Clinical trials: Cornea, open to volunteers
Keratoconus
The Homburg Keratoconus Center (HKC)
Aim of this study is to conduct longitudinal and cross-sectional analyses about the corneal ectatic disease Keratoconus based on data obtained from Keratoconus patients in the Homburg Keratoconus Center (HKC).
- Trial name
- NCT03923101
- Testing
- Topographic, tomographic and biomechanical analysis.
- Where
- Germany
- Volunteers
- 5,000 people
- Sponsor
- Universität des Saarlandes
Cornea Transplant
Study of the Anatomical and Functional Recovery and Quality of Life of Patients Undergoing Corneal Transplantation
Evaluate the well-being of patients and clinicl outcomes of the cornea after transplantation
- Trial name
- NCT06830538
- Where
- Italy
- Volunteers
- 2,000 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Keratoconus, Ectasia of Cornea
Comparison of Epi-ON Corneal Collagen Crosslinking Performed Using an 18-Minute UVA Exposure vs. a 24-Minute UVA Exposure on Eyes With Ectatic Corneal Diseases
The goal of this clinical trial is to study the effects of an experimental (not Food and Drug Administration (FDA)-approved) treatment called corneal crosslinking (CXL) for conditions in which the cornea becomes progressively…
- Conditions
- Keratoconus, Ectasia of Cornea, Pellucid Marginal Corneal Degeneration, Forme Fruste Keratoconus (FFK)
- Trial name
- NCT07124910
- Testing
- Epi-ON corneal cross-linking
- Where
- 12 sites in United States
- Volunteers
- 485 people
- Sponsor
- Woolfson Eye Institute
Keratoconus, Irregular; Contour of Cornea
Scleral Lens Fitting Using Wide-Field OCT
The purpose of this study is to see if OCT technology can optimize scleral contact lens fittings. Subjects with keratoconus, post-penetrating keratoplasty (PK), post-LASIK ectasia, post-radial keratotomy (RK), or a variety of…
- Trial name
- NCT04570020
- Where
- United States
- Volunteers
- 258 people
- Sponsor
- Oregon Health and Science University
Fuchs' Endothelial Dystrophy, Cataract
The Effects of Ripasudil in Patients With FED Undergoing Femtosecond Laser Assisted Cataract Surgery
The purpose of this research is to investigate the effects of ripasudil administered as an ophthalmic solution in patients with FED after femtosecond laser assisted cataract surgery.
- Trial name
- NCT06048380
- Testing
- Ripasudil
- Where
- Singapore
- Volunteers
- 120 people
- Sponsor
- Singapore Eye Research Institute
Bacterial Keratitis, Recalcitrant Infectious Keratitis
Intrastromal Moxifloxacin as an Adjunctive Therapy in Recalcitrant Bacterial Keratitis
Bacterial keratitis is a potentially sight-threatening corneal infection that is commonly treated with intensive topical antibiotics.
- Conditions
- Bacterial Keratitis, Recalcitrant Infectious Keratitis, Corneal Ulcer
- Trial name
- NCT07394257
- Testing
- Intrastromal moxifloxacin injection plus standard topical moxifloxacin therapy, Standard topical moxifloxacin therapy alone
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Minia University
Corneal Edema, Fuchs
Study of EO2002 in Subjects With Corneal Edema Secondary to Corneal Endothelial Dysfunction
This study will evaluate the safety and effectiveness of a single injection of EO2002 at one of two dose levels (150,000 or 500,000 magnetic human corneal endothelial cells [mHCECs]), compared with a placebo injection, in…
- Conditions
- Corneal Edema, Fuchs, Fuchs Dystrophy, Fuchs' Endothelial Dystrophy
- Trial name
- EMERALD (NCT07729137)
- Testing
- 150K cells, 500K cells
- Where
- 10 sites in United States
- Volunteers
- 121 people
- Sponsor
- Emmecell
Pseudophakic Bullous Keratopathy, Fuchs' Endothelial Dystrophy
The OPTIMISE Study
Rationale: The cornea is the most transplanted tissue in the Netherlands, with more than 1,500 procedures performed each year. A minimally invasive technique called Descemet Membrane Endothelial Keratoplasty (DMEK) has become the…
- Conditions
- Pseudophakic Bullous Keratopathy, Fuchs' Endothelial Dystrophy, Intraocular Pressure
- Trial name
- NCT05716945
- Testing
- Fluorometholone 0.1% Oph Susp, Dexamethasone 0.1% ophthalmic suspension, Stop steroids
- Where
- 8 sites in Netherlands
- Volunteers
- 342 people
- Sponsor
- Maastricht University Medical Center
Corneal Scarring Fibrosis
Losartan for Corneal Fibrosis
This is a prospective, randomized, double-blinded, controlled clinical trial designed to evaluate the efficacy and safety of topical losartan in improving visual acuity, contrast sensitivity and reducing corneal densitometry…
- Trial name
- NCT07449000
- Testing
- Topical losartan
- Where
- Mexico
- Volunteers
- 46 people
- Sponsor
- Universidad Autonoma de Nuevo Leon
Myopia
Characterization of the Corneal Biomechanics of Patients Treated by Corneal Lenticule Extraction for Advanced Refractive Correction (CLEAR) to Correct Myopia
This study aims to perform biomechanical tests on extracted CLEAR lenticles that are routinely discarded after surgery. The investigators also aim to perform Brillouin microscopy to get an in-vivo assessment of the patient's…
- Trial name
- CLEAR Biomech (NCT04817592)
- Testing
- Corneal lenticule extraction for advanced refractive correction (CLEAR)
- Where
- Switzerland
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Bern
Corneal Diseases, Retinal Diseases
4D Duke Microscope Integrated Optical Coherence Tomography in a Zeiss Artevo 800
The study team will conduct the first in-human pilot studies using 4D MIOCT for imaging in the operating room. Building on the earlier integration and wet-lab validations, the researchers will assess the system's ease of use…
- Conditions
- Corneal Diseases, Retinal Diseases, Ocular Diseases
- Trial name
- 4D MIOCT (NCT07024719)
- Testing
- 4D MIOCT integrated into a Zeiss Artevo 800
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Duke University
Pseudoexfoliation Syndrome, Biomechanical Parameters
Corneal Biomechanics, Optical Properties and Anterior Segment Structural Features in Patients With Pseudoexfoliation
The purpose of this study is to assess the effect of pseudoexfoliation syndrome on corneal biomechanics, optical clarity of the cornea, and anterior segment structural features.
