Clinical trials: Corneal Cross-Linking
Corneal Ectasia
Three Different Cross-linking Protocols for Treatment of Pediatric Keratoconus
comparison between standard cross-linking protocol and accelerated and transepithelial cross-linking
- Trial name
- NCT05691335
- Testing
- Standard CXL, Accelerated CXL, Transepithelial CXL
- Where
- Egypt
- Volunteers
- 97 people
- Sponsor
- Sohag University
Keratoconus
Riboflavin Mediated Corneal Crosslinking for Stabilizing Progression of Keratoconus
Background: Corneal cross linking is a procedure that induces collagen cross linking of the corneal stroma due to release of reactive oxygen radicals upon activation of topically applied riboflavine A by UVA exposure.
- Trial name
- CCL (NCT00626717)
- Testing
- Riboflavin/UVA crosslinking
- Where
- Germany
- Volunteers
- 30 people
- Sponsor
- University Hospital Freiburg
Hyperopia, Hyperopic Astigmatism
Safety and Efficacy of Corneal Collagen Cross-linking Following LASIK for Treatment of Hyperopia and Hyperopic Astigmatism
The objectives of this study are to evaluate the safety and efficacy, with regards to regression of refractive outcome, as measured by manifest refraction spherical equivalent (MRSE), of two treatment regimens for hyperopic and…
- Trial name
- NCT01893359
- Testing
- riboflavin ophthalmic solution, 0% dextran, UVA Irradiation (30 mW/cm2 for 2 minutes continuous UVA), UVA Irradiation (30 mW/cm2 for 3 minutes pulsed UVA with an on/off cycle of 2 seconds UVA on/1 second UVA off)
- Where
- 5 sites in United States
- Volunteers
- 2 people
- Sponsor
- Glaukos Corporation
Bacterial Keratitis, Fungal Keratitis
Safety and Efficacity of Corneal Collagen Crosslinking in Infectious Keratitis (Bacterial and Fungal ): Randomized,Controlled, Prospective Study. (CXL)
The corneal collagen cross linking is currently used in the treatment of keratoconus but this procedure has also a sterilizing non-specific effect on bacteria and fungus.
- Trial name
- CXL (NCT02088970)
- Testing
- Crosslinking, antibiotic treatment
- Where
- France
- Volunteers
- 21 people
- Sponsor
- Nantes University Hospital
Keratoconus
Epithelium-On Corneal Cross-linking in Subjects 8 to 45 Years of Age With Keratoconus
A Multicenter, Randomized, Double-Masked, Sham-Controlled, Parallel-Group Phase 3 Study to Evaluate the Efficacy and Safety of Epithelium-On Corneal Cross-linking in Subjects 8 to 45 Years of Age With Keratoconus
- Trial name
- Apricity-A (NCT06100939)
- Testing
- Riboflavin and Sodium Iodide solution and Ultraviolet-A treatment
- Where
- 13 sites in United States
- Volunteers
- 396 people
- Sponsor
- Epion Therapeutics
Keratoconus
Theranostic Guided Riboflavin/UV-A Corneal Cross-linking
This is a clinical study consisting of a study arm to validate accuracy and precision of the combined use of theranostic imaging biomarkers, riboflavin score and theranostic score, to assess and predict efficacy of corneal…
- Trial name
- ARGO (NCT05457647)
- Testing
- Riboflavin/UV-A corneal cross-linking
- Where
- 3 sites in Italy
- Volunteers
- 50 people
- Sponsor
- Regensight
Keratoconus, Post-Refractive Ectasia
Corneal Crosslinking in Patients With Keratoconus and Post-Refractive Ectasia
The purpose of this study is to evaluate the effectiveness of using riboflavin and UV light to treat progressive keratoconus or post-refractive corneal ectasia.
- Trial name
- NCT01143389
- Testing
- Riboflavin, UVX light
- Where
- United States
- Volunteers
- 510 people
- Sponsor
- Price Vision Group
Keratoconus, Cornea Ectasia
Dietary Riboflavin (Vitamin B-2) and Cornea Cross-Linking
Corneal ectasia is characterized by irregularity and thinning of the cornea, causing the cornea to bulge forward and cause distorted vision and impaired visual acuity.
- Trial name
- NCT03095235
- Testing
- Dietary riboflavin
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia
Keratoconus
Cross Linking Corneal Biomechanical Evaluation of CATS Tonometer Prism
The purpose of this study is to determine if the device, CATS tonometer prism, measures intraocular pressure significantly differently than the current standard of care tonometer prism (Goldmann) before and after a corneal…
- Trial name
- NCT04180111
- Testing
- CATS Tonometer
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Intuor Technologies, Inc.
