Clinical trials: Coronary Arterioscleroses
Myocardial Infarction
Timing of Complete Revascularization for Multivessel Coronary Artery Disease in STEMI
The study will compare clinical outcomes between complete revascularization during hospitalization for ST elevation myocardial infarction (STEMI) and intervention after 30 days and intervention based on outpatient non-invasive…
- Trial name
- MVD (NCT02756000)
- Testing
- PCI, dobutamine stress echocardiography
- Where
- 4 sites in Serbia
- Volunteers
- 120 people
- Sponsor
- Clinical Hospital Center Zemun
Atrial Fibrillation, Acute Coronary Syndrome
Antithrombotic Triple Therapy in Humans
Background:The acute coronary syndrome (ACS) is a complication of coronary artery disease (CAD) and associated with increased mortality.
- Trial name
- NCT01812200
- Testing
- Dabigatran, Ticagrelor, ASA, Rivaroxaban, Ticagrelor, ASA, Phenprocoumon, Ticagrelor, ASA
- Where
- Austria
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Coronary Artery Disease
Predictive Role of Photon Counting Computed Tomography in Acute Coronary Syndrom Patients
For patients with severe calcification or complex non-calcified plaques, we investigate wether PCCT can enable non-invasive, in vivo precise differentiation and quantitative measurement of plaque components (e.g., spotty…
- Trial name
- NCT07536607
- Testing
- there is no intervention in this study
- Where
- China
- Volunteers
- 180 people
- Sponsor
- Chinese PLA General Hospital
ST Elevation Myocardial Infarction
Shanghai ST-segment Elevation Myocardial Infarction Cohort
ST-segment elevation myocardial infarction(STEMI) remains a major cause of morbidity and mortality worldwide, despite of the early reperfusion therapy, including fibrinolysis, primary percutaneous coronary intervention (PCI),and…
- Trial name
- NCT05450757
- Where
- 7 sites in China
- Volunteers
- 2,000 people
- Sponsor
- Ruijin Hospital
Acute Myocardial Infarction
Therapeutic Use of Ultrasound in Acute Coronary Artery Disease
In acute coronary artery disease, pre-clinical studies have indicated that, during a continuous infusion of intravenous perfluorocarbon containing microbubbles, the ultrasonic power delivered from a diagnostic ultrasound…
- Trial name
- NCT02410330
- Testing
- Therapeutic ultrasound with 20 usec, Repeated diagnostic high mechanical index
- Where
- Brazil
- Volunteers
- 100 people
- Sponsor
- University of Sao Paulo General Hospital
Depression, Coronary Artery Disease
Effects of a Psychotherapy Intervention in Depressed Patients With Coronary Artery Disease
In patients with coronary artery disease (CAD), depressive symptoms are frequent and highly relevant for quality of life, health behaviour, health care costs, and prognosis.
- Trial name
- SPIRR-CAD (NCT00705965)
- Testing
- Psychotherapy, Information session, Usual cardiological care
- Where
- 10 sites in Germany
- Volunteers
- 570 people
- Sponsor
- University of Göttingen
Coronary Artery Disease
Comparison of MECHANISM of Early and Late Vascular Responses Following Treatment of ST-elevation Acute Myocardial Infarction With Two Different Everolimus-eluting Stents: Randomized Controlled Trial Between Biodegradable Polymer and Durable Polymer Stent (MECHANISM-AMI-RCT)
To place two different everolimus-eluting stents (EES), a bioabsorbable polymer EES (Synergy®) and a permanent-type polymer EES (Xience®), randomly to the ST-elevation acute myocardial infarction (AMI) and to observe and compare…
- Trial name
- NCT03726892
- Testing
- PCI
- Where
- Japan
- Volunteers
- 120 people
- Sponsor
- Iwate Medical University
Coronary Artery Disease, Coronary Stenosis
FUnctional diagnoSIs of corONary Stenosis (FUSION)
The purpose of the FUSION study is to validate the diagnostic performance of Virtual Flow Reserve (VFR) by comparing it against a reference standard, fractional flow reserve (FFR).
- Trial name
- FUSION (NCT04356027)
- Testing
- ICA (Invasive Coronary Angiography), OCT, FFR
- Where
- 28 sites in United States
- Volunteers
- 312 people
- Sponsor
- Abbott Medical Devices
Cardiogenic Shock
Study on Early Intra-aortic Balloon Pump Placement in Acute Decompensated Heart Failure Complicated by Cardiogenic Shock
The aim of the study is to demonstrate the superiority of early intra-aortic balloon pump implantation at admission over local clinical practice (pharmacological only) in acute decompensated heart failure patients with…
- Trial name
- Altshock-2 (NCT04369573)
- Testing
- Early intra-aortic balloon pump (IABP) implantation, Standard of care as vasoactive agent
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- Niguarda Hospital
Cardiovascular Diseases, Heart Diseases
Self-Scored Cardiovascular Disease Risk Appraisal
To develop and test a self-scored cardiovascular disease health risk appraisal.
