Clinical trials: Coronary Bifurcation Lesions
Coronary Artery Disease, Bifurcation Lesion
Yao Strategy for the Treatment of de Novo Medina 0,1,0 or 0,0,1 Bifurcation Lesion
Percutaneous coronary intervention for coronary bifurcation lesions represents one of the most challenging procedures in interventional cardiology because of lower angiographic success rate and increased risk of procedural…
- Trial name
- NCT06166459
- Testing
- Drug-coated balloon combined with provisional drug-eluting stent implantation
- Volunteers
- 200 people
- Sponsor
- Xuzhou Third People's Hospital
Coronary Bifurcation Lesion
Efficacy and Safety of Sirolimus-Coated Spiral Balloon for Coronary Bifurcation Lesions
This is a multicenter, prospective randomized controlled study to evaluate the safety and effectiveness of Sirolimus-coated spiral balloon (SuperFlow®) versus Paclitaxel-coated balloon (Bingo™) in the treatment of coronary…
- Trial name
- NCT06618248
- Testing
- Sirolimus coated balloon angioplasty, Paclitaxel coated balloon angioplasty
- Where
- China
- Volunteers
- 280 people
- Sponsor
- Dongguan TT Medical
Coronary Bifurcation Lesion
BOVAS: Bifurcation Optimal Viewing Angle Selection Study
An optimal angiographic viewing angle is critical for correct diagnosis and intervention in coronary bifurcation lesion percutaneous coronary interventions (PCI).
- Trial name
- BOVAS (NCT01300494)
- Volunteers
- 50 people
- Sponsor
- University Hospital, Gasthuisberg
Coronary Artery Disease
Fractional Flow Reserve-guided Provisional Side Branch Intervention
Study purpose: To evaluate fractional flow reserve-guided side branch intervention strategy Method: Provisional side branch intervention if jailed side branch FFR<0.75
- Trial name
- NCT00351780
- Testing
- FFR measurement, side branch angioplasty
- Where
- South Korea
- Volunteers
- 100 people
- Sponsor
- Seoul National University Hospital
Coronary Bifurcation Lesions
Coronary Bifurcations With Ischaemia and Flow Assessment
The coronary arteries are blood vessels that provide oxygen rich blood to the muscle of the heart. If these vessels become narrowed or blocked, this can lead to chest pain (called angina) or heart attacks.
- Trial name
- NCT06971718
- Testing
- Optical coherence tomography and pressure wire assessment of the vessel treated before and after treatment
- Where
- United Kingdom
- Volunteers
- 24 people
- Sponsor
- University of East Anglia
Coronary Artery Disease, Bifurcation Lesion
Using 3D Imaging to Optimize Bifurcation Stenting
The primary purpose of this study is to determine whether bifurcation stenting guided by on-line three-dimensional optical frequency domain imaging (3D-OFDI) is superior to that with angiographic guidance by measuring incomplete…
- Trial name
- NCT02972489
- Testing
- 3D OFDI guidance arm, Angio guidance arm
- Where
- 2 sites in Japan, Netherlands
- Volunteers
- 106 people
- Sponsor
- Increase Co., Ltd.
Coronary Artery Disease (CAD), Chronic Coronary Syndrome
"Expert IVUS-Eye" vs. IVUS-guided Left Main Bifurcation PCI
This is a prospective, randomized, controlled trial comparing two strategies for optimizing stent implantation during bifurcation stenting of the left main coronary artery (LM): an intravascular ultrasound (IVUS)-guided approach…
- Conditions
- Coronary Artery Disease (CAD), Chronic Coronary Syndrome, Left Main Coronary Artery Disease, Coronary Bifurcation Lesion
- Trial name
- EYE-IVUS LM (NCT07711106)
- Testing
- IVUS-Guided LM PCI, "Trained Eye" (Angiography-Guided) LM PCI
- Where
- Russia
- Volunteers
- 50 people
- Sponsor
- Federal State Budgetary Institution, V. A. Almazov Federal North-West Medical Research Centre, of the Ministry of Health
Coronary Artery Disease
A Study of Drug Coated Balloon For Treating the Side Branch in Complex Bifurcation Lesions
Hypothesis: In patients undergoing coronary stenting for the true bifurcation lesions, main branch stenting followed by side branch dilatation with drug coated balloon is superior to the provisional-stenting strategy in terms of…
- Trial name
- STENT-FREE (NCT05222061)
- Testing
- Drug coated balloon for the side brunch, Conventional balloon for the side brunch
- Where
- Russia
- Volunteers
- 80 people
- Sponsor
- Meshalkin Research Institute of Pathology of Circulation
Coronary Bifurcation Lesions
Optical Coherence Tomography (OCT) Findings and Coronary Bifurcation Lesions
To determine the clinical prevalence of vulnerable plaque using OCT in patients with coronary bifurcation lesion.
- Trial name
- NCT03172845
- Testing
- percutaneous coronary intervention
- Where
- China
- Volunteers
- 304 people
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
Coronary Artery Disease
Drug-coating Balloon Angioplasties for True Coronary Bifurcation Lesions
This study is designed to investigate whether drug-coated balloon (DCB) compared to conventional balloon angioplasty for side branch after provisional stenting will lead to lower rates of the composite endpoint of major adverse…
- Trial name
- DCB-BIF (NCT04242134)
- Testing
- Drug-coating balloon
- Where
- China
- Volunteers
- 784 people
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
Coronary Disease
European Bifurcation Club Trial - Two-stent Versus One-stent Technique for Large Bifurcation Lesions
This study will examine use of two-stent versus one-stent techniques for patients with large calibre bifurcation lesions including significant side branch disease.
