Clinical trials: Coronary Atherosclerosis
Coronary Artery Disease, Smoking Cessation
PRISM-GENOMICS-Smoking Cessation for Patients With Coronary Artery Disease Undergoing Cardiac Catheterization or Having a Heart Attack at Barnes Hospital in St. Louis Mo
It has previously been shown that patients with coronary artery disease may have a harder time quitting smoking if they have a specific genetic profile and that these individuals have a better chance at quitting if they receive…
- Trial name
- NCT03383224
- Testing
- genotype-guided therapy, Nicotine patch, Smoking cessation counseling
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Washington University School of Medicine
Chronic Kidney Disease
Oral Paricalcitol in Stage 3 - 5 Chronic Kidney Disease
The purpose of this study is to test the hypothesis that selective vitamin D receptor activation reduces left ventricular hypertrophy and ameliorates inflammation and atherosclerosis in stage 3 -5 chronic kidney disease.
- Trial name
- NCT00796679
- Testing
- paricalcitol
- Where
- 2 sites in Hong Kong
- Volunteers
- 60 people
- Sponsor
- The University of Hong Kong
Ischemic Heart Disease, Atrial Fibrillation
Anticoagulation on Demand After Percutaneous Coronary Intervention in High Bleeding Risk Patients
Preliminary experiences suggest that intermittent anticoagulation guided by continuous electrocardiographic monitoring can reduce the incidence of bleeding in patients with episodes of atrial fibrillation.
- Trial name
- INTERMITTENT (NCT04151680)
- Testing
- Intermittent administration of dabigatran, rivaroxaban, apixaban, or edoxaban, Chronic administration of dabigatran, rivaroxaban, apixaban, or edoxaban
- Where
- 2 sites in Italy
- Volunteers
- 100 people
- Sponsor
- University of Roma La Sapienza
Stable Angina, Ischemic Heart Disease Silent
A Randomized Clinical Evaluation of the BioFreedom™ Stent
The purpose of this study is to demonstrate that a BioFreedom™ Drug Coated Stent is non-inferior to a bare metal stent at one year as measured by the composite safety endpoint of cardiovascular death, myocardial infarction and…
- Conditions
- Stable Angina, Ischemic Heart Disease Silent, ST Elevation (STEMI) and Non-ST Elevation (NSTEMI) Myocardial Infarction, In-stent Coronary Artery Restenosis
- Trial name
- Leaders Free (NCT01623180)
- Testing
- Biofreedom™ Drug Coated Stent (DCS), Gazelle™ Bare Metal Coronary Stent (BMS)
- Where
- Switzerland
- Volunteers
- 2,456 people
- Sponsor
- Biosensors Europe SA
Coronary Heart Disease
A Prospective Evaluation in a Randomized Trial of TAXUS in the Treatment of De Novo Coronary Artey Lesions
This study is to compare the safety and performance of two stents coated with the same drug (the TAXUS Element Paclitaxel-Eluting Coronary Stent System and the TAXUS Express2 Paclitaxel-Eluting Coronary Stent System).
- Trial name
- NCT00693979
- Testing
- TAXUS Element Stent or TAXUS Express Stent
- Sponsor
- National University Hospital, Singapore
Coronary Artery Disease
A Study of the Presillion Stent in de Novo Coronary Lesions
The PRESILLION Study is a non-randomized, multi-center, single-arm study evaluating the safety of an approved Cobalt Chromium bare metal stent system for the treatment of ischemic heart disease attributable to a stenotic de novo…
- Trial name
- PRESILLION (NCT00722579)
- Testing
- PRESILLION cobalt chromium stent
- Where
- Belgium
- Volunteers
- 101 people
- Sponsor
- Cordis US Corp.
Acute Coronary Syndrome
Trajectory of Positive Psychological States in Patients With ACS
The purpose of the study is to to determine the natural history of positive psychological states, health status, and functioning, over an 8 week period following admission for an acute coronary syndrome (ACS).
- Trial name
- PEACEIIa (NCT02298296)
- Volunteers
- 25 people
- Sponsor
- Massachusetts General Hospital
Cardiovascular Diseases, Coronary Disease
Lipid Research Clinics Coronary Primary Prevention Trial (CPPT)
To determine whether reduction of cholesterol by drug therapy significantly lowered the atherosclerotic coronary heart disease rate in a group of hypercholesterolemic but otherwise healthy men.
- Conditions
- Cardiovascular Diseases, Coronary Disease, Heart Diseases, Myocardial Ischemia
- Trial name
- NCT00000488
- Testing
- cholestyramine, diet, fat-restricted
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Chronic Kidney Disease, Kidney Transplant
The Impact of Renal Transplant on Coronary Microvascular Function Among Patients With Advanced Chronic Kidney Disease
People with chronic kidney disease (CKD) often experience faster aging of the heart and blood vessels, which raises the risk of heart problems beyond traditional factors like high blood pressure or cholesterol.
- Conditions
- Chronic Kidney Disease, Kidney Transplant, Coronary Microvascular Dysfunction (CMD), Inflammation
- Trial name
- RESTORE (NCT07222683)
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Brigham and Women's Hospital
Myocardial Infarction, Angina, Unstable
Advantageous Predictors of Acute Coronary Syndromes Evaluation (APACE) Study
The triage of patients with suspected acute coronary syndrome in the emergency room is a time-consuming diagnostic challenge. Therefore high sensitive early markers for myocardial damage are needed for more rapidly rule out of…
- Trial name
- APACE (NCT00470587)
- Where
- 13 sites in Czechia, Italy and 3 more
- Volunteers
- 10,000 people
- Sponsor
- University Hospital, Basel, Switzerland
Atherosclerosis, Cardiovascular Diseases
Progression of Sub-Clinical Atherosclerosis
To determine the rate of progression of sub-clinical cardiovascular disease as measured in carotid intimal medial thickness over a period of 8 to 10 years.
