Clinical trials: Cornea
Fuchs' Endothelial Dystrophy, Phacoemulsification
Fuchs' Torsional Phaco Study
The primary objective is to compare the effect of torsional phacoemulsification and longitudinal phacoemulsification on central and peripheral corneal thickness/volume after cataract surgery in patients with Fuchs' endothelial…
- Trial name
- NCT00781027
- Testing
- Phacoemulsification
- Where
- Netherlands
- Volunteers
- 50 people
- Sponsor
- Maastricht University Medical Center
Scleral Thinning
Comparison Amongst Scleral, Corneal and Amniotic Membrane Grafts to Restore Scleral Thinning
The purpose of this study is to evaluate the use of preserved scleral, corneal and amniotic membrane graft for the surgical repair of scleral thinning of different sizes in patients underwent surgery of pterygium with associated…
- Trial name
- NCT00801073
- Testing
- Human Amniotic Membrane Transplantation
- Volunteers
- 49 people
- Sponsor
- Federal University of São Paulo
Alkaptonuria
Long-Term Study of Nitisinone to Treat Alkaptonuria
This 3-year study will examine the safety and effectiveness of long-term use of nitisinone (Orfadin) for treating joint problems in patients with alkaptonuria, an inherited disease in which a compound called homogentisic acid…
- Trial name
- NCT00107783
- Testing
- Nitisinone (NTBC)
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- National Human Genome Research Institute (NHGRI)
Dry Eye, Dry Eye Syndromes
A Phase 3, Multi-Center Study Evaluating PL9643 in Patients with Dry Eye
This is a multi-center, double-masked, randomized, vehicle-controlled study testing PL9643, an ophthalmic solution to determine if safe and efficacious for dry eye patients.
- Trial name
- MELODY-1 (NCT05201170)
- Testing
- Vehicle Ophthalmic Solution, PL9643 Ophthalmic Solution
- Where
- 18 sites in United States
- Volunteers
- 575 people
- Sponsor
- Palatin Technologies, Inc
Neurotrophic Keratitis
Nerve Growth Factor for the Treatment of Cornea Disease
To determine the efficacy and safety of nerve growth factor in the treatment of limbal stem cell deficiency (LSCD) associated with neurotrophic cornea.
- Trial name
- NCT04552730
- Testing
- Cenegermin-Bkbj
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Stanford University
Scansys, Pentacam
A Study of a Novel Scheimpflug Device in Diagnosing Keratoconus
Comparison of the screening and diagnosis ability of the novel Scheimpflug-based tomography device (Scansys) with Pentacam and the Scheimpflug-based biomechanics device (Corvis ST) for keratoconus.
- Conditions
- Scansys, Pentacam, Corvis ST, Keratoconus
- Trial name
- NCT06119321
- Testing
- Pentacam, Corvis ST and Scansys
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Tianjin Eye Hospital
Contact Lens and Punctal Plug in Preventing Corneal Injuries
A Comparison Between Bandage Contact Lens, Punctal Plugs and Standard Measures in Preventing Corneal Injuries
Study Rationale: The insertion of a bandage contact lens or punctal plug in a defined group of patients admitted to the ICU may be more effective than standard care in decreasing the incidence of corneal injuries.
- Trial name
- COMLENPLSTAN (NCT01961193)
- Testing
- contact lens, punctal plug
- Where
- Israel
- Volunteers
- 105 people
- Sponsor
- Rabin Medical Center
Multiple Myeloma, Neoplasms
A Study to Investigate Safety and Clinical Activity of Belantamab Mafodotin in Combination With Lenalidomide, Dexamethasone and Nirogacestat in Patients With Transplant Ineligible Newly Diagnosed Multiple Myeloma
This is a phase 1/2, open-label study designed to assess the safety and clinical activity of different belantamab mafodotin doses in combination with lenalidomide, dexamethasone and nirogacestat in patients with transplant…
- Conditions
- Multiple Myeloma, Neoplasms, Neoplasm, Plasma Cell, Gammopathy, Monoclonal
- Trial name
- NCT05573802
- Testing
- Belantamab Mafodotin-Blmf, Lenalidomide, Dexamethasone
- Where
- 2 sites in Greece
- Volunteers
- 36 people
- Sponsor
- Hellenic Society of Hematology
Corneal Disease, Neuropathy
QST for Corneal Nerve Function
This study is designed to learn more about the impact different types of stimuli, such as heat, cold and vibration, can have on ocular pain response. This is called quantitative sensory testing (QST).
- Conditions
- Corneal Disease, Neuropathy, Dry Eye Disease, Neurotrophic Keratitis
- Trial name
- NCT05758753
- Testing
- Quantitative Sensory Test
- Where
- United States
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- Tufts Medical Center
Cataract Surgery, Cataract and Fuchs Endothelial Corneal Dystrophy
Trial Comparing Cataract Surgery With Triple-DMEK in Patients With Cataract and Fuchs Endothelial Corneal Dystrophy
The purpose of the study is to investigate whether there is a difference in BCVA in patients who receive one of the following two surgeries: intervention group (arm 1) cataract surgery alone and control group (arm 2) cataract…
- Trial name
- ETCF (NCT06425666)
- Testing
- Intervention group /arm 1 (Cataract surgery alone), Control group /arm 2: Corneal transplantation as Descemet Membrane Endothelial Keratoplasty (DMEK) in combination with cataract surgery (triple-DMEK)
- Where
- 4 sites in Denmark, Germany and 2 more
- Volunteers
- 120 people
- Sponsor
- University of Cologne
Keratoconus
Evaluation of Safety and Efficacy of a Bioengineered Corneal Implant for Treatment of Keratoconus
This is a prospective, Phase I open-label safety study to evaluate the safety, feasibility and initial efficacy of a bioengineered corneal stromal substitute after implantation into the stroma of adults with advanced keratoconus.
