Clinical trials: Coronary Arterioscleroses
Drug-Eluting Stents, Percutaneous Coronary Intervention
Comparison Three vs Twelve Months of Dual Anti-Platelet Therapy After Stent Implantation
This study is a prospective,multi-center, open-label, randomized controlled clinical trial,aims to assess the clinical noninferiority of 3 months (short-term) vs 12 months (long-term) of Dual Anti-Platelet Therapy (DAPT) in…
- Trial name
- NCT03008083
- Testing
- 3 months DAPT, 12 months DAPT
- Where
- China
- Volunteers
- 2,446 people
- Sponsor
- Shanghai MicroPort Medical (Group) Co., Ltd.
Myocardial Infarction, Heart Failure
Levosimendan in Acute Heart Failure Following Acute Myocardial Infarction.
The purpose of this study is to determine the safety and efficacy of a 24 hour infusion with levosimendan in patients with acute myocardial infarction and heart failure after acute percutaneous coronary intervention (PCI)…
- Conditions
- Myocardial Infarction, Heart Failure, Cardiogenic Shock
- Trial name
- NCT00324766
- Testing
- levosimendan
- Where
- Norway
- Volunteers
- 61 people
- Sponsor
- Oslo University Hospital
Coronary Artery Disease, Myocardial Infarction
WENBIT - Western Norway B Vitamin Intervention Trial
PURPOSE OF STUDY Observational studies have demonstrated that elevated levels of plasma total homocysteine is a risk factor for cardiovascular disease.
- Conditions
- Coronary Artery Disease, Myocardial Infarction, Cerebrovascular Stroke
- Trial name
- WENBIT (NCT00354081)
- Testing
- folic acid, vitamin B12 (cyanocobalamin), vitamin B6 (pyridoxine), folic acid, vitamin B12 (cyanocobalamin), vitamin B6 (pyridoxine)
- Where
- 2 sites in Norway
- Volunteers
- 3,096 people
- Sponsor
- Haukeland University Hospital
Conservative Pharmacotherapy, Staged Percutaneous Coronary Intervention
Non-culprit Vessels for ST-Segment Elevation Myocardial Infarction
To compare the different effect of conservative pharmacotherapy and Staged Percutaneous Coronary Intervention (SPCI) on significant non-culprit lesions in patients with ST-segment elevation myocardial infarction (STEMI) at…
- Conditions
- Conservative Pharmacotherapy, Staged Percutaneous Coronary Intervention, Non-culprit Vessels, ST-Segment Elevation Myocardial Infarction
- Trial name
- CPVsSPCI (NCT02154919)
- Testing
- Percutaneous coronary intervention
- Where
- China
- Volunteers
- 306 people
- Sponsor
- Beijing Shijitan Hospital, Capital Medical University
Coronary Artery Disease
Phase 3 Safety and Imaging Study of AI-700 in Patients With Suspected Coronary Artery Disease Undergoing Coronary Angiography
This study was designed to evaluate the ability of AI-700-enhanced rest-stress echocardiography to detect coronary artery disease (CAD) in patients with suspected ischemic heart disease who are indicated for coronary angiography.
- Trial name
- NCT00156845
- Testing
- AI-700 contrast-enhanced echocardiography
- Where
- United States
- Volunteers
- 450 people
- Sponsor
- Acusphere
Coronary Artery Disease, Diabetes Mellitus
The Effect of Remote Ischemic Preconditioning on Diastolic Function in Coronary Artery Bypass Surgery Between Diabetic and Non-Diabetic Patients
This randomized controlled study aims to evaluate the effects of Remote Ischemic Preconditioning (RIPC) on diastolic function in patients undergoing coronary artery bypass grafting (CABG).
