Clinical trials: Corneal Injuries
Corneal Toxicity, Ototoxicity
A Comparison of Infection Rates Between Two Surgical Sites
Does the use of chlorhexidine scrub prior to cutaneous surgery on the face increase the chances of toxicity to the eyes or ears? In addition, does the us eof chlorhexidine scrub on the face prior to cutaneous surgery decrease the…
- Conditions
- Corneal Toxicity, Ototoxicity, Surgical Site Infection
- Trial name
- NCT01263262
- Where
- United States
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Limbal Stem Cells Deficiency
A Clinical Study on Co-transplantation of Autologous Limbal Stem Cells and Corneal Stromal Stem Cells to Repair Corneal Injury
This study aims to: 1) verify the feasibility of treating limbal stem cell deficiency (LSCD) caused by chemical injury with autologous limbal stem cell transplantation combined with corneal stromal stem cell transplantation; 2)…
- Trial name
- NCT06700655
- Testing
- Cornea limbal stem cell transplantation group, Corneal transplantation, Cornea limbal stem cell transplantation combined corneal stromal stem cell group
- Volunteers
- 60 people
- Sponsor
- Zhongshan Ophthalmic Center, Sun Yat-sen University
Corneal Scars and Opacities
To Evaluate the Clinical Safety and Efficacy of Limbal Stem Cell for Treatment of Superficial Corneal Pathologies".
This study proposes to investigate the transplantation of ex-vivo cultivated allogenic limbal stromal cells for the treatment of the corneal pathologies.
- Trial name
- NCT04932629
- Testing
- Ex-vivo cultivated Allogeneic limbal stromal stem cells
- Volunteers
- 20 people
- Sponsor
- L.V. Prasad Eye Institute
Rare Diseases, Aniridia
Validation of Human Drugs Target of Repurposed Drugs and Novel Therapies
The cross-sectional observational clinical study related to rare eye diseases is a multi-center study in which the hypothesis is that neurokinin 1 receptor and/or substance P expression is increased in REDs associated with…
- Conditions
- Rare Diseases, Aniridia, Neurotrophic Keratopathy, Limbal Stem Cell Deficiency
- Trial name
- NCT06412718
- Volunteers
- 274 people, healthy volunteers welcome
- Sponsor
- IRCCS Ospedale San Raffaele
Corneal Epithelial Wound Healing
Cross-linked CMC and Silk Proteins in Corneal Re-epithelization
Data analyses and revision of the corneal re-epithelization in patients who underwent either PRK (Photorefractive Keratectomy), CXL (Corneal Cross-Linking), PTK (phototherapeutic keratectomy), or experienced a corneal abrasion.
- Trial name
- CLCS (NCT06840990)
- Testing
- CXC-SP, CTRL
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- D&V FARMA srl
Retinitis Pigmentosa, Maculopathy, Age Related
High Resolution, High-speed Multimodal Ophthalmic Imaging
Knowledge of the pathogenesis of ocular conditions, a leading cause of blindness, has benefited greatly from recent advances in ophthalmic imaging.
- Conditions
- Retinitis Pigmentosa, Maculopathy, Age Related, Macular Dystrophy, Macular Edema
- Trial name
- IMA-MODE (NCT04129021)
- Testing
- High-resolution retinal imaging through adaptive optics, High-resolution retinal imaging through holographic systems
- Where
- France
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier National d'Ophtalmologie des Quinze-Vingts
Corneal Disease, Pterygium
Corneal Epithelium Repair and Therapy Using Autologous Limbal Stem Cell Transplantation
Corneal disease is a leading cause of blindness in the world. A shortage of corneal donor tissue has prevented many patients from regaining vision.
- Conditions
- Corneal Disease, Pterygium, Myopia, Hyperopia
- Trial name
- NCT02148016
- Testing
- LSCs and amniotic membrane (Modified Technique), Amniotic membrane only (Traditional Technique), PRK, LSCs, and amniotic membrane (Modified Technique)
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Sun Yat-sen University
Cornea Injury
Utilization of Amniotic Membrane Extract Eye Drop (AMEED) on Human Corneal Healing
For severe ocular surface diseases, such as chemical and thermal injuries, Stevens-Johnson syndrome (SJS), Band Keratopathy, Corneal Dystrophies, Refractive (PRK-LASEK), corneal surgery and others, it is important that short time…
- Trial name
- NCT02746848
- Testing
- Amniotic Membrane Extract Eye Drop
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Royan Institute
Corneal Epithelial Wound Healing
Corneal Epithelial Wound Healing Difference Between Human Autoserum and Cord Blood Serum
Human serum eye drops have been successfully used in the treatment of severe ocular surface disorders and the enhancement of corneal wound healing.
- Trial name
- NCT00681642
- Where
- Taiwan
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Corneal Abrasion
Bandage Contact Lens Application for the Management of Corneal Abrasion
The researchers are trying to understand if the application of a bandage contact lens results in better relief than usual treatment for a corneal abrasion.
- Trial name
- NCT04159714
- Testing
- Air Optix contact lens
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Mayo Clinic
Corneal Abrasions
IN PATIENTS WITH CORNEAL ABRASIONS TREATED WITH COLLAGEN CORNEAL SHIELDS IN THE EMERGENCY DEPARTMENT SETTING
This is a single-center, double-arm, patient masked, randomized controlled trial. Subjects will be enrolled in the Emergency Department at the Penn State Milton S. Hershey Medical Center.
