Clinical trials: Coronary Artery Stenoses
Heart Diseases, Angina, Stable
RecoveryPlus Telerehab Platform Pilot Study
In this prospective, single-arm study, we will look at the initiation, participation, sustained engagement, and safety of 100 adult subjects (ages 45 years or older) with recent (within the past 60 days) clinician referral to CR…
- Conditions
- Heart Diseases, Angina, Stable, Angina Pectoris, Myocardial Ischemia
- Trial name
- NCT05804500
- Testing
- Cardiac Telerehabilitation (CTR) via the RecoveryPlus platform
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- NODEHealth Foundation
Coronary Artery Stenosis
Diabetes-Centered Evaluation of Revascularization Strategy of Functional and Imaging-CombiNEd State-of-the-Art Percutaneous Coronary Intervention or Coronary-Artery Bypass Grafting in Patients With Diabetes Mellitus and Multivessel Coronary Artery Disease
The objective of this randomized study was to compare outcomes of imaging-and physiology-guided state-of-the-art percutaneous coronary intervention (PCI) to coronary artery bypass grafting (CABG) in patients with diabetes and…
- Trial name
- DEFINE-DM (NCT05831085)
- Testing
- State-of-the-Art Percutaneous Coronary Intervention, standard CABG
- Where
- 39 sites in United States, Australia and 12 more
- Volunteers
- 1,500 people
- Sponsor
- Duk-Woo Park, MD
Aortic Valve Stenosis
Determination of the Acute Effects of Aortic Stenosis on Coronary Artery Haemodynamics
Narrowing of the main valve which controls blood leaving the heart leads to a marked increase in death. To overcome this narrowing the heart muscle thickens abnormally and contracts more vigorously.
- Trial name
- NCT01118442
- Where
- United Kingdom
- Volunteers
- 6 people
- Sponsor
- Imperial College London
Coronary Stenosis
EluNIR Ridaforolimus Eluting Coronary Stent System in Patients at High Bleeding Risk (HBR)- EluNIR HBR Study
The study will enroll approximately 316 subjects with a wide spectrum of PCI indications (stable angina as well as ACS), who are considered to be at high risk of bleeding.
- Trial name
- NCT03877848
- Testing
- Percutaneous Coronary Intervention (PCI)
- Where
- Israel
- Volunteers
- 319 people
- Sponsor
- Medinol Ltd.
Coronary Artery Disease
Physiological Assessment of Severe Coronary Stenosis for Informing Planned PCI
Traditionally, the severity of a blockage (stenosis) in a coronary artery has been determined by visual angiographic assessment of the diameter of the artery at the level of a blockage compared to a normal healthy area of the…
- Trial name
- REFINE PCI (NCT05491668)
- Testing
- Non-hyperemic pressure ratio assessment pre and post PCI
- Where
- United States
- Volunteers
- 107 people
- Sponsor
- Beth Israel Deaconess Medical Center
Coronary Artery Disease, Myocardial Ischemia
Evaluation of Accuracy of CFD-based RuiXin-FFR by Comparing With Pressure-wire-based FFR
Coronary Artery Disease (CAD) is the top killer nowadays. Pressure-wire-based Fractional Flow Reserve (FFR) is the gold standard for measuring ischemia in coronary arteries.
- Conditions
- Coronary Artery Disease, Myocardial Ischemia, Myocardial Fractional Flow Reserve
- Trial name
- NCT04731285
- Testing
- Pressure wire fractional flow reserve, CFD-based RuiXin-FFR
- Where
- China
- Volunteers
- 316 people
- Sponsor
- Beijing Anzhen Hospital
Coronary Stenosis
Excel Drug-Eluting Stent Pilot Clinical Registry
The Trial aims to evaluate long-term efficiency of Excel stent in the inhibition of restenosis as well as the safety after the cessation of the 6-month anti-platelet drug treatment.
- Trial name
- NCT00385905
- Testing
- Excel Drug-eluting stent
- Where
- China
- Volunteers
- 100 people
- Sponsor
- JW Medical Systems Ltd
Coronary Disease, Coronary Artery Disease
Safety and Efficacy of the ZoMaxx™ Drug-Eluting Stent System in Coronary Arteries
The purpose of this study is to demonstrate the safety and efficacy of the ZoMaxx drug-eluting stent in patients with blockage of native coronary arteries.
- Conditions
- Coronary Disease, Coronary Artery Disease, Coronary Restenosis
- Trial name
- ZoMaxx™ I (NCT00148356)
- Testing
- ZoMaxx™ Drug-Eluting Coronary Stent System, TAXUS™ EXPRESS2™ Paclitaxel Eluting Coronary Stent System
- Where
- 29 sites in Australia, Belgium and 8 more
- Volunteers
- 401 people
- Sponsor
- Abbott Medical Devices
Atherosclerosis, Coronary
Validation of a Computed Tomography (CT) Based Fractional Flow Reserve (FFR) Software Using the 320 Detector Aquilion ONE CT Scanner.
Coronary Computed Tomography Angiography (CCTA) contrast opacification gradients and FFR-CT estimation can aid in the severity estimation of significant atherosclerotic lesions.
- Trial name
- NCT03149042
- Testing
- CCTA
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- State University of New York at Buffalo
Coronary Artery Disease
Validation of Coronary Calcium Subtraction to Improve Diagnostic Accuracy of Coronary CT Angiography
Coronary calcium hampers accurate evaluation of the coronary arteries with coronary computed tomography angiography (CCTA). A novel approach to potentially overcome this limitation is coronary calcium subtraction.
- Trial name
- C-Sub320 (NCT02011061)
- Where
- 2 sites in United States, Denmark
- Volunteers
- 182 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Coronary Artery Stenosis, Coronary Artery Disease
HanYang University Medical Center (HYUMC) Registry
The HYUMC registry is a two-center, real-world registry of percutaneous coronary intervention in patients with coronary artery disease.
- Conditions
- Coronary Artery Stenosis, Coronary Artery Disease, Blood Pressure
- Trial name
- HYUMC (NCT05935397)
- Testing
- percutaneous coronary intervention
- Where
- 3 sites in South Korea
- Volunteers
- 5,000 people
- Sponsor
- Hanyang University Seoul Hospital
Coronary Atherosclerosis, Coronary Restenosis
PIoglitazone for PrEvention of Restenosis in Diabetic Patients
Restenosis requiring reintervention is still a limitation of percutaneous coronary angioplasty. Despite the use of Drug eluting stent (DES), the rate of restenosis remains 7% to 16% in diabetic patients, making it a challenging…
- Conditions
- Coronary Atherosclerosis, Coronary Restenosis, Diabetes
- Trial name
- NCT00376870
- Testing
- Pioglitazone
- Where
- 2 sites in Italy
- Volunteers
- 160 people
- Sponsor
- University of Rome Tor Vergata