- Trial name
- EBC TWO (NCT01560455)
- Testing
- single stent, two stent
- Where
- United Kingdom
- Volunteers
- 200 people
- Sponsor
- Royal Sussex County Hospital
Coronary Artery Disease
A Study of the Cypher Sirolimus-Eluting Stent to Treat Bifurcation Lesions.
The objective of this study is to assess the feasibility and safety of the sirolimus-coated Bx VELOCITY Balloon-Expandable Stent in treating patients with true bifurcation lesions.
- Trial name
- BIFURCATION (NCT00234455)
- Testing
- drug eluting-stent, drug-eluting stent
- Where
- Italy
- Volunteers
- 86 people
- Sponsor
- Cordis US Corp.
Coronary Artery Disease
Two-stent vs Provisional Stenting Techniques for Patients With Complex Coronary Bifurcation Lesions
The purpose of this study is to establish the optimal strategy for stenting in coronary bifurcation lesion.
- Trial name
- DEFINITION-II (NCT02284750)
- Testing
- Percutaneous coronary intervention
- Where
- China
- Volunteers
- 660 people
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
Coronary Artery Disease
Double Rewire Versus Double Kissing Crush Stenting Technique in Left Main Bifurcation Lesions
The DR vs DK trial is designed to elucidate the benefits of Double Rewire crush technique (DR-Crush) over Double Kissing Crush (DK-Crush) technique in patients with Unprotected Left Main Bifurcation lesions (ULMb).
- Trial name
- DR vs DK crush (NCT05258318)
- Testing
- DK crush, DR crush
- Sponsor
- Fundación EPIC
Coronary Artery Disease
Coronary Bifurcation Lesions Treated With Biguard Stent System
This study is designed to test the hypothesis that the Biguard stent system will lead to fewer target lesion failure compared to regular stent system in patients with coronary bifurcation lesions at one year.
- Trial name
- BIGUARD (NCT02597283)
- Testing
- Biguard sirolimus-eluting bifurcation stent system, Sirolimus-eluting stent system
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
Coronary Artery Disease
Jailed-balloon Technique in Coronary Bifurcation Lesion PCI
This study aims to test the hypothesis that jailed-balloon technique(JBT) is superior to jailed-wire technique(JWT) in non-left main coronary bifurcation percutaneous coronary intervention(PCI) by lowering the risk of side…
- Trial name
- JBTinCBL (NCT02167230)
- Testing
- Jailed-balloon technique, Jailed-wire technique
- Where
- 2 sites in China
- Volunteers
- 410 people
- Sponsor
- Guangdong Provincial People's Hospital
Myocardial Ischemia, Ischemia
Bifurcation ABSORB OCT Trial
The Bifurcation ABSORB OCT Trial is a prospective, randomized (1:1) evaluation of the efficacy and performance of single ABSORB everolimus eluting bioresorbable vascular scaffold provisional strategy in the treatment of (a)…
- Conditions
- Myocardial Ischemia, Ischemia, Coronary Disease, Heart Diseases
- Trial name
- BISORB OCT (NCT02928198)
- Testing
- ABSORB BVS
- Where
- Netherlands
- Volunteers
- 3 people
- Sponsor
- J.J. Wykrzykowska
Left Main Coronary Artery Disease
Mini Crush or Double Kissing Crush Stenting Techniques For Complex Left Main Bifurcation Lesions
The Crush technique has evolved significantly since its introduction to the literature by Colombo et al in 2003, with multiple iterations including mini-crush (MC) and double kissing-crush (DKC) stenting techniques.
- Trial name
- NCT06546748
- Where
- Turkey (Türkiye)
- Volunteers
- 531 people, healthy volunteers welcome
- Sponsor
- Istanbul Mehmet Akif Ersoy Educational and Training Hospital
Angina Pectoris, Angina, Unstable
Intravascular Near Infrared Spectroscopy (NIRS) Bifurcation - Lipid Core Plaque Shift Study
This pilot study is going to examine the hypothesis that in coronary arteries, soft lesions that contain lipid cores, but are not calcified or fibrotic and are located in proximity to side branches, are associated with side…
- Conditions
- Angina Pectoris, Angina, Unstable, Atherosclerosis, Coronary Artery Disease
- Trial name
- NCT00905671
- Testing
- LipiScan Coronary Imaging Catheter
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Infraredx
Coronary Disease
Keep bIfurcation Single Stenting Simple
KISS study is an investigator-initiated, multi-centre, prospective, randomized (1:1), parallel, two-arm, non-inferiority trial aiming to compare two bifurcation PCI procedures for Side Branch protection
- Trial name
- KISS (NCT04285372)
- Testing
- Side branch protection/ballooning, No side branch protection/ballooning
- Where
- 20 sites in France, Italy and 4 more
- Volunteers
- 596 people
- Sponsor
- Ceric Sàrl