- Conditions
- Pseudoexfoliation Syndrome, Biomechanical Parameters, Corneal Densitometry
- Trial name
- CorPEX (NCT06731530)
- Testing
- Pentacam-AXL, HD Analyzer, Corvis ST
- Where
- Greece
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- Aristotle University Of Thessaloniki
Limbal Stem-cell Deficiency
Cultivated Limbal Epithelial Transplantation (CLET) for Limbal Stem Cell Deficiency (LSCD)
CLET is a published treatment for the management of corneal failure due to extensive LSCD. Due to our previous studies on this novel treatment, the regulatory agency of Spain "Agencia Española de Medicamentos y Productos…
- Trial name
- CLET-4-LSCD (NCT03884569)
- Where
- Spain
- Volunteers
- 30 people
- Sponsor
- Instituto Universitario de Oftalmobiología Aplicada (Institute of Applied Ophthalmobiology) - IOBA
Keratoconus, Post-Laser Retinal Condition
Investigator Initiated, Prospective Study of Xenia Corneal Lenticule
Cornea ectatic conditions such as keratoconus and post-LASIK (Laser In situ Keratomileusis) ectasia are disorders of the eye that are notorious for its uncontrolled progression over time, leading to loss of vision.
- Trial name
- NCT04741230
- Testing
- Gebauer Lenticule
- Where
- United Kingdom
- Volunteers
- 15 people
- Sponsor
- The Royal Wolverhampton Hospitals NHS Trust
Keratoconus, Pellucid Marginal Corneal Degeneration
Safety and Effectiveness of the PXL-Platinum 330 System for Corneal Cross-Linking in Eyes With Corneal Ectasia
To evaluate the safety and effectiveness of the PXL Platinum 330 system for performing corneal cross-linking (CXL) for the treatment of ectatic disorders.
- Conditions
- Keratoconus, Pellucid Marginal Corneal Degeneration, Corneal Ectasia
- Trial name
- NCT04094090
- Testing
- PXL-330 Platinum device for crosslinking with Peschke riboflavin solution
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- Goodman Eye Center
Keratoconus
Placebo-controlled Study to Evaluate the Safety and Efficacy of GLK-221 Ophthalmic Solution in Subjects With Keratoconus
Multi-center, parallel-group, placebo-controlled trial designed to assess the safety and efficacy of twice-daily topically administered GLK-221 Ophthalmic Solution in subjects with keratoconus.
- Trial name
- NCT07400952
- Testing
- GLK-221 Ophthalmic Solution
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Glaukos Corporation
Limbal Stem Cell Deficiency
Multi-Center, Prospective, Non-Interventional Study in Subjects With Limbal Stem Cell Deficiency
The goal of this non-interventional, observational study is to describe the natural history, clinical course, and management patterns of subjects with limbal stem cell deficiency (LSCD).
- Trial name
- NCT07636590
- Testing
- Non-interventional
- Where
- 8 sites in United States
- Volunteers
- 500 people
- Sponsor
- Claris Biotherapeutics, Inc.
Keratoconus, Ectasia
A Study to Test the Diagnostic Potential of Brillouin Microscopy for Corneal Ectasia
We have developed novel Brillouin microscopy and we are testing its potential for keratoconus and ectasia diagnostics. We plan to perform axial scans of the cornea in human volunteers in order to compare biomechanical properties…
- Conditions
- Keratoconus, Ectasia, Crosslinking, Fuchs' Endothelial Dystrophy
- Trial name
- NCT02118922
- Testing
- Brillouin imaging
- Where
- United States
- Volunteers
- 168 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Healthy Cornea
Evaluation of Corneal Endothelium Health Following Articaine Ophthalmic Solution Administration
The goal of this clinical trial is to evaluate the corneal endothelium health of eyes treated with articaine ophthalmic solution in adult participants.
- Trial name
- NCT07838129
- Testing
- Articaine (CYKLX), Vehicle
- Volunteers
- 165 people, healthy volunteers welcome
- Sponsor
- Laboratoires Thea
Fuchs' Endothelial Dystrophy, Corneal Edema
Plasma Rich in Growth Factors in Corneal Endothelial Transplantation
The purpose of the study is to determine the safety and efficacy of brief intraoperative corneal endothelial graft incubation in plasma rich in growth factors (PRGF) for reducing postoperative endothelial cell loss.
- Trial name
- NCT06261346
- Testing
- Endothelial keratoplasty, PRGF
- Where
- 2 sites in United States
- Volunteers
- 100 people
- Sponsor
- University of Miami