Clinical trials: Corneal Ectasia
Keratoconus
Treatment of Keratoconus Using Collagen Cross-Linking
The purpose of this study is to determine the effectiveness of collagen cross-linking in the cornea in halting the progression and possibly partially reversing the effects of keratoconus.
- Trial name
- NCT00841386
- Testing
- Riboflavin-5-phosphate
- Where
- 2 sites in United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University at Buffalo
Keratoconus
Photorefractive Keratectomy and Corneal Cross-linking in Keratoconus
Evaluation of the safety and efficacy of surface ablation followed by Collagen Cross-linking in patients with keratoconus
- Trial name
- NCT02189447
- Testing
- Simultaneous Photorefractive Keratectomy and Collagen Cross-linking in patients with keratoconus
- Volunteers
- 44 people
- Sponsor
- The Eye Center and The Eye Foundation for Research in Ophthalmology
Keratoconus, Cornea Ectasia
Safety and Efficacy of Corneal Crosslinking Using the PXL-Platinum 330 for Eyes With Corneal Ectatic Conditions
To evaluate the safety and effectiveness of the PXL Platinum 330 device for performing Corneal Crosslinking in patients with corneal thinning conditions.
- Trial name
- NCT04240457
- Testing
- Epithelial-on Corneal Crosslinking with the PXL 330 Platinum system.
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Arbor Center for Eye Care
Corneal Ectasia
Cornea Ectasia Excimer Laser Treatment
To evaluate efficacy, safety, objective and subjective quality of vision after treatment of cornea ectasia with transepithelial topographic guided laser simultaneous Central Corneal Remodeling (CCR) and Cross-linking (CXL).
- Trial name
- NCT04405882
- Testing
- topographic guided trans epithelial excimer laser
- Where
- Italy
- Volunteers
- 8 people
- Sponsor
- Bambino Gesù Hospital and Research Institute
Keratoconus, Corneal Ectasia
Clinical and Structural Outcome of Conventional Versus Accelerated Corneal Collagen Cross-linking (CXL).
Compare different corneal parameters and visual outcome of corneal collagen cross-linking (CXL) with conventional versus accelerated ultraviolet-A irradiation using riboflavin with hydroxypropyl methylcellulose.
- Trial name
- CXL (NCT02883478)
- Testing
- UV-X 1000 (3 mW/cm²), UV-X 2000 (9 mW/cm²), riboflavin with hydroxypropyl methylcellulose
- Volunteers
- 40 people
- Sponsor
- Oslo University Hospital
Corneal Ectasia
Three Different Cross-linking Protocols for Treatment of Pediatric Keratoconus
comparison between standard cross-linking protocol and accelerated and transepithelial cross-linking
- Trial name
- NCT05691335
- Testing
- Standard CXL, Accelerated CXL, Transepithelial CXL
- Where
- Egypt
- Volunteers
- 97 people
- Sponsor
- Sohag University
Keratoconus, Corneal Ectasia
Corneal Crosslinking for Treatment of Progressive Keratoconus or Corneal Ectasia
This randomized study compares 2 variations of corneal crosslinking for treatment of keratoconus or corneal ectasia.
- Trial name
- NCT07841470
- Testing
- Riboflavin 0.1% ophthalmic solution and pulsed light, Riboflavin 0.1% ophthalmic solution and non-pulsed light
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- Price Vision Group
Keratoconus, Post LASIK Keratectasia
Evaluating the Safety and Efficacy of the KXL System for Corneal Collagen Cross-Linking in Eyes Having Keratoconus
The objectives of this study are to evaluate the safety of and efficacy of the KXL system with vibeX Rapid (Riboflavin Ophthalmic Solution) for Corneal Collagen Cross-Linking in eyes having: 1. Keratoconus (KC) , 2.
- Trial name
- NCT02638376
- Testing
- 0.1% Riboflavin ophthalmic solution (KXL System With vibeX Rapid), simultaneous KXL and topography-guided transepithelial photorefractive keratectomy(PRK)
- Where
- Singapore
- Volunteers
- 66 people
- Sponsor
- Singapore Eye Research Institute
Corneal Ectasia
Riboflavin-UVA Induced Collagen Crosslinking Treatment for Corneal Ectasia
This is a hospital-based interventional prospective study. Patients with clinical keratoconus or LASIK keratectasia presenting to the Singapore National Eye Centre who meet the eligibility criteria are recruited for this study.
- Trial name
- NCT01123057
- Testing
- riboflavin-induced collagen cross-linking treatment, Riboflavin-UVA induced collagen cross-linking treatment for corneal ectasia
- Where
- Singapore
- Volunteers
- 30 people
- Sponsor
- Singapore National Eye Centre
Keratoconus
INTACS (Intrastromal Corneal Ring Segments) For Corneal Ectasia
To join established study put on by Addition Technologies, Inc. in the surgical implantation of asymmetrical INTACS segments to treat myopia and astigmatism in patients with keratoconus.