- Conditions
- Cardiovascular Diseases, Heart Diseases, Coronary Heart Disease Risk Reduction
- Trial name
- NCT00005529
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Premature Coronary Heart Disease
Effectiveness of an AI-Enabled Stratified Management System for Premature Coronary Artery Disease
The goal of this clinical trial is to learn if an AI-enabled stratified management system (SMART-CHD) can improve post-discharge outcomes in adults aged 18-45 with premature coronary artery disease.
- Trial name
- SMART-CHD (NCT07031531)
- Testing
- AI-Enabled Stratified Management System, Usual Post-Discharge Care
- Where
- 16 sites in China
- Volunteers
- 4,900 people
- Sponsor
- China National Center for Cardiovascular Diseases
Chronic Obstructive Pulmonary Disease (COPD), Acute Coronary Syndrome
Feasibility Study of a Digital Interactive Life-style Platform for Individuals After Rehabilitation
The goal of this clinical trial is to evaluate the feasibility and usability of a digital lifestyle platform designed to support patients after discharge from inpatient rehabilitation.
- Conditions
- Chronic Obstructive Pulmonary Disease (COPD), Acute Coronary Syndrome, Fragility Fracture, Minor Stroke
- Trial name
- Feas Platf (NCT07597031)
- Testing
- Digital Lifestyle Platform, Usual Care (Standard Post-Rehabilitation Care)
- Where
- 2 sites in Switzerland
- Volunteers
- 240 people
- Sponsor
- Matthias Wilhelm, MD
Coronary Arterial Disease (CAD)
Effects of Heart Rate Variability-guided Training vs Standard Aerobic Prescription on Cardiovagal Modulation and Cardiorespiratory Fitness in Coronary Artery Disease
Coronary artery disease (CAD) is associated with autonomic dysfunction and is characterized by reduced heart rate variability (HRV) and impaired heart rate recovery.
- Trial name
- ParaDox (NCT06919237)
- Testing
- HIIT Intervention, MICT Intervention, HRV-Guided Intervention
- Where
- Portugal
- Volunteers
- 48 people
- Sponsor
- Faculdade de Motricidade Humana
Coronary Artery Disease
Frequency Analysis of Coronary Artery Disease
The purpose of this study is to determine if coronary artery disease can be detected using an electronic, acoustic recording instrument.
- Trial name
- NCT01043237
- Where
- United States
- Volunteers
- 330 people
- Sponsor
- University of Minnesota
Coronary Artery Disease (CAD), Cardiac Rehab
The Effect of Cardiac Rehabilitation on Ferroptosis in Patients With Coronary Artery Disease
Coronary artery disease (CAD) remains a major global health concern and is the leading cause of cardiovascular mortality worldwide.
- Conditions
- Coronary Artery Disease (CAD), Cardiac Rehab, Ferroptosis
- Trial name
- NCT07722637
- Testing
- Cardiac Rehabilitation
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- TC Erciyes University
Acute Coronary Syndrome
Infarction Register
The Aachener Digitale Myokardinfarkt Register (ADMIRE) is a prospektive registry study which was designed in order to obtain data of patients with acute coronary syndrome and herewith control and optimize guideline conform…
- Trial name
- ADMIRE (NCT00763945)
- Testing
- data collection
- Where
- Germany
- Volunteers
- 5,000 people
- Sponsor
- RWTH Aachen University
Myocardial Ischemia
Electromechanical Mapping to Evaluate Heart Muscle
Patients with narrowed heart arteries who undergo coronary angiography (imaging of the heart's blood vessels) may participate in this "heart mapping" study designed to gain information about the condition of different areas of…
- Trial name
- NCT00001895
- Testing
- FDG, NH(3)
- Where
- United States
- Volunteers
- 71 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Acute Coronary Syndromes (ACS)
Prognostic Value of Functional-Nutritional Status in Older Adults With Acute Coronary Syndrome
This study aims to find out whether reduced everyday functioning before the acute illness and malnutrition help predict health outcomes in adults aged 65 years and older hospitalized with acute coronary syndrome (heart attack or…
- Trial name
- FNS-ACS65 (NCT07898345)
- Testing
- Functional-Nutritional Burden
- Where
- 2 sites in Russia
- Volunteers
- 270 people
- Sponsor
- Samara State Medical University
Coronary Artery Disease
FAME II - Fractional Flow Reserve (FFR) Guided Percutaneous Coronary Intervention (PCI) Plus Optimal Medical Treatment (OMT) Verses OMT
The overall purpose of the FAME II trial is to compare the clinical outcomes, safety and cost-effectiveness of FFR-guided PCI plus optimal medical treatment (OMT) versus OMT alone in patients with stable coronary artery disease.
- Trial name
- NCT01132495
- Testing
- Stenting plus OMT, OMT, Standard of care
- Where
- 29 sites in United States, Belgium and 11 more
- Volunteers
- 1,170 people
- Sponsor
- Abbott Medical Devices
Cardiogenic Shock
Hemodynamic Assessment in Cardiogenic Shock Regarding the Etiology
The classic physiopathology of cardiogenic shock is explained by a systolic ventricular failure, responsible for a decrease in cardiac output associated with high systemic vascular resistances (SVR).
- Trial name
- NCT03283995
- Testing
- Cardiac Volume Monitoring VolumeView, echocardiography
- Where
- France
- Volunteers
- 64 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
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