Clinical trials: Corneal Deformity
Fuchs Endothelial Corneal Dystrophy, Pseudophakic Bullous Keratopathy
The Postoperative Head Position as a Predictor of the Surgical Outcome After DMEK
This study aims to investigate the influence of postoperative head position on clinical outcomes after DMEK via a wearable sensor.
- Conditions
- Fuchs Endothelial Corneal Dystrophy, Pseudophakic Bullous Keratopathy, Chemical Burn of Cornea, Posterior Polymorphous Corneal Dystrophy
- Trial name
- NCT04387331
- Where
- Germany
- Volunteers
- 50 people
- Sponsor
- Peter Wiedemann
Fuchs' Endothelial Dystrophy
OCT-guided DSAEK Graft Shaping and Smoothing
The primary goal of this study is to determine if excimer laser smoothing of the cornea before Descemet's stripping automated endothelial keratoplasty (DSAEK)improves postoperative Best Spectacle Corrected Visual Acuity (BSCVA).
- Trial name
- DSAEK (NCT01586234)
- Testing
- DSAEK with graft shaping and smoothing, Standard DSAEK
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Oregon Health and Science University
Dystrophic Epidermolysis Bullosa, DEB - Dystrophic Epidermolysis Bullosa
A Study Comparing KB803 and Matched Placebo in Patients With Dystrophic Epidermolysis Bullosa
KB803-EYE-01 is a Phase 3 double-blind, randomized, placebo-controlled, crossover study to evaluate the safety and efficacy of KB803 versus matched placebo in pediatric and adult subjects with recurrent corneal abrasions due to…
- Conditions
- Dystrophic Epidermolysis Bullosa, DEB - Dystrophic Epidermolysis Bullosa, Recessive Dystrophic Epidermolysis Bullosa, Dominant Dystrophic Epidermolysis Bullosa
- Trial name
- IOLITE (NCT07016750)
- Testing
- KB803
- Where
- 5 sites in United States
- Volunteers
- 16 people
- Sponsor
- Krystal Biotech, Inc.
Keratoconus, Fuchs' Endothelial Dystrophy
Long Term Cornea Graft Survival Study
Corneal transplantation have been performed for several decades, follow-up time in some centers now exceeds 30 years. Published long term (10 years and up) graft survivals vary considerably from center to center.
- Trial name
- BELIEvE (NCT02849808)
- Where
- France
- Volunteers
- 564 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Corneal Endothelial Decompensation, Fuchs' Endothelial Dystrophy
Impact of Donor Diabetes on DMEK Success and Endothelial Cell Loss
This double-masked multi-center trial will evaluate the association of diabetes in the cornea donor with transplant success and loss of endothelial cells through 1 year following Descemet membrane endothelial keratoplasty (DMEK).
- Trial name
- DEKS (NCT05134480)
- Testing
- Descemet membrane endothelial keratoplasty
- Where
- 2 sites in United States
- Volunteers
- 1,097 people
- Sponsor
- Case Western Reserve University
Fuchs Dystrophy, Corneal Edema
A Comparison Between Full Thickness and Partial Thickness Corneal Transplantation for Corneal Edema
The objectives of this study are to compare the visual and refractive outcomes of deep lamellar endothelial keratoplasty (DLEK) with penetrating keratoplasty as treatment for certain cases of corneal edema due to endothelial…
- Trial name
- NCT00346138
- Testing
- Corneal transplantation
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- Mayo Clinic
Macular Corneal Dystrophy
Fresh Corneal Lenticule Implantation in Macular Corneal Distrophy With Relex Smile Surgery
The aim of the study is to examine the effect of fresh corneal lenticule implantation as allogenic graft taken from myopic patients to implanted in patients with macular corneal dystrophy using Visumax Femtosecond Laser Smile…
- Trial name
- NCT04642729
- Testing
- Fresh Corneal Lenticule Implantation using Relex-Smile Surgery
- Where
- Kosovo
- Volunteers
- 15 people
- Sponsor
- Eye Hospital Pristina Kosovo
Fuchs' Endothelial Dystrophy
DMEK Versus DSAEK Study
The purpose of this study is to determine whether corneal transplantation by Descemet Membrane Endothelial Keratoplasty more favourable and cost-effective is compared to Descemet Stripping Automated Endothelial Keratoplasty for…
- Trial name
- DMEK (NCT02793310)
- Testing
- DMEK, DSAEK
- Where
- Netherlands
- Volunteers
- 54 people
- Sponsor
- Maastricht University Medical Center
Alkaptonuria
Long-Term Study of Nitisinone to Treat Alkaptonuria
This 3-year study will examine the safety and effectiveness of long-term use of nitisinone (Orfadin) for treating joint problems in patients with alkaptonuria, an inherited disease in which a compound called homogentisic acid…
- Trial name
- NCT00107783
- Testing
- Nitisinone (NTBC)
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- National Human Genome Research Institute (NHGRI)
Mucopolysaccharidoses
Validation and Reliability of Iris Cameras in Mucopolysaccharidoses
To assess the reliablity and validity of 2 new iris cameras in the assement of corneal opacification in mucopolysaccharidoses
- Trial name
- NCT05354219
- Testing
- Imaging
- Where
- United Kingdom
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Manchester University NHS Foundation Trust
Fuchs' Endothelial Dystrophy, Fuchs Dystrophy
TTHX1114(NM141) in Combination With DWEK/DSO
Open label, single-treatment, with a concurrent non-treatment control
- Conditions
- Fuchs' Endothelial Dystrophy, Fuchs Dystrophy, Fuchs
- Trial name
- NCT04676737
- Testing
- TTHX1114(NM141)
- Where
- 11 sites in United States
- Volunteers
- 49 people
- Sponsor
- Trefoil Therapeutics, Inc.