- Conditions
- Atherosclerosis, Cardiovascular Diseases, Heart Diseases, Carotid Artery Diseases
- Trial name
- NCT00241787
- Volunteers
- 2,900 people
- Sponsor
- Tufts Medical Center
Cardiogenic Shock
Clinical Effects of Intra-aortic Balloon Support in Early Acute Coronary Syndrome and Non-Acute Coronary Syndrome Related Cardiogenic Shock
The goal of this randomized controlled trial is to appraise the impact of intra-aortic balloon pump (IABP) in the treatment of early stages of cardiogenic shock, irrespective of etiology.
- Trial name
- IABP ON-TIME (NCT06414187)
- Testing
- Intra-Aortic Balloon Pump
- Where
- Netherlands
- Volunteers
- 400 people
- Sponsor
- Erasmus Medical Center
Chronic Ischemic Heart Disease, Heart Failure
Human Umbilical-Cord-Derived Mesenchymal Stem Cell Therapy in Ischemic Cardiomyopathy
Phase I-II Clinical Trial-Safety and efficacy of umbilical cord derived mesenchymal stem cells (UC-MSCs) in patients with chronic heart ischemia cohort and perspective study.
- Conditions
- Chronic Ischemic Heart Disease, Heart Failure, Angina
- Trial name
- UCMSC-Heart (NCT02439541)
- Testing
- UCMSC group
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Affiliated Hospital to Academy of Military Medical Sciences
Myocardial Ischemia
Increased CRP Concentrations in Patients Admitted to the Emergency Department With Troponin Elevation Aids to Rule Out Coronary Ischemia
The investigators hypothesized that the CRP/troponin ratio measured in patients presenting to the ED with elevated troponin levels could differentiate between patients with cardiac ischemia and those who present due to a systemic…
- Trial name
- NCT04522583
- Testing
- Diagnosis of Myocardial Ischemia
- Where
- Israel
- Volunteers
- 15,000 people
- Sponsor
- Hillel Yaffe Medical Center
Myocardial Infarction, Acute Coronary Syndrome
LPS and Platelet Activation in Myocardial Infarction
Platelets play a key role in the athero-thrombotic process. However, the in vivo mechanism accounting for thrombus growth at site of coronary atherosclerotic lesion has not been fully elucidated.
- Trial name
- NCT03675789
- Where
- Italy
- Volunteers
- 150 people
- Sponsor
- University of Roma La Sapienza
ST-segment Elevation Myocardial Infarction
Sonothrombolysis in Patients With STEMI
This study evaluates what effect sonothrombolysis may have on spontaneous reperfusion, microvascular obstruction, left ventricular function and infarct size in patients presenting with their first ST-segment Elevation Myocardial…
- Trial name
- NCT03092089
- Testing
- Definity, (Lipid Microspheres) Intravenous Suspension, Myocardial Contrast Echocardiography, Repurfusion therapy with PPCI
- Where
- Canada
- Volunteers
- 15 people
- Sponsor
- Harald Becher
Coronary Artery Disease
The Oxford Optimisation of PCI Study (OXOPT-PCI Study)
The OxOPT-PCI study addresses patients with coronary artery disease who are referred to the John Radcliffe Hospital because of the need for treatment with an intra-coronary stent (metal scaffold) for clinical reasons.
- Trial name
- OXOPT-PCI (NCT03111940)
- Testing
- Optimisation of the result of intracoronary stenting according to specific algorithm
- Where
- United Kingdom
- Volunteers
- 35 people
- Sponsor
- Oxford University Hospitals NHS Trust
Arterial Disease, Surgery
Measuring the ACT During Non-cardiac Arterial Procedures.
Aim of the MANCO study is to establish for once and for all that monitoring the effect of heparin during NCVI (Non-Cardiac Vascular Interventions) is essential to ensure the individual patient of safe and tailor-made…
- Conditions
- Arterial Disease, Surgery, PTA, Peripheral Arterial Disease
- Trial name
- MANCO (NCT03426293)
- Testing
- Measuring the ACT to determine effect of heparin
- Where
- 3 sites in Netherlands
- Volunteers
- 1,000 people
- Sponsor
- Dijklander Ziekenhuis
Myocardial Infarction, Death
Prognostic Impact of Organ Damage in STEMI Patients
Besides contrast-induced acute kidney injury (CI-AKI), adscititious vital organ damage such as hypoxic liver injury (HLI) may affect the survival in patients with ST-elevation myocardial infarction (STEMI).
- Conditions
- Myocardial Infarction, Death, Acute Kidney Injury, Hepatic Insufficiency
- Trial name
- NCT02800421
- Volunteers
- 668 people
- Sponsor
- Inha University Hospital
Acute Coronary Syndrome
Clinical Study and Molecular Mechanism of Xuesaitong Soft Capsule in the Treatment of Acute Coronary Syndrome
To evaluate the platelet function, clinical efficacy, prognosis and safety of Xuesaitong soft capsule in the treatment of acute coronary syndrome, 50 patients with acute coronary syndrome after PCI were treated with Xuesaitong…
- Trial name
- NCT06618495
- Testing
- Xuesaitong soft capsule (main ingredient is Panax notoginseng saponins)
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Xiyuan Hospital of China Academy of Chinese Medical Sciences
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