Clinical trials: Corneal Ulcer
Corneal Ulcer
Studying the Relationship Between Contact Lens Packaging Solutions and Bacterial Binding to Surface Eye Cells
The goal of this study is to investigate the overall theory that the use of chemically preserved solutions associated with contact lenses promotes an increase in bacterial infection.
- Trial name
- NCT01104961
- Testing
- Contact lens packaging solution, Balanced salt solution (BSS)
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Corneal Ulcer
Village Integrated Eye Workers Trial
VIEW is a community-randomized trial designed to determine whether it is possible to prevent corneal ulcers on a large scale. The study compares the incidence of corneal ulceration between villages in which volunteers are trained…
- Trial name
- VIEW (NCT01969786)
- Testing
- Corneal ulcer prevention program
- Where
- Nepal
- Volunteers
- 223,671 people
- Sponsor
- University of California, San Francisco
Corneal Opacity, Keratitis, Herpetic
Topical Anesthesia for Closed PKP vs Retrobulbar Anesthesia for Open-sky PKP
Penetrating keratoplasty (PKP) is an open-sky surgery that fundamentally has not changed for more than 100 years. Because conventional PKP is associated with the potential for the development of devastating complications such as…
- Conditions
- Corneal Opacity, Keratitis, Herpetic, Corneal Ulcer, Corneal Dystrophies, Hereditary
- Trial name
- NCT02826174
- Testing
- closed PKP under topical anesthesia, open-sky PKP under retrobulbar anesthesia, Anti-Rejection Agents
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Wenzhou Medical University
Corneal Ulcer
Effect of Various Treatment Modalities on Dendritic Vial Ulcer
Eye infection is a prevalent problem in primary care and remains a crucial healthcare concern. According to the American Academy of Ophthalmology (AAO), herpes simplex virus (HSV) keratitis (HSK) is the leading cause of…
- Trial name
- NCT05313828
- Testing
- Acyclovir, Tobramycin, Fluorometholone
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Sohag University
Corneal Ulcer, Corneal Disease
Treatment of Patients With Inflammatory-dystrophic Diseases of the Cornea Using Autologous Stem Cells
Treatment of patients with inflammatory-dystrophic diseases of the cornea using autologous limbal stem cells (corneal epithelial stem cells) or adipose-derived mesenchymal stem cells
- Conditions
- Corneal Ulcer, Corneal Disease, Corneal Dystrophy
- Trial name
- NCT04484402
- Testing
- mesenchymal stem cells, limbal stem cells, standard treatment
- Where
- Belarus
- Volunteers
- 25 people
- Sponsor
- Institute of Biophysics and Cell Engineering of National Academy of Sciences of Belarus
CNLDO - Congenital Nasolacrimal Duct Obstruction, Amblyopia
Improving the Follow up Rate for Pediatric Patients
Follow-up of pediatric patients is important for their regular ocular morbidity monitoring, especially for amblyopia management.
- Conditions
- CNLDO - Congenital Nasolacrimal Duct Obstruction, Amblyopia, Conjunctivitis, Eye Injuries
- Trial name
- NCT04837534
- Testing
- Counseling group, SMS and phone call reminder group
- Where
- Nepal
- Volunteers
- 264 people
- Sponsor
- Seva Foundation
Platelet-rich Fibrin, Macular Holes
Platelet-rich Fibrin(PRF) Membrane in Ophthalmic Diseases
The goal of this clinical trial is to observe the role of PRF in treating ophthalmic diseases.The efficacy and safety of PRF were validated for four ophthalmic conditions: macular hole, pterygium, corneal ulcer, and patients…
- Conditions
- Platelet-rich Fibrin, Macular Holes, Pterygium, Glaucoma
- Trial name
- NCT06200727
- Testing
- PRF membrane tamponade surgery in macular hole, ILM peeling in macular hole, PRF membrane grafting in pterygium
- Where
- China
- Volunteers
- 170 people
- Sponsor
- Lei Du
Corneal Ulcer, Infectious Keratitis
Cross-linking for Corneal Ulcers Treatment Trial
The primary purpose of this study is to determine if patients randomized to corneal collagen cross-linking plus medical therapy will have a lower prevalence of positive bacterial or fungal cultures immediately after the procedure…
- Conditions
- Corneal Ulcer, Infectious Keratitis, Bacterial Ulcer, Fungal Ulcer
- Trial name
- CLAIR (NCT02570321)
- Testing
- Corneal Cross-linking, Anti Fungal Drug
- Where
- 2 sites in United States, India
- Volunteers
- 147 people
- Sponsor
- University of California, San Francisco
Keratitis, Corneal Ulcer
Safety and Effectiveness of the PXL Platinum 330 System With Riboflavin Solution for Previously Untreated Corneal Ulcers
This study is being conducted to evaluate the safety and effectiveness of using the PXL Platinum 330 System with riboflavin solution for performing corneal collagen crosslinking (CXL) for the treatment of previously untreated…
- Trial name
- NCT05255107
- Testing
- Standard of Care Therapy + CXL + Riboflavin 0.23% L Solution
- Where
- 12 sites in United States
- Volunteers
- 468 people
- Sponsor
- Peschke GmbH
Keratitis, Ulcerative, Antibiotic Resistance, Microbial
Au-Ag-Cu2O NG With PTT Anti Drug-resistant Microbial Keratitis
This clinical study was conducted to evaluate the efficacy and safety of gold-silver cuprous oxide composite nanogels combined with photothermal therapy system in the treatment of severe drug-resistant bacterial keratitis…
- Conditions
- Keratitis, Ulcerative, Antibiotic Resistance, Microbial, Photothermal Therapy
- Trial name
- NCT05268718
- Testing
- Hollow gold and silver alloy cuprous oxide shell nano-shell hydrogel, Voriconazole eye drops, Normal saline
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Keratitis
Microbiological Keratitis in a Countryside City of Brazil
The purpose of this study is to identify the predisposing factors, epidemiological features and clinical and microbiological diagnosis of infectious keratitis in two public referral centers of ophthalmology in a countryside city…
- Trial name
- NCT00949468
- Where
- Brazil
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Sao Jose do Rio Preto Medical School
Fungal Keratitis
A Clinical Trial of the Treatment of Fungal Corneal Ulcers With Povidone-Iodine
The purpose of this study is to determine the effectiveness of 1.25% povidone-iodine ophthalmic solution for the treatment of small to medium sized fungal corneal ulcers compared with an antifungal antibiotic.
