Clinical trials: Coronary Atherosclerosis
Hypertriglyceridemia (TG>200<500), Hyperlipidemia
The Triglyceride Lowering Effect of an Omega-3 Fat (DHA) in Addition to Statin Therapy for Patients With CAD or Diabetes
This study will explore the ability of an algae (ocean plant) omega-3 fat supplement (DHA) to reduce triglyceride levels in patients currently being treated with statin therapy (Zocor or simvastatin, Lipitor or atorvastatin…
- Conditions
- Hypertriglyceridemia (TG>200<500), Hyperlipidemia, Coronary Artery Disease, Coronary Risk Equivalent
- Trial name
- NCT00360217
- Testing
- docosahexanoic acid (DHA)
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Maine Center for Lipids and Cardiovascular Health
Cardiovascular Diseases, Coronary Disease
Rapid Early Action for Coronary Treatment (REACT)
To evaluate the impact of community educational interventions on patient delay time from onset of symptoms and signs of an acute myocardial infarction (AMI) to arrival at a hospital Emergency Department (ED).
- Conditions
- Cardiovascular Diseases, Coronary Disease, Heart Diseases, Myocardial Infarction
- Trial name
- NCT00000550
- Testing
- health education
- Sponsor
- Carelon Research
Acute Coronary Syndrome
Assessment of Thrombotic Status in Patients With Acute Coronary Syndrome
Impaired thrombotic status is associated with adverse cardiovascular events. Patients with acute coronary syndrome (ACS) are at increased cardiovascular risk.
- Trial name
- NCT02562690
- Testing
- Thrombin generation assays, TEG and GTT
- Where
- United Kingdom
- Volunteers
- 500 people
- Sponsor
- University of Hertfordshire
Myocardial Infarction
Relationship Between Primary Percutaneous Coronary Intervention, Door-to-balloon Times, and Mortality for Heart Attack Patients Across England
The degree to which elevated mortality associated with weekend or night-time hospital admissions reflects poorer quality of care ('off-hours effect') is a contentious issue.
- Trial name
- NCT02374190
- Testing
- Standard Hospital Care
- Where
- United Kingdom
- Volunteers
- 42,677 people
- Sponsor
- London School of Economics and Political Science
Coronary Artery Disease
Characterization of Changes in Ventricular Mechanics in Response to Lexiscan Stress Using Tagged Cine Cardiac Magnetic Resonance Imaging
The purpose of this study is to measure the changes in cardiac function during a Lexiscan pharmacologic stress test using cardiac magnetic resonance imaging test.
- Trial name
- NCT02115308
- Testing
- Regadenoson
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Timothy M. Bateman
Angina Pectoris, Arteriosclerosis
Dan-NICAD - Danish Study of Non-Invasive Diagnostic Testing in Coronary Artery Disease
1. The primary purpose of this study is to determine the diagnostic accuracy of the CADscore System, a new danish technology that records sounds from turbulence of bloodflow in the coronary vessels. And secondary: 1.
- Conditions
- Angina Pectoris, Arteriosclerosis, Coronary Artery Disease, Myocardial Ischemia
- Trial name
- NCT02264717
- Testing
- SPECT, Cardiac MRI
- Where
- 3 sites in Denmark
- Volunteers
- 1,676 people
- Sponsor
- University of Aarhus
Ischemic Heart Disease, Acute Coronary Syndromes
Effects of Atorvastatin Versus Pravastatin on Platelet Inhibition by Clopidogrel
Clopidogrel and statins are frequently coadministered in patients with ischemic heart diseases. Recent reports suggested that clopidogrel's effectiveness in inhibiting adenosine diphosphate (ADP)-induced platelets aggregation is…
- Trial name
- NCT00405717
- Testing
- atorvastatin,pravastatin
- Where
- China
- Volunteers
- 1,300 people
- Sponsor
- Shenyang Northern Hospital
Cardiovascular Diseases, Coronary Disease
Genetic Epidemiology of Hypertriglyceridemia
To determine prospectively the role of elevated plasma triglyceride (TG) as a risk factor for 20-year coronary heart disease (CHD) mortality in familial combined hyperlipidemia (FCHL) and familial hypertriglyceridemia (FHTG), the…
- Conditions
- Cardiovascular Diseases, Coronary Disease, Hyperlipidemia, Familial Combined, Hyperlipoproteinemia Type iv
- Trial name
- NCT00005368
- Sponsor
- University of Washington
Cardiovascular Disease
Polypill Effects on Sub Clinical Atherosclerosis (PESCA) Trial
Medications that lower blood pressure and cholesterol are known to improve the shape and function of our blood vessels. These improvements include a reduction in the thickness of the wall of the carotid artery (the main artery…
- Trial name
- PESCA (NCT01326676)
- Testing
- Polypill: Red Heart Pill, Usual medication
- Where
- 3 sites in Ireland, Netherlands and 1 more
- Sponsor
- Imperial College London
Stable Angina
Aspirin Resistance and Percutaneous Coronary Intervention (PCI)
The objective of this study is to evaluate if aggressive antiplatelet therapy would reduce ischemic events in aspirin (ASA) resistant patients after percutaneous coronary intervention (PCI).
