Clinical trials: Corneal Cross-Linking
Progressive Keratoconus, Corneal Ectasia
Corneal Collagen Cross-Linking for the Treatment of Progressive Keratoconus and Corneal Ectasia
Prospective, randomized, single site study to determine the safety and effectiveness of performing corneal collagen cross-linking (CCCL)using riboflavin and UVA light in eyes with corneal ectasia or progressive keratoconus.
- Trial name
- CL (NCT00567671)
- Testing
- Corneal collagen
- Where
- United States
- Volunteers
- 160 people
- Sponsor
- Emory University
Corneal Epithelial Wound Healing, Post Operative Pain
Insulin Eye Drops and Epithelial Healing After Corneal Cross-linking
The goal of this clinical trial was to learn if topical insulin eye drops affected corneal epithelial wound healing after corneal collagen cross-linking.
- Trial name
- NCT07812129
- Testing
- Insulin eye drops, standard post-operative topical drops
- Where
- Egypt
- Volunteers
- 24 people
- Sponsor
- Cairo University
Corneal Thinning, Keratoconus
PXL-Platinum 330 in Eyes With Corneal Thinning Conditions
This study is being conducted to evaluate the safety and effectiveness of using the PXL Platinum 330 system for performing corneal collagen cross-linking (CXL) for the treatment of corneal thinning disorders.
- Trial name
- NCT05489510
- Testing
- Pulsed or continuous lighting
- Where
- United States
- Sponsor
- Vishal Jhanji
Keratoconus
Donors Predisposed by Corneal Collagen Cross-linking in Deep Lamellar Keratoplasty for the Patients With Keratoconus
The Study was designed as a randomized controlled study with the following objectives: To investigate whether use of donors predisposed by corneal collagen cross-linking (CXL) reduced myopic refractive errors for keratoconic eyes…
- Trial name
- NCT05905978
- Testing
- Corneal donors predisposed by CXL, Corneal donors stored in corneal storage media
- Where
- China
- Volunteers
- 70 people
- Sponsor
- Zhongshan Ophthalmic Center, Sun Yat-sen University
Mycotic Corneal Ulcer
Clinical & Visual Outcomes of Collagen Cross Linking for Fungal Keratitis
The study is a randomised control trial to assess the visual and clinical outcomes of collagen cross linking in fungal keratitis.
- Trial name
- NCT02328053
- Testing
- collagen crosslinking group, Topical anti-fungal therapy
- Where
- India
- Volunteers
- 20 people
- Sponsor
- Aravind Eye Care System
Keratoconus
Effectiveness and Safety of Corneal Collagen Cross Linking After Induction of Stromal Emphysema in Keratoconus
in this study we evaluated the effectiveness and safety of corneal collagen cross-linking in keratoconic eyes with thin cornea after induction of stromal emphysema prior to riboflavin instillation and UV-A corneal irradiation
- Trial name
- NCT07426029
- Testing
- Corneal collagen cross-linking with induction of corneal stromal emphysema
- Where
- Egypt
- Volunteers
- 39 people
- Sponsor
- Cairo University
Corneal Transplant Failure
ExCrossV Multi Site Trial for Vascularized High Risk Keratoplasty
The main objective of this study is to determine the safety of Ex Vivo Cross Linking (CXL) of donor corneal tissue in participants who have undergone high-risk penetrating keratoplasty.
- Trial name
- ExCrossV (NCT06753916)
- Testing
- Corneal Donor Tissue with Cross Linking, Corneal Donor Tissue without Cross Linking
- Where
- 12 sites in United States
- Volunteers
- 96 people
- Sponsor
- Massachusetts Eye and Ear Infirmary
Keratoconus
Impact of Keratoconus, Cross-linking and Cross-linking Combined With Topo-guided Photorefractive Keratectomy on Self-reported Quality of Life. A Three-year Update.
Study Hypothesis: Former investigators indicated that keratoconus has a negative impact on vision-specific quality of life. This study attempts to confirm this statement and assess whether cross-linking and cross-linking combined…
- Trial name
- NCT01845714
- Testing
- Corneal Cross Linking, Corneal Cross Linking combined with topoguided PRK
- Volunteers
- 28 people
- Sponsor
- Democritus University of Thrace
Keratoconus, Pellucid Marginal Degeneration
Corneal Cross Linking and Topography Guided Excimer Laser Treatment
Topography guided laser treatment enables the surgeon to correct higher order aberrations in corneas with irregular astigmatism.
- Trial name
- NCT01682993
- Testing
- Topography guided Excimer Laser treatment and Corneal Cross Linking, Corneal Cross Linking
- Where
- Austria
- Volunteers
- 30 people
- Sponsor
- Medical University of Vienna
Keratoconus
Evaluation of the Keratoconic Cornea After Corneal Collagen Cross Linking.
Aim of work: To detect abnormal corneal thinning in keratoconus using pachymetry maps measured by high-speed anterior segment optical coherence tomography (OCT).
- Trial name
- NCT03879421
- Testing
- Accelerated corneal collagen cross linking
- Where
- Egypt
- Volunteers
- 44 people
- Sponsor
- Reham Mahmoud Abdelrahman
Keratoconus, Corneal Ectasia
Study of the Safety and Effectiveness of Collagen Cross-Linking at an Irradiance of 9 mW/cm2 and 18 mW/cm2
The primary objective of this study is to determine the effectiveness and safety of corneal collagen cross-linking at irradiance levels of 9 and 18 mW/cm2.
- Trial name
- NCT02009709
- Testing
- Riboflavin 0.1% ophthalmic solution, CCL-VARIO UV lamp, CCL-VARIO at 18 mW/cm2
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Robert Mack, M.D.
Keratoconus, Corneal Ectasia
Safety & Efficacy of Corneal Collagen Cross-Linking in Eyes With Keratoconus or Corneal Ectasia After Refractive Surgery
The objectives of this study are to evaluate and compare the safety and efficacy of three treatment regimens for corneal collagen cross-linking performed with VibeX (riboflavin ophthalmic solution) and the KXL System in impeding…
- Trial name
- NCT01459679
- Testing
- KXL System (15 mW/cm2), KXL System (30 mW/cm2), KXL System (45 mW/cm2)
- Where
- 83 sites in United States, Puerto Rico
- Volunteers
- 1,721 people
- Sponsor
- American-European Congress of Ophthalmic Surgery