Clinical trials: Corneal Damage
Pterygium, Corneal Ulcer
The Application of Fibrin Glue in Ocular Surface Diseases
This clinical trial tries to use tissue fibrin glues (Tisseel) to treat various ocular surface diseases or surgeries, which includes pterygium surgery, corneal melting/perforation, Gunderson's flap, conjunctival laceration, and…
- Trial name
- NCT00155402
- Testing
- tissue fibrin glue application (Tisseel)
- Where
- Taiwan
- Volunteers
- 30 people
- Sponsor
- National Taiwan University Hospital
Corneal Scarring Fibrosis
Losartan for Corneal Fibrosis
This is a prospective, randomized, double-blinded, controlled clinical trial designed to evaluate the efficacy and safety of topical losartan in improving visual acuity, contrast sensitivity and reducing corneal densitometry…
- Trial name
- NCT07449000
- Testing
- Topical losartan
- Where
- Mexico
- Volunteers
- 46 people
- Sponsor
- Universidad Autonoma de Nuevo Leon
Cornea
Evaluation of the Efficacy of OMK2 in Recovering Corneal Neural Damage in Patients With Diabetes
This will be a single-centre, randomized, pilot study. 30 patients with diabetes who previously had received Argon laser photocoagulation will be enrolled.
- Trial name
- NCT03906513
- Testing
- OMK2
- Where
- Italy
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Milan
Corneal Diseases, Corneal Scars and Opacities
Validation of the Use of Terahertz Scanning System on Corneal Scars and Corneal Edema
This observational study aims to validate the use of THz scanning system in corneal edema and corneal scars, and to investigate the accuracy and performance on the use of THz scanning system in the evaluation of the progression…
- Conditions
- Corneal Diseases, Corneal Scars and Opacities, Corneal Edema
- Trial name
- NCT06983652
- Testing
- THz scanning using THz Imaging system.
- Where
- Singapore
- Volunteers
- 150 people
- Sponsor
- Singapore Eye Research Institute
Corneal Perforation, Corneal Stromal Lenticule,Sandwich Technique
A Novel Sandwich Technique of Minimally Invasive Keratoplasty for Corneal Perforation
The goal of this type of study to describe a new sandwich technique of minimally invasive keratoplasty (STMIK) by using SMILE-extracted lenticules for treatment corneal perforation and effectiveness.
- Trial name
- STMIK (NCT06233409)
- Where
- China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Tianjin Eye Hospital
Keratitis, Corneal Ulcer
Corneal Lesions in Intensive Care Unit (ICU) Clinical Trial for Proposing Interventions and Evaluating Outcomes of Nursing in the Adult Intensive Care Center Clinical Trial for Proposing Interventions and Evaluating Outcomes of Nursing in the Adult Intensive Care Center
The purpose of the study is find out the better measure to achieve corneal protection in an Intensive Care Unit.
- Trial name
- CORNEALPREV (NCT02293876)
- Testing
- LACRIBELL®, LIPOSIC®, Glad wrap
- Where
- Brazil
- Volunteers
- 360 people
- Sponsor
- Hospital Risoleta Tolentino Neves
Corneal Ulcer, Corneal Perforation
Topical Insulin - Utility and Results in Neurotrophic Keratopathy in Stages 2 and 3
Purpose: To evaluate the clinical outcome of patients with refractory Neurotrophic Keratopathy (NK) in stages 2 and 3 treated with topical insulin.
- Conditions
- Corneal Ulcer, Corneal Perforation, Corneal Epithelium Defect, Neurotrophic Keratitis
- Trial name
- NCT04820010
- Testing
- Topical Insulin
- Where
- Portugal
- Volunteers
- 20 people
- Sponsor
- Centro Hospitalar de Vila Nova de Gaia/Espinho, E.P.E.
Pain, Postoperative, Pain, Chronic
fMRI and IVCM Cornea Microscopy of CXL in Keratoconus
Evaluation of neuroplasticity of pain pathways and corneal afferent nerve regeneration following corneal crosslinking (CXL) in keratoconus patients using fMRI and corneal In Vivo Confocal Microscopy (IVCM).
- Conditions
- Pain, Postoperative, Pain, Chronic, Pain, Acute, Surgical Injury
- Trial name
- NCT04439552
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Boston Children's Hospital
Corneal Abrasion
The Debridement To Treat The Traumatic Corneal Abrasion
Patients who signed informed consent to participate in the study will receive corneal epithelial deplasia. The patient was instructed to follow up closely in the following year, and the recurrence of the patient was collected…
- Trial name
- NCT05534217
- Testing
- corneal debridement of corneal abrasion
- Where
- China
- Volunteers
- 156 people, healthy volunteers welcome
- Sponsor
- Zhongshan Ophthalmic Center, Sun Yat-sen University
Corneal Perforation
Combined Amniotic Membrane and Platelet Rich Plasma Clot for Management of Central Corneal Perforation
Use of amniotic membrane(AMT) and platelet rich plasma (PRP) clot for closure of central corneal perforation
- Trial name
- NCT03500796
- Testing
- Platelet rich plasma clot implantation, Wound closure with amniotic membrane
- Where
- Egypt
- Volunteers
- 10 people
- Sponsor
- Minia University
Endophthalmitis, Trauma, Corneal
Use Of Intracameral Moxifloxacin For Prophylaxis Of Open Globe Endophthalmitis
Endophthalmitis is a severe inflammatory eye condition with profound impairment of vision, which can lead to irreversible visual loss and requires immediate treatment.
