Clinical trials: Coronary Bypass
Anticoagulation, Coronary Endarterectomy
Antithrombotic Therapy After Coronary Artery Bypass Grafting Combined With Coronary Endarterectomy
Coronary endarterectomy (CE) combined with coronary artery bypass grafting (CABG) can be the final option for achieving complete revascularization in diffuse coronary artery disease patients.
- Trial name
- NCT05782270
- Testing
- Warfarin, DAPT, CE+CABG
- Where
- China
- Volunteers
- 202 people
- Sponsor
- China National Center for Cardiovascular Diseases
Coronary Artery Bypass Graft (CABG), Cardiac Surgery Subjects
Multisensory and Cognitive Interventions in the ICU: Effects on Health and Recovery
The goal of this clinical trial is to examine the effects of sensory and cognitive stimulation on physiological, psychological, and functional recovery in adult patients after cardiac surgery who are treated in the intensive care…
- Conditions
- Coronary Artery Bypass Graft (CABG), Cardiac Surgery Subjects, Postoperative Care
- Trial name
- MICU-CARE (NCT07116941)
- Testing
- Cognitive Exercises, Auditory Stimulation, Multisensory Stimulation
- Where
- Turkey (Türkiye)
- Volunteers
- 124 people
- Sponsor
- Abant Izzet Baysal University
Delirium - Postoperative, BDNF
The Relationship Between Delirium and BDNF in Coronary Artery Bypass Graft Surgery
This study is aimed at finding a correlation between postoperative delirium occurrence, severity and duration after cardiac surgery and the level of brain-derived neurotrophic factor (BDNF) in plasma as a marker of brain injury…
- Conditions
- Delirium - Postoperative, BDNF, CABG
- Trial name
- NCT06967779
- Where
- Poland
- Volunteers
- 107 people
- Sponsor
- Pomeranian Medical University Szczecin
Reperfusion Injury
Cardiac REperfusion With Intralipid® at Reperfusion
This study will evaluate the benefit of Intralipid® or placebo administered prior to reperfusion to limit ischemia reperfusion injury as measured by the geometric mean difference of the release of troponin I over 72 hours after…
- Trial name
- CREW-I (NCT02807727)
- Testing
- Intralipid 20%, Modified Ringers Lactate
- Where
- South Africa
- Volunteers
- 30 people
- Sponsor
- Nkanyiso Hadebe
Cardiac Disease, Coronary Artery Bypass
Distraction Therapy Using Virtual Reality in Cardiac Rehabilitation
The European Society of Cardiology has been putting forward the need for new adjuncts or models that optimise outcomes from CR programmes.
- Trial name
- NCT06898827
- Testing
- IVR using the Morpheus Programme, Cardiac Rehabilitation control group
- Where
- Malta
- Volunteers
- 20 people
- Sponsor
- University of Malta
Coronary Artery Disease
Effect of Intravenous Ferric Carboxymaltose on Hemoglobin Response and Transfusion in Patients With Iron Deficiency Anemia After Off-Pump Coronary Artery Bypass Grafting
In this prospective open-label randomized tral, 100 patients with elective off-pump coronary artery bypass (OPCAB) or minimal invasive direct coronary bypass (MIDCAB) surgery were enrolled.
- Trial name
- NCT04898569
- Testing
- Ferinject, Normal Saline Flush
- Where
- South Korea
- Volunteers
- 100 people
- Sponsor
- Yonsei University
Priming, Cardiac Surgery
Comparison of Two Different Heart-lung Machine Filling Methods: Precoating Versus Colloidal Fluids
The study is a single-center, randomized, un-blinded treatment study in which patients (>78 years) with the use off a heart-lung machine were provided into two study arms.
- Conditions
- Priming, Cardiac Surgery, Cardio Pulmonary Bypass
- Trial name
- NCT01247051
- Testing
- Precoating, Standard priming
- Where
- Germany
- Volunteers
- 90 people
- Sponsor
- Johann Wolfgang Goethe University Hospital
Kidney Failure, Intraoperative Complications
Hemodilution and Outcome in Cardiac Surgery
An hematocrit of 21-25% is supposed to perform the best organ protection during cardiopulmonary bypass for cardiac surgery. The investigators want to establish the best timing for a transfusion (in patients with a predicted low…
- Trial name
- NCT00364494
- Testing
- Different timing of red blood cells transfusion (substudy 1); Acute hemodilution versus no hemodilution (substudy 2)
- Where
- Italy
- Sponsor
- Università Vita-Salute San Raffaele
Acute Kidney Injury
Arterial Stiffness and AKI Post-CABG
Acute Kidney Injury is a condition where your kidneys suddenly stop working properly and usually occurs if you are already unwell with an illness and can happen after having surgery.
