Clinical trials: Coronary Artery Disease Progression
Coronary Artery Disease
Effect of Statins on the Radial Intima-media Thickness After Transradial Angioplasty
The first event of the atherosclerotic plaque formation is the accumulation of the low density lipoprotein-cholesterol (LDL-cholesterol) in to the intima of the arterial wall.
- Trial name
- NCT00952770
- Testing
- transradial coronary intervention
- Where
- South Korea
- Volunteers
- 140 people
- Sponsor
- Chungnam National University
Chronic Kidney Failure, Inflammation
Vascular Calcification's Risk Factors in Haemodialysis Patients
A not randomized , cross sectional study will be done to determine the possible association of coronary artery calcification (CAC) score assessed by multirow spiral computed tomography (MSCT) with specific and non specific uremic…
- Conditions
- Chronic Kidney Failure, Inflammation, Vascular Calcification
- Trial name
- NCT00694824
- Where
- Italy
- Volunteers
- 253 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Cardiovascular Disease
A Study of the Effect of Dalcetrapib on Artherosclerotic Disease in Patients With Coronary Artery Disease
This multicenter, double-blind, randomized, placebo-controlled study will evaluate the effect of dalcetrapib 600 mg on artherosclerotic disease progression, lipid profile and biomarker profile and long-term safety profile of…
- Trial name
- NCT01059682
- Testing
- Dalcetrapib
- Where
- 110 sites in United States, Canada and 3 more
- Volunteers
- 936 people
- Sponsor
- Hoffmann-La Roche
Coronary Stenosis
Factors Related to the Progression of Non-target Coronary Lesions
The goal of this observational study is to learn about correlation between traditional risk factors and emerging risk factors on the progression of non-target coronary lesions in patients with non-target lesions on at least two…
- Trial name
- NCT06248138
- Volunteers
- 1,111 people
- Sponsor
- Mei Gao
Atherosclerosis, Type 2 Diabetes Mellitus
Effect of Sitagliptin on Progression of Coronary Intermediate Lesion
This study was to investigate the Effect of Sitagliptin, a dipeptidyl peptidase-4 inhibitor, on Progression of Coronary Intermediate Lesion.
- Trial name
- NCT02655757
- Testing
- Sitagliptin
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Li Bo
Coronary Artery Disease Progression
Sirtuin-1 and Advanced Glycation End-products in Postmenopausal Women With Coronary Disease
Higher consumption of fruits and vegetables promote greater availability of phenolic compounds and these compounds were associated with vascular health.
- Trial name
- NCT03943459
- Testing
- Quercetin
- Where
- Brazil
- Volunteers
- 60 people
- Sponsor
- InCor Heart Institute
Coronary Artery Disease
Atorvastatin Plus Ezetimibe on Coronary Plaque Progression
Atherosclerosis is a progressive disease. Lipid lowering therapy was the standard treatment for patients with coronary artery disease.
- Trial name
- AEPP (NCT01086020)
- Testing
- atorvastatin, atorvastatin plus ezetimibe
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Type 2 Diabetes, Coronary Artery Disease
Progression of Coronary Atherosclerosis in Asymptomatic Diabetic Subjects
The purpose of the study is to identify a sub-group of diabetic patients at higher risk of progression of coronary disease and also more likely to suffer from heart attack/angina and heart failure.
- Trial name
- PROCEED (NCT02109835)
- Where
- 5 sites in United Kingdom
- Volunteers
- 250 people
- Sponsor
- British Cardiac Research Trust
Percutaneous Coronary Revascularization, Coronary Stenosis
Evaluation of Effectiveness and Safety of Hybrid Coronary Revascularization
This study evaluated the effectiveness and safety of Hybrid Coronary Revascularization in real-world practice.
- Conditions
- Percutaneous Coronary Revascularization, Coronary Stenosis, Coronary Artery Disease Progression, Coronary Artery Bypass Grafting
- Trial name
- HCR registry (NCT03788369)
- Testing
- Hybrid Coronary Revascularization
- Where
- South Korea
- Volunteers
- 6 people
- Sponsor
- Seung-Jung Park
Coronary Heart Disease
A Study of the Effect of RO4607381 on Atherosclerotic Plaque in Patients With Coronary Heart Disease
This study will assess the effect of RO4607381, compared to placebo, on atherosclerotic plaque in patients with coronary heart disease (CHD) including patients with other CHD risk factors.
- Trial name
- NCT00655473
- Testing
- Dalcetrapib (RO4607381)
- Where
- 12 sites in United States, Canada
- Volunteers
- 130 people
- Sponsor
- Hoffmann-La Roche
Coronary Syndrome
The Effect of Rosuvastatin and Olmesartan on the Progression of Coronary Atherosclerotic Disease
1. Stains have demonstrated consistent benefits to reduce cardiovascular events in several primary and secondary prevention trials.
