Clinical trials: Coronary Artery Occlusive Disease
Cardiomyopathy, Cardiovascular Diseases
Improving Mitral Repair for Functional Mitral Regurgitation
The investigators are interested in determining the best surgical technique to correct functional mitral regurgitation, as there is currently not one technique that is established to work better than the other.
- Conditions
- Cardiomyopathy, Cardiovascular Diseases, Congestive Heart Failure, Coronary Artery Disease
- Trial name
- IMPROVE-FMR (NCT03366649)
- Testing
- Undersizing Mitral Annuloplasty, Papillary Muscle Approximation
- Where
- 3 sites in United States
- Volunteers
- 34 people
- Sponsor
- Emory University
Coronary Artery Disease, Ischemic Heart Disease
Comparison of PROVISIONal 1-stent Strategy with DEB Versus Planned 2-stent Strategy in Coronary Bifurcation Lesions.
[The Purpose of the Clinical Study] The purpose of this randomized comparison study is to compare the 1-stent strategy with a drug-eluting balloon and the 2-stent strategy in patients with non-LM coronary true-bifurcation…
- Trial name
- PROVISIONDEB (NCT06002932)
- Testing
- Procedure: planed 2-stent strategy, Procedure: provisional 1-stent plus DEB strategy
- Where
- South Korea
- Volunteers
- 750 people
- Sponsor
- Saint Vincent's Hospital, Korea
Atherosclerotic Cardiovascular Disease, Metabolic Syndrome
Multicenter Trial of Meditation and Health Education for Cardiometabolic Disease in Black Women
This randomized controlled trial compared the efficacy of stress reduction with meditation to a health education (HE) group in 201 older African American women over a one-year study period.
- Trial name
- NCT06443814
- Testing
- Health Education, Transcendental Meditation
- Where
- 2 sites in United States
- Volunteers
- 201 people
- Sponsor
- Robert Schneider, MD
Coronary Artery Disease
The Association Between Monocyte Subsets and Coronary Collateral Development in Diabetes Mellitus
Monocyte heterogeneity in peripheral blood seems to be important in coronary collateral development in non-diabetic patients with stable coronary artery disease.
- Trial name
- NCT01671306
- Volunteers
- 83 people
- Sponsor
- Samsun Education and Research Hospital
Coronary Artery Disease, Coronary Artery Bypass Grafting
Effects of PEEP on Parameters of Tissue Perfusion in Patients Post Cardiac Surgery
Pulmonary dysfunction is a condition inherent in cardiac surgery because of various interventions, such as general anesthesia, a median sternotomy, cardiopulmonary bypass and establishment of internal thoracic artery dissection.
- Conditions
- Coronary Artery Disease, Coronary Artery Bypass Grafting, Acute Lung Injury
- Trial name
- NCT03753022
- Testing
- Group G5, Group G10, Group G15
- Volunteers
- 125 people
- Sponsor
- Federal University of São Paulo
Coronary Artery Disease
High Definition CT Coronary Angiography Accuracy Trial
CT technology is evolving at a rapid pace, with introduction of multidetector row CT scanners (MDCT) and electrocardiographic (ECG) gating resulting in increasing numbers of heart scans CTCA (CT Coronary Angiography).
- Trial name
- NCT01946737
- Testing
- HD-CTCA with Adaptive statistical iterative reconstruction (ASIR), Active Comparator: Invasive coronary angiography (ICA)
- Where
- United Kingdom
- Volunteers
- 302 people
- Sponsor
- University Hospital Plymouth NHS Trust
Coronary Artery Disease
FIM-BR - First-in-Man Study (Brazil Part) With Sirolimus-Coated BX VELOCITY Stent
This is a single center, non-randomized study. Patients will be treated with the sirolimus coated Bx VELOCITY Balloon-Expandable Stent mounted on the Raptor OTW SDS.
- Trial name
- NCT00233792
- Testing
- sirolimus coated Bx VELOCITY stent - fast release, sirolimus coated Bx VELOCITY stent - slow release
- Where
- Brazil
- Volunteers
- 30 people
- Sponsor
- Cordis US Corp.
Coronary Artery Disease
The DECISION-CTO Extended 10 Y Follow-up
The goal of this study is to compare the 10-year clinical outcomes of an initial strategy of percutaneous coronary intervention (PCI) for chronic total occlusion (CTO-PCI) with an initial strategy of no CTO-PCI in patients with…
- Trial name
- DecisionCTO10Y (NCT06908499)
- Where
- 19 sites in India, Indonesia and 3 more
- Volunteers
- 804 people
- Sponsor
- Seung-Jung Park
Cerebrovascular Accident, Chronic Obstructive Pulmonary Disease
Tocilizumab for the Treatment of Cytokine Release Syndrome in Patients With COVID-19 (SARS-CoV-2 Infection)
This phase III trial compares the effect of adding tocilizumab to standard of care versus standard of care alone in treating cytokine release syndrome (CRS) in patients with SARS-CoV-2 infection.
- Conditions
- Cerebrovascular Accident, Chronic Obstructive Pulmonary Disease, Chronic Renal Failure, Coronary Artery Disease
- Trial name
- NCT04361552
- Testing
- Best Practice, Tocilizumab
- Where
- United States
- Sponsor
- Emory University
Myocardial Perfusion Imaging, Computed Tomography
Utility of Regadenoson Low-dose Dynamic Computed Tomography for Myocardial Perfusion Assesment (ULYSSES Study).
