Clinical trials: Corona Virus Disease
Corona Virus Infection
The Impact of Camostat Mesilate on COVID-19 Infection
SARS-CoV-2, one of a family of human coronaviruses, was initially identified in December 2019 in Wuhan city. This new coronavirus causes a disease presentation which has now been named COVID-19.
- Trial name
- CamoCO-19 (NCT04321096)
- Testing
- Camostat Mesilate
- Where
- 11 sites in Denmark, Sweden
- Volunteers
- 206 people
- Sponsor
- University of Aarhus
COVID
Study of Mavrilimumab (KPL-301) in Participants Hospitalized With Severe Corona Virus Disease 2019 (COVID-19) Pneumonia and Hyper-inflammation
Interventional, randomized, double-blind, placebo-controlled study encompassing 2 development phases (Phase 2 and Phase 3).
- Trial name
- NCT04447469
- Testing
- mavrilimumab
- Where
- 32 sites in United States, Brazil and 3 more
- Volunteers
- 814 people
- Sponsor
- Kiniksa Pharmaceuticals International, plc
Corona Virus Infection
Differential Expression of Cytokines, Transcriptome and miRNA in Coronavirus Disease 2019 (COVID-19) Egyptian's Patients
The aim of this effort is to study host-pathogen interaction in Egyptian patients infected with COVID-19. The investigators will perform genome-wide miRNA and transcriptome screens in the infected patients along with healthy ones…
- Trial name
- NCT04583566
- Testing
- COVID-19 Diagnostic and Assessment Tests
- Where
- 2 sites in Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Tanta University
Visual Impairment
Validity of at Home Visual Acuity Measurements for Telemedicine During Corona Virus (COVID-19) Pandemic
Prompted by the current COVID-19 pandemic, the American Academy of Ophthalmology has recommended the use of telemedicine to continue ophthalmic care while maintaining patient and provider social distancing.
- Trial name
- NCT04391166
- Testing
- Non invasive visual acuity testing
- Where
- United States
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
COVID-19
Glassy Trial for Effects of Wearing Glasses
Randomized trial testing 6 forms of a communication summarizing the results of a recent study (about the effects of wearing glasses on reducing covid infection risk).
- Trial name
- NCT05642754
- Testing
- Overall uncertainty language
- Where
- Norway
- Volunteers
- 960 people, healthy volunteers welcome
- Sponsor
- Trustees of Dartmouth College
COVID-19, Virus Diseases
Personalised Immunotherapy for SARS-CoV-2 (COVID-19) Associated With Organ Dysfunction
Our aim is to conduct one trial of personalized immunotherapy in patients with SARS-CoV-2 (COVID-19) associated with organ dysfunction and with laboratory findings of macrophage activation syndrome or immune dysregulation.
- Conditions
- COVID-19, Virus Diseases, Macrophage Activation Syndrome, Corona Virus Infection
- Trial name
- ESCAPE (NCT04339712)
- Testing
- Anakinra, Tocilizumab
- Where
- 17 sites in Greece
- Volunteers
- 102 people
- Sponsor
- Hellenic Institute for the Study of Sepsis
Lung Cancer, COVID
Study of the Immunity of Patients With Lung Cancer and COVID-19 Infection
Observational, retrospective data collection and prospective IgG analysis, and multicenter study. The main objective of the study is th description of the characteristics and evolution of patients with lung cancer who have…
- Conditions
- Lung Cancer, COVID, Corona Virus Infection
- Trial name
- SOLID (NCT04407143)
- Testing
- IgG test
- Where
- 68 sites in Spain
- Volunteers
- 1,980 people
- Sponsor
- Fundación GECP
Covid19
Viral Clearance, PK and Tolerability of Ensovibep in COVID-19 Patients
This study will investigate how ensovibep is distributed throughout the body, the viral clearance and the tolerability of ensovibep in patients with symptomatic COVID-19 disease
- Trial name
- NCT04834856
- Testing
- ensovibep
- Where
- Netherlands
- Volunteers
- 12 people
- Sponsor
- Molecular Partners AG
Respiratory Viral Infection
A Clinical Trial Evaluating the Safety and Efficacy of AP1189 Versus Placebo as an add-on to Standard of Care in Participants With Respiratory Insufficiency Expected to be Caused by Infection With Respiratory Viruses
A clinical study to evaluate the efficacy and safety of once daily oral dosing of 100 mg AP1189 or placebo administered for 14 days, as an add-on to standard of care (SOC) in participants with respiratory insufficiency expected…
- Trial name
- RESPIRE (NCT07633288)
- Testing
- AP1189, 100 mg
- Where
- 11 sites in Bosnia and Herzegovina, Montenegro and 2 more
- Volunteers
- 96 people
- Sponsor
- SynAct Pharma Aps
Coronavirus Infection, COVID-19
Pulsed Inhaled Nitric Oxide for the Treatment of Patients With Mild or Moderate COVID-19
The search for novel therapies to address the ongoing coronavirus (COVID-19) pandemic is ongoing. No proven therapies have been identified to prevent progression of the virus.
- Conditions
- Coronavirus Infection, COVID-19, Pneumonia, Viral
- Trial name
- NCT04358588
- Testing
- iNO (inhaled nitric oxide) delivered via the INOpulse Delivery System
- Sponsor
- Bellerophon
Covid19, SARS (Severe Acute Respiratory Syndrome)
A Study To Evaluate The Performance of the Lucira Health All-In-One COVID-19 Test Kit vs Hologic Panther Fusion
This Lucira COVID-19 All-In-One Test Kit performance study will be used to establish the performance of the Lucira COVID-19 All-In-One Test Kit as compared to a known high sensitivity RT-PCR molecular assay.
