Clinical trials: Coronary Artery Bypass Surgery
Coronary Artery Disease
MIDCAB Versus DES in Proximal LAD Lesions
Percutaneous coronary intervention with a sirolimus-coated stent compared to minimally invasive bypass surgery in patients with isolated proximal left anterior descending coronary arteries in terms of non-inferiority of an end…
- Trial name
- NCT00299429
- Testing
- Stenting and minimally invasive bypass surgery, PCI with DES
- Where
- Germany
- Volunteers
- 130 people
- Sponsor
- University of Leipzig
Coronary Heart Disease
Efficacy and Safety of Aspirin Therapy With CABG
evaluate the safety of preoperative aspirin therapy when performing bypass surgery in conditions of artificial blood circulation
- Trial name
- NCT02942680
- Testing
- acetylsalicylic acid started for 24 hours before surgery, acetylsalicylic acid stayed for 5 days before surgery
- Where
- Russia
- Volunteers
- 350 people
- Sponsor
- Meshalkin Research Institute of Pathology of Circulation
Acute Kidney Injury
Arterial Stiffness and AKI Post-CABG
Acute Kidney Injury is a condition where your kidneys suddenly stop working properly and usually occurs if you are already unwell with an illness and can happen after having surgery.
- Trial name
- Heart-AKI (NCT02364427)
- Testing
- Arterial stiffness - Vicorder to measure pulse wave velocity
- Where
- United Kingdom
- Volunteers
- 180 people
- Sponsor
- King's College Hospital NHS Trust
Coronary Artery Disease, Mitral Valve Insufficiency
Mitral Valve Repair Combined Coronary Artery Bypass Grafting(CABG) Verus CABG Alone on Functional Ischemic Mitral Regurgitation
Coronary artery bypass grafting(CABG) is an effective procedure in treating severe coronary artery disease(CAD). Optimal surgical method for CAD patients with functional ischemic mitral regurgitation(FIMR) is still controversial.
- Trial name
- NCT03525041
- Testing
- CABG, mitral valve annuloplasty
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Beijing Anzhen Hospital
Coronary Artery Disease With Need for Bypass Surgery, Myocardial Ischemia, Angina Pectoris
Bypass Surgery and CD133 Marrow Cell Injection for Treatment of Ischemic Heart Failure
Cell transplantation for treatment of heart failure is a novel field of translational research that offers the perspective of developing curative approaches by regenerating or "rejuvenating" lost and/or diseased myocardium and…
- Conditions
- Coronary Artery Disease With Need for Bypass Surgery, Myocardial Ischemia, Angina Pectoris, Congestive Heart Failure, Previous Myocardial Infarction
- Trial name
- Cardio133 (NCT00462774)
- Testing
- Intramyocardial injection of autologous CD133+ marrow cells
- Where
- Germany
- Volunteers
- 60 people
- Sponsor
- German Heart Institute
Coronary Artery Disease, Postoperative Cognitive Dysfunction
Cerebral Oximetry and Neurocognitive Functions in Cardiosurgical Patients
It is previously reported that the cerebral oxygen desaturation during cardiac surgery is associated with an increased incidence of cognitive impairment.
- Conditions
- Coronary Artery Disease, Postoperative Cognitive Dysfunction, Neurological Impairment
- Trial name
- NCT00917124
- Testing
- INVOS
- Where
- Croatia
- Volunteers
- 200 people
- Sponsor
- University of Zagreb
Gastrointestinal Ulcer (Peptic) or Erosion, Anti-Platelet Therapy
Proton Pump Inhibitor Preventing Upper Gastrointestinal Injury In Patients On Dual Antiplatelet Therapy After CABG
The purpose of this study is to compare the efficacy and safety for 12- vs. 1-month of pantoprazole treatment in preventing dual antiplatelet therapy (DAPT)-related upper gastrointestinal mucosal injury after coronary artery…
- Conditions
- Gastrointestinal Ulcer (Peptic) or Erosion, Anti-Platelet Therapy, Coronary Artery Bypass
- Trial name
- DACAB-GI-2 (NCT03908593)
- Testing
- Pantoprazole
- Where
- China
- Volunteers
- 232 people
- Sponsor
- Ruijin Hospital
Coronary Heart Disease (CHD)
Continuous Comprehensive Nursing for Post-CABG Recovery
This study evaluates the effectiveness of a continuous comprehensive nursing (CCN) system compared to routine care for patients after coronary artery bypass graft (CABG) surgery.