- Conditions
- Coronary Artery Disease, Diabetes Mellitus, Diastolic Function
- Trial name
- NCT06841757
- Testing
- Remote ischemic preconditioning
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Alzahraa Khalil Marie
Myocardial Infarction, Mitral Regurgitation
Medical Versus Surgical Management of Moderate Mitral Regurgitation Following Percutaneous Coronary Intervention
The pilot prospective randomized trial is designed to determine the safety and feasibility of enrolling patients to surgically correct residual Mitral Regurgitation (MR) following Percutaneous Coronary Intervention (PCI) for…
- Trial name
- NCT01156441
- Testing
- surgical mitral valve repair w/ mitral valve annuloplasty
- Where
- United States
- Sponsor
- Southern Illinois University
Atherosclerosis, Cardiovascular Diseases
Bogalusa Heart Study
To determine the natural history of atherosclerosis, coronary artery disease, and hypertension in children and adults from birth through mid-life in a total biracial community.
- Conditions
- Atherosclerosis, Cardiovascular Diseases, Heart Diseases, Coronary Disease
- Trial name
- BHS (NCT00005129)
- Where
- United States
- Volunteers
- 11,737 people
- Sponsor
- Tulane University
Diabetes Mellitus
Aspirin Twice Daily in Diabetic Patients With Coronary Artery Disease
The aim of the study is to evaluate platelet function variations according to the delay since last aspirin intake (12 vs 24 hours)in a population of diabetic patients with previous Coronary Artery Disease.
- Trial name
- NCT01617031
- Where
- France
- Volunteers
- 92 people
- Sponsor
- Hopital Lariboisière
Atherosclerosis, Coronary Artery Disease
COroNary CT Angiography Evaluation For Clinical Outcomes: An InteRnational Multicenter Registry (CONFIRM)
The CONFIRM study was developed to examine the prognostic value of cardiac computed tomographic angiography (CCTA) findings for prediction of future adverse cardiac events related to coronary artery disease (CAD) in a large…
- Conditions
- Atherosclerosis, Coronary Artery Disease, Cardiovascular Disease
- Trial name
- CONFIRM (NCT01443637)
- Where
- 20 sites in United States, Austria and 5 more
- Volunteers
- 34,000 people
- Sponsor
- Weill Medical College of Cornell University
Acute Coronary Syndrome, Atherosclerosis
Change in Plaque Characteristics With Atorvastatin
To examine effects of intensive lipid lowering therapy with atorvastatin on stabilization of coronary plaque by using optical coherence tomography (OCT) in patients with acute coronary syndrome.
- Conditions
- Acute Coronary Syndrome, Atherosclerosis, Dyslipidemia
- Trial name
- EASY-FIT (NCT00700037)
- Testing
- high-dose atorvastatin, low-dose atorvastatin
- Where
- Japan
- Volunteers
- 70 people
- Sponsor
- Wakayama Medical University
Cardiovascular Diseases, Heart Diseases
Diet and Plasma Cholesterol - Secular Trend Analysis
To define the role of dietary variables on changes in plasma cholesterol levels over time in the Framingham cohort and the Framingham Offspring cohort.
- Conditions
- Cardiovascular Diseases, Heart Diseases, Coronary Disease, Hypercholesterolemia
- Trial name
- NCT00005257
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Coronary Artery Bypass Surgery, Stable Angina
Optimal Dose of Acetylsalicylic Acid After Coronary Artery Bypass Grafting
This is a single-center, open-label, randomized controlled trial. Patients with stable angina pectoris without use of dual antiplatelet therapy or anticoagulation therapy scheduled for coronary artery bypass grafting (CABG) at…
- Trial name
- NCT02482857
- Testing
- Acetylsalicylic acid
- Volunteers
- 45 people
- Sponsor
- Karolinska University Hospital
Ischemic Heart Disease
Outcomes Following Myocardial Revascularization: On and Off Cardiopulmonary Bypass
Ischemic heart disease is one of the most frequent diagnoses in the VA system. Moreover, 5,819 coronary artery bypass graft (CABG-only) procedures were performed in the VA in Fiscal Year (FY) 1999.
