Clinical trials: Coronary Artery Vasospasm
Coronary Microvascular Dysfunction, Microvascular Angina
Randomized Trial to Examine a Differential Therapeutic Response in Symptomatic Patients With Non-obstructive Coronary Artery Disease
EXAMINE-CAD-DZHK22 is a prospective, randomized, double-blind, placebo-controlled, crossover trial investigating the efficacy of beta blocker (bisoprolol) and calcium channel blocker (diltiazem) therapy in symptomatic patients…
- Conditions
- Coronary Microvascular Dysfunction, Microvascular Angina, Vasospasm, Coronary, Vasospastic Angina
- Trial name
- EXAMINE-CAD (NCT05294887)
- Testing
- Bisoprolol, Diltiazem
- Where
- 15 sites in Germany, Switzerland
- Volunteers
- 132 people
- Sponsor
- Charite University, Berlin, Germany
Coronary Microvascular Dysfunction, Coronary Artery Vasospasm
Belgian Registry on Coronary Function Testing
The goal of this prospective, multicenter registy is to describe the 'real-world' use of coronary function tests, which may consist of bolus thermodilution measurements of coronary microvascular function and/or invasive…
- Trial name
- BELmicro (NCT06089031)
- Testing
- Coronary Function Test
- Where
- 13 sites in Belgium
- Volunteers
- 650 people
- Sponsor
- University Hospital, Antwerp
Coronary Artery Disease
Uric Acid Levels and Endothelial Functions
Uric acid is a risk factor for coronary artery disease (CED) in postmenopausal women but the association with inflammation and coronary microvascular endothelial dysfunction is not well-defined.
- Trial name
- NCT02862522
- Testing
- Questionnaire of overall health
- Where
- United States
- Volunteers
- 229 people
- Sponsor
- Mayo Clinic
Coronary Artery Disease, Ischemia and No Obstructive Coronary Arteries
Coronary Microcirculatory Disease and Inflammation in Patients With Chronic Coronary Syndrome and no Significant Coronary Artery Stenosis
Patients with chronic coronary syndromes (CCS) diagnosed without significant lesions in invasive coronary angiography (ischemia non-obstructive coronary artery disease - INOCA) represent approximately 50% of all patients with…
- Conditions
- Coronary Artery Disease, Ischemia and No Obstructive Coronary Arteries, Ischemic Heart Disease, Microvascular Angina
- Trial name
- MOSAIC-COR (NCT05313919)
- Testing
- Comprehensive functional diagnostics of coronary circulation
- Where
- Poland
- Volunteers
- 160 people
- Sponsor
- Bartlomiej Guzik
Angina Pectoris, Variant
BVS Implantation in Patients With Variant Angina and MODerate Coronary Artery Disease
The purpose of this study is to determine whether BVS(Bioresorbable Vascular Scaffold) implantation with optimal medical therapy can improve the outcome of patients with variant angina and moderate coronary artery disease.
- Trial name
- BIVA-pilot (NCT02932553)
- Testing
- BVS+OMT
- Where
- South Korea
- Sponsor
- Seung-Jung Park
Vasospastic Angina
Safety and Efficacy Study of Cilostazol to Treat Vasospastic Angina
This study will be conducted in accordance with the local regulation of New Drug Application. Overall duration of this trial will be 3 years after approval of MFDS.
- Trial name
- STELLA_Ext (NCT02094469)
- Testing
- Cilostazol
- Where
- South Korea
- Volunteers
- 65 people
- Sponsor
- Korea Otsuka Pharmaceutical Co., Ltd.
Microvascular Angina, Vasospastic Angina
Transcutaneous Electrical Nerve Stimulation in Patients With Angina and Non-Obstructive Coronary Arteries
In patients with angina pectoris undergoing a coronary angiography (CAG) up to 40% do not have obstructive coronary artery disease (CAD).
