Clinical trials: Coronary Arterioscleroses
Coronary Artery Disease
Assessment of Coronary Artery Disease in Stroke Patients
This study is to evaluate the prevalence, plaque characteristics (plaque types, stenosis degree, remodeling) and predictors of coronary atherosclerosis in stroke patients with coronary CT angiography.
- Trial name
- ACADIS (NCT01850693)
- Where
- South Korea
- Volunteers
- 1,657 people
- Sponsor
- Seoul National University Hospital
Chronic Total Occlusions of Coronary Arteries, Chronic Total Occlusion (CTO)
Clinical Outcomes of Drug-Coated Balloons in the Treatment of Patients With Coronary De Novo Chronic Total Occlusion Lesions
The aim of this study is to evaluate the long-term efficacy and safety of drug-coated balloon (DCB) strategies, including DCB alone or hybrid strategies of DCB and drug-eluting stent (DES), compared to DES-only in patients with…
- Conditions
- Chronic Total Occlusions of Coronary Arteries, Chronic Total Occlusion (CTO), Coronary Artery Disease (CAD)
- Trial name
- DCB-CTO (NCT07463664)
- Testing
- DES Implantation, DCB Angioplasty
- Where
- 18 sites in China
- Volunteers
- 200 people
- Sponsor
- The First Affiliated Hospital of Zhengzhou University
Ischemic Heart Disease
Patterns of Antiacids Use in Patients With IHD Admitted to Department of Internal Medicine
There is substantial, continuing, and unexplained rise in prescribing of proton pump inhibitors. It is unknown whether their use in practice has corresponded to their licensed indications.
- Trial name
- NCT00392964
- Where
- 2 sites in Israel
- Volunteers
- 1,200 people
- Sponsor
- Rambam Health Care Campus
Intensive Care Medicine, Respiratory Distress Syndrome (RDS)
Improving Sedation Practice in Critically Ill Adult Patients Using a Co-designed Sedation Protocol
Sedation (painkillers and sedative drugs) treats pain, reduces suffering, and helps patients in the intensive care unit (ICU) receiving extracorporeal membrane oxygenation (ECMO) remain comfortable.
- Conditions
- Intensive Care Medicine, Respiratory Distress Syndrome (RDS), Sedation and Analgesia, ExtraCorporeal Membrane Oxygenation (ECMO)
- Trial name
- ECMO-SED (NCT07032987)
- Testing
- Not an intervention study
- Where
- United Kingdom
- Volunteers
- 120 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Type 2 Diabetes, Coronary Artery Disease
Intensive Blood Pressure and LDL Lowering in Diabetic Patients With Coronary Artery Disease
The purpose of this study is to determine whether intensive blood pressure and low density lipoprotein (LDL) cholesterol lowering could improve survival and cardiovascular outcome in Japanese diabetic patients with coronary…
- Conditions
- Type 2 Diabetes, Coronary Artery Disease, Hypertension, Dyslipidemia
- Trial name
- NCT01422421
- Testing
- intensive control, standard control
- Where
- 2 sites in Japan
- Volunteers
- 798 people
- Sponsor
- Takeshi Morimoto
Atherosclerosis, Myocardial Infarction
Assessment of a B-Mode Ultrasound Technique for the Measurement of Carotid Artery Intima-Media Thickness
This minimal risk protocol is designed to assess the reproducibility of B-mode ultrasound measurements of carotid intima media thickness (IMT) when the scans are performed in CC Radiology and read using a computerized edge…
- Trial name
- NCT00001904
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Diabetes Mellitus, Myocardial Infarction
Pioglitazone Protects Diabetes Mellitus (DM) Patients Against Re-Infarction (PPAR Study)
To evaluate whether the pioglitazone could reduce the recurrence of myocardial infarction (MI) in patients with DM and old myocardial infarction
- Trial name
- NCT00212004
- Testing
- pioglitazone, control
- Where
- Japan
- Volunteers
- 630 people
- Sponsor
- National Cerebral and Cardiovascular Center, Japan
Acute Coronary Syndromes, Percutaneous Coronary Intervention
Effects of Intensive Antiplatelet Therapy for Patients With Clopidogrel Resistance After Coronary Stent Implantation
Clopidogrel resistance (CR) or low-responsiveness is associated with increased risk of ischemic events and can be detected by laboratory tests.
- Conditions
- Acute Coronary Syndromes, Percutaneous Coronary Intervention, Clopidogrel Low Responsiveness
- Trial name
- NCT01094457
- Testing
- aspirin, clopidogrel, aspirin, clopidogrel, cilostazol
- Where
- 3 sites in China
- Volunteers
- 840 people
- Sponsor
- Shenyang Northern Hospital
ST Elevation Myocardial Infarction
The Effect of Low-Level Tragus Stimulation on Echocardiographic Parameters in Patients With ST-Segment Elevation Myocardial Infarction - A Single-Centre Randomized Control Trial
The goal of this clinical trial is to learn the effect of low level tragus stimulation (LLTS) on echocardiographic parameter in patient with ST-segment Elevation Myocardial Infarction (STEMI) who undergo primart percutaneous…
- Trial name
- ELITE-STEMI (NCT07058857)
- Testing
- Parasym Neuromodulation Device (Treatment Group)
- Where
- Indonesia
- Volunteers
- 100 people
- Sponsor
- Universitas Diponegoro
Acute Coronary Syndrome, Atrial Fibrillation
Ongoing WARfarin and Coronary STENTing
Patients on warfarin treatment pose particular problems when undergoing percutaneous coronary intervention with stent implantation (PCI-S), because of the poor definition of the optimal antithrombotic strategies to be adopted…
- Trial name
- WAR-STENT (NCT00722319)
- Where
- Italy
- Volunteers
- 1,000 people
- Sponsor
- War-Stent Investigators
Heterozygous Familial Hypercholesterolemia, Premature Coronary Heart Disease
A Study of VERVE-102 in Patients With Familial Hypercholesterolemia or Premature Coronary Artery Disease
VT-10201 is an Open-label, Phase 1b, Single-ascending Dose Study That Will Evaluate the Safety of VERVE-102 Administered to Patients With Heterozygous Familial Hypercholesterolemia (HeFH) or Premature Coronary Artery Disease…
- Trial name
- NCT06164730
- Testing
- VERVE-102
- Where
- 27 sites in United States, Australia and 4 more
- Volunteers
- 85 people
- Sponsor
- Verve Therapeutics, Inc.