- Trial name
- NCT02516826
- Testing
- Rosuvastatin, Olmesartan, Combination
- Where
- South Korea
- Volunteers
- 504 people
- Sponsor
- Samsung Medical Center
Coronary Artery Disease, Coronary Artery Disease Progression
Disease Characteristics of R-CAD
The present case-control study is designed to investigate the disease characteristics of rapidly progressive coronary artery disease (R-CAD) by comparing the demographics, clinical features, lab results, imaging findings, and…
- Conditions
- Coronary Artery Disease, Coronary Artery Disease Progression, Coronary Stenosis, Coronary Restenosis
- Trial name
- NCT07239921
- Testing
- Protocol-defined Examinations and Evaluations
- Volunteers
- 52 people
- Sponsor
- Peking Union Medical College Hospital
Coronary Arterial Disease (CAD), Coronary Arteriosclerosis
PRogression of Atheroma Evaluated by CT Angiography and IntraCoronary Imaging tEchniques
This is a combined cohort study with retrospectively and prospectively enrolled coronary artery disease (CAD) patients. All the patients will undergo clinical follow-up for up to 5 years, and repeat coronary CTA will be conducted…
- Trial name
- PRACTICE (NCT06794684)
- Where
- 2 sites in China
- Volunteers
- 50,000 people
- Sponsor
- Ruijin Hospital
Coronary Artery Disease, Diabetes Mellitus
Coronary Artery Disease Progression in Patients With Acute Coronary Syndromes and Diabetes Mellitus
A total of 100 patients with non-ST-segment elevation acute coronary syndromes with or without diabetes mellitus will be included.
- Trial name
- PROGRESSION (NCT03890822)
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- Humanitas Hospital, Italy
Coronary Artery Disease
The Heartflow Coronary Disease Progression Evaluation Study
Invasively measured fractional flow reserve (FFR) has proven to be useful in guiding coronary revascularization. Several studies have shown that it is justified to treat lesions with a value of 0.80 or lower and safe to defer…
- Trial name
- THRONE (NCT04052256)
- Testing
- Coronary computed tomography angiography
- Where
- Netherlands
- Volunteers
- 250 people
- Sponsor
- Erasmus Medical Center
Atherosclerosis, Cardiovascular Diseases
Prevalence & Progression of Subclinical Atherosclerosis
To evaluate subclinical atherosclerotic disease in menopausal women.
- Conditions
- Atherosclerosis, Cardiovascular Diseases, Coronary Arteriosclerosis, Carotid Artery Diseases
- Trial name
- NCT00006503
- Sponsor
- Rush University Medical Center
Diabetes Mellitus
Efficacy Study of Pioglitazone Compared to Glimepiride on Coronary Atherosclerotic Disease Progression in Subjects With Type 2 Diabetes Mellitus
The purpose of this study was to determine the efficacy of pioglitazone, once daily (QD), compared to glimepiride on atherosclerotic disease measured by intravascular ultrasound.
- Trial name
- PERISCOPE (NCT00225277)
- Testing
- Pioglitazone, Glimepiride
- Where
- 79 sites in United States, Argentina and 2 more
- Volunteers
- 547 people
- Sponsor
- Takeda
Adverse Effect, Atherosclerosis, Coronary
Effect of Pioglitazone on Insulin Resistance, Atherosclerosis Progression and Clinical Course of Coronary Heart Disease
Pioglitazone, a medication of thiazolidinedione group, is capable of triggering the peroxisome proliferator-activated receptors (PPAR-γ).
- Conditions
- Adverse Effect, Atherosclerosis, Coronary, Insulin Resistance Syndrome
- Trial name
- EFFORT (NCT03011775)
- Testing
- Pioglitazone 15 mg Tablet, Isosorbide Dinitrate 10Mg Tablet, Acetylsalicylic Acid 75Mg Tablet
- Where
- Ukraine
- Volunteers
- 43 people
- Sponsor
- Ukrainian Medical Stomatological Academy
Coronary Heart Disease
Progression of AtheRosclerotic PlAque DetermIned by Computed TomoGraphic Angiography Imaging(PARADIGM)
To describe the natural history of the coronary atherosclerotic plaque development and progression over time by CCTA with demographic and laboratory data for refinement of risk stratification of patients referred for CCTA.
- Trial name
- PARADIGM (NCT02803411)
- Volunteers
- 2,000 people
- Sponsor
- Yonsei University
Coronary Atherosclerosis
Atheroma Progression and Vulnerability Under Continuous Glucose Monitoring
The OPTIMAL is a single-center, randomized trial to evaluate the efficacy of CGM-based glycemic control on atheroma progression in T2DM patients with CAD by using serial intravascular ultrasound (IVUS) and near-infrared…
- Trial name
- OPTIMAL (NCT04559191)
- Testing
- continuous glucose monitoring (CGM)
- Where
- Japan
- Volunteers
- 90 people
- Sponsor
- National Cerebral and Cardiovascular Center, Japan