Clinical trials: Coronary; Ischemic
Stable Coronary Artery Disease
A Study of the Antiplatelet Effects Comparing Ticagrelor (Ticag. - AZD6140) With Clopidogrel (Clop.) Responder and Non-responders
The purpose of this study is to see how Ticagrelor, a new oral reversible anti-platelet medication, affects platelets. Anti-platelet agents are medications that block the formation of blood clots by preventing the clumping of…
- Trial name
- RESPOND (NCT00642811)
- Testing
- Ticagrelor, Clopidogrel, Aspirin
- Where
- 10 sites in United States, Canada and 2 more
- Volunteers
- 98 people
- Sponsor
- AstraZeneca
Coronary Artery Disease
The Cardiac Benefit of Testosterone Replacement in Men With Low Testosterone Levels With Coronary Artery Disease After Successful Intervention of the Blockage or Narrowed Heart Artery
The purpose of the study is to find out if giving the study drug, Androgel (testosterone) as a testosterone replacement help bring the testosterone to an acceptable level and to find out if it will help improve heart condition in…
- Trial name
- NCT00413244
- Testing
- AndroGel 5 Grams
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
STEMI, NSTEMI
Prediction of Adverse Events From Non-PCI Coronary Plaques Using Machine Learning
The aim of our project is to predict, with the help of artificial intelligence (AI) and machine learning techniques, the natural history of non-flow-limiting coronary stenoses and to develop and validate a machine learning risk…
- Conditions
- STEMI, NSTEMI, Chronic Coranary Sindrome, Unstable Angina (UA)
- Trial name
- Predict AI (NCT07866144)
- Where
- Italy
- Volunteers
- 600 people
- Sponsor
- A.O.U. Città della Salute e della Scienza
Coronary Heart Disease
Intracoronary Stenting and Antithrombotic Regimen: ADjusting Antiplatelet Treatment in PatienTs Based on Platelet Function Testing
Clopidogrel low response is associated with a significantly higher risk for ischemic complications after percutaneous coronary intervention.
- Trial name
- ISAR ADAPT PF (NCT01456364)
- Testing
- Ticagrelor, Prasugrel
- Where
- 3 sites in Germany, Hungary
- Volunteers
- 70 people
- Sponsor
- Deutsches Herzzentrum Muenchen
Coronary Atherosclerosis, Adipokines
Adipokines of Epicardial Adipose Tissue and Atherosclerosis of Coronary Arteries
The aim of the study is to investigate whether the expression and production of adipokines secreted by the epicardial adipose tissue correlate with the degree of coronary atherosclerosis.
- Trial name
- NCT03322332
- Where
- Greece
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- University Hospital, Ioannina
Coronary Disease, Coronary Artery Bypass Grafting
Low Molecular Weight Heparin vs Unfractionated Heparin at Cardiac Surgery
Because the impairment of platelet function may cause excess peri-operative bleeding, pre-operative aspirin discontinuation and heparin bridging are common at cardiac surgery.
- Trial name
- NCT00420667
- Testing
- Enoxaparin
- Where
- Italy
- Volunteers
- 43 people
- Sponsor
- G. d'Annunzio University
Percutaneous Coronary Intervention, Ischemic Symptoms
SAFE-PCI for Women
The hypothesis of the SAFE-PCI for women trial is that, compared with transfemoral PCI, transradial PCI will result in a significant reduction in bleeding and vascular complications.
- Trial name
- SAFE-PCI (NCT01406236)
- Testing
- Transradial PCI, Transfemoral PCI
- Volunteers
- 1,787 people
- Sponsor
- Duke University
Coronary Artery Disease, Coronary Disease
Fractional Flow Reserve Versus Angiography Randomization for Graft Optimization Trial
The FARGO trial is a prospective, randomized (1:1), multicenter study. The aim of the study is to assess the importance of fractional flow reserve (FFR) assessment prior to coronary artery bypass grafting (CABG) with respect to…
- Conditions
- Coronary Artery Disease, Coronary Disease, Myocardial Ischemia, Arteriosclerosis
- Trial name
- FARGO (NCT02477371)
- Testing
- Fractional flow reserve-guided CABG, Angiography-guided CABG
- Where
- 3 sites in Denmark
- Volunteers
- 100 people
- Sponsor
- Odense University Hospital
Coronary Artery Disease, PreDiabetes
Anti-atherosclerotic Efficacy of Selected Antidiabetic Drugs in Patients With Coronary Artery Disease and Pre-diabetes
The purpose of the study is to compare the anti-atherosclerotic efficacy of oral treatment with a GLP-1 analogue (semaglutide) or an SGLT-2 (so-called "flozin") inhibitor (dapagliflozin) versus routine treatment (metformin) in…
- Trial name
- CASCADES (NCT07254572)
- Testing
- Semaglutide 14 MG [Rybelsus], Dapagliflozin (Forxiga), Metformin
- Where
- Poland
- Volunteers
- 300 people
- Sponsor
- National Institute of Cardiology, Warsaw, Poland
Coronary Arterial Disease (CAD), NSTEMI - Non-ST Segment Elevation Myocardial Infarction (MI)
Safety and Effectiveness of the Crystalline Sirolimus-Eluting Device in Patients With Coronary Artery Disease
This prospective, multicenter, post-market observational study aims to evaluate the safety and effectiveness of the crystalline sirolimus-coated balloon (SeQuent® Sirolimus-Coated Balloon) for the treatment of coronary artery…
- Conditions
- Coronary Arterial Disease (CAD), NSTEMI - Non-ST Segment Elevation Myocardial Infarction (MI), Stable Angina, Unstable Angina, NSTEMI, Drug Coated Balloon
- Trial name
- SECuRE (NCT07444957)
- Where
- Spain
- Volunteers
- 1,118 people
- Sponsor
- Fundación Interhospitalaria para la Investigación Cardiovascular FIC
Chronic Total Occlusion of Coronary Artery, Angina Pectoris
Observational Registry on Clinical Outcome After Diagnosis of Chronic Total Occlusions
This registry aims at enrolling all consecutive patients presenting with at least one chronic total occlusion at coronary angiogram as diagnosed during angiography in our catheterization laboratory during 1 year.