- Trial name
- NCT00516399
- Testing
- povidone-iodine 1.25% ophthalmic solution, natamycin ophthalmic suspension, USP 5%
- Volunteers
- 78 people
- Sponsor
- University of California, Los Angeles
Corneal Ulcer
Follow-up Compliance for Corneal Ulcer Patients With SMS Reminder
Corneal ulcer is defined as the loss of corneal epithelium with underlying stromal infiltration and suppuration, accompanied by signs of inflammation, with or without hypopyon1.
- Trial name
- NCT07377513
- Testing
- SMS reminder
- Where
- Nepal
- Volunteers
- 310 people
- Sponsor
- Seva Canada Society
Cornea Disease
A Single-Center Clinical Study Evaluating the Efficacy and Safety of Allogeneic Natural Killer (NK) Cell Transplantation for Mooren's Ulcer
Given that the definitive pathogenesis of Mooren's ulcer has not been fully clarified and clinical relapse occurs frequently, natural killer (NK)-cells demonstrate unique therapeutic potential.
- Trial name
- NCT07782138
- Testing
- Allogeneic natural killer (NK)-cell transplantation
- Volunteers
- 6 people
- Sponsor
- Suxia Li
Corneal Ulcer, Persistent Corneal Epithelial Defect
Use of a Biological Lens of Amniotic Membrane (LV-Visio-AMTRIX) in the Treatment of Trophic Ulcers
The purpose of this open, multicenter pilot trial is to assess the impact of the use of an amniotic membrane on the healing of a persistent epithelial lesion or of a corneal ulcer.
- Trial name
- NCT05172349
- Testing
- LV-Visio-AMTRIX
- Sponsor
- TBF Genie Tissulaire
Cornea Ulcer
Platelet Rich Plasma as a Treatment For Resistant Corneal Ulcers
This prospective study involved 14 patients aged > 18 years with RCUs not responding to conventional treatment. All patients were treated with E-PRP drops (one drop), preservative-free artificial tears, antibiotic eye drop four…
- Trial name
- NCT05515731
- Testing
- Autologous platelet-rich plasma (PRP) eye drops
- Where
- Egypt
- Volunteers
- 14 people
- Sponsor
- Alaa Gamal
Infectious Keratitis, Bacterial Keratitis
Collagen Cross-linking in Infectious Keratitis Trial
The purpose of this study is to evaluate the efficacy of collagen cross-linking for treatment of infectious keratitis.
- Conditions
- Infectious Keratitis, Bacterial Keratitis, Fungal Keratitis
- Trial name
- NCT01831206
- Testing
- Collagen cross-linking
- Where
- Thailand
- Volunteers
- 30 people
- Sponsor
- Chulalongkorn University
Corneal Ulcer Caused by Acanthamoeba
Evaluation of Resveratrol and Its Loaded Nanoparticles on Acanthamoeba
Acanthamoeba is a free-living amoeba responsible for severe human infections. There are at least twenty-two different genotypes of Acanthamoeba (T1-T22).
- Trial name
- NCT07148752
- Volunteers
- 50 people
- Sponsor
- Assiut University
Acute Bacterial Corneal Ulcers, Bacterial Keratitis
Safety and Efficacy Study of Gatifloxacin Compared With Ciprofloxacin in Patients With Acute Bacterial Corneal Ulcers
This study evaluates the safety and efficacy of gatifloxacin 0.3% ophthalmic solution compared with ciprofloxacin 0.3% ophthalmic solution in patients with acute bacterial corneal ulcers
- Trial name
- NCT00651586
- Testing
- Gatifloxacin 0.3% ophthalmic solution, Ciprofloxacin 0.3% ophthalmic solution
- Where
- 2 sites in United States, India
- Volunteers
- 129 people
- Sponsor
- Allergan
Corneal Ulcer
Randomized Double Blinded Study Evaluating CACICOL20 Efficiency Versus Placebo Corneal Chronic Ulcers Healing
CACICOL20 is a biodegradable nanopolymer engineered to mimic glycosaminoglycans such as heparan sulfates. Applied to the corneal lesion, it replaces damaged heparan sulfates in the matrix scaffold.
- Trial name
- UNICOL (NCT01242839)
- Testing
- CACICOL20
- Where
- 21 sites in France
- Volunteers
- 139 people
- Sponsor
- Organ, Tissue, Regeneration, Repair and Replacement