Clinical trials: Coronary Artery Aneurysm
Artery; Dilatation
Safety and Tolerability of Nitro for Radial Artery Dilation
Phase 1, single-center, open-label clinical study to assess the safety and efficacy of topical nitroglycerin on dilation of the radial artery.
- Trial name
- RADial (NCT05239013)
- Testing
- Nitroglycerin ointment
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Thomas Jefferson University
Ectasia, Coronary Artery Disease
Coronary Artery Ectasia in Elective Coronary Angiography : Predictors, Outcomes and Management
Coronary artery ectasia (CAE) is the diffuse dilatation of coronary artery. It is defined as a dilatation with a diameter of 1.5 times the adjacent normal coronary artery .
- Trial name
- NCT03896321
- Testing
- Antiplatelet Agents, Anticoagulants
- Where
- Egypt
- Volunteers
- 79 people, healthy volunteers welcome
- Sponsor
- Assiut University
Kawasaki Disease, Children
Anakinra and Kawasaki Disease
The study is designed to assess the efficacy and safety of anakinra, an interleukin 1 receptor antagonist, in patients with Kawasaki disease who failed to respond to standard treatment:e.g.
- Trial name
- KAWAKINRA (NCT02390596)
- Testing
- Anakinra
- Where
- France
- Volunteers
- 16 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Thoracic Aortic Aneurysm
HEART: Pilot Randomized Controlled Trial
The purpose of this study is to determine whether spironolactone reduces aortic stiffness, measured by carotid-femoral pulse wave velocity (cfPWV), compared with placebo, in patients with degenerative thoracic aortic aneurysms.
- Trial name
- NCT07483177
- Testing
- Spironolactone
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Mayo Clinic
Cardio-pulmonary Bypass, AORTIC VALVE DISEASES
Clinical Validation of a Novel Handsfree Doppler Ultrasound Device, RescueDoppler, in Adult Cardiac Surgery Patients
The goal of this study is to evaluate a new device called RescueDoppler (RD), which measures continuous blood flow in the common carotid artery. The device is handsfree and operator- independent.
- Conditions
- Cardio-pulmonary Bypass, AORTIC VALVE DISEASES, Coronary Arterial Disease (CAD), Aortic Aneurysm of the Proximal Arch
- Trial name
- RD_CPB (NCT06637540)
- Testing
- RescueDoppler
- Where
- 3 sites in Norway
- Volunteers
- 42 people
- Sponsor
- St. Olavs Hospital
Abdominal Aortic Aneurysm, Coronary Artery Disease
White Blood Cell Counts and Onset of Cardiovascular Diseases: a CALIBER Study
The complete blood count is a commonly performed blood test, and previous small studies have suggested that the counts of some types of white blood cell in the complete blood count may be related to the onset of cardiovascular…
- Conditions
- Abdominal Aortic Aneurysm, Coronary Artery Disease, Stroke, Heart Failure
- Trial name
- CALIBER (NCT02014610)
- Volunteers
- 800,000 people, healthy volunteers welcome
- Sponsor
- University College, London
Coronary Artery Ectasia
Endothelial NO Synthase Polymorphic Gene in Coronary Artery Dilation Disease
Introduction: The coronary artery dilatations disease (Coronary artery aneurysm/coronary artery ectasia) characterized by inappropriate coronary artery dilations.
- Trial name
- NCT06220682
- Testing
- The specific genetic PCR laboratory test were performed for all selected patients for eNOS SNPs
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Cairo University
Coronary Artery Ectasia
Effect of Diltiazem on Coronary Artery Ectasia
Coronary artery ectasia (CAE) has been defined as localized or diffuse dilatation of epicardial coronary arteries more than 1.5 fold of adjacent normal segments.
- Trial name
- NCT02024919
- Testing
- intracoronary administration of diltiazem, intracoronary injection of 5 mL saline
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ankara University
Ischemic Heart Disease, Cardiac Arrest
Registry of Multicenter Brain-Heart Comorbidity in China
This study is a multi-center, prospective, registry study. This research was supported by the National Key Research and Development Program.
- Conditions
- Ischemic Heart Disease, Cardiac Arrest, Atrial Fibrillation, Heart Failure
- Trial name
- BHC-C (NCT05961748)
- Testing
- Multi-disciplinary assessment
- Where
- 14 sites in China
- Volunteers
- 100,000 people
- Sponsor
- Beijing Tiantan Hospital
Cardiopulmonary Arrest, Aortic Aneurysm, Thoracic
Noninvasive Neuromonitoring of Surgery of the Thoracic Aorta
The aim of this prospective, explorative study of noninvasive neuromonitoring was to search potential and practical methods associated with neurological outcome in the perioperative and immediate postoperative setting of surgery…
- Conditions
- Cardiopulmonary Arrest, Aortic Aneurysm, Thoracic, Aortic Diseases, Coronary Artery Disease
- Trial name
- NCT02876263
- Where
- Finland
- Volunteers
- 61 people
- Sponsor
- University of Helsinki
Intracranial Aneurysm, Natural History
The Prospective Cohort Study on the Benefit-risk of Antithrombotic or Anticoagulant Therapy in Patients With Unruptured Intracranial Aneurysms Associated With Ischemic Heart Disease or Ischemic Cerebrovascular Disease
This is a registry study of the natural course of unruptured intracranial aneurysms (UIA). In addition, the investigators will analyze the benefit-risk of antithrombotic or anticoagulant therapy in patients with unruptured…
- Conditions
- Intracranial Aneurysm, Natural History, Ischemic Heart Disease, Ischemic Cerebrovascular Disease
- Trial name
- NCT03153878
- Volunteers
- 1,800 people
- Sponsor
- Liu Zhiyong
Abdominal Aortic Aneurysm, Arterial Stiffness
EndoVascular Aneurysm Repair: Heart Remodeling and Aortic Stiffness Study
Abdominal aortic aneurysm (AAA) is associated with a high burden of cardiovascular morbidity and mortality. Although endovascular aneurysm repair (EVAR) has become the preferred treatment for many patients with infrarenal AAA…
- Conditions
- Abdominal Aortic Aneurysm, Arterial Stiffness, Left Ventricle Remodeling
- Trial name
- EVAR-HRAS (NCT07722793)
- Where
- Croatia
- Volunteers
- 60 people
- Sponsor
- Josip Juraj Strossmayer University of Osijek
Coronary Artery Ectasia, Acute Coronary Syndromes (ACS)
Multicenter Trial of Antithrombotic Strategies in Acute Coronary Syndrome With Coronary Artery Ectasia
Coronary artery ectasia (CAE) is a condition in which a coronary artery becomes abnormally dilated, measuring at least 50% larger than the adjacent normal segment.
