Clinical trials: Coronary Artery Bypass Surgery
Coronary Artery Stenosis
Comparing the Protective Effects of Two Cardioplegic Solutions, on Cardiac Metabolism, as Assessed Using Microdialysis
An estimated 8% to 15% of patients hospitalized for a coronary pathology undergo coronary revascularization surgery with extracorporeal circulation (ECC).
- Trial name
- Cardioplégie (NCT01401140)
- Testing
- St Thomas, Custodiol
- Where
- France
- Volunteers
- 29 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Coronary Artery Bypass Graft Surgery, Valve Replacement
Inspiratory Muscle Training Prior to Conventional and Minimal Invasive Heart Surgery
The main objective of this study is to evaluate the effect of pre-operative Inspiratory muscle training (IMT) using an IMT Threshold device (Philips), on early postoperative lung function recovery and on the occurrence of…
- Conditions
- Coronary Artery Bypass Graft Surgery, Valve Replacement, Post-Op Complications, Physiotherapy
- Trial name
- PRIMUS (NCT04717817)
- Testing
- Inspiratory muscle training (IMT) using an IMT Threshold device (Philips), Standard physiotherapy
- Sponsor
- Universitair Ziekenhuis Brussel
Smoking Cessation
Effect of Pre-op NRT on Peri-operative Complications and Long-term Abstinence: A Pilot Trial in Patients Undergoing CABG Surgery
This study will determine whether or not patients who use a Nicotine Replacement Therapy (NRT) patch prior to their by-pass surgery are more likely to be smoke-free 6 months after their surgery and have fewer post-operative…
- Trial name
- NCT02918500
- Testing
- Nicoderm Patch
- Where
- Canada
- Volunteers
- 4 people
- Sponsor
- Ottawa Heart Institute Research Corporation
Coronary Disease, Coronary Artery Disease
MACBIS50 in Patients Undergoing CAG During Normothermic CPB Phase.
Background: We determined the minimum alveolar concentration (MAC) of sevoflurane for maintaining bispectral index (BIS) below 50 (MACBIS50) in patients undergoing coronary artery bypass grafting during normothermic…
- Trial name
- NCT02711384
- Where
- Brazil
- Volunteers
- 15 people
- Sponsor
- Instituto Dante Pazzanese de Cardiologia
Coronary Artery Disease
No-Touch Versus Conventional Saphenous Vein Harvesting Technique
This study evaluates the short-term patency of vein graft harvested by the No-Touch technique compared to that by the conventional approach in patients undergoing isolated on-pump/off-pump coronary artery bypass graft (CABG)…
- Trial name
- NCT03126409
- Testing
- No-Touch vein harvesting technique, Conventional vein harvesting
- Where
- China
- Volunteers
- 2,655 people
- Sponsor
- China National Center for Cardiovascular Diseases
Coronary Artery Disease
Comparison of Heparin Types; Efficacy and Safety
Heparin, a blood thinner, is used routinely in Open-heart surgery. Do different brands of this drug have differing clinical effects despite both having exactly the same regulation and marketing specifications?
- Trial name
- NCT01343381
- Testing
- Hepalean Heparin, PPC Heparin
- Where
- Canada
- Volunteers
- 21 people
- Sponsor
- McMaster University
Coronary Heart Disease, Graft Occlusion, Vascular
A Study of RO4905417 in Patients Undergoing Coronary Artery Bypass Graft (CABG) Surgery
This randomized double-blind, placebo-controlled study will evaluate the efficacy and safety of RO4905417 in the prevention of saphenous vein graft disease in patients undergoing elective or urgent coronary artery bypass (CABG)…
- Trial name
- NCT01245634
- Testing
- RO4905417
- Where
- 38 sites in United States, Canada
- Volunteers
- 384 people
- Sponsor
- Hoffmann-La Roche
ERAS, Cardiac Surgery
Impact of a Technology Platform Based on Enhanced Recovery After(ERAS) Surgery on Length of Stay After Coronary Artery Bypass Grafting: Timely Project
Cardiovascular diseases continue to be the leading cause of death worldwide. Among them, coronary artery disease has the greatest impact, being characterized as one of the main causes of death in Brazil over the last decade.
- Conditions
- ERAS, Cardiac Surgery, Cardiac Surgery-CABG, Digital Health
- Trial name
- REPLICCARIII (NCT06786819)
- Testing
- ERACS with Digital Platform
- Where
- 2 sites in Brazil
- Volunteers
- 480 people
- Sponsor
- University of Sao Paulo General Hospital
Coronary Artery Bypass Grafting (CABG) Surgery, Saphenectomy
Adductor Canal Block: Efficacy in Postoperative Pain Management for Cardiac Surgery
Adductor Canal Block: Efficacy in Postoperative Pain Management for Cardiac Surgery
- Trial name
- AddEase (NCT07732465)
- Testing
- Aductor canal bloc, Control adductor canal block
- Where
- Canada
- Volunteers
- 120 people
- Sponsor
- Montreal Heart Institute
Coronary Artery Disease
Coronary Bypass Surgery Trial: Complete Arterial Revascularization and Conventional Coronary Artery Surgery
This is a randomized, prospective European Multicenter Study comparing complete arterial revascularization of the coronary arteries using arterial graft material exclusively and "conventional" coronary artery bypass surgery using…
- Trial name
- NCT00317265
- Testing
- Coronary bypass surgery
- Where
- 14 sites in Austria, Czechia and 5 more
- Volunteers
- 2,000 people
- Sponsor
- Medical University of Vienna
Cognitive Dysfunction
Brain-Induced Neurotrophic Factor Levels in Patients Undergoing Coronary Artery Bypass Surgery
In patients undergoing coronary artery bypass surgery, the relationship between neurocognitive changes seen in the early period and brain-induced neurotrophic factor serum levels will be investigated.
