Clinical trials: Corneal Ulcer
Corneal Ulcer, Fusarium Infection
Fusarium Keratitits in Spain 2012 to 2014
The aim of this study was to describe the clinical-epidemiological characteristics of a series of cases of fungal keratitis associated with Fusarium spp., In Spain during the years 2012 to 2014.
- Trial name
- NCT02984904
- Testing
- survey
- Volunteers
- 23 people
- Sponsor
- Miguel Armando Mosquera Gordillo, MD
Neurotrophic Ulcer, Neurotrophic Keratitis
OCT Evaluation of Neurotrophic Ulcer Following Treatment With Oxervate
Neurotrophic keratitis (NK) is a condition where the cornea, or clear outer covering of the eye, has reduced sensation due to a variety of reasons.
- Conditions
- Neurotrophic Ulcer, Neurotrophic Keratitis, Neurotrophic Corneal Ulcer, Neurotrophic Keratoconjunctivitis
- Trial name
- NCT04573647
- Testing
- Cenegermin-Bkbj 0.002% Ophthalmic Solution [OXERVATE]
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Sight Medical Doctors PLLC
Neurotrophic Keratitis, Keratitis
Evaluation of Safety and Efficacy of rhNGF in Patients With Stage 2 and 3 Neurotrophic Keratitis.
This study is aimed at assessing the safety and the efficacy of two dose regimens of recombinant human nerve growth factor (rhNGF) eye drops solution compared to vehicle for inducing a complete healing of stage 2 (persistent…
- Conditions
- Neurotrophic Keratitis, Keratitis, Corneal Ulcer
- Trial name
- REPARO (NCT01756456)
- Testing
- rhNGF 10 μg/ml, rhNGF 20 μg/ml, vehicle
- Where
- 34 sites in France, Germany and 4 more
- Volunteers
- 174 people
- Sponsor
- Dompé Farmaceutici S.p.A
Fungal Keratitis, Corneal Ulcer
Fungal Ulcer Treatment Augmented With Natamycin and Cyclosporine A
The goal of this clinical trial is to learn if adjunctive topical Cyclosporine A eye drops combined with standard of care topical Natamycin treatment improves vision outcomes in patients with fungal keratitis.
- Trial name
- FANCY (NCT06658002)
- Testing
- Cyclosporine A
- Where
- 2 sites in United States, India
- Volunteers
- 150 people
- Sponsor
- University of California, San Francisco
Chronic Inflammatory Demyelinating Polyneuropathy
Prevalence of Decreased Corneal Sensation in Patients With Chronic Inflammatory Demyelinating Polyneuropathy
Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is a demyelinating chronic progressive or relapsing neuropathy believed to be secondary to an autoimmune response against peripheral nerve antigens.5 We have…
- Trial name
- NCT01379833
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- State University of New York at Buffalo
Keratitis
Automated Quantitative Ulcer Analysis Study
This is a multiple site observational study that will review patient features (clinical and morphologic) over a 90 day period during care of participants with microbial keratitis with presence of clinically significant ≥2mm…
- Trial name
- AQUA (NCT04420962)
- Testing
- Visual Acuity
- Where
- 2 sites in United States, India
- Volunteers
- 124 people
- Sponsor
- University of Michigan
Bacterial Corneal Ulcer
Evaluating the Use of ProKera Plus® in the Management of Bacterial Corneal Ulcers
The study design is a prospective, randomized, controlled interventional study to compare the outcome of ProKera Plus® with conventional treatment in patients with vision-threatening bacterial corneal ulcers.
- Trial name
- NCT04850313
- Testing
- ProProKera Plus®
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- University of Arkansas
Corneal Ulcer
ACRO Biocornea Clinical Trial in Taiwan
The goal of this clinical trial is to investigate the safety and clinical performance of ABCcolla Collagen Ophthalmic Matrix used for anterior lamellar keratoplasty in patients suffering from corneal ulcer.
- Trial name
- NCT04054817
- Testing
- Lamellar keratoplasty-ABCcolla® Collagen Ophthalmic Matrix
- Where
- 3 sites in Taiwan
- Volunteers
- 6 people
- Sponsor
- ACRO Biomedical Co. Ltd
Vaccinia
Evaluation and Treatment of Eye Complications of Vaccinia Vaccination
This study will evaluate patients with eye complications related to vaccination against smallpox to learn more about these conditions. Vaccinia vaccination has been used for more than 100 years for preventing smallpox.
- Trial name
- NCT00081835
- Testing
- NP-016 Vaccine Immune Globulin (IV-VIG)
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- National Eye Institute (NEI)
Corneal Ulcer
Painless Subconjunctival Antibiotic and Antifungal Injection in Corneal Ulcer Patients
The propose of this study is to determine the efficacy of 2% xylocaine in reducing pain due to subconjunctival antibiotic and antifungal injection.
- Trial name
- NCT00789646
- Testing
- Lidocaine/NSS, NSS/Lidocaine
- Volunteers
- 10 people
- Sponsor
- Mahidol University
Keratitis, Ulcerative, Corneal Ulcer
Wharton's Jelly Eye Drops in the Treatment of Chronic Keratitis
The purpose of this open, non-comparative, multicenter trial is to assess the impact of eye drops made of Wharton's jelly extract in the treatment of chronic keratitis that failed available therapies.