Keratoconus
Epithelium-on Cross-linking Versus Observation of Fellow Eyes of Patients With Unilateral Clinically Evident Keratoconus
Keratoconus (KC) is a bilateral asymmetric progressive corneal degenerative disease. The management of young patients, diagnosed with clinically evident KC in one eye and with no clinical signs of KC in the other eye, represents…
- Trial name
- NCT06267495
- Testing
- Epithelium-on corneal cross-linking (epi-on CXL)
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Assiut University
Corneal Ectasia of Both Eyes
Collagen Cross-linking Clinical and Oct Study
1. Assessment of corneal changes in AS-OCT after collagen cross-linking (corneal thickness and demarcation line). 2. Assessment of the effect of collagen cross-linking on best-corrected visual acuity
- Trial name
- NCT05717517
- Testing
- anterior segment oct
- Volunteers
- 100 people
- Sponsor
- Assiut University
Keratoconus
Effect of CACICOL20 on Corneal Epithelial Healing After Cross-linking in Patients With Keratoconus
CACICOL20 is an ophthalmic solution based on the technology of RGTAs (ReGeneraTingAgents). It consists of large biopolymers, imitating the structure of heparansulphate.
- Trial name
- NCT02119039
- Testing
- RGTA OTR 4120 (CACICOL20), Genteal HA eye drops
- Where
- Austria
- Volunteers
- 40 people
- Sponsor
- Medical University of Vienna
Keratoconus
Transepithelial Customized Cross-linking
Customized remodeled vision (CuRV) is a new corneal cross-linking protocol for keratoconus, combining a transepithelial approach with customized energy application.
- Trial name
- NCT04820608
- Testing
- Cross-linking
- Where
- Greece
- Volunteers
- 50 people
- Sponsor
- Ophthalmica Eye Institute
Keratoconus
Preoperative Corneal Measurements Estimate the Corrected Distance Visual Acuity After Corneal Cross-linking
This study aims to determine if objective markers describing corneal optical density (COD), thinnest corneal thickness (TCT), anterior (ARC), and posterior (PRC) surface radii over the 3mm thinnest region of the cornea could…
- Trial name
- NCT06522789
- Testing
- corneal cross-linking procedure
- Where
- North Macedonia
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- Sistina Ophthalmology Hospital
Keratoconus and Ectasia
Safety and Effectiveness Study of the VEGA UV-A System for Cross-linking in Eyes With Keratoconus and Ectasia
The purpose of this research study is to evaluate the long tern safety and effectiveness of cross-linking in eyes with keratoconus and ectasia.
- Trial name
- NCT01398852
- Testing
- Riboflavin, VEGA UV-A Illumination System
- Where
- 13 sites in United States
- Volunteers
- 500 people
- Sponsor
- Topcon Medical Systems, Inc.
Refractive Surgery
Accelerated Versus Standard CXL in the Treatment of Ectasia Post Refractive Surgery and Penetrating Keratoplasty.
WHAT WAS KNOWN *Standard CXL is the common procedure for treating progressive corneal ectasia. Modifications of the standard protocol were introduces to reduce its complications especially long exposure to ultraviolet rays.
- Trial name
- NCT03791684
- Testing
- Cross linking
- Volunteers
- 111 people
- Sponsor
- Menoufia University
Keratoconus
Blurring Strength & Aberrometric Changes Following Corneal Cross-linking (CxL) and CxL Combined With Photorefractive Keratectomy (PRK) in Keratoconus
Primary objective of this study was to assess the impact of the two prevalent therapeutic options, CxL and CxL combined with topography-guided photorefractive keratectomy (t-PRK), on both anterior and posterior corneal High order…
- Trial name
- NCT01527721
- Testing
- Corneal Collagen Cross-Linking (CxL), Corneal Collagen Cross-Linking combined with t-PRK
- Where
- Greece
- Volunteers
- 32 people
- Sponsor
- Democritus University of Thrace
Keratoconus
Corneal Collagen Cross-linking With Hypotonic Riboflavin in Corneas Thinner Than 400 Microns
Corneal ectasia is a relative weakness in the structure of the cornea, which produces a progressive change in its shape which results in visual distortion.
- Trial name
- HypotonicRibo (NCT00890266)
- Testing
- Collagen cross-linking with hypotonic riboflavin
- Where
- United Kingdom
- Volunteers
- 5 people
- Sponsor
- Moorfields Eye Hospital NHS Foundation Trust
Progressive Keratoconus
Evaluation of Corneal Hysteresis and Corneal Resistance Factor After Corneal Cross-linking for Keratoconus
This study attempts to compare Corneal Hysteresis (CH) and Corneal Resistance Factor (CRF) in a series of keratoconic eyes before and after Corneal collagen cross-linking (CXL).
- Trial name
- NCT01411384
- Testing
- Corneal collagen cross-linking, Ocular Response Analyzer (ORA)
- Volunteers
- 80 people
- Sponsor
- Democritus University of Thrace
Keratoconus, Ectasia
Corneal Collagen Cross-Linking (CXL) Performed With "Epi-ON" Versus "Epi-OFF" in Eyes With Keratoconus and Other Corneal Ectatic Disorders
This is a prospective, randomized, single investigative site study to compare the safety and effectiveness of Epi-OFF CXL treatment (performed using Ricrolin+ and VEGA UV-A system) compared to Epi-ON CXL (performed using…
- Trial name
- NCT03858036
- Testing
- Ricrolin+, VEGA UV-A system
- Where
- United States
- Volunteers
- 550 people
- Sponsor
- Center for Sight, Sacramento, CA