- Conditions
- Covid19, SARS (Severe Acute Respiratory Syndrome), Corona Virus Infection
- Trial name
- NCT04720794
- Testing
- Lucira COVID-19 All-In-One test kit
- Where
- United States
- Volunteers
- 101 people
- Sponsor
- Lucira Health Inc
Thyroid Dysfunction, Hypothyroidism
Fetal and Neonatal Thyroid in Pregnancies With Severe Acute Respiratory Syndrome Coronavirus 2 ( SARS- COV2 ) COVID-19
The thyroid gland has been shown to be a common target for COVID 19 virus. Babies born to mothers positive for COVID 19 infections were noticed to have elevated thyroid stimulating hormone ( TSH ) levels on screening.
- Conditions
- Thyroid Dysfunction, Hypothyroidism, Hyperthyroidism
- Trial name
- COVID-19 (NCT05385029)
- Testing
- Thyroxine
- Where
- Saudi Arabia
- Volunteers
- 95 people
- Sponsor
- OMER B ABDELBASIT
Coronavirus Infections, Pneumonia, Viral
Colchicine Counteracting Inflammation in COVID-19 Pneumonia
Cytokines and chemokines are thought to play an important role in immunity and immunopathology during virus infections [3]. Patients with severe COVID-19 have higher serum levels of pro-inflammatory cytokines (TNF-α, IL-1 and…
- Trial name
- ColCOVID-19 (NCT04322565)
- Testing
- Colchicine
- Where
- Italy
- Volunteers
- 193 people
- Sponsor
- Azienda Ospedaliero-Universitaria di Parma
Corona Virus Infection, Pregnancy Related
Characteristics of COVID-19 Infection Among PREGnant Women
In December 2019, Coronavirus infection (COVID-19) was identified as causing serious respiratory infection in humans. Initially COVID-19 was propagated by infected symptomatic individuals; currently the disease is disseminated by…
- Trial name
- CCOVID-PREG (NCT04398264)
- Testing
- COVID-19 positive via testing
- Where
- United States
- Volunteers
- 650 people
- Sponsor
- Inova Health Care Services
COVID, COVID-19
Efficacy of Chloroquine or Hydroxychloroquine in Treating Pneumonia Caused by SARS-Cov-2 - COVID-19
Facing the challenge of finding an efficient treatment for COVID-19, the viral pneumonia caused by the Coronavirus SARS-Cov-2, this study intended to test if Chloroquine or Hydroxychloroquine, two drugs with strong in-vitro…
- Conditions
- COVID, COVID-19, SARS-CoV 2, Coronavirus
- Trial name
- NCT04420247
- Testing
- Chloroquine, Hydroxychloroquine, standard care
- Where
- Brazil
- Volunteers
- 142 people
- Sponsor
- Centro de Estudos e Pesquisa em Emergencias Medicas e Terapia Intensiva
COVID-19, Corona Virus Infection
Pre-exposure Prophylaxis for SARS-Coronavirus-2
Objective: To determine if pre-exposure prophylaxis with hydroxychloroquine is effective for the prevention of COVID-19 disease.
- Conditions
- COVID-19, Corona Virus Infection, ARDS, Acute Respiratory Distress Syndrome
- Trial name
- NCT04328467
- Testing
- Hydroxychloroquine
- Where
- 2 sites in United States
- Volunteers
- 1,483 people
- Sponsor
- University of Minnesota
Corona Virus Infection, ARDS
Microbiota in COVID-19 Patients for Future Therapeutic and Preventive Approaches
In light of the rapidly emerging pandemic of SARS-CoV-2 infections, the global population and health care systems are facing unprecedented challenges through the combination of transmission and the potential for severe disease.
- Conditions
- Corona Virus Infection, ARDS, Coinfection
- Trial name
- MICRO-COV (NCT04410263)
- Testing
- Sampling (EDTA blood, pharyngeal and nose swabs, bronchoalveolar lavage ,urine)
- Where
- Switzerland
- Volunteers
- 300 people
- Sponsor
- University of Zurich
COVID-19
Corona Virus Disease 2019 Patients Whose Nucleic Acids Changed From Negative to Positive
To investigate the mechanism, clinical outcome and therapeutic efficacy with favipiravir of Corona Virus Disease 2019 patients whose nucleic acids changed from negative to positive.
- Trial name
- NCT04333589
- Testing
- Favipiravir
- Where
- 8 sites in China
- Volunteers
- 210 people
- Sponsor
- Peking University First Hospital
Corona Virus Disease 2019 (COVID-19)
Theranostic Implication of Complementary Medicines Against Interleukin Receptors and Gp-130 Proteins
IL-6 is an inflammatory marker, secrete by the cells in many pathological conditions like COVID-19 pneumonia. Interleukin 6 bind with its receptors (IL-6R) on cells surface and recruited a protein for its activation known as…
- Trial name
- NCT04690920
- Testing
- Tocilizumab
- Where
- Pakistan
- Volunteers
- 200 people
- Sponsor
- University of Lahore
Covid19, Corona Virus Infection
Nitazoxanide Therapy for Patients With COVID-19 Pneumonia
Multicenter, randomized, placebo-controlled, parallel, blinded, interventional, treatment clinical trial with two arms. Population: 500 Hospitalized patients with pneumonia derived from COVID-19 (Coronavirus Disease-19), either…
- Conditions
- Covid19, Corona Virus Infection, Pneumonia, Viral
- Trial name
- NCT04561219
- Testing
- Nitazoxanide
- Where
- Brazil
- Volunteers
- 500 people
- Sponsor
- Universidade Federal do Rio de Janeiro