- Trial name
- NCT05200000
- Testing
- SygeLIX-Coll-T
- Where
- 6 sites in France
- Volunteers
- 20 people
- Sponsor
- TBF Genie Tissulaire
Chemical Injuries, Unspecified Complication of Corneal Transplant
Use of Cross-linked Donor Corneas as Carriers for the Boston Keratoprosthesis
The purpose of the pilot study is to test the efficacy and safety of riboflavin/Ultraviolet A (UVA) cross-linked human donor corneas as carriers for the Boston Keratoprosthesis (Boston KPro) in patients with higher risk for…
- Conditions
- Chemical Injuries, Unspecified Complication of Corneal Transplant, Autoimmune Diseases, Ocular Cicatricial Pemphigoid
- Trial name
- NCT01582880
- Testing
- Riboflavin
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Joseph B. Ciolino, MD
Keratitis, Corneal Ulcer
Safety and Effectiveness of the PXL Platinum 330 System With Riboflavin Solution for Refractory Corneal Ulcers
This study is being conducted to evaluate the safety and effectiveness of using the PXL Platinum 330 System with riboflavin solution for performing corneal collagen crosslinking (CXL) for the treatment of refractory corneal…
- Trial name
- NCT05255016
- Testing
- PXL Platinum 330 system + Riboflavin 0.25% TE Solution
- Where
- 12 sites in United States
- Volunteers
- 488 people
- Sponsor
- Peschke GmbH
Corneal Ulcers, Corneal Melting
Safety Study of a Sutureless Amniotic Membran Transplantation to Treat Ocular Surface Disorders (Expanded Access)
The investigators aimed at developing a technique to apply amniotic membrane to a diseased ocular surface without surgical intervention (sutureless amniotic membrane transplantation).
- Trial name
- AmnioClip (NCT02168790)
- Testing
- Amniotic membrane ring
- Where
- Germany
- Volunteers
- 7 people
- Sponsor
- Klinikum Chemnitz gGmbH
Corneal Ulcer of Bilateral Eyes
Studying the Effect of Ethanol Applied on the Corneal Surface During PRK Surgery.
The goal of this observational study is to learn about the effects of the duration of ethanol contact with the corneal surface. The main question it aims to answer is: Does this affect the behavior of corneal epithelial healing?
- Trial name
- NCT06540131
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- Minia University
Corneal Ulcer
Corneal Ulcer Prevention Through Health Education
A community-randomized trial comparing villages randomized to receive an intervention consisting of a trained community health volunteer who brings patients to the nearest Vision Centers or Primary Health Care Centers for…
- Trial name
- CUP (NCT02284698)
- Testing
- Health Education
- Volunteers
- 98,207 people, healthy volunteers welcome
- Sponsor
- Aravind Eye Care System
Corneal Ulcer, Eye Infections, Fungal
Mycotic Ulcer Treatment Trial I
The purpose of this study is to determine if natamycin or voriconazole results in better visual outcomes in fungal corneal ulcers, especially visual acuity.
- Trial name
- MUTT I (NCT00996736)
- Testing
- Natamycin, Voriconazole
- Where
- 3 sites in United States, India
- Volunteers
- 323 people
- Sponsor
- University of California, San Francisco
Acanthamoeba Keratitis
Parasitic Ulcer Treatment Trial Pilot
This is a study of optimal treatments for acanthamoeba keratitis. In the first part of the study, participants will be randomized to chlorhexidine monotherapy or chlorhexidine plus povidone iodine.
- Trial name
- NCT03484507
- Testing
- Chlorhexidine, Povidone-Iodine, Prednisolone Sodium Phosphate
- Where
- 2 sites in India
- Volunteers
- 49 people
- Sponsor
- University of California, San Francisco
Dry Eyes, Sjogren's Disease With Dry Eyes
Treating Dry Eyes and Corneal Ulcers With Fingerprick Autologous Blood
To investigate if fresh finger prick autologous blood (FAB) instead of serum from venesection, is a safe and effective treatment for dry eyes and corneal ulcers/ epithelial defects.
- Conditions
- Dry Eyes, Sjogren's Disease With Dry Eyes, Persistent Corneal Epithelial Defects, Chronic Corneal Ulcers
- Trial name
- FAB (NCT02153515)
- Testing
- Your own ( autologous) finger prick of blood produced with a diabetic lancet
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- Bedford Hospital NHS Trust
Acanthamoeba Keratitis
Parasitic Ulcer Treatment Trial
The Parasitic Ulcer Treatment Trial (PUTT) is a multi-center, parallel-group, randomized clinical trial. The purpose of this study is to determine whether including topical corticosteroids in a regimen for acanthamoeba keratitis…
- Trial name
- PUTT (NCT06213649)
- Testing
- Polyhexamethylene biguanide (PHMB), Topical corticosteroid
- Where
- 22 sites in United States, Brazil and 2 more
- Volunteers
- 232 people
- Sponsor
- Jeremy Keenan, MD, MPH