Clinical trials: Coronary Artery Disease (CAD)
Ischemic Cardiomyopathy
Genetics of Ischemic Cardiomyopathy
Background:Ischemic heart disease is one of the heaviest health-related burdens worldwide.We aimed to identify the common hub mRNA and pathways that are involved in pathological progression of ischemic cardiomyopathy.
- Trial name
- NCT05508269
- Testing
- quantitative polymerase chain reaction(QPCR) for four genes, Cardiac biopsy, blood sampling
- Where
- Egypt
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Cairo University
Microvascular Disease
MICRO: a Registry Study in Patients With Microvascular Angina
The evidence above demonstrates that microvascular dysfunction is an important determinant of patient prognosis, which however remains poorly classified.
- Trial name
- MICRO (NCT04612322)
- Testing
- Assessment of microvascular function with intracoronary hemodilution
- Where
- Germany
- Volunteers
- 1,000 people
- Sponsor
- Johannes Gutenberg University Mainz
Coronary Artery Disease
Both Exercise and Adenosine Stress Testing
The purpose of this study is to compare the 2-year cardiac outcomes for women with limited exercise capability based on the resuls of either pharmacological stress myocardial perfusion imaging or a combined protocol that…
- Trial name
- NCT00200629
- Testing
- Adenosine SPECT myocardial perfusion imaging, Combined adenosine / exercise SPECT myocardial perfusion imaging
- Where
- 20 sites in United States
- Volunteers
- 200 people
- Sponsor
- Midwest Heart Foundation
Coronary Artery Disease (CAD) (E.G., Angina, Myocardial Infarction, and Atherosclerotic Heart Disease (ASHD)), Acute Coronary Syndromes
AI-Assisted Coronary Syndrome Subtyping From Admission History of Present Illness: A Clinician Reader Study
This study will evaluate whether an OCR-LLM-based clinical decision support framework improves clinicians' accuracy in classifying coronary syndrome subtypes from admission history of present illness.
- Conditions
- Coronary Artery Disease (CAD) (E.G., Angina, Myocardial Infarction, and Atherosclerotic Heart Disease (ASHD)), Acute Coronary Syndromes, ST-segment Elevation Myocardial Infarction (STEMI), Non-ST-Segment Elevation Myocardial Infarction (NSTEMI)
- Trial name
- OCR-LLM-CHD (NCT07449429)
- Testing
- OCR-Prompt-LLM Information Extraction and Classification Workflow (OCR-Prompt-LLM), Manual Clinical Data Review
- Where
- China
- Volunteers
- 10 people
- Sponsor
- China National Center for Cardiovascular Diseases
Angina Pectoris, Coronary Artery Disease
A Safety Study of ABI-007 for In-Stent Restenosis
This trial will treat patients with a new chemotherapeutic medicine who have undergone a successful and uncomplicated de novo stent placement in up to two native coronary arteries.
- Trial name
- NCT00093223
- Testing
- Paclitaxel Nanoparticle Albumin Bound
- Where
- United States
- Volunteers
- 76 people
- Sponsor
- Celgene
Coronary Artery Disease, Aortic Valve Disease
Cardiac Index, SVR/SVRI During Weaning From ECC- Data Obtained From Femoral and Radial Artery Transducer
Swan Ganz catheter-Edwards Lifesciences obtains values of cardiac output/index and systemic vascular resistance/index using the mean artery pressure of either radial or femoral artery.
- Conditions
- Coronary Artery Disease, Aortic Valve Disease, Mitral Valve Disease
- Trial name
- RaFe (NCT06112561)
- Testing
- CO/CI/SVR
- Volunteers
- 50 people
- Sponsor
- George Papanicolaou Hospital
Type 2 Diabetes, Coronary Artery Disease (CAD)
Effect of a Low Advanced Glycation End Products Diet of Patients With Type 2 Diabetes Mellitus
The present study showed that a reduction of approximately 56% in CML consumption promoted a 30% reduction in this blood biomarker.
- Trial name
- NCT07303842
- Testing
- a low-CML diet, Control
- Where
- Brazil
- Volunteers
- 36 people
- Sponsor
- InCor Heart Institute
PRS-based Primary Prevention of CVD
Polygenic Risk Driven Pragmatic Statin Trial for Heart Disease Prevention
This research investigates the potential advantages of intensive preventive statin treatment for healthy men aged 45-80 and women aged 55-80 who possess a high genetic predisposition to coronary artery disease (CAD).
- Trial name
- EE-PRS (NCT06820086)
- Testing
- Rosuvastatin 20mg
- Where
- 2 sites in Estonia
- Volunteers
- 2,714 people
- Sponsor
- Mikk JÜRISSON
Lupus Erythematosus, Systemic, Coronary Artery Disease
CMR-Lupus Comprehensive Approach by Cardiovascular Magnetic Resonance Tomography
In systemic lupus erythematosus (SLE), cardiac manifestations, e.g. coronary artery disease (CAD) and myocarditis are leading causes of morbidity and mortality. The prevalence of subclinical heart disease in SLE is unknown.
