Clinical trials: Coronary Artery Bypass, Off-Pump
Coronary Artery Disease (CAD), Bypass, Cardiopulmonary
Multivessel Minimally Invasive Coronary Bypass Grafting as HYBRID Revascularization Versus Conventional Off-pump Coronary Artery Bypass Grafting
The MICRA-HYBRID trial is a prospective, multicenter, randomized controlled study comparing multivessel hybrid coronary revascularization (HCR) as minimally invasive arterial bypass grafting to left-sided coronary targets (LAD…
- Conditions
- Coronary Artery Disease (CAD), Bypass, Cardiopulmonary, Minimally Invasive Coronary Revascularization Surgery, Off-pump Coronary Artery Bypass
- Trial name
- MICRA-HYBRID (NCT07314138)
- Testing
- Multivessel Hybrid Coronary Revascularization, Off-pump coronary arterial bypass grafting (OPCAB)
- Where
- 2 sites in Belgium, Netherlands
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Catharina Ziekenhuis Eindhoven
Ischemic Heart Disease
Effect of Remote Ischemic Preconditioning on Cognitive Function After Off-Pump Coronary Artery Bypass Graft
The aim of this study is to evaluate the effects of remote ischemic preconditioning on cognitive function in patients undergoing off-pump coronary artery bypass graft.
- Trial name
- NCT00953368
- Testing
- remote ischemic preconditioning
- Where
- South Korea
- Volunteers
- 270 people
- Sponsor
- Asan Medical Center
Prevention of Hypotension
Point Of Care Ultrasound For Prediction Of Fluid Responsiveness in Off Pump Coronary Artery Bypass Grafting Surgery
To exclude hypovolemia before starting off pump coronary artery grafting surgeries by an efficient and good predictive test. We will assess the sensitivity and specificity of dynamic IVC-derived parameters (dispensability index)…
- Trial name
- NCT05968040
- Testing
- Inferior vena cava diameter measurement by ultrasonography, difference between peak velocities of carotid artery by ultrasound, cardiac output be transthoracic echocardiography
- Volunteers
- 40 people
- Sponsor
- Ain Shams University
Ischemic Heart Disease
Arrhythmia in on Pump vs. Off Pump Coronary Artery Bypass Grafting
The aim of this research is to know the incidence of arrhythmias in on vs. off pump CABG and to know their relations to the patient's morbidity and mortality, hospital stay and hospital costs.
- Trial name
- NCT04093817
- Testing
- cardio pulmonary bypass machine
- Volunteers
- 50 people
- Sponsor
- Assiut University
Hemodynamic Instability, Postoperative Complications
Fluid Responsiveness: SVV vs esSVV in Mechanically Ventilated and Spontaneously Breathing Patients
Postoperative period after off-pump coronary artery bypass grafting (OPCAB) can be a challenging area for emerging methods for less-invasive continuous hemodynamic monitoring.
- Trial name
- NCT04786652
- Testing
- estimated stroke volume variation (esSVV, Nihon Kohden, Japan), Assessment of fluid responsiveness in mechanically ventilated patients after OPCAB, Assessment of fluid responsiveness in spontaneously breathing patients at 18 hrs of the postoperative period
- Where
- Russia
- Volunteers
- 32 people
- Sponsor
- Northern State Medical University
Postoperative Acute Kidney Injury After Off-pump Coronary Artery Bypass Graft
Effect of N-acetylcysteine on Prevention of Acute Kidney Injury in High Risk Patients Undergoing Off-pump Coronary Artery Bypass Graft
N-acetylcysteine may prevent acute kidney injury in high risk patients undergoing off-pump coronary artery bypass graft.
- Trial name
- NCT01394419
- Testing
- N-acetylcysteine, Saline
- Where
- South Korea
- Volunteers
- 115 people
- Sponsor
- Yonsei University
Coronary Artery Bypass Graft
High Frequency Ventilation During Off Pump Coronary Artery Bypass Graft (CABG)
This study is to test the safety of high frequency-low volume ventilation during off pump coronary artery bypass as reflected in the near infrared spectroscopy values for cerebral oxygenation.
- Trial name
- VHF (NCT00863044)
- Testing
- Apnea, High frequency ventilation
- Where
- Canada
- Volunteers
- 80 people
- Sponsor
- Montreal Heart Institute
Cardiac Surgery, Coronary Artery Bypass Surgery
Comparing Angiomax to Heparin With Protamine Reversal in Patients OPCAB
The purpose of this study is to examine the safety and efficacy of Angiomax as an alternative anticoagulant to heparin with protamine reversal in patients undergoing off-pump coronary artery bypass graft surgery.
- Trial name
- OPCAB (NCT00073593)
- Testing
- Bivalirudin, Heparin, Protamine
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- The Medicines Company
Ischemic Heart Disease
Pulse Pressure Variation (PPV) to Predict Fluid Responsiveness During Cardiac Displacement in Patients Undergoing Off-pump Coronary Artery Bypass Surgery (OPCAB)
Pulse pressure variation (PPV) known as a dynamic preload index is increasingly being used for guide of fluid management under various clinical situations.
- Trial name
- NCT01041742
- Testing
- fluid loading
- Where
- South Korea
- Volunteers
- 35 people
- Sponsor
- Seoul National University Hospital
Coronary Artery Disease
Hemodynamic Changes in Off-pump Coronary Artery Bypass Grafting
The purpose of this study is to study the positioning and stabilization of different cardiac walls performed during off-pump coronary artery bypass grafting (CABG) may have dissimilar impact on hemodynamics.