- Trial name
- ROOBY (NCT00032630)
- Testing
- Coronary artery bypass - on-pump, Coronary artery bypass - off-pump
- Where
- 17 sites in United States
- Volunteers
- 2,203 people
- Sponsor
- US Department of Veterans Affairs
Coronary Heart Disease, Coronary Artery Disease
Study of Sivelestat Sodium in OPCABG
The goal of this clinical trial is to learn if drug Sivelestat Sodium works to improve the prognosis of off-pump coronary artery bypass grafting (OPCABG) in adults. It will also learn about the safety of drug Sivelestat Sodium.
- Conditions
- Coronary Heart Disease, Coronary Artery Disease, Coronary Arterial Disease (CAD)
- Trial name
- NCT07118930
- Testing
- Sivelestat Sodium injection 2 h after OPCABG for 72 h, Saline (0.9% NaCl)
- Where
- China
- Volunteers
- 62 people
- Sponsor
- Affiliated Hospital of Nantong University
Ischemic Heart Disease, Stenotic Coronary Lesion
RESOLUTE ONYX China RCT Study
It is a randomized controlled trial to evaluate the safety and efficacy of the Medtronic Resolute Onyx™ Zotarolimus-Eluting Coronary Stent System in comparison with the Medtronic Resolute Integrity™ Zotarolimus-Eluting coronary…
- Conditions
- Ischemic Heart Disease, Stenotic Coronary Lesion, Cardiovascular Diseases, Arteriosclerosis
- Trial name
- NCT03466151
- Testing
- Resolute Onyx™ Zotarolimus-Eluting Coronary Stent System, Resolute Integrity™ Zotarolimus-Eluting Coronary Stent System
- Where
- 2 sites in China
- Volunteers
- 550 people
- Sponsor
- Medtronic Vascular
Observational
Use of FFR-CT in Stable Intermediate Chest Pain Patients With Severe Coronary Calcium Score
A prospective, blinded multicenter study for evaluation of chest pain patients with severe coronary calcium (Agatston score > 399).
- Trial name
- FACC (NCT03548753)
- Where
- Denmark
- Volunteers
- 278 people
- Sponsor
- Odense University Hospital
Coronary Heart Disease, GI Bleeding
Platelet Inhibitory Effect of Clopidogrel in Patients Treated With Omeprazole, Pantoprazole, or Famotidine
Current guidelines recommend the addition of proton pump inhibitors (PPI) to patients taking double anti-platelet therapy (Aspirin and Clopidogrel) to prevent upper GI bleeding1.
- Trial name
- NCT00950339
- Testing
- omeprazole, 20mg twice daily, famotidine 40mg twice daily, pantoprazole 40mg once daily
- Where
- Israel
- Volunteers
- 63 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Coronary Arteriosclerosis
68Ga-DOTATATE PET-CTA Imaging for the Early Detection of Progressing Coronary Atherosclerosis
68Ga-DOTATATE is a PET radiotracer with high affinity and selectivity for somatostatin receptor 2 (SSTR 2) and is approved clinically for the evaluation of patients with neuroendocrine tumors.
- Trial name
- iPROGRESS (NCT04043377)
- Testing
- injection of 68Ga-DOTATATE
- Where
- France
- Volunteers
- 12 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Cardiovascular Diseases, Myocardial Infarction
Home Use of Automatic External Defibrillators to Treat Sudden Cardiac Arrest
To compare home use of an automatic external defibrillator (AED) to the use of local emergency medical system in treating survivors of sudden cardiac arrest.
- Conditions
- Cardiovascular Diseases, Myocardial Infarction, Heart Diseases, Death, Sudden, Cardiac
- Trial name
- HAT (NCT00047411)
- Testing
- Cardiopulmonary Resuscitation, Automatic External Defibrillation
- Where
- United States
- Volunteers
- 7,001 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
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