- Conditions
- Coronary Artery Ectasia, Acute Coronary Syndromes (ACS), STEMI - ST Elevation Myocardial Infarction, NSTEMI - Non-ST Segment Elevation Myocardial Infarction (MI)
- Trial name
- OVER-TIME II (NCT07511257)
- Testing
- Aspirin 100 mg, Clopidogrel 75 mg, Rivaroxaban 15 mg
- Where
- Mexico
- Volunteers
- 326 people
- Sponsor
- Instituto Nacional de Cardiologia Ignacio Chavez
Coronary Artery Disease, Abdominal Aortic Aneurysm
Abdominal Aortic Aneurysm Screening Before Coronary Artery Bypass Surgery
Coronary artery disease (CAD) and abdominal aortic aneurysm (AAA) are two separate entities with common risk factors such as hypertension, advanced age, male sex.
- Trial name
- NCT05449509
- Testing
- Abdominal aortic Duplex ultrasound
- Where
- Turkey (Türkiye)
- Volunteers
- 170 people
- Sponsor
- Başakşehir Çam & Sakura City Hospital
Coronary Artery Disease, Postoperative Complications
Preoperative Intravenous Ferric Carboxymaltose and Placebo in the Treatment of Patients Undergoing Cardiac Surgery
This study evaluates the efficacy and safety of single dose preoperative ferric carboxymaltose in the prevention of postoperative infections and blood transfusions in patients scheduled for cardiac surgery.
- Conditions
- Coronary Artery Disease, Postoperative Complications, Aortic Valve Stenosis, Mitral Valve Disease
- Trial name
- PREFER-CABG (NCT03574311)
- Testing
- Ferric carboxymaltose, Physiological saline
- Where
- Finland
- Volunteers
- 210 people
- Sponsor
- Turku University Hospital
Coronary Artery Ectasia
Coronary Artery Ectasia, Efficacy of Various Anti Thrombotic Regimens.
1. To evaluate short and intermediate clinical outcome of different anti-thrombotic regimens on major adverse cardiac events (MACE) and quality of life in coronary artery ectasia patients. 2.
- Trial name
- NCT05718531
- Testing
- Rivaroxaban 2.5 Mg Oral Tablet twice daily, Clopidogrel 75 Mg Oral Tablet, Aspirin tablet 75 mg
- Volunteers
- 200 people
- Sponsor
- Assiut University
Abdominal Aortic Aneurysm
Biomarker Profiling in Abdominal Aortic Aneurysm Patients
The BIOMArCS-AAA study aims to investigate the associations of (temporal patterns of) blood biomarkers with aneurysm growth in patients with abdominal aortic aneurysm (AAA), with particular attention to biomarkers that have…
- Trial name
- BIOMArCS-AAA (NCT03703947)
- Where
- 2 sites in Netherlands
- Volunteers
- 440 people
- Sponsor
- Erasmus Medical Center
Percutaneous Coronary Intervention (PCI), Coronary Artery Disease
Use of Coils During Percutaneous Coronary Intervention
Use of coils during percutaneous coronary interventions (PCI) is sometimes life-saving and useful althought currently off-label and with unknown clinical outcomes.
- Trial name
- COILSEAL (NCT06720935)
- Where
- Italy
- Volunteers
- 143 people
- Sponsor
- San Luigi Gonzaga Hospital
Coronary Arteriosclerosis
Dietary Nitrate and Nitrite to Increase Nitric Oxide in Patients With Coronary Artery Disease
This study will determine whether dietary nitrates and nitrites can produce nitric oxide in the body and dilate blood vessels in patients with coronary artery disease.
- Trial name
- NCT00069654
- Testing
- Forearm blood flow study, Brachial artery reactivity study, Treadmill exercise test
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Acute Coronary Syndrome, Angiographic Evidence if Coronary Aneurysms
The Italian Coronary Artery Aneurysm and Ectasia In Patients With Acute Coronary Syndrome
The ITACA study is a prospective, observational no profit registry enrolling patients with Acute Coronary Syndrome and angiographic evidence of coronary aneurysms and/or ectasia.
- Conditions
- Acute Coronary Syndrome, Angiographic Evidence if Coronary Aneurysms, Ectasia
- Trial name
- ITACA (NCT05051917)
- Where
- 2 sites in Italy
- Volunteers
- 500 people
- Sponsor
- Federico II University