- Trial name
- NCT05079854
- Testing
- Intraocular Instillation Solution, Moxifloxacin Ophthalmic
- Where
- Brazil
- Volunteers
- 100 people
- Sponsor
- Federal University of São Paulo
Corneal Abrasions, Corneal Infiltrates
High-resolution Imaging of Corneal Lesions With Optical Coherence Tomography (OCT) - A Pilot Study
Corneal lesions such as corneal abrasions and corneal infiltrates are common in clinical practice. The current study seeks to investigate whether high-resolution OCT is suitable for imaging of these corneal lesions.
- Trial name
- NCT01753583
- Testing
- Optical Coherence Tomography (OCT), Slit lamp biomicroscopy
- Where
- Austria
- Volunteers
- 4 people
- Sponsor
- Medical University of Vienna
Benign Intracranial Hypertension
Axial Length and Central Corneal Thickness in Benign Intracranial Hypertension
Patients in for treatment of benign intracranial hypertension will undergo two tests that are not routinely performed for these patients: central corneal thickness and axial length of the eye.
- Trial name
- NCT02541994
- Testing
- Pachette3, Lenstar-Think
- Volunteers
- 5 people
- Sponsor
- Ochsner Health System
Eye Injuries, Critically Ill
Does the Use of a Moisture Chamber Decrease the Incidence of Corneal Abrasions in Critically Ill Pediatric Patients?
The purpose of this study is to identify the incidence of scratches on the surface of the eye in children who cannot blink due to medication use and to identify how best to reduce the risk of a scratch on the surface of the eye…
- Trial name
- NCT00129077
- Testing
- plastic wrap over eye & lubrication applied q6 hrs
- Where
- 2 sites in United States
- Volunteers
- 207 people
- Sponsor
- Ann & Robert H Lurie Children's Hospital of Chicago
Corneal Perforation
Role of AS-OCT in Assessment of Corneal Perforation
Assessment of healing of thin and perforated cornea after surgical treatment by anterior segment optical coherence tomography
- Trial name
- OCT (NCT06422897)
- Testing
- anterior segment optical coherence tomography
- Where
- Egypt
- Volunteers
- 13 people
- Sponsor
- Minia University
Endothelial Cell Loss, Corneal, Cataract and Intraocular Lens (IOL) Surgery
Effect of Vitamin C Supplementation in Corneal Endothelial Damage in Phacoemulsification of Patients with Hard Cataracts
The goal of this clinical trial is to analyze the protective effects of oral ascorbic acid on the corneal endothelial layer undergoing oxidative stress due to phacoemulsification in patients with hard cataracts.
- Trial name
- NCT06781970
- Testing
- Oral Vitamin C
- Where
- 2 sites in Indonesia
- Volunteers
- 120 people
- Sponsor
- Universitas Indonesia
Corneal Perforation, Exposure Keratitis
The Role of OmniLenz® in the Treatment of Small Corneal Perforations Secondary to Exposure Keratitis in ICU Patients
Case series of 5 ICU patients in Farwaniya Hospital who developed exposure keratitis and a subsequent small corneal perforation between April 2022 and April 2024.
- Conditions
- Corneal Perforation, Exposure Keratitis, Infectious Keratitis
- Trial name
- NCT06539663
- Testing
- OmniLenz®
- Where
- Kuwait
- Volunteers
- 5 people
- Sponsor
- Farwaniya Hospital
Endothelial Cell Loss, Corneal, Cataract
Quantification of Factors Influencing Endothelial Damage During Phacoemulsification
The aim of this study is to determine the principal factors that influence endothelial cell loss three month post cataract surgery. Methods: Multi center observational Cohort study, inclusion period from 12/01/2022 to 10/06/2022.
- Conditions
- Endothelial Cell Loss, Corneal, Cataract, Phacoemulsification
- Trial name
- PREDICSPILOT (NCT05529485)
- Testing
- Cataract surgery by phacoemulsification
- Where
- France
- Volunteers
- 121 people
- Sponsor
- Centre Hospitalier Régional Metz-Thionville
Healthy Volunteers
Study of the Safety of USB005 in Healthy Volunteers
This study will evaluate the safety, tolerability and pharmacokinetics of USB005 (aclerastide) Ophthalmic Solution.
- Trial name
- NCT03615196
- Testing
- USB005 (aclerastide) Ophthalmic Solution
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- US Biotest, Inc.