Corneal Dystrophy, Macular Dystrophy
The Efficacy of Hyperemesis Gravidarum on Macular Thickness, Corneal Thickness and Intraocular Pressure in Pregnancy
Aim Physiological changes in intraocular pressure as well as in the cornea and macula may occur during pregnancy. In the literature, there are limited data on ocular findings in hyperemesis gravidarum.
- Conditions
- Corneal Dystrophy, Macular Dystrophy, Hyperemesis Gravidarum - Severe
- Trial name
- NCT05927740
- Testing
- Optic coherence tomography
- Where
- Turkey (Türkiye)
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Batman Training and Research Hospital
Hereditary Corneal Dystrophy, Corneal Abnormality
Safety and Efficacy Study of GEB-101 Injection in Subjects With TGFBI-related Corneal Dystrophy
The goal of this clinical trial is to evaluate the safety and efficacy of GEB-101 injection in subjects with TGFBI-related Corneal Dystrophy
- Conditions
- Hereditary Corneal Dystrophy, Corneal Abnormality, Corneal Dystrophies, Corneal Dystrophies, Hereditary
- Trial name
- CLARITY (NCT07750678)
- Testing
- GEB-101 Injection
- Where
- 2 sites in United States, China
- Volunteers
- 30 people
- Sponsor
- GenEditBio Limited
Keratoconus, Corneal Opacity
OCT in Diagnosis of Irregular Corneas
This main goal of this study is to improve the detection, classification, monitoring, and treatment of irregular corneas due to keratoconus, warpage, dry eye, scar, stromal dystrophies, and other corneal conditions.
- Conditions
- Keratoconus, Corneal Opacity, Corneal Dystrophy
- Trial name
- NCT03504800
- Testing
- Optical Coherence Tomography
- Where
- United States
- Volunteers
- 445 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Fuchs Endothelial Corneal Dystrophy
A Study to Evaluate the Safety and Efficacy of K-321 Eye Drops After Descemetorhexis in Participants With Fuchs Endothelial Corneal Dystrophy (FECD)
A study to assess the safety and efficacy of K-321 in participants with FECD after descemetorhexis.
- Trial name
- NCT05795699
- Testing
- Ripasudil
- Where
- 50 sites in United States, Canada and 4 more
- Volunteers
- 107 people
- Sponsor
- Kowa Research Institute, Inc.
Herpetic Keratitis
Topical Ganciclovir Versus Systemic Aciclovir in the Treatment of Herpetic Keratitis
Traditional antiviral treatments, including systemic acyclovir, have shown effectiveness in resolving keratitis but can also lead to complications, including ocular surface toxicity and the development of acyclovir-resistant…
- Trial name
- NCT06757907
- Testing
- Acyclovir 400 MG, Ganciclovir (GCV)
- Where
- Egypt
- Volunteers
- 20 people
- Sponsor
- Al-Azhar University
Mucolipidosis Type IV
The Natural History of Mucolipidosis Type IV
The purpose of this study is to define the natural history of Mucolipidosis Type IV and identify potential clinical outcome measures.
- Trial name
- NCT01067742
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Baylor Research Institute
Endothelial Corneal Dystrophy
Predictive Factors of Good Results After Primary Descemet's Membrane Endothelial Keratoplasty (DMEK)
Aim: Identify predictive factors of good results after primary Descemet's Membrane Endothelial Keratoplasty (DMEK) in Fuchs Endothelial Corneal Dystrophy (FECD).
- Trial name
- GOODRMEK (NCT04469933)
- Volunteers
- 102 people
- Sponsor
- Centre Hospitalier Régional Metz-Thionville
Cataract, Fuchs' Endothelial Dystrophy
Impact of Cataract Surgery on Keratoplasty Graft Survival
The follow up time after keratoplasty now routinely exceeds multiple decades. It is common for keratoplasty patients to also undergo cataract surgery at a later date in their lives.
- Conditions
- Cataract, Fuchs' Endothelial Dystrophy, Keratoconus
- Trial name
- IGREC (NCT02875145)
- Testing
- Cataract surgery
- Where
- France
- Volunteers
- 453 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Corneal Diseases, Keratoconus
Keratoconus, Corneal Diseases and Transplant Registry
The cornea is the clear layer in front of the iris and pupil. It protects the iris and lens and helps focus light on the retina.
- Conditions
- Corneal Diseases, Keratoconus, Corneal Ulcer, Corneal Trauma
- Trial name
- KCDTR (NCT04164407)
- Where
- France
- Volunteers
- 800 people
- Sponsor
- University Hospital, Montpellier