- Trial name
- RESIST (NCT01103440)
- Testing
- Intravenous Glycoprotein inhibitor + ASA, Clopidogrel, Antiplatelet Therapy (ASA, Clopidogrel)
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Acute Coronary Syndrome
Strut Coverage With SYNERGY Stents and Bioresorbable Vascular Scaffold in Acute Myocardial Infarction
To assess strut coverage in patients presenting an acute myocardial infarction and treated either with the SYNERGY stent or the Bioresorbable Vascular Scaffold, through a parallel group design.
- Trial name
- COVER-AMI (NCT02890589)
- Testing
- SYNERGY stent, ABSORB (Everolimus-eluting Bioresorbable Vascular Scaffold)
- Where
- France
- Volunteers
- 22 people
- Sponsor
- University Hospital, Toulouse
Coronary Heart Disease (CHD), Coronary Arterial Disease (CAD)
Effectiveness of a Tele-cardiac Rehabilitation (Tele-CR) Program
This study represents the second phase of a three-year research project aimed at evaluating both the short- and long-term effects of a six-month tele-cardiac rehabilitation (tele-CR) program in patients with coronary heart…
- Trial name
- NCT07110389
- Testing
- A tele-CR program, Attention-controlled
- Where
- Taiwan
- Volunteers
- 126 people
- Sponsor
- Chang Gung University of Science and Technology
Coronary Artery Disease, Coronary Artery Bypass Grafting
Extensive BITA Grafting in the Canary Islands: an IPTW Analysis
Coronary artery bypass grafting (CABG) remains the preferred revascularization strategy for patients with complex multivessel coronary artery disease.
- Conditions
- Coronary Artery Disease, Coronary Artery Bypass Grafting, Myocardial Revascularization
- Trial name
- BITA-SURV (NCT07796750)
- Where
- Spain
- Volunteers
- 666 people
- Sponsor
- Hospital Universitario de Gran Canaria Doctor Negrín
Coronary Artery Stenosis
Multivessel Disease Diagnosed at the Time of PPCI for STEMI: Complete Revascularization Versus Conservative Strategy.
The aim of the study is to find the optimal management of patients with acute myocardial infarction with ST elevations treated by primary PCI who have at least one significant stenosis of non-culprit coronary artery.
- Trial name
- Prague-13 (NCT01332591)
- Testing
- Percutaneous coronary intervention
- Where
- Czechia
- Volunteers
- 213 people
- Sponsor
- St. Anne's University Hospital Brno, Czech Republic
Atrial Fibrillation, Coronary Heart Disease
EMPOWER-1: A Multi-site Clinical Cohort Research Study to Reduce Health Inequality
Health inequality and genetic disparity are a significant issue in the United Kingdom (UK). This study focuses on diseases that are associated with significant morbidity and mortality in the UK, and specifically examines the…
- Conditions
- Atrial Fibrillation, Coronary Heart Disease, Cardiovascular Diseases, Heart Failure
- Trial name
- EMPOWER (NCT03987633)
- Where
- United Kingdom
- Volunteers
- 200,000 people, healthy volunteers welcome
- Sponsor
- Future Genetics Limited
Aortic Valve Disorder, Aortic Valve Insufficiency
Clinical Trial of the Edwards Aortic Bioprosthesis, Model 11000
The purpose of this observational trial is to gather further clinical data to confirm the safety and performance of the Edwards Pericardial Aortic Bioprosthesis, Model 11000 in this trial population.
- Conditions
- Aortic Valve Disorder, Aortic Valve Insufficiency, Aortic Valve Stenosis, Heart Failure
- Trial name
- NCT01651052
- Testing
- Heart Valve Surgery
- Where
- 2 sites in Poland
- Volunteers
- 133 people
- Sponsor
- Edwards Lifesciences
Cardiogenic Shock
Scoring Model for Predicting Outcome in Patients With Cardiogenic Shock
This study aims to develop a predictive model for the outcomes of patients with cardiogenic shock
- Trial name
- NCT04850248
- Testing
- no intervention, this is an observational study
- Volunteers
- 999 people
- Sponsor
- National Taiwan University Hospital
Coronary Syndrome
The Effect of Rosuvastatin and Olmesartan on the Progression of Coronary Atherosclerotic Disease
1. Stains have demonstrated consistent benefits to reduce cardiovascular events in several primary and secondary prevention trials.
- Trial name
- NCT02516826
- Testing
- Rosuvastatin, Olmesartan, Combination
- Where
- South Korea
- Volunteers
- 504 people
- Sponsor
- Samsung Medical Center
Coronary Heart Disease
Ticagrelor Versus Clopidogrel for CMD in Patients With AMI: A Retrospective Study Based on the Angio-IMR
Coronary microvascular dysfunction (CMD) is increasingly recognized as an important indicator for long-term prognosis in patients with acute myocardial infarction (AMI).
- Trial name
- NCT05978726
- Testing
- Dual antiplatelet therapy with aspirin and either ticagrelor or clopidogrel
- Where
- China
- Volunteers
- 325 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Cardiovascular Diseases, Heart Diseases
Epidemiology of Genetic Factors in Lipid Metabolism
To investigate the genetics and epidemiology of fasting and postprandial lipid, lipoprotein, and apolipoprotein levels.
- Conditions
- Cardiovascular Diseases, Heart Diseases, Atherosclerosis
- Trial name
- NCT00005214
- Volunteers
- healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston
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