Clinical trials: Coronary Artery Disease Progression, open to volunteers
Type 2 Diabetes Mellitus (T2DM), Coronary Artery Disease
SGLT2 Inhibitors on Coronary Atherosclerosis Progression Via Perivascular Adipose Tissue in Diabetes
This study is a multicenter, randomized controlled trial to test whether an SGLT2 inhibitor (dapagliflozin), a type of diabetes medication, can slow down or even reverse the progression of coronary atherosclerosis (plaque buildup…
- Conditions
- Type 2 Diabetes Mellitus (T2DM), Coronary Artery Disease, Atherosclerosis
- Trial name
- SCOPE (NCT07614230)
- Testing
- Dapagliflozin (DAPA), Standard Care (Treatment as Usual)
- Where
- 2 sites in China
- Volunteers
- 144 people
- Sponsor
- Junjie Yang
Coronary Arterial Disease (CAD), Coronary Arteriosclerosis
PRogression of Atheroma Evaluated by CT Angiography and IntraCoronary Imaging tEchniques
This is a combined cohort study with retrospectively and prospectively enrolled coronary artery disease (CAD) patients. All the patients will undergo clinical follow-up for up to 5 years, and repeat coronary CTA will be conducted…
- Trial name
- PRACTICE (NCT06794684)
- Where
- 2 sites in China
- Volunteers
- 50,000 people
- Sponsor
- Ruijin Hospital
Coronary Disease, Coronary Arteriosclerosis
Effects of a Healthy Nordic Diet on Atherosclerosis in Patients with Coronary Heart Disease
Diet can play a key role in atherosclerosis and coronary heart disease (CHD), but little interventional data exists, and the mediators of possible anti-atherosclerotic effects of diet are unclear.
- Conditions
- Coronary Disease, Coronary Arteriosclerosis, Myocardial Infarction, Chronic Coronary Syndrome
- Trial name
- NORDHEART (NCT06701968)
- Testing
- Healthy Nordic Diet, Usual Care
- Where
- Sweden
- Volunteers
- 150 people
- Sponsor
- Uppsala University
Coronary Artery Disease, Coronary Atherosclerosis
Effects of Switching From Cigarettes to Tobacco Heating System on Coronary Atherosclerosis Progression
Objective: To evaluate the impact of heated versus combustion tobacco products on progression of atherosclerosis in patients with CAD unable(unwilling) to quit smoking.
- Conditions
- Coronary Artery Disease, Coronary Atherosclerosis, Nicotine Dependence
- Trial name
- SWITCH (NCT05660798)
- Testing
- heated tobacco - lifestyle intervention
- Where
- Poland
- Volunteers
- 180 people
- Sponsor
- National Institute of Cardiology, Warsaw, Poland
Coronary Artery Disease
AI-Based CT Analysis of Coronary Plaque Evolution
This retrospective, multicenter, observational study will evaluate an artificial intelligence-based system for quantitative assessment and risk stratification of coronary atherosclerotic plaque.
- Trial name
- AI-CT-PLAQUE (NCT07886996)
- Where
- 5 sites in China
- Volunteers
- 326 people
- Sponsor
- Zhejiang Hospital
CAD - Coronary Artery Disease
REWRITE-CAD Protocol: Risk Evaluation With AI-CPA to Reduce Progression and Improve Lifetime Care for Patients With Known Coronary Artery Disease
REWRITE-CAD is a prospective, randomized, multi-center trial assessing the management of asymptomatic participants with a history of PCI or MI who will undergo a blinded CCTA and be randomly assigned to either the test arm in…
- Trial name
- REWRITE-CAD (NCT07834372)
- Testing
- Heartflow Analysis
- Where
- United States
- Volunteers
- 350 people
- Sponsor
- HeartFlow, Inc.