- Trial name
- PETS-CTO (NCT04145167)
- Where
- Belgium
- Volunteers
- 400 people
- Sponsor
- Ziekenhuis Netwerk Antwerpen (ZNA)
Myocardial Infarction
The Effects of Lovaza® in Acute Myocardial Infarction
This study will explore the safety and effectiveness of adding Lovaza® to the therapeutic program utilized internationally for the treatment of individuals with acute coronary syndromes.
- Trial name
- OmegaMI (NCT01155336)
- Testing
- Lovaza®
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- University of Rochester
Myocardial Infarction, Angina Pectoris
Improving Intermediate Risk Management. MARK Study
Cardiovascular risk functions fail to identify more than 50% of patients who develop cardiovascular disease. This is especially evident in the intermediate-risk patients in which clinical management becomes difficult.
- Conditions
- Myocardial Infarction, Angina Pectoris, Stroke, Peripheral Arterial Disease
- Trial name
- MARK (NCT01428934)
- Where
- Spain
- Volunteers
- 2,495 people, healthy volunteers welcome
- Sponsor
- Fundacio d'Investigacio en Atencio Primaria Jordi Gol i Gurina
Coronary Artery Disease
Identification for High Risk of Coronary Heart Disease Based on Quantitative Analysis of Fundus Vessels and Metabolic Molecules
This ambidirectional observational cohort study builds upon and expands an existing coronary artery disease (CAD) cohort based on retinal fundus imaging (ChiCTR2200066429).
- Trial name
- NCT07773064
- Where
- 3 sites in China
- Volunteers
- 3,000 people
- Sponsor
- Beijing Hospital
Myocardial Infarction
Optical Coherence Tomography in Patients With Acute Myocardial Infarction and Nonobstructive Coronary Artery Disease
The purpose of this study is to evaluate the prevalence and morphological features of coronary plaques by means of OCT in patients with acute myocardial infarction but without any significant coronary stenosis at coronary…
- Trial name
- SOFT-MI (NCT02783963)
- Testing
- OCT and CMR imaging
- Where
- Poland
- Volunteers
- 38 people
- Sponsor
- National Institute of Cardiology, Warsaw, Poland
Coronary Artery Disease
Treatment of Primary Coronary Artery Vascular Lesions With Biolimus Coated Coronary Balloon Dilation Catheter
The purpose of the study was to further evaluate the long-term safety and efficacy of the Biolimus Coated Coronary Artery Balloon Dilation Catheter in the real world.
- Trial name
- NCT06385067
- Testing
- Biolimus Coated Coronary Artery Balloon Dilation Catheter
- Where
- 2 sites in China
- Volunteers
- 400 people
- Sponsor
- JW Medical Systems Ltd
Myocardial Infarction
Myocardial Infarction Rates Overview During COVID-19 Pandemic In France: MODIF Study
In late December 2019, an emerging disease due to a novel coronavirus (named SARS-CoV-2) rapidly spread in China and outside. France is currently facing the COVID-19 wave with more than 131 863 confirmed cases and almost 25 201…
- Trial name
- MODIF (NCT04357314)
- Where
- France
- Volunteers
- 6,332 people
- Sponsor
- French Cardiology Society
ST-elevation Myocardial Infarction (STEMI)
Long-term Clinical Outcome in Patients Undergoing Remote Ischemic Conditioning Before Primary Percutaneous Coronary Intervention for ST-elevation Myocardial Infarction: a Follow-up Study
The aim of this prospective follow-up study is to investigate 5-year clinical outcome in patients with ST-elevation myocardial infarction undergoing remote ischemic conditioning before primary percutaneous coronary intervention.
- Trial name
- NCT01665365
- Testing
- Remote ischemic perconditioning
- Where
- Denmark
- Volunteers
- 251 people
- Sponsor
- University of Aarhus
Coronary Artery Disease
Drug-Eluting Stenting Followed by Cilostazol tREAtment Reduces SErious Adverse Cardiac Events (DECREASE-PCI)
The DECREASE-PCI trial is a prospective, randomized, placebo controlled, double-blind, phase 4 study to evaluate efficacy and safety of triple anti-platelet therapy compared with dual antiplatelet therapy in patients treated with…
- Trial name
- NCT01346865
- Testing
- Cilostazol
- Where
- 12 sites in South Korea
- Volunteers
- 402 people
- Sponsor
- Seung-Jung Park
Stable Chronic Angina, Ischemic Heart Disease
Effect of Remote Intervention in Patients With SCAD
The study was a multicenter, two-arm, parallel, open-label, prospective clinical trial that evaluated a remote intervention with 1 year of follow-up.
- Conditions
- Stable Chronic Angina, Ischemic Heart Disease, Coronary Artery Disease, Heart Diseases
- Trial name
- NCT04795492
- Testing
- remote intervention, Routine outpatient follow-up
- Where
- China
- Sponsor
- Chinese Academy of Medical Sciences, Fuwai Hospital
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