Clinical trials: Corneal Endothelial Dystrophy
Retinal Diseases, Fuchs Endothelial Dystrophy
DISCOVER Study: Microscope-integrated Intraoperative OCT Study
Optical coherence tomography (OCT )provides high resolution information regarding the anatomic structure of the tissues of the eye in a cross-sectional and 3 dimensional view.
- Conditions
- Retinal Diseases, Fuchs Endothelial Dystrophy, Macular Hole, Epiretinal Membrane
- Trial name
- DISCOVER (NCT02423213)
- Where
- United States
- Volunteers
- 2,911 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Fuchs Endothelial Corneal Dystrophy, Cataract
Comparison of Outcomes Between Femtosecond Laser-Assisted and Conventional Phacoemulsification in Fuchs Endothelial Corneal Dystrophy Patients With Cataracts
The goal of this observational study is to compare the mid- to long-term efficacy of femtosecond laser-assisted cataract surgery (FLACS) and conventional phacoemulsification surgery (CPS) in patients with moderate to severe…
- Trial name
- NCT06966167
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Eye & ENT Hospital of Fudan University
Fuchs' Endothelial Dystrophy
Eye Drops for Early Morning-Associated Corneal Swelling of the Cornea
This study evaluates the efficacy of hyperosmolar eye drops on early morning edema of the cornea in patients with Fuchs' endothelial corneal dystrophy (FECD).
- Trial name
- EDEMAS (NCT04140422)
- Testing
- Hyperosmolar eye drops
- Where
- Germany
- Volunteers
- 68 people
- Sponsor
- University Eye Hospital, Freiburg
Fuchs' Endothelial Dystrophy
Glanatec(R) for Descemet Stripping in Fuch's Endothelial Dystrophy
In brief, the objective of this study is to investigate whether the drug Glanatec ® which is approved in Japan for glaucoma and ocular hypertension, can be used in patients with Fuchs endothelial dystrophy who have had a descemet…
- Trial name
- NCT03249337
- Testing
- Ripasudil hydrochloride hydrate 0.4% ophthalmic solution
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Marian Macsai, MD
Fuchs' Endothelial Dystrophy, Phacoemulsification
Fuchs' Torsional Phaco Study
The primary objective is to compare the effect of torsional phacoemulsification and longitudinal phacoemulsification on central and peripheral corneal thickness/volume after cataract surgery in patients with Fuchs' endothelial…
- Trial name
- NCT00781027
- Testing
- Phacoemulsification
- Where
- Netherlands
- Volunteers
- 50 people
- Sponsor
- Maastricht University Medical Center
Fuchs Dystrophy, Pseudophakic Bullous Keratopathy
OCT in Fuchs' Dystrophy
This is an observational study using optical coherence tomography (OCT) technology to quantify corneal edema in Fuchs' endothelial dystrophy and predict refractive shift from resolving corneal edema after surgical treatments.
- Trial name
- NCT04258787
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Oregon Health and Science University
Fuchs Endothelial Corneal Dystrophy
A Study to Investigate the Safety and Efficacy of K-321 Eye Drops After Simultaneous Cataract Surgery and Descemetorhexis in Participants With Fuchs Endothelial Corneal Dystrophy (FECD)
A study to assess the safety and efficacy of K-321 in participants with FECD after simultaneous cataract surgery and descemetorhexis.
- Trial name
- NCT05826353
- Testing
- Ripasudil
- Where
- 43 sites in United States, Canada and 4 more
- Volunteers
- 110 people
- Sponsor
- Kowa Research Institute, Inc.
Fuchs' Dystrophy, Corneal Edema
Comparison of Corticosteroid Dosing Regimens After Endothelial Keratoplasty
Graft rejection has traditionally been one of the leading causes of cornea transplant failure. To help prevent rejection, corticosteroid eye drops are used for an extended period after transplant surgery.
- Trial name
- NCT01853696
- Testing
- loteprednol etabonate, prednisolone acetate 1%
- Where
- United States
- Volunteers
- 167 people
- Sponsor
- Cornea Research Foundation of America
Corneal Dystrophies, Hereditary
Descemet Stripping (Automated) Endothelial Keratoplasty (DSEK or DSAEK)
To evaluate the transplantation of a posterior corneal disc for the management of corneal endothelial disorders in Descemet Stripping Endothelial Keratoplasty (DSEK) or Descemet Stripping Automated Endothelial Keratoplasty…
- Trial name
- DSAEK (NCT00543660)
- Testing
- Descemet Stripping Automated Endothelial Keratoplasty (DSAEK)
- Where
- Netherlands
- Volunteers
- 20 people
- Sponsor
- Netherlands Institute for Innovative Ocular Surgery
Fuchs' Endothelial Dystrophy
Assessment of Corneal Graft Attachment in Patients With Fuchs Endothelial Corneal Dystrophy Following DMEK Using Ultra-high Resolution OCT
Fuchs endothelial corneal dystrophy (FECD) is a progressive disease characterized by the loss of endothelial cells, thickening of Descemet's membrane and deposition of extracellular matrix in the form of guttae.
- Trial name
- NCT02542644
- Testing
- Ultrahigh resolution Spectral Domain OCT
- Where
- 2 sites in Austria
- Volunteers
- 12 people
- Sponsor
- Medical University of Vienna
Corneal Endothelial Dystrophy, Corneal Edema
Loteprednol Etabonate 0.25% for Prevention of Cornea Transplant Rejection
The purpose of this study is to assess off-label use of loteprednol etabonate 0.25% ophthalmic suspension (Eysuvis) for prevention of immunologic rejection in the first year after Descemet membrane endothelial keratoplasty…
- Trial name
- NCT05136443
- Testing
- loteprednol etabonate 0.25% ophthalmic suspension
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Price Vision Group
Fuchs' Endothelial Dystrophy, Corneal Edema
Plasma Rich in Growth Factors in Corneal Endothelial Transplantation
The purpose of the study is to determine the safety and efficacy of brief intraoperative corneal endothelial graft incubation in plasma rich in growth factors (PRGF) for reducing postoperative endothelial cell loss.