Coronary Heart Disease (CHD)
AI-Driven Dynamic Prediction of Non-Target Lesion Progression After PCI: A Chinese Multicenter Cohort Study
Coronary artery disease remains a leading cause of global mortality. Although percutaneous coronary intervention (PCI) improves patient outcomes, the long-term risk of major adverse cardiovascular events (MACE) driven by the…
- Trial name
- VISION-PCI (NCT07312318)
- Testing
- percutaneous coronary intervention
- Where
- China
- Volunteers
- 12,000 people
- Sponsor
- China-Japan Friendship Hospital
Coronary Disease, Young Adult
Risk Prediction of Disease Progression in Early-Onset Coronary Atherosclerosis
This study is part of a nationwide research project in China that aims to better understand how coronary artery disease develops and progresses in young adults.
- Trial name
- NCT07316452
- Where
- China
- Volunteers
- 10,000 people
- Sponsor
- Fu Wai Hospital, Beijing, China
Coronary Artery Disease, Coronary Artery Disease Progression
Clinical Features, Current Treatment and Clinical Outcomes in Patients With INR-CAD: a Cohort Study
This is a cohort study to investigate the clinical features, current treatment and clinical outcomes in patients with inflammation-associated non-rapidly-progressive coronary artery disease (INR-CAD).
- Conditions
- Coronary Artery Disease, Coronary Artery Disease Progression, Coronary Artery Stenosis, Coronary Artery Restenosis
- Trial name
- NCT06845410
- Testing
- Healthy life style, Secondary prevention for atherosclerotic coronary artery disease, Immunosuppressive Therapy
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Peking Union Medical College Hospital
Coronary Artery Disease, Aneurysms
Progression, Management, and Clinical Outcomes of Coronary Artery Aneurysms
This study aimed to characterize the progression and risk fators of coronary artery aneurysms, and copmpare the outcomes across different management strategies
- Conditions
- Coronary Artery Disease, Aneurysms, Coronary Intervention
- Trial name
- NCT07764081
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
Coronary Heart Disease (CHD)
REsiduAL rISk Under Intensive Lipid-lowering Therapy In Coronary Heart Disease
Intensive lipid-lowering therapy is a cornerstone treatment for coronary heart disease (CHD). However, coronary plaque progression persists in a subset of patients even under intensive lipid-lowering therapy, which may be…
- Trial name
- REALISTIC (NCT06936111)
- Testing
- Assessment of residual cholesterol and inflammatory risk factors
- Where
- China
- Volunteers
- 900 people
- Sponsor
- Shanghai Zhongshan Hospital
Acute Heart Failure, Acute Coronary Syndrome
Heart Failure-USB: Prediction and Progression
This retrospective cohort study is to identify triggers of heart failure (HF) development and drivers of HF progression as well as the underlying cardiac disease (phenotype) to identify patients at risk and predict the clinical…
- Trial name
- HF-USB (NCT04000061)
- Testing
- medical chart review, data generated by direct IT export
- Where
- Switzerland
- Volunteers
- 6,000 people
- Sponsor
- University Hospital, Basel, Switzerland
Coronary, Coronary Artery Disease
CAPRA-EVO: a Randomized Serial PCCT Trial of Early Evolocumab After ACS
The CAPRA-EVO trial is a single-center, randomized, open-label study with blinded endpoint assessment comparing early evolocumab plus standard lipid-lowering therapy versus standard-of-care lipid-lowering therapy in patients with…
- Trial name
- CAPRA-EVO (NCT07612774)
- Testing
- Evolocumab, Serial photon-counting coronary computed tomography angiography, Standard Lipid-Lowering Therapy
- Where
- 2 sites in China
- Volunteers
- 232 people
- Sponsor
- West China Hospital
Obesity & Overweight, Coronary Heart Disease
Effect of Mazdutide on Coronary Plaque in Patients With Coronary Atherosclerosis and Overweight or Obesity
