Clinical trials: Coronary Artery Bypass Surgery
Symptomatic Ischemic Saphenous Vein Graft Disease
Symbiot III: A Prospective Randomized Trial Evaluating the Symbiot Covered Stent System in Saphenous Vein Grafts
The objective of the Symbiot III Clinical Trial was to evaluate the safety and effectiveness of the Symbiot Covered Stent System in the treatment of symptomatic ischemic saphenous vein bypass graft disease.
- Trial name
- NCT00283413
- Testing
- Covered Stent System, Bare metal stent
- Where
- 49 sites in United States, Canada
- Volunteers
- 514 people
- Sponsor
- Boston Scientific Corporation
Internal Mammary Artery Syndrome, Vasodilation
Effect of Topically-applied Milrinone or Nitroglycerin on Internal Mammary Artery Free Flow
Forty-six consecutive patients undergoing elective primary coronary artery bypass grafting were enrolled. After the left IMA was harvested, free flow was measured under controlled hemodynamic conditions before any intervention…
- Trial name
- NCT06301880
- Testing
- The topical application of a vasodilator on the LIMA graft
- Where
- Syria
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Damascus University
Bleeding and Cardiac Surgery, Allogeneic Blood Transfusion
Comparison of Aprotinin and Tranexamic Acid in Routine Cardiac Surgery
The hypothesis of this study is that the antifibrinolytic drugs aprotinin and tranexamic acid equally influence bleeding tendency and transfusion requirement in patients undergoing first time cardiac procedures with a low risk of…
- Conditions
- Bleeding and Cardiac Surgery, Allogeneic Blood Transfusion, Aortic Valve Replacement, Coronary Artery Bypass Graft Surgery
- Trial name
- NCT00396760
- Testing
- aprotinin or tranexamic acid
- Where
- Germany
- Volunteers
- 220 people
- Sponsor
- German Heart Center
Acute Myocardial Infarction
Transcutaneous Electrical Nerve Stimulation Improves Vascular Conductance After Coronary Artery Bypass Graft Surgery
The investigators will test the hypothesis that transcutaneous electrical nerve stimulation (TENS) may attenuate peripheral vasoconstriction and to improve blood flow redistribution during handgrip exercise in acute myocardial…
- Trial name
- TEBCABG (NCT01777659)
- Testing
- Transcutaneous electrical nerve stimulation
- Where
- Brazil
- Volunteers
- 38 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Acute Myocardial Infarction, Coronary Artery Disease
Use of Intra-aortic Balloon Pump Before Surgery for Acute Myocardial Infarction
The optimal timing of surgery in patients with acute myocardial infarction (AMI) and the utilization of preoperative intra-aortic balloon pumps (IABP) in these patients are subjects of ongoing discussion and disagreement.
- Conditions
- Acute Myocardial Infarction, Coronary Artery Disease, Coronary Bypass Graft Stenosis of Autologous Vessel, Troponin
- Trial name
- NCT06468982
- Testing
- Intra-aortic Balloon Pump
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 156 people
- Sponsor
- Ataturk University
Coronary Artery Disease, Hyponatremia
Hyponatremia and Hypoalbuminemia is Morbimortality Predictors in Coronary Artery Bypass Graft Surgery
Coronary artery disease is a common medical disease in many populations. The pathogenesis of this disease is very complex. Surgery is one of the treatment choices. Assessing the risk factors will improve the surgical outcome.
- Conditions
- Coronary Artery Disease, Hyponatremia, Hypoalbuminemia
- Trial name
- NCT02765061
- Volunteers
- 1,157 people
- Sponsor
- Ankara University
Cardiac Index
Reliability of Cardiac Output Monitoring Based on Uncalibrated Pulse Contour Analysis
The aim of our study was to evaluate the reliability of uncalibrated cardiac index monitoring based on arterial waveform analysis in patients undergoing off-pump coronary artery bypass grafting.
- Trial name
- NCT01773720
- Where
- Russia
- Volunteers
- 40 people
- Sponsor
- Northern State Medical University
Healthy, Coronary Artery Bypass Graft
Cardioprotective Effects of Increased Endogenous Erythropoietin After Normobaric Oxygen Breathing
Tissue hypoxia is the only accepted trigger for erythropoietin (EPO) production. However, in healthy subjects EPO concentrations have also increased after oxygen breathing. The aim of our study is to confirm these observations.
- Trial name
- NCT00824759
- Testing
- pure oxygen breathing versus air
- Where
- Belgium
- Volunteers
- healthy volunteers welcome
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Coronary Artery Disease
Saphenous Vein as Y-composite Versus Aortocoronary Conduit for CABG
Left internal thoracic artery (LITA) has been acknowledged as the first graft of choice for coronary artery bypass grafting (CABG).
- Trial name
- CONFIG2 (NCT05704296)
- Testing
- Y-composite grafting, Aortocoronary grafting
- Where
- South Korea
- Volunteers
- 290 people
- Sponsor
- Ho Young Hwang
Coronary Artery Bypass Graft Surgery, Pain
Effect of Using Walking Aid on Mobility
The goal of this clinical trial is to evaluate the effect of using walking aid during out-of-bed mobilization of patients who underwent open coronary artery bypass graft surgery on levels of pain and mobility.
