Clinical trials: Corona Virus Disease
SARS-CoV Infection, Corona Virus Infection
Microbiome Therapy in Covid-19 Primary Care Support
This double-blind, randomized, placebo-controlled study aims to investigate whether a throat spray containing probiotic bacteria (i.e.
- Trial name
- MiCel (NCT04793997)
- Testing
- Microbiome spray
- Where
- Belgium
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University Hospital, Antwerp
COVID-19, Corona Virus Infection
Hydroxychloroquine as Prophylaxis for COVID-19 in Healthcare Workers (HCQPreP)
This a double-blind, randomized, placebo-controlled clinical trial to determine if primary prophylaxis with hydroxychloroquine in healthcare workers reduces symptomatic COVID-19 infection.
- Conditions
- COVID-19, Corona Virus Infection, Wuhan Coronavirus, Prophylaxis
- Trial name
- HCQPreP (NCT04363450)
- Testing
- Hydroxychloroquine
- Where
- 2 sites in United States
- Volunteers
- 1,700 people, healthy volunteers welcome
- Sponsor
- Louisiana State University Health Sciences Center in New Orleans
Corona Virus Disease 19 (COVID-19), COVID
Rehabilitation for People With COVID-19 in ICU
COVID-19 DISEASE Coronavirus disease 2019 (COVID-19) is a respiratory tract infection caused by a newly emergent coronavirus, severe acute respiratory syndrome from COVID-19, that was first recognized in Wuhan, China, in December…
- Conditions
- Corona Virus Disease 19 (COVID-19), COVID, Acute Lung Injury/Acute Respiratory Distress Syndrome (ARDS), Critical Illness
- Trial name
- COVID_REHAB (NCT04381338)
- Testing
- Pulmonary and Motor Rehabilitation
- Where
- 2 sites in Italy
- Volunteers
- 96 people
- Sponsor
- University of Padova
Coronavirus Disease (COVID-19)
Long-Term Follow-up Survey of COVID-19 Vaccine After Vaccination
This study is a long-term follow-up survey of Japanese people after their second vaccination with the Moderna COVID-19 vaccine. The study sponsor will not be involved in how the participants are treated but will provide…
- Trial name
- NCT04941144
- Testing
- COVID-19 Vaccine
- Where
- Japan
- Volunteers
- 8,538 people, healthy volunteers welcome
- Sponsor
- ModernaTX, Inc.
Covid19
Conversations You Want About Corona Virus Disease (COVID-19)
Web-enabled virtual topical guide: develop virtual conversations for each concern and intensity level
- Trial name
- COVID-19 (NCT05191420)
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
COVID-19 Pneumonia
Study of F-652 in Subjects With Corona Virus Disease 2019 (COVID-19) Pneumonia
This is a phase 2a, multicenter, randomized, double-blinded, placebo controlled, dose escalation study in adult subjects with COVID-19 pneumonia.
- Trial name
- NCT05205668
- Testing
- F-652
- Sponsor
- EVIVE Biotechnology
Corona Virus Disease 2019(COVID-19)
Treatment With Human Umbilical Cord-derived Mesenchymal Stem Cells for Severe Corona Virus Disease 2019 (COVID-19)
COVID-19 caused clusters of severe respiratory illness and was associated with 2% mortality. No specific anti-viral treatment exists.
- Trial name
- NCT04288102
- Testing
- UC-MSCs, Saline containing 1% Human serum albumin（solution without UC-MSCs）
- Where
- 3 sites in China
- Volunteers
- 100 people
- Sponsor
- Beijing 302 Hospital
COVID-19, SARS-CoV 2
Rapid Salivary Test to Detect SARS-CoV-2 (COVID-19)
The present Diagnostic Accuracy study aims at experimentally validating the use of a rapid salivary test to detect SARS-CoV-2 infection in both symptomatic and asymptomatic individuals as a preliminary approach to a mass…
- Conditions
- COVID-19, SARS-CoV 2, Corona Virus Infection
- Trial name
- NCT04357327
- Testing
- rapid salivary test
- Where
- Italy
- Volunteers
- 122 people, healthy volunteers welcome
- Sponsor
- Università degli Studi dell'Insubria
Suspected or Confirmed COVID-19
NBT-NM108 as an Early Treatment for Suspected or Confirmed Symptomatic COVID-19 Patients
This open-label, randomized, and controlled clinical trial aims to determine the feasibility and effectiveness of using NBT-NM108, a novel botanical-based fixed-combination drug, to modulate the gut microbiota and treat…
- Trial name
- COVGUT20 (NCT04540406)
- Testing
- NBT-NM108, Usual Care Only
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Notitia Biotechnologies Company
Corona Virus Disease (COVID-19), Respiratory Distress Syndrome
Fenofibrate for Patients With COVID-19 Requiring Hospitalization
This is an open-label run-in followed by a randomized, double-blind drug treatment study of COVID-19 infected patients requiring inpatient hospital admission.
