Clinical trials: Corneal Cross-Linking
Keratoconus
Safety Study of the VEGA UV-A System to Treat Keratoconus
The purpose of this research study is to test the safety, tolerability, and effectiveness of corneal collagen cross-linking (CXL), when used to treat keratoconus.
- Trial name
- NCT01190306
- Testing
- The VEGA UV-A Illumination System, Riboflavin
- Where
- 9 sites in United States
- Volunteers
- 127 people
- Sponsor
- Topcon Medical Systems, Inc.
Keratoconus, Corneal Diseases
Collagen Cross-Linking With Ultraviolet-A in Asymmetric Corneas
This study will assess changes in visual acuity and corneal symmetry after corneal collagen cross-linking (CXL) of asymmetric corneas.
- Conditions
- Keratoconus, Corneal Diseases, Eye Diseases, Photosensitizing Agents
- Trial name
- NCT03029104
- Testing
- CXLO Corneal Strengthening Solution and UVA Illumination Device
- Where
- 9 sites in United States
- Volunteers
- 2,228 people
- Sponsor
- Cxlusa
Keratoconus
Accelerated Corneal Cross-linking With Different Riboflavin Solutions
Following the Bunsen-Roscoe law, accelerated cross-linking protocols with higher irradiation intensities and shorter irradiation times have been introduced.
- Trial name
- NCT03187912
- Testing
- Riboflavin
- Where
- Austria
- Volunteers
- 60 people
- Sponsor
- Medical University of Vienna
Keratoconus, Ectasia
Higher Irradiance in Keratoconus Ectasia
The purpose of the study is to see if brighter lights will allow for shortening of the treatment time required to stabilize the eyes of patients with keratoconus or a bulging cornea.
- Trial name
- NCT01789333
- Testing
- UVA Light with irradiance exposure of 9 mW/cm2, Riboflavin 0.1% ophthalmic solution
- Where
- United States
- Sponsor
- Stephen Trokel
Corneal Ectasia Disorders Including Keratoconus
The Effects of Corneal Collagen Cross-linking
The corneal collagen cross-linking treatment has been used with increasing success to treat corneal dystrophies such as "keratoconus." Recent advances have allowed different techniques for performing this cross-linking treatment.
- Trial name
- NCT01708538
- Testing
- CXL
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Rush Eye Associates
Keratoconus
Safety and Efficacy Study of Corneal Collagen Cross-Linking in Eyes With Keratoconus
The objectives of this study are to evaluate the safety and efficacy of corneal collagen cross-linking performed with VibeX (riboflavin ophthalmic solution) and the KXL System as compared to placebo in impeding the progression…
- Trial name
- NCT01344187
- Testing
- riboflavin solution, KXL System
- Where
- 10 sites in United States
- Volunteers
- 236 people
- Sponsor
- Glaukos Corporation
Corneal Ulcers
Safety and Effectiveness of the UV-X System for Corneal Collagen Cross-Linking in Eyes With Refractory Corneal Infection
This study will evaluate the Safety and Effectiveness of the UV-X System for Corneal Collagen Cross-Linking in Eyes with Corneal Infection.
- Trial name
- NCT02068430
- Testing
- Riboflavin 0.1%, UV-X™ Illumination System
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Stephen Trokel
Keratoconus
Epithelium-On Corneal Cross-linking in Subjects 8 to 45 Years of Age With Keratoconus
A Multicenter, Randomized, Double-Masked, Sham-Controlled, Parallel-Group Phase 3 Study to Evaluate the Efficacy and Safety of Epithelium-On Corneal Cross-linking in Subjects 8 to 45 Years of Age With Keratoconus
- Trial name
- Apricity-B (NCT06100952)
- Testing
- Riboflavin and Sodium Iodide solution and Ultraviolet-A treatment
- Where
- 12 sites in United States
- Volunteers
- 398 people
- Sponsor
- Epion Therapeutics
Keratoconus
Study of the Safety and Effectiveness of Photochemically Induced Collagen Cross-Linking in Eyes With Keratoconus.
This study is being conducted to assess the safety and effectiveness of photochemically induced collagen cross- linking (CCL) at irradiance of 18mW/cm2 in eyes with Keratoconus and Ecstasia.
- Trial name
- NCT02762253
- Testing
- Riboflavin drops
- Where
- 11 sites in United States
- Volunteers
- 320 people
- Sponsor
- Nvision Laser Eye Centers
Keratoconus
A Randomized Clinical Trial of Ex Vivo Corneal Cross-Linking of Donor Keratoplasty Tissue for Keratoconus Used for Keratoplasty in Keratoconus Patients
This randomized clinical trial will assess corneal astigmatism and visual outcomes in participants who have undergone corneal transplantation for keratoconus with ex vivo cross-linked donor corneal tissue versus participants who…
- Trial name
- EVOKE (NCT04584125)
- Testing
- Riboflavin 5'-phosphate in 20% dextran ophthalmic solution) 0.146% with UV light, Riboflavin 5'-phosphate in 20% dextran ophthalmic solution) 0.146% without UV light
- Where
- United States
- Volunteers
- 216 people
- Sponsor
- Joseph B. Ciolino, MD
Keratoconus
CXL-04 A Study of Collagen Crosslinking With Ultraviolet-A in Asymmetric Corneas
The purpose of this study is to evaluate the efficacy of ultraviolet-A (UVA)-induced cross-linking of corneal collagen (CXL) as a method to increase the biomechanical and biochemical stability of the cornea by inducing additional…
- Trial name
- NCT01956474
- Testing
- Theralight crosslinking and Riboflavin
- Where
- 6 sites in United States
- Volunteers
- 1,324 people
- Sponsor
- Cxlusa
Keratoconus
Corneal Uptake of Riboflavin Eye Drops
The overall objective of this study is to optimise the corneal cross-linking standard protocol in terms of a more economical use of the resource "medical personnel" and in terms of increased patient participation.