- Trial name
- TENS-ANOCA (NCT06401291)
- Testing
- Transcutaneous Electrical Nerve Stimulation
- Where
- Netherlands
- Volunteers
- 20 people
- Sponsor
- Catharina Ziekenhuis Eindhoven
Vasovagal Syndrome VVS, Cardioinhibitory Carotid Sinus Syndrome CSS
POLish Registry of CArdioneuroablation and CArdioneuromodulation
The multicentre observational study POL-CA involves a wide spectrum of patients with a history of syncopy. The study recruits patients with diagnosed vasovagal syndrome, cardioinhibitory carotid sinus syndrome, symptomatic sinus…
- Conditions
- Vasovagal Syndrome VVS, Cardioinhibitory Carotid Sinus Syndrome CSS, Symptomatic Sinus Bradycardia SB or Atrioventricular Block AV, Postural Orthostatic Tachycardia Syndrome POTS
- Trial name
- POL-CA (NCT07196397)
- Testing
- cardioneuroablation, SN sparing hybrid ablation, Cardiac sympathetic denervation
- Where
- Poland
- Volunteers
- 1,000 people
- Sponsor
- SABAMED Medical Center Ltd.
Chronic Coronary Syndrome, Coronary Artery Disease
Advanced Invasive Diagnosis for Patients With Chronic Coronary Syndromes Undergoing Coronary ANGIOgraphy (AID-ANGIO)
AID-ANGIO is an observational, prospective, single arm, longitudinal study. Its objective is to investigate the diagnostic yield of the systematic use of a diagnostic strategy hierarchically addressing both obstructive and…
- Conditions
- Chronic Coronary Syndrome, Coronary Artery Disease, Microvascular Angina, Coronary Vasospasm
- Trial name
- AID-ANGIO (NCT05635994)
- Testing
- AID strategy
- Where
- 4 sites in Spain
- Volunteers
- 260 people
- Sponsor
- Hospital San Carlos, Madrid
Coronary Artery Disease, Ischemic Heart Disease (IHD)
Gangwon PCI Prospective Registry
This prospective, multicenter registry will consecutively enroll patients of all ages undergoing percutaneous coronary intervention (PCI) at four university hospitals in Gangwon Province, Republic of Korea.
- Conditions
- Coronary Artery Disease, Ischemic Heart Disease (IHD), Unstable Angina (UA), Non-ST Elevated Myocardial Infarction
- Trial name
- GWPCI (NCT02038127)
- Testing
- Percutaneous Coronary Intervention (PCI)
- Where
- 4 sites in South Korea
- Volunteers
- 10,000 people
- Sponsor
- Yonsei University
Angina Pectoris; Angiospastic
SCS for Vasospastic Angina Vasospastic Angina Pectoris - a Prospective Study
According to the 2020 Dutch guideline on chest pain (AP) without obstructive coronary artery disease, 70% of female and 30% of male patients undergoing a coronary angiogram (CAG), have no obstructive coronary artery disease.In…
- Trial name
- VAP (NCT06176391)
- Testing
- Spinal Cord Stimulation
- Volunteers
- 10 people
- Sponsor
- Amsterdam UMC, location VUmc
Vasospastic Angina
The Impact of Vericiguat on Microvascular Function in Patients With Documented Vasospastic Angina Pectoris
Vasospastic angina is increasingly recognized as an important contributor to anginal symptoms in patients with non-obstructive coronary artery disease (ANOCA).