- Trial name
- NCT07062432
- Testing
- Continuous Comprehensive Nursing System, Routine Postoperative Care
- Where
- China
- Volunteers
- 120 people
- Sponsor
- The First Hospital of Hebei Medical University
Gastric Ulcer Induced by Antiplatelet Agent, Ulcer of the Gastrointestinal Tract
Proton Pump Inhibitor Prevent Dual Antiplatelet Agents Induced Gastrointestinal Ulcer After Coronary Artery Bypass Graft
The purpose of this study is to determine whether 12-month prophylactic treatment with pantoprazole is superior to 1-month therapy without major cardiovascular events (MACE) increased significantly, in prevention of dual…
- Conditions
- Gastric Ulcer Induced by Antiplatelet Agent, Ulcer of the Gastrointestinal Tract, Proton Pump Inhibitor
- Trial name
- DACAB-GI-2 (NCT03038009)
- Testing
- Pantoprazole
- Where
- China
- Sponsor
- Ruijin Hospital
Coronary Artery Disease
The Use of Aging Biomarkers to Predict Adverse Outcomes After Cardiac Surgery
Cardiac surgery associated acute kidney injury (CSA-AKI) has been recognized as the second most common cause of hospital acquired AKI.
- Trial name
- NCT02496234
- Where
- United States
- Volunteers
- 186 people
- Sponsor
- Sapere Bio
Postoperative Atrial Fibrillation
The Effect of Ligament of Marshall Excision During Minimally Invasive Cardiac Surgery-Coronary Artery Bypass Grafting (MICS-CABG) on the Prevention of Postoperative New-Onset Atrial Fibrillation: A Multicenter, Prospective, Randomized, Triple-Blinded Study
After heart bypass surgery, many patients develop a heart rhythm problem called postoperative atrial fibrillation, or POAF for short. This issue happens to 20%-40% of all bypass patients.
- Trial name
- NCT07755072
- Testing
- MICS-CABG combined with excision of the Ligament of Marshall
- Where
- China
- Volunteers
- 628 people
- Sponsor
- Peking University Third Hospital
Coronary Artery Bypass Graft Surgery, Spine Surgery
Does Pre-operative Carbohydrate Loading Reduce Insulin Resistance and Improve Outcomes in Elective Surgical Patients?
The recent development of an oral carbohydrate drink for consumption prior to elective surgical procedures has been shown to improve insulin sensitivity.
- Trial name
- Preop (NCT00618592)
- Testing
- PreOp carbohydrate drink
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- Unity Health Toronto
Acute Kidney Injury
The Effect of Ulistin on Acute Renal Injury in Patients Undergoing OPCAB (Off Pump Coronary Artery Bypass): a Propensity Score Matched Study
Acute kidney injury (AKI) is a frequent complication after cardiac surgery. AKI has been reported as 7-40% depending on the type of surgery, and is known to increase to about 50% when there are risk factors.
- Trial name
- NCT04473144
- Testing
- Ulinastatin
- Volunteers
- 500 people
- Sponsor
- Ajou University School of Medicine
Diabetes Mellitus, Type 2, Coronary Artery Disease
POST-CABGDM: Empagliflozin in Perioperative CABG
Introduction: Diabetes Mellitus (DM) is a condition known to be associated with coronary artery disease (CAD) and its role as promoter of atherosclerosis is well stablished.