- Trial name
- NCT04062435
- Testing
- Drop application in the inferior fornix, Drop application on the cornea
- Where
- Switzerland
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Luzerner Kantonsspital
Keratoconus
Corneal Sensitivity Cross-linking Keratoconus
To evaluate corneal sensitivity changes following corneal cross-linking (CXL) in patients with progressive lower stage keratoconus.
- Trial name
- CSK (NCT01743443)
- Testing
- Cochet-Bonnet esthesiometer central corneal sensitivity
- Where
- Brazil
- Volunteers
- 19 people
- Sponsor
- Instituto de Olhos de Goiania
Keratoconus
Cross-Linking ACcéléré Iontophorèse Confocal kératocONE
A monocentric, parallel-arm, prospective, randomized therapeutic trial that compares the efficacy of two curative keratoconus treatment techniques by cross-linking collagen (accelerated conventional technique or iontophoresis).
- Trial name
- CLACICONE (NCT03429569)
- Testing
- Cross linking
- Where
- France
- Volunteers
- 40 people
- Sponsor
- University Hospital, Clermont-Ferrand
Corneal Scars and Opacities
Limbus-derived Stem Cells for Prevention of Postoperative Corneal Haze
This is a investigator-initiated pilot clinical trial to ascertain the safety and efficacy of application of ex-vivo cultivated limbal stem cells in human eyes for treating Corneal Haze after Photo-Therapeutic/Refractive…
- Trial name
- NCT03295292
- Testing
- Stem cells, Vehicle
- Where
- India
- Volunteers
- 15 people
- Sponsor
- L.V. Prasad Eye Institute
Keratoconus
Safety and Efficacy Study of Corneal Collagen Cross-Linking in Eyes With Keratoconus
The objectives of this study are to evaluate the safety and efficacy of corneal collagen cross-linking performed with VibeX (riboflavin ophthalmic solution) and the KXL System as compared to placebo in impeding the progression…
- Trial name
- NCT01643226
- Testing
- riboflavin solution, KXL System
- Where
- 8 sites in United States
- Volunteers
- 230 people
- Sponsor
- Glaukos Corporation
Corneal Ectasia
Safety and Efficacy Study for Corneal Collagen Cross-Linking in Eyes With Corneal Ectasia After Refractive Surgery
The objectives of this study are to evaluate the safety and efficacy of corneal collagen cross-linking performed with VibeX (riboflavin ophthalmic solution) and the KXL System as compared to placebo in impeding the progression…
- Trial name
- NCT01643252
- Testing
- riboflavin: 0.12% riboflavin ophthalmic solution with the KXL system
- Sponsor
- Glaukos Corporation
Keratoconus
Combined Corneal Wavefront-guided TPRK and ACXL Following ICRS Implantation in Management of Moderate Keratoconus
Background: Keratoconus leads to gradual progressive loss of vision in young and adult patients. For visual rehabilitation and to hinder keratoconus progressionthe investigators designed this study to help the keratoconus…
- Trial name
- NCT04383301
- Testing
- Intracorneal ring segment implantaion as the first stage, ACXL and wafe front guieded TPRK as the second stage
- Where
- Saudi Arabia
- Volunteers
- 36 people
- Sponsor
- Shaaban Elwan
Chemical Injuries, Unspecified Complication of Corneal Transplant
Use of Cross-linked Donor Corneas as Carriers for the Boston Keratoprosthesis
The purpose of the pilot study is to test the efficacy and safety of riboflavin/Ultraviolet A (UVA) cross-linked human donor corneas as carriers for the Boston Keratoprosthesis (Boston KPro) in patients with higher risk for…
- Conditions
- Chemical Injuries, Unspecified Complication of Corneal Transplant, Autoimmune Diseases, Ocular Cicatricial Pemphigoid
- Trial name
- NCT01582880
- Testing
- Riboflavin
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Joseph B. Ciolino, MD
Progressive Keratoconus
Efficacy and Safety ofCACXL in the Treatment of Keratoconus With Thin Corneas
The aim of this study is to detect the safety and effectiveness of contact lens assisted corneal cross linking in managing progressive keratoconus with thin corneas CACXL was done for 40 eyes of 30 of keratoconic patients…
- Trial name
- CACXL (NCT04504578)
- Testing
- contact lens assisted corneal cross linking
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Kasr El Aini Hospital