- Trial name
- NCT07225699
- Testing
- Oasis 72-Hour collagen shield
- Volunteers
- 60 people
- Sponsor
- Milton S. Hershey Medical Center
Corneal Scar
Study to Evaluate the Safety and Efficacy of CSB-001 Ophthalmic Solution 0.1% in Subjects With Corneal Scars
This study will enroll subjects with recently formed corneal scars that resulted from a corneal insult presenting and diagnosed within the past approximately 30 days and not less than approximately 7 days.
- Trial name
- NCT06257355
- Testing
- CSB-001 Ophthalmic Solution 0.1%
- Where
- 7 sites in United States
- Volunteers
- 20 people
- Sponsor
- Claris Biotherapeutics, Inc.
Corneal Abrasion
Effect of Tetracaine on Pain Management and Corneal Healing in Patients With Acute Corneal Abrasion
Corneal abrasions are associated with significant discomfort during a 24-48 hrs healing phase. Current practice guidelines discourage the use of topical anesthetics in treating these patients due to concerns that these…
- Trial name
- NCT02483897
- Testing
- Tetracaine 0.5% ophthalmic drops
- Sponsor
- Queen's University
Corneal Persistent Epithelial Defect
NEXAGON for the Treatment of Corneal Persistent Epithelial Defects Following Severe Ocular Injuries
This study will enroll participants with a non-infected, corneal persistent epithelial defect (PED) resulting from an ocular chemical and/or thermal ocular injury which is non-responsive or refractory to current standard of care…
- Trial name
- EXPEDE (NCT04081103)
- Testing
- Nexagon® (lufepirsen) High Dose Concentration, Nexagon® (lufepirsen) Low Dose Concentration, Vehicle
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Glaukos Corporation
Corneal Injuries, Corneal Burns
Stem Cells Therapy for Corneal Blindness
This is a investigative initiated, comparative pilot clinical trial to ascertain the safety of application of ex-vivo cultivated limbal stem cells in human eyes for treating different superficial corneal pathologies.
- Conditions
- Corneal Injuries, Corneal Burns, Corneal Scars and Opacities
- Trial name
- ExCell (NCT02948023)
- Testing
- Ex-vivo cultivated limbal stem cell pool
- Where
- India
- Volunteers
- 100 people
- Sponsor
- L.V. Prasad Eye Institute
Junctional Epidermolysis Bullosa, Epidermolysis Bullosa (EB)
Pilot Study of ELK-003 Eye Drops for Treating Ocular Manifestations of Epidermolysis Bullosa
This study consists of two phases: an Observational Phase to evaluate the natural history of ocular manifestations in subjects with Dystrophic and Junctional Epidermolysis Bullosa, followed by a Treatment Phase to assess the…
- Conditions
- Junctional Epidermolysis Bullosa, Epidermolysis Bullosa (EB), Dystrophic Epidermolysis Bullosa, Recessive Dystrophic Epidermolysis Bullosa
- Trial name
- GOTAS-ELK-EB (NCT06713434)
- Testing
- ELK-003 (Standarized Amniotic Fluid Secretome Eye Drops)
- Where
- Chile
- Volunteers
- 20 people
- Sponsor
- Fundación DEBRA Chile, Niños Piel de Cristal
Limbal Stem Cell Deficiency, Stevens-johnson Syndrome
Clinical Trial on the Effect of Autologous Oral Mucosal Epithelial Sheet Transplantation
To investigate the effect of ocular surface reconstruction and assess the safety in cultivated oral mucosal epithelial cell sheet transplantation (COMET) regarding patients with cicatricial change of ocular surface.
- Conditions
- Limbal Stem Cell Deficiency, Stevens-johnson Syndrome, Ocular Cicatricial Pemphigoid, Chemical Burn
- Trial name
- NCT02149732
- Testing
- cultivated oral mucosal epithelial sheet transplantation
- Where
- 2 sites in South Korea
- Sponsor
- Seoul National University Hospital
Corneal Dystrophy, Epithelial Basement Membrane, Epithelial Recurrent Erosion Dystrophy
Cacicol20® in Corneal Wound Healing and Nerve Regeneration After Phototherapeutic Keratectomy
The objective of this clinical study is to test the efficacy of CACICOL20® (RGTA OTR 4120) in improving wound healing and nerve regeneration in the anterior cornea, in a patient population undergoing therapeutic laser treatment…
- Conditions
- Corneal Dystrophy, Epithelial Basement Membrane, Epithelial Recurrent Erosion Dystrophy, Corneal Erosions
- Trial name
- CACICOL-PTK (NCT02373397)
- Testing
- Cacicol20
- Where
- 2 sites in Sweden
- Volunteers
- 40 people
- Sponsor
- Neil Lagali
Corenal Diseases
A Single-Center Clinical Study to Evaluate the Efficacy and Safety of Sutureless Ophthalmic Hydrogel for Corneal Wound Repair
Corneal blindness is one of the leading causes of blindness worldwide. For various infectious and non-infectious corneal diseases, current clinical repair strategies include corneal lesion debridement, conjunctival flap coverage…
- Trial name
- NCT07638215
- Testing
- Sutureless Ophthalmic Hydrogel for Corneal Stromal Defects
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Suxia Li
Contact Lens and Punctal Plug in Preventing Corneal Injuries
A Comparison Between Bandage Contact Lens, Punctal Plugs and Standard Measures in Preventing Corneal Injuries
Study Rationale: The insertion of a bandage contact lens or punctal plug in a defined group of patients admitted to the ICU may be more effective than standard care in decreasing the incidence of corneal injuries.
- Trial name
- COMLENPLSTAN (NCT01961193)
- Testing
- contact lens, punctal plug
- Where
- Israel
- Volunteers
- 105 people
- Sponsor
- Rabin Medical Center