Clinical trials: Coronary Atherosclerosis
Multi Vessel Coronary Artery Disease, Ischemic Heart Disease
'MInimalist' or 'MOre Complete' Strategies for Revascularization in Octogenarians
Older patients with co-morbidity are increasingly represented in interventional cardiology practice. They have been historically excluded from studies regarding the optimal management of NSTEACS.
- Conditions
- Multi Vessel Coronary Artery Disease, Ischemic Heart Disease, Acute Coronary Syndrome, Heart Diseases
- Trial name
- NCT04252703
- Testing
- Percutaneous coronary intervention (PCI)
- Where
- Denmark
- Volunteers
- 3 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Coronary Artery Disease
Fluid Responsiveness Through the Corrected Carotid Flow Time, Before and After Sternotomy
Perioperative fluid management is used to maintain the perfusion of vital organs, prevent hypovolemia, inadequate tissue perfusion, and tissue edema, and cardiovascular complications caused by the infusion of large amounts of…
- Trial name
- NCT06967142
- Testing
- Correcte Carotid flow measurement by USG Doppler
- Where
- Turkey (Türkiye)
- Volunteers
- 45 people
- Sponsor
- Ankara City Hospital Bilkent
Myocardial Ischemia
Effect of Timi3 Ultrasound on Myocardial Blow Flow in the Hibernating Myocardium
The purpose of this study is to evaluate whether the use application of low frequency ultrasound, administered by the Timi3 ultrasound device, increases myocardial blood flow to the heart, in subjects with reduced myocardial…
- Trial name
- NCT00655070
- Testing
- Timi3 Transthoracic ultrasound
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- University of California, San Francisco
Coronary Artery Disease
Effect of Cold Application on Pain, Ecchymosis, and Comfort After Transradial Coronary Angiography
This randomized controlled experimental study aimed to examine the effect of cold application after transradial coronary angiography on pain, bruising (ecchymosis), and comfort levels in patients.
- Trial name
- NCT07797179
- Testing
- Standard Post-Procedural TR Band Care, Cold Application
- Where
- Turkey (Türkiye)
- Volunteers
- 104 people
- Sponsor
- Bezmialem Vakif University
Ischemic Heart Disease, Acute Coronary Syndrome
Rotational Atherectomy: Long-term Results From a Single Center Experience
The RA-BIA Registry is a single-center observational study. The study included consecutive patients from 2008 who met inclusion criteria and were treated with RA.
- Trial name
- RA-BIA (NCT05787886)
- Where
- Poland
- Volunteers
- 1,200 people
- Sponsor
- Medical University of Bialystok
Essential Hypertension, Chronic Stable Angina
Study to Compare the Pharmacokinetic Characteristics and Safety of Dilatrend SR Capsule 32mg and Dilatrend Tablet 25mg
The purpose of this study is to compare the pharmacokinetic characteristics and safety of dilatrend SR capsule 32mg and Dilatrend tablet 25mg in healthy male subjects.
- Conditions
- Essential Hypertension, Chronic Stable Angina, Congestive Heart Failure
- Trial name
- NCT01819870
- Testing
- Dilatrend SR capsule 32mg, Dilatrend IR tablet 25mg
- Where
- South Korea
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Chong Kun Dang Pharmaceutical
Coronary Artery Disease, Postoperative Pulmonary Complications
Flow-Controlled vs. Pressure-Controlled Ventilation in CABG: Effects on Lung Aeration and Diaphragm Function
Pulmonary atelectasis and loss of lung aeration are common complications following cardiac surgery with cardiopulmonary bypass (CPB) and are associated with impaired oxygenation and prolonged mechanical ventilation.
- Conditions
- Coronary Artery Disease, Postoperative Pulmonary Complications, Pulmonary Atelectasis, Postoperative, Diaphragm Dysfunction
- Trial name
- FCV-PCV-DTI-LU (NCT07800741)
- Testing
- Flow-Controlled Ventilation, Pressure-Controlled Ventilation (PCV)
- Where
- Turkey (Türkiye)
- Volunteers
- 154 people
- Sponsor
- Koşuyolu Kartal Heart Training and Research Hospital
Angina Pectoris, Coronary Heart Disease
Evaluate the Efficacy and Safety of MUSK Pill on Coronary Microvascular Dysfunction
Objective to evaluate the effect of Shexiang Baoxin Pill on myocardial ischemia in patients with coronary microvascular dysfunction (non obstructive coronary heart disease) through a randomized, double-blind, placebo-controlled…
- Conditions
- Angina Pectoris, Coronary Heart Disease, X Syndrome, Angina, Non Obstructive Coronary Artery Disease
- Trial name
- NCT04984954
- Testing
- MUSK pill
- Where
- China
- Volunteers
- 264 people
- Sponsor
- Shanghai Hutchison Pharmaceuticals Limited
Coagulation Disorder, Ischemic Heart Disease
Thrombin Generation Values and Percutaneous Coronary Intervention Results.
Cardiovascular diseases are the most common cause of death in the western world. Myocardial infarction pathogenesis usually involves the development of an atherosclerotic plaque and thrombus.
- Conditions
- Coagulation Disorder, Ischemic Heart Disease, Artery Coronary Stenosis
- Trial name
- NCT03391622
- Testing
- Calibrated Automated Thrombogram
- Where
- Israel
- Volunteers
- 128 people
- Sponsor
- HaEmek Medical Center, Israel
Atherosclerosis, Cardiovascular Diseases
Gene-Specific Responses to Exercise in Discordant Twins
To test whether specific genes affect lipoprotein and weight responses to vigorous exercise in identical twins.