- Trial name
- NCT06261346
- Testing
- Endothelial keratoplasty, PRGF
- Where
- 2 sites in United States
- Volunteers
- 100 people
- Sponsor
- University of Miami
Corneal Edema, Corneal Endothelial Dysfunction
Study of Safety and Tolerability of EO2002 in the Treatment of Corneal Edema
Corneal edema is the most common indication for corneal transplantation, accounting for approximately 70% of penetrating keratoplasty (PK), and 100% of endothelial keratoplasty (EK) procedures annually.
- Conditions
- Corneal Edema, Corneal Endothelial Dysfunction, Corneal Endothelial Dystrophy, Fuchs Dystrophy
- Trial name
- NCT04894110
- Testing
- EO2002, EO2002 low dose, EO2002 mid dose
- Where
- 8 sites in United States
- Volunteers
- 42 people
- Sponsor
- Emmecell
Corneal Endothelial Cell Loss, Fuchs' Endothelial Dystrophy
Technique And Results In Endothelial Keratoplasty
To assess and compare the complications and results of different lamellar endothelial keratoplasty techniques and its variations.
- Trial name
- TREK (NCT02470793)
- Testing
- Descemet Stripping Automated Endothelial Keratoplasty, Descemet Membrane Endothelial Keratoplasty
- Where
- Spain
- Volunteers
- 62 people
- Sponsor
- EDUARD PEDEMONTE-SARRIAS
Cataract Surgery, Cataract and Fuchs Endothelial Corneal Dystrophy
Trial Comparing Cataract Surgery With Triple-DMEK in Patients With Cataract and Fuchs Endothelial Corneal Dystrophy
The purpose of the study is to investigate whether there is a difference in BCVA in patients who receive one of the following two surgeries: intervention group (arm 1) cataract surgery alone and control group (arm 2) cataract…
- Trial name
- ETCF (NCT06425666)
- Testing
- Intervention group /arm 1 (Cataract surgery alone), Control group /arm 2: Corneal transplantation as Descemet Membrane Endothelial Keratoplasty (DMEK) in combination with cataract surgery (triple-DMEK)
- Where
- 4 sites in Denmark, Germany and 2 more
- Volunteers
- 120 people
- Sponsor
- University of Cologne
Corneal Disease, Fuch's Dystrophy
Cornea Donor Study
The Cornea Donor Study (CDS) was designed as a prospective cohort study with the following objectives: To determine whether the graft-failure rate over a 5-year follow-up period following corneal transplantation is the same when…
- Conditions
- Corneal Disease, Fuch's Dystrophy, Pseudophakic Corneal Edema
- Trial name
- CDS (NCT00006411)
- Testing
- corneas assigned by donor age group
- Where
- United States
- Volunteers
- 1,090 people
- Sponsor
- National Eye Institute (NEI)
Fuchs' Endothelial Dystrophy, Fuchs Dystrophy
Ripasudil 0.4% Eye Drops in Fuchs Endothelial Corneal Dystrophy
The cornea forms our "window to the world". Hence, its transparency is of utmost importance for vision. Corneal endothelium plays a central role in the maintenance of a transparent corneal stroma.
- Conditions
- Fuchs' Endothelial Dystrophy, Fuchs Dystrophy, Corneal Endothelial Dystrophy, Corneal Endothelial Cell Loss
- Trial name
- NCT03575130
- Testing
- Ripasudil eye drops, Optive eye drops, Descemetorhexis
- Where
- Germany
- Volunteers
- 21 people
- Sponsor
- University of Erlangen-Nürnberg Medical School
Fuchs Endothelial Dystrophy, Corneal Edema
Study of Eye Bank Pre-cut Donor Grafts for Endothelial Keratoplasty
Descemet's stripping with endothelial keratoplasty (DSEK) is a cornea-sparing transplant technique that replaces only the diseased endothelial cell layer of the patient's cornea.
- Trial name
- NCT00624221
- Testing
- Descemet's stripping endothelial keratoplasty
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Cornea Research Foundation of America
Fuchs' Endothelial Corneal Dystrophy, Descemet Membrane Endothelial Keratoplasty
Predictive Factors of Graft Detachment Following Dmek
The aim of this study was to identify the predictive factors of graft detachment after Descemet Membrane Endothelial Keratoplasty (DMEK) surgery.
- Conditions
- Fuchs' Endothelial Corneal Dystrophy, Descemet Membrane Endothelial Keratoplasty, Pseudophakic Bullous Keratopathy, Graft Detachment
- Trial name
- PDF DMEKDETACH (NCT05531760)
- Testing
- Descemet Membrane Endothelial Keratoplasty
- Where
- France
- Volunteers
- 170 people
- Sponsor
- Centre Hospitalier Régional Metz-Thionville
Fuchs' Corneal Endothelial Dystrophy
Evaluating Results of Neusidl Corneal Inserter in Descemet's Stripping Automated Endothelial Keratoplasty (DSAEK)
This project compares the Neusidl Corneal Injector (NCI) device developed by Fischer Surgical, Inc. for the delivery of tissue into the eye in DSAEK surgery to the current standard forceps insertion DSAEK technique.
- Trial name
- NCT01357122
- Testing
- NCI Insertion, Standard Forceps Insertion
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Legacy Health System