- Trial name
- NCT04250935
- Testing
- Patients with cognitive dysfunction
- Where
- Turkey (Türkiye)
- Volunteers
- 45 people
- Sponsor
- Bozok University
Adult Patients Undergoing CABG
Effect of Preoperative Stellate Ganglion Block on Postoperative Atrial Fibrillation After Coronary Artery Bypass Grafting
The primary objective of this study is to determine the feasibility of preoperative stellate ganglion block in reducing the incidence of postoperative atrial fibrillation in patients undergoing CABG.
- Trial name
- NCT07271615
- Testing
- Stellate Ganglion Block
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Xijing Hospital
Complications Due to Coronary Artery Bypass Graft
Effects of Segmental Breathing Exercise in Patients Awaiting Coronary Artery Bypass Graft Surgery (CABG)
To determine the effects of preoperative segmental breathing exercise on postoperative pulmonary complications in patients awaiting coronary artery bypass graft surgery (CABG). This study will be a randomized controlled trial.
- Trial name
- NCT05585138
- Testing
- segmental breathing exercise, deep breathing
- Where
- Pakistan
- Volunteers
- 44 people
- Sponsor
- Riphah International University
Coronary Artery Disease Progression, Coronary Artery Disease of Significant Bypass Graft
Registry of Secondary Revascularization
The study will evaluate patients with, at least, one previous procedure of coronary revascularization (surgical, percutaneous or both), that are referred for a new, clinically indicated, diagnostic coronary angiography, to…
- Conditions
- Coronary Artery Disease Progression, Coronary Artery Disease of Significant Bypass Graft, Stent Stenosis, Stent Restenosis
- Trial name
- REVASEC (NCT03349385)
- Where
- Spain
- Volunteers
- 869 people
- Sponsor
- Hospital San Carlos, Madrid
Mechanical Complication of Coronary Artery Bypass Graft, Respiratory Depression
Effects of Osteopathic Treatment on Pulmonary Function After Coronary Artery Bypass Graft Surgery
The purpose of this study is to determine the short and long term effects of osteopathic treatment on pulmonary function, pain and quality of life in patients after coronary artery bypass graft (CABG) surgery.
- Conditions
- Mechanical Complication of Coronary Artery Bypass Graft, Respiratory Depression, Pain, Quality of Life
- Trial name
- OSTinCARE (NCT01714791)
- Testing
- Usual care, Osteopathic treatment
- Where
- Belgium
- Volunteers
- 112 people
- Sponsor
- Hartcentrum Hasselt
Low Cardiac Output
Efficacy, Safety of Hypertonic Lactate Soln. as Fluid Resuscitation Compared With Ringer's Lactate in Post-CABG Pats
Prospective, randomized, open-label study to assess the efficacy and safety of hypertonic lactate solution, compared to Ringer's Lactate as fluid resuscitation to maintain hemodynamic stability in post-coronary artery bypass…
- Trial name
- NCT00529490
- Testing
- Hypertonic lactate, Ringer's lactate
- Where
- Indonesia
- Volunteers
- 230 people
- Sponsor
- Innogene Kalbiotech Pte. Ltd
Pulmonary Hypertension
Does Oral Sildenafil (Viagra) Decrease Mean Pulmonary Artery Pressure After Cardiac Surgery?
Post-operative pulmonary hypertension is a risk factor for right ventricular failure and an increasing cause of morbidity and mortality in patients undergoing high-risk cardiac surgery.
- Trial name
- NCT00334490
- Testing
- Sildenafil
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- Unity Health Toronto
Coronary Artery Disease, Type II Diabetes Mellitus
Innovative Strategies For Risk Reduction Following CABG
Background: Treatment targets for cardiac risk factor reduction are not being met. Therefore, there is a need for new strategies to assist patients in meeting these goals.
- Trial name
- NCT00462436
- Testing
- Consumption of Dietary Portfolio
- Where
- Canada
- Volunteers
- 35 people
- Sponsor
- Unity Health Toronto
Coronary Artery Disease, Anesthesia
Xenon as an Adjuvant to Propofol Anaesthesia in Patients Undergoing Off-pump Coronary Artery Bypass Graft Surgery.
The investigators hypothesize that the application of 30% xenon as an adjuvant to general anesthesia with a target-controlled infusion of propofol is superior to general anesthesia with propofol alone with respect to hemodynamic…
- Trial name
- NCT01948765
- Testing
- Xenon and propofol, propofol
- Where
- Belgium
- Volunteers
- 50 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Coronary Artery Disease
Ticagrelor and Aspirin for the Prevention of Cardiovascular Events After Coronary Artery Bypass Surgery
Subjects will be consented to the study prior to Coronary Artery Bypass Graft (CABG) and randomly assigned to receive either ticagrelor 90 mg bid or placebo bid starting within 48 hours of surgery.
- Trial name
- TAP-CABG (NCT01373411)
- Testing
- ticagrelor
- Where
- Canada
- Volunteers
- 70 people
- Sponsor
- Cardiology Research UBC
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