- Conditions
- Lupus Erythematosus, Systemic, Coronary Artery Disease, Myocardial Disease
- Trial name
- NCT03488654
- Testing
- Cardiovascular magnetic resonance
- Where
- Switzerland
- Volunteers
- 30 people
- Sponsor
- University Hospital, Basel, Switzerland
Coronary Arteriosclerosis
A Study To Evaluate the Effect of Rosuvastatin On Intravascular Ultrasound-Derived Coronary Atheroma Burden (ASTEROID)
The purpose of this study is to see if 40 mg of rosuvastatin taken daily will reduce the atherosclerosis (fatty deposits) in your arteries
- Trial name
- NCT00240318
- Testing
- Rosuvastatin calcium
- Where
- 61 sites in United States, Australia and 6 more
- Volunteers
- 450 people
- Sponsor
- AstraZeneca
Coronary Arterial Disease (CAD)
Drug-Coated Coronary Balloons in Different Clinical Scenarios
Coronary stents are the best treatment method ever accepted in the treatment of coronary artery stenoses. Due to some limitations and complications of stent use, the operators tried to find new solutions.
- Trial name
- DCB-DCS (NCT06915597)
- Where
- 5 sites in Turkey (Türkiye)
- Volunteers
- 1,500 people
- Sponsor
- Kutahya Health Sciences University
Cardiovascular Diseases, Heart Diseases
Trial of Pulse Steroid Therapy in Kawasaki Disease--Pediatric Heart Network
The primary endpoint is coronary artery diameter, normalized for body surface area, 5 weeks after randomization. Secondary endpoints include duration of fever, CRP levels, and adverse events.
- Conditions
- Cardiovascular Diseases, Heart Diseases, Infection, Coronary Aneurysm
- Trial name
- NCT00132080
- Testing
- Steroids
- Volunteers
- 199 people
- Sponsor
- Carelon Research
Coronary Artery Disease
Clopidogrel and Aspirin Together: The Effect on C-Reactive Protein Trial
Inflammation is associated with worsening outcomes among individuals with CAD; C-reactive protein is a well-known marker of inflammation.
- Trial name
- NCT00343876
- Testing
- aspirin, clopidogrel
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Intermountain Health Care, Inc.
Coronary Artery Disease
The Clinical Evaluation of the Cinatra™ Corolimus-Eluting Coronary Stent in De Novo Lesions in Native Coronary Arteries
To investigate the safety and efficacy of the Cinatra™ Corolimus Drug Eluting Stent for the treatment of de novo lesions in native coronary arteries.
- Trial name
- VANTAGE-1 (NCT01025869)
- Testing
- Cinatra™ Corolimus Eluting Coronary Stent System
- Where
- 4 sites in New Zealand
- Volunteers
- 31 people
- Sponsor
- Atrium Medical Corporation
Coronary Disease
Evaluating New Radiation Techniques for Cardiovascular Imaging
Title: Evaluating New Radiation Techniques for Cardiovascular Imaging Background: Cardiac CT angiography is associated with radiation exposure.
- Trial name
- NCT01621594
- Testing
- Cannon Aquilion ONE CT system
- Where
- United States
- Volunteers
- 5,000 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Coronary Heart Disease
Project 3: ACHIEVE- CHD
This project is part of the ACHIEVE GREATER (Addressing Cardiometabolic Health In Populations Through Early Prevention in the Great Lakes Region) Center (IRB 100221MP2A), the purpose of which is to reduce cardiometabolic health…
- Trial name
- NCT05918380
- Testing
- PAL2, CINEMA
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- University Hospitals Cleveland Medical Center
Chronic Kidney Disease, Kidney Transplant
The Impact of Renal Transplant on Coronary Microvascular Function Among Patients With Advanced Chronic Kidney Disease
People with chronic kidney disease (CKD) often experience faster aging of the heart and blood vessels, which raises the risk of heart problems beyond traditional factors like high blood pressure or cholesterol.
- Conditions
- Chronic Kidney Disease, Kidney Transplant, Coronary Microvascular Dysfunction (CMD), Inflammation
- Trial name
- RESTORE (NCT07222683)
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Brigham and Women's Hospital
Coronary Artery Disease, Ischemic Heart Disease
Coronary and Structural Interventions Ulm - Bioresorbable Vascular Scaffold
To evaluate the safety, performance and efficacy of the bioresorbable vascular scaffold (BVS) system in patients with coronary artery disease
- Conditions
- Coronary Artery Disease, Ischemic Heart Disease, Stable Angina, Unstable Angina
- Trial name
- CSI-Ulm-BVS (NCT02162056)
- Testing
- use of bioresorbable vascular scaffolds
- Where
- Germany
- Volunteers
- 326 people
- Sponsor
- University of Ulm
Myocardial Infarction
Previous Cardiovascular Disease, Cardiovascular Risk Factors and Chest Pain in First Myocardial Infarction
Some myocardial infarctions (MI) occur as the first manifestation of atherosclerotic disease. Such MIs are important because of the high likelihood of missed opportunities for prevention.
- Trial name
- NCT01379131
- Where
- United Kingdom
- Volunteers
- 9,000 people
- Sponsor
- London School of Hygiene and Tropical Medicine
STEMI, Coronary Artery Disease
STEMI and Incretins Treatment
ST elevation myocardial infarction (STEMI) patients affected by multivessels coronary artery stenosis, represent a clinical relevant problem. The management and prognosis of these patents are supported by few literature data.
- Conditions
- STEMI, Coronary Artery Disease, Coronary Syndrome, Coronary Arteriosclerosis
- Trial name
- NCT03312179
- Testing
- PCI and DES stenting, Incretins
- Where
- Italy
- Volunteers
- 900 people
- Sponsor
- University of Campania Luigi Vanvitelli
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