- Conditions
- Corona Virus Disease (COVID-19), Respiratory Distress Syndrome, SARS-CoV-2 Infection
- Trial name
- FENOC (NCT04661930)
- Testing
- TriCor® 145mg tablets, Usual care
- Where
- 3 sites in Israel
- Volunteers
- 55 people
- Sponsor
- Yaakov Nahmias
Corona Virus Infection, COVID-19
Angiotensin Receptor Blockers and Angiotensin-converting Enzyme Inhibitors and Adverse Outcomes in Patients With COVID19
Suspension of Angiotensin Receptor Blockers and Angiotensin-converting Enzyme Inhibitors and Adverse Outcomes in Hospitalized Patients With Coronavirus Infection.
- Trial name
- BRACE-CORONA (NCT04364893)
- Testing
- Suspension or Maintenance of Angiotensin Receptor Blockers and Angiotensin-converting Enzyme Inhibitors
- Where
- Brazil
- Volunteers
- 700 people
- Sponsor
- D'Or Institute for Research and Education
Extracellular Fluid Alteration, Corona Virus Infection
Extracellular Water in Covid 19 Pneumonia
According to various studies Covid 19 pneumonia has a very similar clinical course to Acute Respiratory Distress Syndrome (ARDS) which has clarified by Berlin definition.
- Trial name
- NCT04416009
- Testing
- NİCaS
- Where
- Turkey (Türkiye)
- Volunteers
- 52 people
- Sponsor
- Gaziosmanpasa Research and Education Hospital
COVID-19
The Efficacy and Safety of Pyramax in Mild to Moderate COVID-19 Patients (Phase3)
This study is a multi-center, randomized, double-blind, parallel, placebo-controlled, phase III clinical trial to evaluate efficacy and safety of pyramax in mild to moderate COVID-19 patients.
- Trial name
- NCT05084911
- Testing
- Pyramax
- Where
- 66 sites in Argentina, Chile and 4 more
- Volunteers
- 1,807 people
- Sponsor
- Shin Poong Pharmaceutical Co. Ltd.
COVID-19
The Efficacy and Safety of Pyramax in Mild to Moderate COVID-19 Patients
This study is a multi-center, randomized, double-blind, parallel, placebo-controlled, phase Ⅱ clinical trial to evaluate efficacy and safety of Pyramax in mild to moderate COVID-19 patients.
- Trial name
- NCT04475107
- Testing
- Pyronaridine-Artesunate
- Where
- 13 sites in South Korea
- Volunteers
- 113 people
- Sponsor
- Shin Poong Pharmaceutical Co. Ltd.
COVID-19
101-PGC-005 for the Treatment of COVID-19
This is a prospective, randomized, comparative, multi-centric, adaptive design clinical study to evaluate efficacy, safety, and tolerability of 101-PGC-005 ('005) when used alongside standard of care (SOC) for the treatment of…
- Trial name
- NCT05656521
- Testing
- 101-PGC-005, Dexamethasone
- Where
- 5 sites in India
- Volunteers
- 62 people
- Sponsor
- 101 Therapeutics
Covid19
Blood Coagulation Abnormalities in COVID-19 (Corona Virus Disease-19) Patients
The role of the coagulation parameters in predicting the severity of COVID-19 disease will be assessed
- Trial name
- NCT04982263
- Testing
- Blood coagulation profile
- Where
- 2 sites in Egypt
- Volunteers
- 125 people
- Sponsor
- Sohag University
COVID, SARS-CoV 2
COVID-19 Immune Repertoire Sequencing
This concerns a single-center prospective interventional cohort study. Laboratory-confirmed COVID-19 patients will be asked to donate blood at at least two different timepoints.
- Conditions
- COVID, SARS-CoV 2, Corona Virus Infection, RDT
- Trial name
- IMSEQ (NCT04368143)
- Where
- Belgium
- Volunteers
- 84 people
- Sponsor
- Institute of Tropical Medicine, Belgium
COVID-19 Acute Respiratory Distress Syndrome, Respiratory Distress Syndrome
Safety and Effectiveness of Placental Derived Exosomes and Umbilical Cord Mesenchymal Stem Cells in Moderate to Severe Acute Respiratory Distress Syndrome (ARDS) Associated With the Novel Corona Virus Infection (COVID-19)
Recent advances have been made in prevention of the viral infection via vaccines but there is still need for effective treatment options for patients. Novel therapies need to be developed to further improve clinical outcomes.
- Trial name
- NCT05387278
- Testing
- EV-Pure™ and WJ-Pure™
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Vitti Labs, LLC
COVID-19 Testing, Decision Making
Understanding Communications Included With COVID-19 (Corona Virus Disease of 2019) Home Testing Kits
To test competing sets of information for consumers on how to interpret hypothetical SARS-CoV-2 home test kit results and whether they report plans to take CDC-recommended actions to protect themselves and others given their test…
- Trial name
- NCT04758299
- Testing
- decision science-based design
- Where
- United States
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- Barry Dewitt
COVID-19
Targeting de Novo Pyrimidine Biosynthesis by Leflunomide for the Treatment of COVID-19 Virus Disease
The global COVID-19 pandemic has caused unprecedented strain on health care services around the world.The absence of specific anti-viral medications to treat the underlying infection led to a proliferation of clinical studies and…
- Trial name
- DEFEAT-COVID (NCT05007678)
- Testing
- leflunomide
- Where
- United Kingdom
- Volunteers
- 178 people
- Sponsor
- Ashford and St. Peter's Hospitals NHS Trust