Clinical trials: Corneal Ulcer
Keratitis, Corneal Ulcer
Efficacy and Safety Assessment of T4020 Versus Vehicule in Patients With Chronic Neurotrophic Keratitis or Corneal Ulcer
The purpose of this study is to assess the efficacy and safety of T4020 versus vehicle.
- Trial name
- NCT01794312
- Testing
- T4020, Vehicle
- Where
- France
- Volunteers
- 152 people
- Sponsor
- Laboratoires Thea
Corneal Ulcers
Safety and Effectiveness of the UV-X System for Corneal Collagen Cross-Linking in Eyes With Refractory Corneal Infection
This study will evaluate the Safety and Effectiveness of the UV-X System for Corneal Collagen Cross-Linking in Eyes with Corneal Infection.
- Trial name
- NCT02068430
- Testing
- Riboflavin 0.1%, UV-X™ Illumination System
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Stephen Trokel
Keratitis, Corneal Ulcer
Corneal Lesions in Intensive Care Unit (ICU) Clinical Trial for Proposing Interventions and Evaluating Outcomes of Nursing in the Adult Intensive Care Center Clinical Trial for Proposing Interventions and Evaluating Outcomes of Nursing in the Adult Intensive Care Center
The purpose of the study is find out the better measure to achieve corneal protection in an Intensive Care Unit.
- Trial name
- CORNEALPREV (NCT02293876)
- Testing
- LACRIBELL®, LIPOSIC®, Glad wrap
- Where
- Brazil
- Volunteers
- 360 people
- Sponsor
- Hospital Risoleta Tolentino Neves
Mycotic Corneal Ulcer
Clinical & Visual Outcomes of Collagen Cross Linking for Fungal Keratitis
The study is a randomised control trial to assess the visual and clinical outcomes of collagen cross linking in fungal keratitis.
- Trial name
- NCT02328053
- Testing
- collagen crosslinking group, Topical anti-fungal therapy
- Where
- India
- Volunteers
- 20 people
- Sponsor
- Aravind Eye Care System
Corneal Diseases, Keratoconus
Keratoconus, Corneal Diseases and Transplant Registry
The cornea is the clear layer in front of the iris and pupil. It protects the iris and lens and helps focus light on the retina.
- Conditions
- Corneal Diseases, Keratoconus, Corneal Ulcer, Corneal Trauma
- Trial name
- KCDTR (NCT04164407)
- Where
- France
- Volunteers
- 800 people
- Sponsor
- University Hospital, Montpellier
Corneal Ulcer, Corneal Perforation
Topical Insulin - Utility and Results in Neurotrophic Keratopathy in Stages 2 and 3
Purpose: To evaluate the clinical outcome of patients with refractory Neurotrophic Keratopathy (NK) in stages 2 and 3 treated with topical insulin.
- Conditions
- Corneal Ulcer, Corneal Perforation, Corneal Epithelium Defect, Neurotrophic Keratitis
- Trial name
- NCT04820010
- Testing
- Topical Insulin
- Where
- Portugal
- Volunteers
- 20 people
- Sponsor
- Centro Hospitalar de Vila Nova de Gaia/Espinho, E.P.E.
Porcine Corneal Xenograph
Xenogenic Keratoplasty From Porcine Cornea
Acellular porcine cornea is a valid substitution for human cornea because of its similar biological structure, corneal superficial curvature and good histocompatibility toward human.
- Trial name
- XKFPC (NCT01443559)
- Testing
- Xenogenic cornea, homogenic cornea
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Xiamen University
Corneal Ulcer
Transplantation of Acellular Corneal Matrix to Treat Corneal Ulcer
This study is to develop a lamellar keratoplasty method for corneal ulcer using acellular corneal matrix (ACM) and to make an analysis among patients for its therapeutic effect.
- Trial name
- NCT01244776
- Testing
- acellular corneal matrix
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Shaanxi Aierfu Activtissue Engineering
Bacterial Keratitis, Fungal Keratitis
The Antibiogram and Outcomes of Antimicrobial Regimens in Microbial Keratitis: A Prospective Cohort Study
This study is an observational prospective cohort study which aims to generate an antibiogram and to assess the clinical responses and outcomes of microbial keratitis patients, treated with empiric topical antimicrobial…
- Conditions
- Bacterial Keratitis, Fungal Keratitis, Mixed Bacterial and Fungal Keratitis, Microbial Keratitis
- Trial name
- NCT05655689
- Testing
- Moxifloxacin Ophthalmic 0.5% Ophthalmic Solution, Ceftazidime 5% + vancomycin 5%, Gentamicin 1.4% + vancomycin 5%
- Where
- Egypt
- Volunteers
- 123 people
- Sponsor
- Alexandria University
Amniotic Membrane Extract Eye Drops, Resistant Corneal Ulcers
Role of Amniotic Membrane Extract Eye Drops as an Adjunctive Therapy in Resistant Corneal Ulcers
This study aimed to assess the efficacy of amniotic membrane extract eye drops (AMEED) as a supplementary treatment for refractory corneal ulcers.