- Conditions
- Atherosclerosis, Cardiovascular Diseases, Heart Diseases
- Trial name
- NCT00083837
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Cardiovascular Diseases, Coronary Disease
Hostility and Coronary Risk--Role of Weak Vagal Function
To determine whether deficient vagal antagonism of sympathetic nervous system (SNS) actions on the heart contributed to increased coronary heart disease risk in hostile persons.
- Conditions
- Cardiovascular Diseases, Coronary Disease, Heart Diseases, Myocardial Ischemia
- Trial name
- NCT00005337
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Cardiovascular Diseases, Heart Diseases
Molecular Epidemiology of Essential Hypertension
To localize individual genes, called blood pressure quantitative trait genes [BPQTGs], which influence blood pressure levels in the population-at- large, and to determine if these genes are able to predict the occurrence of…
- Conditions
- Cardiovascular Diseases, Heart Diseases, Coronary Disease, Hypertension
- Trial name
- NCT00005377
- Volunteers
- 573 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston
Telemetry Usage, Chest Pain
A Randomized Trial of Telemetry Compared With Unmonitored Floor Admissions in ED Patients With Low-Risk Chest Pain
This study aims to determine, relative to telemetry admission, if admission to an unmonitored floor bed saves resources without an increased rate of adverse events in emergency department (ED) patients admitted with chest pain…
- Conditions
- Telemetry Usage, Chest Pain, Unstable Angina, Resource Utilization
- Trial name
- NCT03906812
- Testing
- Telemetry, Unmonitored
- Where
- United States
- Sponsor
- Vanderbilt University Medical Center
Myocardial Infarction
The Relationship Between Myocardial Blush Grade and T-P-e Interval and QRS Width: Impact on In-Hospital Outcome After Successful Primary Percutaneous Coronary Intervention
Aim of the work: Primary aim; is to assess relation between non invasive ECG findings, Tpe interval and QRS width and MBG in in patients with successful PCI in patients with STEMI.
- Trial name
- NCT05593822
- Testing
- primary percutaneous intervention
- Volunteers
- 80 people
- Sponsor
- Assiut University
Acute Coronary Syndrome
Relationship Between Inflammatory (Hs-CRP, Neutrophil-to-Lymphocyte Ratio) and Cardiac (Troponin) Biomarkers, and Cardiac Dysfunction in Acute Coronary Syndrome.
Acute Coronary Syndrome (ACS) remains a leading cause of morbidity and mortality worldwide, accounting for a significant proportion of cardiovascular-related deaths.
- Trial name
- NCT07551102
- Volunteers
- 144 people
- Sponsor
- Assiut University
Heart Diseases
Effect of a High Intensity Interval Training in Older Adults With Coronary Artery Disease
A study comparing 2 groups: interval training and control group. Interval training group will perform a physiotherapy program based in exercises, at a high intensity, and stretching of muscles at the end.
- Trial name
- NCT04425057
- Testing
- Interval training
- Volunteers
- 90 people
- Sponsor
- University of Valencia
Coronary Artery Disease
Drug-Coated Balloon in Anticoagulated and Bleeding Risk Patients Undergoing PCI
The purpose of this study is to compare DCB with DES in stable CAD or ACS patients who are at high risk of bleeding. The hypothesis of the DEBATE trial is that the strategy using DCB and a shorter DAPT regimen is non-inferior to…
- Trial name
- DEBATE (NCT04814212)
- Testing
- Percutaneous coronary intervention using drug-coated balloon, Percutaneous coronary intervention using drug-eluting stent
- Where
- 14 sites in Finland, France and 2 more
- Volunteers
- 546 people
- Sponsor
- North Karelia Central Hospital
Myocardial Infarction
Randomized Trial of Immediate Versus Early and Selective Invasive Percutaneous Coronary Intervention in NSTEMI
In non-ST-elevation the optimal time of percutaneous coronary intervention (PCI) is unclear. Some studies showed benefit of very early PCI, some others early PCI between 12-48 hours and others even showed a benefit of a selective…
- Trial name
- LIPSIA-NSTEMI (NCT00402675)
- Testing
- Timing of percutaneous coronary intervention
- Where
- 5 sites in Germany
- Volunteers
- 600 people
- Sponsor
- University of Leipzig
Acute Coronary Syndrome, Percutaneous Coronary Intervention
Optimized Antiplatelet Therapy on the Prognosis of ACS Patients With Non-predominant Coronary Artery Disease After PCI
The study is to evaluate the effect of optimized 12-month step-down antiplatelet therapy (APT) compared with standard 12-month dual antiplatelet therapy in clinical net adverse events, cardiovascular and cerebrovascular adverse…
- Trial name
- NCT04338919
- Testing
- Percutaneous coronary intervention, Ticagrelor plus aspirin
- Where
- China
- Volunteers
- 2,020 people
- Sponsor
- Fujian Medical University
Frail Elderly Syndrome, Acute Coronary Syndrome
Frailty Assessment in Elderly Patients With Acute Coronary Syndrome
Frailty is known as an independent risk factor for morbidity and mortality in older cardiac patients . It is an important factor on the cardiologist decision between conservative and invasive treatment in older patient with acute…
- Trial name
- NCT03365505
- Volunteers
- 200 people
- Sponsor
- Meir Medical Center
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