- Trial name
- ViVA (NCT06415227)
- Testing
- Vericiguat
- Where
- Netherlands
- Volunteers
- 57 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
ANOCA - Angina With Non-obstructive Coronary Arteries, Coronary Microvascular Dysfunction (CMD)
Invasive Evaluation and Phenotype-Guided Treatment of ANOCA in Women
This prospective single-center interventional study will include women with angina and non-obstructive coronary arteries. Participants will undergo a standardized invasive coronary assessment combining coronary physiology…
- Conditions
- ANOCA - Angina With Non-obstructive Coronary Arteries, Coronary Microvascular Dysfunction (CMD), Vasospastic Angina
- Trial name
- ANOCA-UY (NCT07593157)
- Testing
- Invasive Coronary Functional and Morphological Assessment, Pharmacological treatment will be individualized according to the invasive coronary phenotype identified. Treatment may include antianginal therapy, vasodilator therapy, endothelial function-targeted
- Where
- Uruguay
- Volunteers
- 50 people
- Sponsor
- Hospital de Clínicas Dr. Manuel Quintela
Variant Angina
Evaluate the Efficacy and Safety of Pletaal (Cilostazol) in Subjects With Vasospastic Angina
The objective of this study is to investigate the efficacy and safety of Pletaal (Cilostazol) in comparison with placebo for 4 weeks in vasospastic angina patients who have an insufficient response to Amlodipine (Calcium channel…
- Trial name
- STELLA (NCT01444885)
- Where
- 10 sites in South Korea
- Volunteers
- 50 people
- Sponsor
- Korea Otsuka Pharmaceutical Co., Ltd.
Coronary Vasospasm
Effect of Glucose on Ocular Blood Flow
The primary objective is to assess the effect of glucose on retinal vascular diameter in otherwise healthy vasospastic subjects compared to non-vasospastic controls.
- Trial name
- NCT00350129
- Where
- Switzerland
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Vasospastic Angina
A Therapeutic Confirmatory Study to Evaluate the Efficacy and Safety of Cilostazol in Subjects With Vasospastic Angina
This study will be conducted in accordance with the local regulation of New Drug Application. Overall duration of this trial will be 3 years after approval of KFDA.
- Trial name
- STELLA (NCT02087007)
- Testing
- Cilostazol
- Where
- South Korea
- Volunteers
- 100 people
- Sponsor
- Korea Otsuka Pharmaceutical Co., Ltd.
Coronary Microvascular Dysfunction (CMD), Vasospasm, Coronary
CompREhensive Diagnostic Assessment of Coronary Endothelial Function Impairment and Vasospasm With CoNtinuous ThErmodilution in Patients With Suspected Coronary Microvascular and Vasomotor Dysfunction
The goal of this observational study is to learn more about the diagnosis of coronary endothelium function and coronary vasospasm using a dedicated invasive protocol in patients who has angina without obstruction in their main…
- Trial name
- REDEFINE-CMD (NCT07337005)
- Testing
- Invasive coronary physiological measurements
- Volunteers
- 100 people
- Sponsor
- Mid and South Essex NHS Foundation Trust
Sleep Apnea, Obstructive, Hypoxia
"Reversibility of Cardiovascular Injury With CPAP Use: Mechanisms Involved"
The purpose of this study is to determine the factors that are associated with improved cardiovascular function with the use of CPAP therapy on subjects diagnosed with moderate to severe obstructive sleep apnea.
- Conditions
- Sleep Apnea, Obstructive, Hypoxia, Hypercapnia, Sleep Disorders
- Trial name
- NCT01317329
- Testing
- Clinically prescribed CPAP therapy
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- University of Wisconsin, Madison
Angina Pectoris, Variant, Statins, HMG-CoA
Statin Therapy In Patients With Vasospastic Angina
The purpose of this study is to evaluate whether statin is effective in the treatment of vasospastic angina.
- Trial name
- STAVA (NCT02790528)
- Testing
- Atorvastatin
- Where
- South Korea
- Sponsor
- Seung-Jung Park
Coronary Vasospasm, Coronary Microvascular Dysfunction
The NetherLands Registry of Invasive Coronary Vasomotor Function Testing (NL-CFT)
The goal of this registry is to collect data on patients referred for clinically indicated coronary vasomotor function test (CFT) and answer different questions on prevalence, safety and outcomes. The registry is observational.
- Conditions
- Coronary Vasospasm, Coronary Microvascular Dysfunction, Non-Obstructive Coronary Atherosclerosis
- Trial name
- NL-CFT (NCT06083155)
- Testing
- Coronary Function Test, Patient questionnaires
- Where
- 15 sites in Netherlands
- Volunteers
- 2,000 people
- Sponsor
- Radboud University Medical Center