- Trial name
- NCT06909149
- Testing
- Amniotic membrane extract eye drops, Specific treatment
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Tanta University
Corneal Ulcer, Fungal Keratitis
Mycotic Antimicrobial Localized Injection for Treatment of Corneal Ulcers
Mycotic Antimicrobial Localized Injection (MALIN) is a randomized, masked, two-arm clinical trial investigating intrastromal voriconazole in the treatment of fungal corneal ulcers.
- Trial name
- MALIN (NCT02731638)
- Testing
- Intrastromal voriconazole, Natamycin
- Where
- 2 sites in United States, India
- Volunteers
- 70 people
- Sponsor
- University of California, San Francisco
Pterygium, Corneal Ulcer
The Application of Fibrin Glue in Ocular Surface Diseases
This clinical trial tries to use tissue fibrin glues (Tisseel) to treat various ocular surface diseases or surgeries, which includes pterygium surgery, corneal melting/perforation, Gunderson's flap, conjunctival laceration, and…
- Trial name
- NCT00155402
- Testing
- tissue fibrin glue application (Tisseel)
- Where
- Taiwan
- Volunteers
- 30 people
- Sponsor
- National Taiwan University Hospital
Corneal Ulcer (Diagnosis)
Diagnosing Corneal Infection
Microbial keratitis is a common and serious eye disease in Edinburgh. Prompt treatment with antibiotics can prevent sight loss, and identification of the micro-organism and its antibiotic sensitivities are key to appropriate…
- Trial name
- NCT04230811
- Testing
- Corneal impression membrane (Millicell Cell Culture Insert, 12mm, hydrophilic PTFE 0.4µm (PICM01250))
- Where
- United Kingdom
- Sponsor
- University of Edinburgh
Neurotrophic Keratopathy
Efficacy and Safety of Topical Insulin for Neurotrophic Corneal Ulcers
To evaluate Safety and efficacy of topical insulin in treatment of neurotrophic corneal ulcers
- Trial name
- NCT06331910
- Testing
- insulin eye drops
- Volunteers
- 14 people
- Sponsor
- Assiut University
Infected Corneal Ulcers, CXL
Effectiveness of Riboflavin-Moxifloxacin Amniotic Membrane as an Adjuvant for PACK-CXL in Moderate to Severe Infectious Keratitis
This study aims to evaluate the effectiveness of a specialized amniotic membrane preparation as an adjuvant therapy for patients with moderate-to-severe infected corneal ulcers.
- Trial name
- NCT07559149
- Testing
- Riboflavin-Moxifloxacin Amniotic Membrane, Standard PACK-CXL
- Where
- Indonesia
- Volunteers
- 32 people
- Sponsor
- Gadjah Mada University
Neurotrophic Corneal Ulcer, Neurotrophic Keratitis
Corneal Neurotization as a Treatment for Neurotrophic Keratopathy
The purpose of this study is to assess the efficacy of sural nerve transfer and cadaveric nerve graft to re-establish corneal sensation in patients with neurotrophic keratopathy.
- Conditions
- Neurotrophic Corneal Ulcer, Neurotrophic Keratitis, Cranial Nerve V Diseases
- Trial name
- NCT05809245
- Testing
- Corneal neurotization
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Stanford University
Corneal Ulcer, Leukoma
Safety and Effectiveness of Collagen-phosphorylcholine Bioengineered Cornea in Patients Requiring Lamellar Keratoplasty
In this study the safety and effectiveness of biosynthetic cornea, comprising interpenetrating networks of recombinant human collagen and phosphorylcholine, will be tested in patients with severe corneal pathology (corneal ulcers…
- Trial name
- NCT02277054
- Testing
- Collagen-MPC cornea
- Where
- Ukraine
- Volunteers
- 5 people
- Sponsor
- The Filatov Institute of Eye Diseases and Tissue Therapy