The ULYSSES study is a single-center, prospective study aimed at evaluation of myocardial ischemia using regadenoson low-dose dynamic computed tomography myocardial perfusion imaging (CTP) in patients diagnosed with intermediate…
- Conditions
- Myocardial Perfusion Imaging, Computed Tomography, Coronary Artery Disease
- Trial name
- ULYSSES (NCT03917199)
- Where
- Poland
- Volunteers
- 60 people
- Sponsor
- National Institute of Cardiology, Warsaw, Poland
Acute Coronary Syndrome
Transition From Ticagrelor to Clopidogrel Following Acute Coronary Syndrome: To Bolus or Not?
After a heart attack patients are routinely started on drugs to inhibit platelets. Ticagrelor is a powerful anti-platelet drug with clinical benefits.
- Trial name
- NCT02054663
- Testing
- Clopidogrel
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- Ottawa Heart Institute Research Corporation
Cardiovascular Diseases, Myocardial Ischemia
Cohort Study of Heart Rate Variability
To examine factors affecting heart rate variability (HRV) and the role of HRV in heart disease. Specifically, to examine the role of HRV: as a predictor of fatal and nonfatal ischemic heart disease over a six year follow-up of…
- Conditions
- Cardiovascular Diseases, Myocardial Ischemia, Carotid Stenosis, Hypertension
- Trial name
- NCT00005399
- Testing
- No interventions
- Volunteers
- 111,654 people
- Sponsor
- University of North Carolina, Chapel Hill
Coronary Heart Disease, Chronic Total Occlusion of Coronary Artery
CTO Registry From Insight of IVUS in Fuwai Hospital
To evaluate the long-term outcome of chronic total occlusion (CTO) patients underwent contemporary percutaneous coronary intervention (PCI) techniques, we design this single-center, large-sample, prospective registry with…
- Conditions
- Coronary Heart Disease, Chronic Total Occlusion of Coronary Artery, Percutaneous Coronary Intervention, Intravascular Ultrasound
- Trial name
- FWCTO (NCT03461367)
- Where
- China
- Volunteers
- 5,000 people
- Sponsor
- China National Center for Cardiovascular Diseases
Acute Coronary Syndrome, STEMI
The Effect of Colchicine on Inflammation in ACS Patients
This study will evaluate whether the anti-inflammatory effect of colchicine is beneficial in ACS patients
- Trial name
- NCT06054100
- Testing
- Colchicine Tablets
- Where
- Egypt
- Volunteers
- 88 people
- Sponsor
- Ain Shams University
Coronary Artery Disease, Hypertriglyceridemia
Efficacy of LCQ908 on Cardiovascular Risk
This is a study designed to evaluate the potential for the pradigastat (LCQ908) to impact cardiovascular risk.
- Trial name
- NCT01474434
- Testing
- pradigastat (LCQ908)
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- Novartis Pharmaceuticals
Coronary Artery Disease, Decreased Left Ventricular Function
Glucagon-like Peptide 1 Agonist Exenatide for Improved Glucose Control and Cardiac Function in Patients With Aortocoronary Bypass
GLP-1 has not only beneficial effects on glucose metabolism but also direct positive effects on cardiac function and metabolism in both experimental models and in patients with type 2 diabetes mellitus.
- Trial name
- Executive (NCT01373216)
- Testing
- Exenatide
- Where
- Czechia
- Volunteers
- 38 people
- Sponsor
- Charles University, Czech Republic
Genetic Polymorphism, Coronary Artery Disease
Association Study of Gene Polymorphisms With Cardiac Performance
The purpose of this study is to determine whether polymorphisms in G protein subunits, namely Galphas and Galphaq, are associated with altered cardiac performance in heart failure patients.
- Conditions
- Genetic Polymorphism, Coronary Artery Disease, Hemodynamics
- Trial name
- NCT00730899
- Where
- Germany
- Volunteers
- 500 people
- Sponsor
- University Hospital, Essen
Heterozygous Familial Hypercholesterolemia (HeFH)
EDIT-401 in Adults Who Require Additional Lowering of Low-Density Lipoprotein Cholesterol (LDL-C)
A phase 1/2, two-part trial consisting of an open label dose-escalation part and a randomized, double blind, placebo-controlled part to investigate safety, tolerability, pharmacokinetics, and efficacy with EDIT-401 gene editing…
- Trial name
- NCT07894887
- Testing
- Drug: EDIT-401
- Where
- 2 sites in Australia
- Volunteers
- 56 people
- Sponsor
- Editas Medicine, Inc.
Type 2 Diabetes Mellitus, Coronary Artery Disease
Exercise Training Improves Coronary Endothelial Dysfunction in Diabetes Mellitus Type 2 and Coronary Artery Disease
Patients with type 2 diabetes mellitus suffer from accelerated coronary artery disease. We will assess the effects of exercise training on coronary endothelial function, vascular structure, and inflammation both in serum and…
- Trial name
- NCT00693537
- Testing
- Exercise training
- Where
- Austria
- Sponsor
- Paracelsus Medical University
Ischemic Heart Disease, Stenotic Coronary Lesion
RESOLUTE ONYX China Single Arm Study
It is a single arm clinical evaluation of safety and efficacy of the Medtronic Resolute Onyx™ zotarolimus-eluting coronary stent system in subjects who are eligible for percutaneous transluminal coronary angioplasty (PTCA) in de…
- Conditions
- Ischemic Heart Disease, Stenotic Coronary Lesion, Cardiovascular Diseases, Arteriosclerosis
- Trial name
- NCT03471845
- Testing
- Resolute Onyx™ Zotarolimus-Eluting Coronary Stent System
- Where
- China
- Volunteers
- 591 people
- Sponsor
- Medtronic Vascular
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