- Conditions
- Coronary Artery Bypass Graft Surgery, Pain, Early Mobilization, Walking, Difficulty
- Trial name
- NCT05830682
- Testing
- using a walking aid
- Where
- Turkey (Türkiye)
- Volunteers
- 56 people
- Sponsor
- Trakya University
Cardiovascular Disease, Ischemic Heart Disease
Can Dipyridamole Induce Protection Against Ischemia and Reperfusion Injury in Patients Undergoing Elective Coronary Artery Bypass Grafting (CABG)?
Rationale: Due to western lifestyle human coronary arteries are prone to develop atherosclerotic plaques. Hence the heart is an important target organ for atherothrombotic complications: myocardial ischemia, arrhythmias…
- Trial name
- NCT01295567
- Testing
- Dipyridamole
- Where
- Netherlands
- Volunteers
- 95 people
- Sponsor
- Radboud University Medical Center
Coronary Artery Disease
Coronary Artery Bypass and Nitrate Oral Supplementation
The purpose of this study is to determine whether oral sodium nitrate administration prior to coronary artery bypass surgery can reduce perioperative levels of troponin T.
- Trial name
- CABANOS (NCT01348971)
- Testing
- Sodium nitrate, Sodium chloride
- Where
- Sweden
- Volunteers
- 100 people
- Sponsor
- Karolinska Institutet
Coronary Artery Disease, Atrial Fibrillation New Onset
Effect of Left Posterior Pericardiotomy for the Prevention of POAF
This study is planned to evaluate the effect of left posterior pericardiotomy for the prevention of postoperative atrial fibrillation after coronary artery bypass grafting.
- Conditions
- Coronary Artery Disease, Atrial Fibrillation New Onset, Pericardial Effusion
- Trial name
- ELIMINATE-AF (NCT06159985)
- Testing
- left posterior pericardiostomy
- Where
- South Korea
- Volunteers
- 270 people
- Sponsor
- Seoul National University Hospital
Acute Kidney Injury
Acute Kidney Injury After Cardiac Surgery Based on KDIGO Criteria
The aim of this study was to apply the acute kidney injury criteria based on KDIGO classification in a population of patients undergoing cardiac surgery [coronary artery bypass grafting (CABG) or cardiac valve surgery (CVS)] and…
- Trial name
- NCT00777465
- Where
- Brazil
- Volunteers
- 2,804 people
- Sponsor
- Hospital de Base
AKI
Effect of RBT-1 on Preconditioning Response Biomarkers in Subjects Undergoing CABG and/or Cardiac Valve Surgery
The purpose of this study is to evaluate the effect of RBT-1 (stannous protoporphyrin [SnPP]/iron sucrose [FeS]) on preconditioning response biomarkers in subjects who are at risk for AKI following cardiac surgery.
- Trial name
- START (NCT04564833)
- Testing
- Low Dose RBT-1, High Dose RBT-1
- Where
- 25 sites in United States, Australia and 1 more
- Volunteers
- 152 people
- Sponsor
- Renibus Therapeutics, Inc.
Coronary Artery Bypass Grafting (CABG) Surgery, Myocardial Protection
Impact of Different Cardioplegia Solutions on Indicators of Myocardial Injury During Coronary Surgery
The aim of the present study is to investigate intra-operative changes in markers of myocardial injury during ischemia and reperfusion, comparing three methods of myocardial protection; St.
- Trial name
- Cardioplegia2 (NCT07358221)
- Testing
- The intervention is the use of a specific cardioplegia solution for myocardial protection
- Where
- Syria
- Volunteers
- 30 people
- Sponsor
- Damascus University
Cardiomyopathy, Cardiovascular Diseases
Improving Mitral Repair for Functional Mitral Regurgitation
The investigators are interested in determining the best surgical technique to correct functional mitral regurgitation, as there is currently not one technique that is established to work better than the other.
- Conditions
- Cardiomyopathy, Cardiovascular Diseases, Congestive Heart Failure, Coronary Artery Disease
- Trial name
- IMPROVE-FMR (NCT03366649)
- Testing
- Undersizing Mitral Annuloplasty, Papillary Muscle Approximation
- Where
- 3 sites in United States
- Volunteers
- 34 people
- Sponsor
- Emory University
Postoperative Hemorrhage
Hetastarch and Bleeding Complications After Off-Pump Coronary Bypass Surgery
There has been continuing debate about whether use of hetastarch for volume replacement in coronary artery bypass surgery [CABG] increases the risk of postoperative bleeding.
- Trial name
- NCT00307138
- Testing
- hetastarch
- Where
- United States
- Volunteers
- 330 people
- Sponsor
- Kaiser Permanente
Chronic Ischemic Heart Disease, Coronary Artery Disease
Cell Therapy in Severe Chronic Ischemic Heart Disease
Patients with advanced coronary artery disease usually undergo incomplete myocardial revascularization due to the extension and diffuseness of the disease, with very poor distal arterial beds unsuitable for direct…
- Conditions
- Chronic Ischemic Heart Disease, Coronary Artery Disease, Angina Pectoris
- Trial name
- MiHeart (NCT01727063)
- Testing
- Cell Therapy
- Where
- Brazil
- Volunteers
- 143 people
- Sponsor
- Ministry of Health, Brazil
Coronary Artery Bypass Grafting
Effects of CUrcuminoids on Coronary Artery byPass graftIng-related myocarDial Infarction Study
It is well-established that myocardial infarction (MI) associated with coronary artery bypass graft surgery (CABG) predicts the poor outcome.
- Trial name
- CUPID (NCT01528514)
- Testing
- Curcuminoids
- Where
- Thailand
- Volunteers
- 200 people
- Sponsor
- Wanwarang Wongcharoen, MD.
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