- Trial name
- INTACS (NCT02512432)
- Testing
- INTACS
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Refractive Surgery
Accelerated Versus Standard CXL in the Treatment of Ectasia Post Refractive Surgery and Penetrating Keratoplasty.
WHAT WAS KNOWN *Standard CXL is the common procedure for treating progressive corneal ectasia. Modifications of the standard protocol were introduces to reduce its complications especially long exposure to ultraviolet rays.
- Trial name
- NCT03791684
- Testing
- Cross linking
- Volunteers
- 111 people
- Sponsor
- Menoufia University
Keratoconus, Post-Refractive Ectasia
Corneal Crosslinking in Patients With Keratoconus and Post-Refractive Ectasia
The purpose of this study is to evaluate the effectiveness of using riboflavin and UV light to treat progressive keratoconus or post-refractive corneal ectasia.
- Trial name
- NCT01143389
- Testing
- Riboflavin, UVX light
- Where
- United States
- Volunteers
- 510 people
- Sponsor
- Price Vision Group
Ectasia
Corneal Collagen Cross-Linking for Ectasia (CXL)
Prospective, randomized multicenter study to determine the safety and effectiveness of performing corneal collagen cross-linking (CXL) using riboflavin and UVA light in eyes with ectasia after refractive surgery.
- Trial name
- CXL (NCT00674661)
- Testing
- riboflavin ophthalmic solution, UVA Irradiation
- Where
- 10 sites in United States
- Volunteers
- 130 people
- Sponsor
- Glaukos Corporation
Corneal Ectasia, Keratoconus
KeratoConus Data Acquisition With Topography and Aberrometry
This observational study aims to collect real-world wavefront aberrometry and corneal/scleral topography data from individuals with keratoconus and other corneal ectatic disorders.
- Trial name
- KC-DATA (NCT06859398)
- Testing
- Ocular Topography and Wavefront Aberrometry
- Where
- 2 sites in Belgium, Netherlands
- Volunteers
- 52 people
- Sponsor
- Azalea Vision
Corneal Ectasia
Corneal Topographic Changes in Different Grades of OSA
Corneal topographic parameters in different degrees of obstructive sleep apnea
- Trial name
- NCT06347900
- Testing
- Pentacam (corneal topographic changes detection), Polysymnography
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Sohag University
Keratoconus, Corneal Ectasia
Safety & Efficacy of Corneal Collagen Cross-Linking in Eyes With Keratoconus or Corneal Ectasia After Refractive Surgery
The objectives of this study are to evaluate and compare the safety and efficacy of three treatment regimens for corneal collagen cross-linking performed with VibeX (riboflavin ophthalmic solution) and the KXL System in impeding…
- Trial name
- NCT01459679
- Testing
- KXL System (15 mW/cm2), KXL System (30 mW/cm2), KXL System (45 mW/cm2)
- Where
- 83 sites in United States, Puerto Rico
- Volunteers
- 1,721 people
- Sponsor
- American-European Congress of Ophthalmic Surgery
Progressive Keratoconus, Corneal Ectasia
Corneal Collagen Cross-Linking for the Treatment of Progressive Keratoconus and Corneal Ectasia
Prospective, randomized, single site study to determine the safety and effectiveness of performing corneal collagen cross-linking (CCCL)using riboflavin and UVA light in eyes with corneal ectasia or progressive keratoconus.
- Trial name
- CL (NCT00567671)
- Testing
- Corneal collagen
- Where
- United States
- Volunteers
- 160 people
- Sponsor
- Emory University
Ectasia
Eye Rubbing and Transient Change in Corneal Parameters
This study addresses the research question: How does eye rubbing affect corneal (clear part of eye) parameters in healthy volunteers The study objectives are: 1. To determine the corneal changes following eye rubbing 2.
- Trial name
- NCT02131740
- Testing
- Eye rubbing, No eye rubbing
- Where
- United Kingdom
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Sussex Eye Hospital
Keratoconus, Corneal Ectasia
Accelerated Corneal Collagen Crosslinking for Keratoconus and Ectasia Using Pulse or Continuous UV-A Light
Corneal collagen crosslinking has been demonstrated as an effective method of reducing progression of both keratoconus and post-refractive corneal ectasia, as well as decreasing the steepness of the cornea in these pathologies.
- Trial name
- NCT05027295
- Testing
- riboflavin ophthalmic solution
- Where
- United States
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- Cornea and Laser Eye Institute
Keratoconus
PRoTECT: Corneal Wavefront Guided PRK + Epi-off CXL vs. PTK+Epi-off CXL in Keratoconus
Keratoconus causes irregular astigmatism and reduced vision. Epi-off corneal crosslinking (CXL) stabilizes the cornea but often leaves higher-order aberrations uncorrected.
- Trial name
- PRoTECT (NCT07372911)
- Testing
- Schwind AMARIS excimer laser, Corneal collagen crosslinking epi-off accelerated
- Where
- Mexico
- Volunteers
- 50 people
- Sponsor
- Instituto de Oftalmología Fundación Conde de Valenciana