- Trial name
- NCT00967278
- Where
- Brazil
- Sponsor
- University of Sao Paulo
Ischemic Heart Disease
Randomized Anticoagulation Trial in Opcab (RATIO)
The RATIO Study is a multicenter, nationwide, randomized, controlled, single blinded, unfunded trial of n. 900 patients undergoing multivessel OPCAB (≥2 grafts).
- Trial name
- RATIO (NCT02812355)
- Testing
- Heparin
- Where
- 3 sites in China, Italy
- Volunteers
- 900 people
- Sponsor
- Azienda Ospedaliera di Lecco
Acute Kidney Injury
The Effect of Ulistin on Acute Renal Injury in Patients Undergoing OPCAB (Off Pump Coronary Artery Bypass): a Propensity Score Matched Study
Acute kidney injury (AKI) is a frequent complication after cardiac surgery. AKI has been reported as 7-40% depending on the type of surgery, and is known to increase to about 50% when there are risk factors.
- Trial name
- NCT04473144
- Testing
- Ulinastatin
- Volunteers
- 500 people
- Sponsor
- Ajou University School of Medicine
Coronary Artery Disease, Postoperative Complications
Intraoperative Targeted Versus Liberal Blood Pressure Management in Patients Undergoing Off-pump Coronary Artery Bypass Grafting
The goal of this clinical trial is to learn whether two approaches to anesthesia and blood pressure management can improve care for adults having off-pump coronary artery bypass grafting (OPCAB).
- Trial name
- NCT07787364
- Testing
- Targeted Blood Pressure Management, Liberal Blood Pressure Management, Remimazolam
- Volunteers
- 416 people
- Sponsor
- Chinese Academy of Medical Sciences, Fuwai Hospital
Multi Vessel Coronary Artery Disease
Dual Antiplatelet Therapy in Patients With Clopidogrel Resistance Following Off-Pump Coronary Artery Bypass
Ticagrelor, a direct-acting oral P2Y12-receptor antagonist, provides greater and more consistent platelet inhibition than clopidogrel.
- Trial name
- NCT05166538
- Testing
- Ticagrelor, Clopidogrel
- Where
- South Korea
- Volunteers
- 204 people
- Sponsor
- Yonsei University
Acute Normovolemic Hemodilution, Off-Pump Coronary Artery Bypass Surgery
Acute Normovolemic Hemodilution in Off-pump CABG
To study the effects of Acute normovolemic hemodilution on central and peripheral perfusion in patients Undergoing off-pump coronary artery bypass grafting surgery
- Trial name
- NCT04042883
- Testing
- Acute normovolemic hemodilution
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Assiut University
A Total of 234 Patients With Acute Coronary Syndrome Who Will Undergo OPCAB.
Impact of High-dose Pretreatment of Rosuvastatin in Patients With Acute Coronary Syndrome Following Off-pump Coronary Artery Bypass: Results From the HIROP-ACS (HIgh-dose Pretreatment of Rosuvastatin During Off-Pump Coronary Bypass in Acute Coronary Syndrome) Study
Periprocedural treatment with high-dose statins is known to have cardioprotective and pleiotropic effects, such as anti-thrombotic and anti-inflammatory actions.
- Trial name
- NCT01971606
- Testing
- Rosuvastatin
- Where
- South Korea
- Volunteers
- 234 people
- Sponsor
- Yonsei University
Coronary Artery Bypass, Off-Pump
The Effects of Dexmedetomidine on cTnI and GP-BB in Patients Undergoing OPCABG
The purpose of this study is to observe the impact of dexmedetomidine on Cardiac Troponin I and Glycogen Phosphorylase Isoenzyme BB in patients undergoing off-pump coronary artery bypass Grafting.
- Trial name
- NCT03163693
- Testing
- dexmedetomidine, normal saline
- Where
- China
- Volunteers
- 40 people
- Sponsor
- General Hospital of Ningxia Medical University
Coronary Artery Occlusive Disease
Effects of Ulinastatin on Coagulation in High Risk Patients Undergoing Off Pump Coronary Artery Bypass Graft Surgery
Ulinastatin reduce the amount of bleeding and fibrinolysis in high risk patients undergoing off-pump coronary bypass surgery (OPCAB).
- Trial name
- NCT01084044
- Testing
- ulinastatin, saline solution
- Where
- South Korea
- Volunteers
- 80 people
- Sponsor
- Yonsei University
Mechanical Ventilation Complication, Postoperative Pulmonary Atelectasis
Perioperative Mechanical Ventilation and Postoperative Monitoring of IPI
This study evaluates the influence of alveolar recruitment maneuver, protocolized liberation from respiratory support and monitoring of Integrated Pulmonary Index on the duration of the mechanical ventilation and the number of…
- Trial name
- WEAN-IPI (NCT02524522)
- Testing
- INTELLiVENT-ASV mode, SIMV mode
- Where
- Russia
- Volunteers
- 40 people
- Sponsor
- Northern State Medical University
Coronary Artery Disease, Bypass Complication
Early Silent Graft Failure in Off-pump Coronary Artery Bypass Grafting: A Computed Tomography Analysis
Aortocoronary bypass surgery is one of the most common operations in the western world. The goal of the surgeon is to perform a complete revascularization of the coronary arteries with the best, available bypass material.
- Conditions
- Coronary Artery Disease, Bypass Complication, Graft Failure
- Trial name
- NCT03657199
- Testing
- Cardiac computed tomography
- Volunteers
- 192 people
- Sponsor
- Triemli Hospital