This multicenter, randomized, double-blind, placebo-controlled trial aims to evaluate the effect of mazdutide, a dual GLP-1/GCG receptor agonist, on coronary plaque progression assessed by coronary computed tomography angiography…
- Trial name
- NCT07657676
- Testing
- Mazdutide
- Where
- China
- Volunteers
- 116 people
- Sponsor
- China National Center for Cardiovascular Diseases
Coronary Artery Disease, Coronary Artery Disease Progression
Disease Characteristics of R-CAD
The present case-control study is designed to investigate the disease characteristics of rapidly progressive coronary artery disease (R-CAD) by comparing the demographics, clinical features, lab results, imaging findings, and…
- Conditions
- Coronary Artery Disease, Coronary Artery Disease Progression, Coronary Stenosis, Coronary Restenosis
- Trial name
- NCT07239921
- Testing
- Protocol-defined Examinations and Evaluations
- Volunteers
- 52 people
- Sponsor
- Peking Union Medical College Hospital
Air Pollution, Atherosclerosis
Using Indoor Air Filtration to Slow Atherothrombosis Progression in Adults With Ischemic Heart Disease History
This double-blind, randomized, crossover trial aims to test the hypothesis that longer-term indoor air filtration intervention can slow atherothrombosis progression by reducing indoor fine particulate matter (PM2.5) exposure in…
- Trial name
- SAPIA (NCT05867381)
- Testing
- HEPA filtration
- Where
- United States
- Volunteers
- 112 people
- Sponsor
- University of Southern California
Coronary Artery Disease Progression
Plaque Reversal With Early, Aggressive Lipid Lowering Therapy
This study evaluates whether plaques in young patients with familial hypercholesterolemia (aged below 50 years) are susceptible to significant plaque regression with early, intensive lipid lowering therapy.
- Trial name
- EAGLE (NCT05783804)
- Where
- Netherlands
- Volunteers
- 60 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Coronary Artery Disease, Coronary Artery Stenosis
Efficacy and Safety of Comprehensive Treatment in Patients With IR-CAD: a Self-controlled Cohort Study
This is a self-controlled cohort study to evaluate the efficacy and safety of comprehensive treatment in patients with inflammation-associated rapidly-progressive coronary artery disease (IR-CAD) by comparing the study endpoints…
- Conditions
- Coronary Artery Disease, Coronary Artery Stenosis, Coronary Artery Restenosis, Coronary Artery Disease Progression
- Trial name
- NCT05860400
- Testing
- Healthy life style, Secondary prevention for atherosclerotic coronary artery disease, Immunosuppressive therapy
- Where
- China
- Volunteers
- 39 people
- Sponsor
- Peking Union Medical College Hospital
Systemic Sclerosis (SSc), Pulmonary Arterial Hypertension (PAH)
Home-Based Clinical Management of Cardiac Complications in Systemic Sclerosis
The goal of this observational pilot trial is to evaluate the feasibility of home monitoring for patients with systemic sclerosis-associated pulmonary arterial hypertension (SSc-PAH).
- Conditions
- Systemic Sclerosis (SSc), Pulmonary Arterial Hypertension (PAH), Home Monitoring Follow-up
- Trial name
- Nor-SScCare (NCT06865118)
- Where
- Norway
- Volunteers
- 20 people
- Sponsor
- Oslo University Hospital
Recurrent Angina After Coronary Artery Bypass Graft, Graft Failure
Prior CABG Patients Evaluated for Saphenous VeIn grAft DysfUnction and Progression of Coronary arTery Disease
This is a multi-center, observational cohort study including patients with prior coronary artery bypass grafting (CABG) and ≥1 saphenous vein grafts (SVG) presenting with recurrent ischemic symptoms.
- Conditions
- Recurrent Angina After Coronary Artery Bypass Graft, Graft Failure, Coronary Artery Disease Progression
- Trial name
- VIADUCT (NCT04772768)
- Where
- Netherlands
- Volunteers
- 500 people
- Sponsor
- Amsterdam UMC, location VUmc