Myocardial Infarction
Invasive vs. Conservative Management in Cancer Patients With Non-ST Elevation MI (CAN-NSTEMI)"
This retrospective study investigates the impact of invasive versus conservative management strategies in cancer patients presenting with non-ST elevation myocardial infarction (non-ST MI).
- Trial name
- CAN-NSTEMI (NCT06702436)
- Testing
- Observational Study
- Where
- Turkey (Türkiye)
- Volunteers
- 12,500 people
- Sponsor
- Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital
Ischaemic Heart Disease, Ischemic Heart Disease
The OCTOBER Trial - European Trial on Optical Coherence Tomography Optimized Bifurcation Event Reduction (OCTOBER)
The purpose is to compare median two-year clinical outcome after OCT guided vs. standard guided revascularization of patients requiring complex bifurcation stent implantation
- Trial name
- OCTOBER (NCT03171311)
- Testing
- Angiographic guided PCI, OCT guided PCI
- Where
- 38 sites in Belgium, Denmark and 11 more
- Volunteers
- 1,201 people
- Sponsor
- Aarhus University Hospital Skejby
STEMI, NSTEMI
Prediction of Adverse Events From Non-PCI Coronary Plaques Using Machine Learning
The aim of our project is to predict, with the help of artificial intelligence (AI) and machine learning techniques, the natural history of non-flow-limiting coronary stenoses and to develop and validate a machine learning risk…
- Conditions
- STEMI, NSTEMI, Chronic Coranary Sindrome, Unstable Angina (UA)
- Trial name
- Predict AI (NCT07866144)
- Where
- Italy
- Volunteers
- 600 people
- Sponsor
- A.O.U. Città della Salute e della Scienza
Coronary Artery Disease, Angina Pectoris
Comparison of Cypher Select and Taxus Express Coronary Stents
Randomized nine months clinical comparison of implantation of Taxol eluting (Taxus Express) and Sirolimus eluting (Cypher Select) stents in non-selected patients with coronary artery disease.
- Trial name
- SORT-OUTII (NCT00388934)
- Testing
- Drug eluting stent
- Volunteers
- 2,095 people
- Sponsor
- Aarhus University Hospital Skejby
Coronary Artery Disease, Mitral Valve Insufficiency
The Effects of Sevoflurane, Isoflurane and Propofol During Cardiac Surgery
Abstract Anaesthetic support for cardiac surgery significantly influences the course of the intraoperative period and the success of the postoperative period.
- Conditions
- Coronary Artery Disease, Mitral Valve Insufficiency, Aortic Valve Insufficiency
- Trial name
- NCT05695287
- Testing
- Propofol, Isoflurane, Sevoflurane
- Where
- Kazakhstan
- Volunteers
- 89 people
- Sponsor
- Astana Medical University
Ischemic Heart Disease
Functional ComprEhensive AssessmenT by IVUS Reconstruction in Patients With Suspected IschEmic Heart Disease (FEATURE)
Investigating the diagnostic accuracy of online Ultrasonic Flow Ratio (UFR) assessment to identify hemodynamically significant coronary stenosis in patients with suspected ischemic heart disease using angiography-derived…
- Trial name
- NCT05694065
- Where
- China
- Volunteers
- 112 people
- Sponsor
- Ruijin Hospital
Myocardial Ischemia, Physical Exercise
Randomized Clinical Trial by Conglomerates on the Efficacy of Maintenance of Physical Exercise in Myocardial Ischemia
Main objective: To assess the efficacy of a phase III cardiac rehabilitation program (CRP), based on counseling in the maintenance of physical exercise (time of physical exercise per week) for patients with myocardial ischemia…
- Trial name
- CarPE3 (NCT04251611)
- Testing
- Maintenance of physical exercise
- Where
- Spain
- Volunteers
- 101 people
- Sponsor
- Núria Santaularia Capdevila
Coronary Artery Disease
Effect of Beet Juice Supplementation on Vascular and Inspiratory Muscle Function
Older adults with coronary artery disease (CAD) have impaired vascular and inspiratory muscle function. The overarching goal of this double-blind, randomized, crossover, placebo-controlled pilot trial was to inform the…
- Trial name
- NCT04920799
- Testing
- Nitrate rich beetroot juice, Nitrate depleted beetroot juice
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of Florida
Coronary Artery Disease, Myocardial Ischemia
Primary FIbrinolysis and Secondary STenting Versus immEdiate Stenting in ST-segment Elevation Myocardial Infarction
This prospective, multicenter, randomized, controlled, open-label clinical study has a target enrollment of 240 subjects. It will explore whether STEMI patients transferred to a PCI center following thrombolytic therapy and…
- Conditions
- Coronary Artery Disease, Myocardial Ischemia, Acute Coronary Syndrome, Heart Diseases
- Trial name
- FISSTEMI (NCT04663932)
- Testing
- immediate stenting group(one-step strategy), deferred stenting group (two-step strategy)
- Where
- China
- Volunteers
- 240 people
- Sponsor
- Harbin Medical University
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