- Trial name
- LinkCor (NCT04653922)
- Testing
- LinkCor Bioengineered Corneal Implant
- Where
- 2 sites in India, Iran
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- LinkoCare Life Sciences AB
Corneal Ulcer of Bilateral Eyes
Studying the Effect of Ethanol Applied on the Corneal Surface During PRK Surgery.
The goal of this observational study is to learn about the effects of the duration of ethanol contact with the corneal surface. The main question it aims to answer is: Does this affect the behavior of corneal epithelial healing?
- Trial name
- NCT06540131
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- Minia University
Neurotrophic Keratitis, Neurotrophic Keratopathy
Open-label Trial to Evaluate Efficacy and Safety of rhNGF on Corneal Thickness Via AS-OCT in Neurotrophic Keratitis
Primary Objective: To assess the efficacy of cenegermin-bkbj (20 mcg/mL) ophthalmic solution on overall corneal thickness via AS-OCT in patients with stage 3 neurotrophic keratitis with respect to change from baseline at weeks 4…
- Conditions
- Neurotrophic Keratitis, Neurotrophic Keratopathy, Corneal Ulcer
- Trial name
- IMAGO (NCT06411145)
- Testing
- OXERVATE® 0.002%
- Sponsor
- Dompé Farmaceutici S.p.A
Corneal Ulcer
Effect of Various Treatment Modalities on Dendritic Vial Ulcer
Eye infection is a prevalent problem in primary care and remains a crucial healthcare concern. According to the American Academy of Ophthalmology (AAO), herpes simplex virus (HSV) keratitis (HSK) is the leading cause of…
- Trial name
- NCT05313828
- Testing
- Acyclovir, Tobramycin, Fluorometholone
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Sohag University
Keratoconus, Keratoconus of Right Eye
Fresh Corneal Lenticule Implantation and Autologous Serum - Case Report
The aim of our study is to investigate the feasibility and the effect of fresh lenticule implantation as allogenic graft that will be taken from myopic patients to implant in patients with keratoconus disease using VisuMax…
- Conditions
- Keratoconus, Keratoconus of Right Eye, Keratoconus, Unstable, Right Eye
- Trial name
- NCT04594512
- Testing
- Fresh corneal lenticule and autologous serum in advanced keratoconus using ReLex Smile surgery
- Where
- Kosovo
- Volunteers
- 1 people
- Sponsor
- Eye Hospital Pristina Kosovo
Fuchs' Corneal Endothelial Dystrophy
Evaluating Results of Neusidl Corneal Inserter in Descemet's Stripping Automated Endothelial Keratoplasty (DSAEK)
This project compares the Neusidl Corneal Injector (NCI) device developed by Fischer Surgical, Inc. for the delivery of tissue into the eye in DSAEK surgery to the current standard forceps insertion DSAEK technique.
- Trial name
- NCT01357122
- Testing
- NCI Insertion, Standard Forceps Insertion
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Legacy Health System
Cornea, Skin Diseases
OCT Vibrography for Biomechanical Properties of Tissues
The overall goal of this study is to develop OCT Vibrography (aka OCT elastography) as a novel tool for measuring biomechanical properties of human tissues in vivo.
- Conditions
- Cornea, Skin Diseases, Gingival Diseases
- Trial name
- NCT05759780
- Testing
- Optical imaging of the tissues
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Dry Eye Syndromes, Keratoconjunctivitis Sicca
Efficacy and Safety Study of ATs in Patients With Dry Eye Syndrome
The purpose of this study is to determine whether artificial tears are safe and effective in the treatment of Dry Eye Syndrome.
- Trial name
- NCT00788229
- Testing
- AT01, AT02, AT03
- Where
- South Korea
- Volunteers
- 72 people
- Sponsor
- Dhp Korea Co., Ltd.
Corneal Endothelial Cell Loss
Corneal Endothelium in Diabetics Undergoing Phacoemulsification
evaluate and compare the changes in corneal endothelial cell count density between diabetic and non diabetic patients undergoing phacoemulsification surgery, and to evaluate the effect of duration, and control of diabetes on…
- Trial name
- NCT05522842
- Volunteers
- 50 people
- Sponsor
- Assiut University
Corneal Epithelial Wound Healing, Post Operative Pain
Insulin Eye Drops and Epithelial Healing After Corneal Cross-linking
The goal of this clinical trial was to learn if topical insulin eye drops affected corneal epithelial wound healing after corneal collagen cross-linking.
- Trial name
- NCT07812129
- Testing
- Insulin eye drops, standard post-operative topical drops
- Where
- Egypt
- Volunteers
- 24 people
- Sponsor
- Cairo University