Ataxia
A Study of Vatiquinone for the Treatment of Participants With Friedreich Ataxia
The primary objective of the study is to assess the pharmacokinetics (PK) and safety of vatiquinone administered in participants with Friedreich ataxia (FA) younger than 7 years.
- Trial name
- NCT05485987
- Testing
- Vatiquinone
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- PTC Therapeutics
Dyssynergia, Constipation
Fecobionics in Biofeedback Therapy in Dyssynergia Patients
Constipation affects 12-19% of Americans. Pelvic floor dyssynergia is considered to play an important role in constipation but the underlying mechanisms are not well understood in individual patients.
- Trial name
- NCT05807321
- Testing
- Fecobionics
- Where
- 2 sites in United States
- Volunteers
- 24 people
- Sponsor
- The California Medical Innovations Institute, Inc.
Friedreich's Ataxia
A Study of Efficacy, Safety and Tolerability of Idebenone in the Treatment of Friedreich's Ataxia (FRDA) Patients
The purpose of this trial is to study the efficacy, safety and tolerability of idebenone in 12 months of treatment in children and adults with Friedreich's Ataxia.
- Trial name
- MICONOS (NCT00905268)
- Testing
- idebenone
- Where
- 13 sites in Austria, Belgium and 4 more
- Volunteers
- 232 people
- Sponsor
- Santhera Pharmaceuticals
Friedreich's Ataxia
Pilot Study of Varenicline (Chantix®) in the Treatment of Friedreich's Ataxia
The purpose of this study is to determine if varenicline is effective in treating symptoms of Friedreich's ataxia.
- Trial name
- NCT00803868
- Testing
- varenicline
- Where
- 2 sites in United States
- Volunteers
- 28 people
- Sponsor
- University of South Florida
Periodontitis, Gingivitis and Periodontal Diseases
MERC Proteins in Saliva and GCF in Periodontal Disease (ELISA Study)
This observational cross-sectional study investigates the levels of mitochondria-endoplasmic reticulum contact site (MERC) proteins in saliva and gingival crevicular fluid (GCF) of individuals with different periodontal…
- Conditions
- Periodontitis, Gingivitis and Periodontal Diseases, Biomarker Discovery and Validation, Pathways
- Trial name
- EKNMERC-GCF-SL (NCT07601685)
- Testing
- ELISA Biomarker Analysis, Calcium Measurement
- Where
- Turkey (Türkiye)
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Inonu University
Friedreich Ataxia, Rare Diseases
Understanding the Natural History Early in the Course or Presentation of Friedreich Ataxia
Multicenter, prospective, observational natural history and outcome measure study of children and young adults with Friedreich ataxia.
- Trial name
- EARLY-FA (NCT06560346)
- Testing
- Geneticlly confirmed disease causing FXN mutatuion, Healthy Control
- Where
- 7 sites in United States, Australia and 3 more
- Volunteers
- healthy volunteers welcome
- Sponsor
- Friedreich's Ataxia Research Alliance
Ataxia, Cerebrovascular Accident
PET Scan to Study Brain Control of Human Movement
Positron Emission Tomography (PET) is a technique used to investigate activity in areas of the brain. The PET technique allows researchers to study the normal processes in the brain (central nervous system) of normal individuals…
- Conditions
- Ataxia, Cerebrovascular Accident, Healthy, Movement Disorder
- Trial name
- NCT00001324
- Where
- United States
- Volunteers
- 510 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Cerebellar Ataxia
Longitudinal Monitoring of Energy Expenditure, Dynamic Stability and Fatigue During Gait in Patients With Cerebellar Ataxia Gene
Genetic cerebellar ataxias involves progressive degeneration of the cerebellum. Their overall prevalence is estimated at 2-4 cases per 100 000 people.
- Trial name
- NCT02903290
- Testing
- Longitudinal Monitoring of Energy Expenditure, Dynamic Stability and Fatigue During Gait, walking track GAITRite,manual dynamometer, and treadmill
- Where
- France
- Volunteers
- 15 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Constipation, Chronic Constipation
Balloon Inflation in Biofeedback
Chronic constipation, particularly due to dyssynergic defecation, is common and impacts quality of life. Biofeedback therapy (BFT) is the most effective conservative treatment, teaching patients to coordinate abdominal and anal…
- Conditions
- Constipation, Chronic Constipation, Dyssynergia, Anismus
- Trial name
- NCT07705542
- Testing
- Inflating anorectal catheter balloon to defecatory desired volume during push manoeuvres in biofeedback therapy., No intervention
- Where
- United Kingdom
- Volunteers
- 8 people
- Sponsor
- Hull University Teaching Hospitals NHS Trust
Hereditary Ataxia
Genotype-phenotype Correlation and Pathogenic Mechanism in Hereditary Ataxia
The investigators aimed to find appropriate biomarkers such as serum neurofilament light chain in reflecting disease severity in hereditary ataxia from a large cohort during long-term follow-up.
- Trial name
- NCT05160870
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Friedreich's Ataxia
A Study to Characterize the Cardiac Phenotype of Individuals With Friedreich's Ataxia (CARFA Study)
Friedreich's ataxia (FA) is an autosomal recessive disease with an incidence of 1/50,000 in the Caucasian population. The main manifestations of FA are progressive sensory and cerebellar ataxia and cardiomyopathy (CM).
- Trial name
- NCT02840669
- Testing
- Cardiac magnetic resonance imaging (CMR), Exercise-stress test, Echocardiography (ECHO)
- Where
- France
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Adverum Biotechnologies, Inc.
Spinocerebellar Degenerations
High-Dose Intravenous Immunoglobulin to Treat Cerebellar Degeneration
This study will examine whether high-dose intravenous immunoglobulin (IVIG) is safe and effective for treating cerebellar ataxia-degeneration of the cerebellum, the part of the brain responsible for coordinating muscle movements…
- Trial name
- NCT00034242
- Testing
- high-dose intravenous immunoglobulin (IVIG)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Ataxia Telangiectasia, Dysmetria
Videoocular Assessment of Eye Movement Activity in an Ataxia Telangiectasia
Ataxia-telangiectasia (A-T) is a multisystem auto-somal recessive disorder linked to the A-T mutated gene (ATM) on chromosome 11q22-23, and characterized by progressive neural degeneration, immunodeficiency, and progressive…
- Trial name
- NCT05471310
- Where
- Russia
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Federal Research Institute of Pediatric Hematology, Oncology and Immunology