- Conditions
- Diabetes Mellitus, Type 2, Coronary Artery Disease, Coronary Artery Bypass Surgery, Acute Kidney Injury
- Trial name
- POST-CABGDM (NCT04523064)
- Testing
- Empagliflozin 25 MG
- Where
- Brazil
- Volunteers
- 155 people
- Sponsor
- University of Sao Paulo General Hospital
Coronary Artery Disease, Coronary Artery Bypass
Preload Dependency Evaluation With Stroke Volume Variation During Alveolar Recruitment Manoeuvres
The principal aim is to assess impact of alveolar recruitment manoeuvres (ARM) on stroke volume variation, evaluated by trans-oesophageal echocardiography (TEE).
- Conditions
- Coronary Artery Disease, Coronary Artery Bypass, Hypovolemia, Anesthesia, General
- Trial name
- PreDeARM (NCT02678559)
- Testing
- tee measurement, flotrac measurement, clearsight measurement
- Where
- France
- Volunteers
- 24 people
- Sponsor
- University Hospital, Clermont-Ferrand
Atrial Fibrillation
The Effect of Arrhythmia Surgery on Quality of Life in Patients With Atrial Fibrillation Undergoing Cardiac Surgery
Atrial fibrillation (AF) is connected with an increased morbidity and mortality. In addition, quality of life is diminished due to palpitations, dyspnea, dizziness and syncope.
- Trial name
- NCT00886080
- Testing
- Pulmonary vein isolation using microwave energy
- Where
- Netherlands
- Volunteers
- 150 people
- Sponsor
- Maastricht University Medical Center
Coronary Artery Bypass Surgery
Myocardial Protection With Multiport Antegrade Cold Blood Cardioplegia
In spite improvements in methods of myocardial protection, peri-operative myocardial damage is still the commonest cause of early morbidity and mortality after technically successful CABG Surgery.
- Trial name
- MACBC (NCT02303704)
- Testing
- multiport antegrade cardioplegia, Aortic root antegrade cardioplegia
- Volunteers
- 448 people
- Sponsor
- Chaudhry Pervaiz Elahi Institute of Cardiology
All Cause Mortality, MACE
ROOBY Trial Follow-up Extension
The Department of Veterans Affairs "Randomized On/Off Bypass" (ROOBY) Trial (CSP #517) was funded in 2001. ROOBY was designed to compare the short-term (30-day) and intermediate-term (1-year) outcomes for patients undergoing…
- Trial name
- NCT01924442
- Where
- United States
- Volunteers
- 2,203 people
- Sponsor
- VA Office of Research and Development
Breathing Exercises
Comparative Effects of ACBT and Diaphragmatic Breathing on Pulmonary Function and Sputum Diary After CABG
To compare the effects of active cycle of breathing technique and diaphragmatic breathing on pulmonary functions and sputum diary after coronary artery bypass graf
- Trial name
- NCT05936788
- Testing
- Active cycle of breathing technique, diaphragmatic breathing
- Where
- Pakistan
- Volunteers
- 32 people
- Sponsor
- Riphah International University
Acute Coronary Syndrome (ACS), High On-treatment Platelet Reactivity (HTPR)
The Effect of IV Cangrelor and Oral Ticagrelor Study
Major heart attacks are caused by a number of factors, the two major of which are furring up of a coronary artery with atheroma and then sudden clot formation on this area leading to a blockage and interruption of blood flow.
- Conditions
- Acute Coronary Syndrome (ACS), High On-treatment Platelet Reactivity (HTPR), Microvascular Obstruction (MVO), ST-segment Elevation Myocardial Infarction (STEMI)
- Trial name
- NCT02733341
- Testing
- Cangrelor, Ticagrelor
- Where
- United Kingdom
- Volunteers
- 100 people
- Sponsor
- The Royal Wolverhampton Hospitals NHS Trust
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