- Trial name
- Heart-AKI (NCT02364427)
- Testing
- Arterial stiffness - Vicorder to measure pulse wave velocity
- Where
- United Kingdom
- Volunteers
- 180 people
- Sponsor
- King's College Hospital NHS Trust
Intracranial Embolism and Thrombosis, Postoperative Complications
TCD Detection of Gas and Solid Micro-Emboli in Patients Undergoing Coronary Artery Bypass Grafting (CABG): The Influence of Proximal Anastomosis Technique
The purpose of this study is to test the hypothesis that using three different techniques to anastomose coronary grafts to the aorta: partial occlusion, single cross clamp, or using the Heartstring anastomotic device, will change…
- Trial name
- NCT00294814
- Testing
- Proximal anastomosis using Heartstring anastomotic device
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- Rambam Health Care Campus
Coronary Disease
Using Intraoperative Coronary Bypass Graft Imaging to Improve Graft Patency
The primary objective of the proposed study is to determine if a strategy of intraoperative patency assessment and graft revision can decrease the rate of graft occlusion or significant stenosis (>50%) at 6-12 weeks after…
- Trial name
- GRIIP (NCT00187421)
- Testing
- Indocyanine green intraoperative angiogram and transit-time flowmetry
- Where
- Canada
- Volunteers
- 156 people
- Sponsor
- Sunnybrook Health Sciences Centre
Cognitive Dysfunction
Effects of Dexmedetomidine on Cognitive Outcome and Brain Injury Markers
Dexmedetomidine is a drug with sedative, anxiolytic, and analgesic properties. Benefits of its use covers good sedations without respiratory suppression, reduced circulating catecholamines due to decreased sympathetic…
- Trial name
- NCT03585452
- Testing
- Dexmedetomidine Infusion, Propofol based general anesthesia
- Where
- Poland
- Volunteers
- 23 people
- Sponsor
- Michał Kowalczyk
Coronary Disease
A Study to Determine the Effect of Bi-Ventricular Pacing on Cardiac Hemodynamics After Coronary Artery Bypass Graft
The purpose of this study is to determine, using echocardiography, whether bi-ventricular pacing improves the contractile force by resynchronizing both ventricles, thereby improving and/or correcting the paradoxical septal…
- Trial name
- NCT00316368
- Testing
- Ethicon TPW32 60 cm (pacing wires x 2)
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- Unity Health Toronto
Coronary Artery Disease, Atrial Fibrillation
Postoperative Lactate and Atrial Fibrillation After CABG
Postoperative atrial fibrillation (POAF) is associated with increased mortality and morbidity in patients undergoing isolated coronary artery bypass grafting (CABG).
- Trial name
- NCT05448521
- Where
- Turkey (Türkiye)
- Volunteers
- 250 people
- Sponsor
- Başakşehir Çam & Sakura City Hospital
Coronary Arteriosclerosis
Antiplatelet Effect of Low Doses of Aspirin Taken Every 12 Hours in Patients Undergoing Coronary Artery Bypass Graft and/or Aortic Valve Surgery
This study is a randomized open label study that implies the administration of asprin according to three different regimens. The aims of the study are: to establish whether coronary artery bypass surgery and / or aortic valve…
- Trial name
- ASABYVALV (NCT01466452)
- Testing
- Aspirin
- Where
- Italy
- Volunteers
- 99 people
- Sponsor
- Centro Cardiologico Monzino
Heart Valve Disease
The Effects of Levosimendan on Haemodynamics in Patients Undergoing Elective Aortic Valve Replacement (AVR)Together With Coronary Artery Bypass Grafting (CABG) Surgery
Patients undergoing aortic valve replacement (AVR) surgery with coronary artery bypass grafting (CABG) are at risk of left ventricular dysfunction.
- Trial name
- NCT01210976
- Testing
- levosimendan
- Where
- Finland
- Volunteers
- 24 people
- Sponsor
- Tampere University Hospital
Frail Elderly Syndrome, Coronary Heart Disease
Frailty Syndrome in Daily Practice of Interventional Cardiology Ward
The impact of frailty on immediate and long term outcomes of invasive treatment of coronary artery disease is not fully characterized.
- Conditions
- Frail Elderly Syndrome, Coronary Heart Disease, Acute Coronary Syndrome, Coronary Artery Bypass Grafting
- Trial name
- FRAPICA (NCT03209414)
- Where
- Poland
- Volunteers
- 1,000 people
- Sponsor
- Medical University of Silesia
Cognitive Dysfunction, Postoperative, Cognitive Dysfunction
Assessment of Brain Oxygen Drops During Surgery and Related Risk Factors for Cognitive Problems After Heart Surgery
This study examines whether decreases in brain oxygen levels during cardiac surgery are linked to postoperative cognitive dysfunction and identifies other factors that may increase the risk of cognitive impairment.
- Conditions
- Cognitive Dysfunction, Postoperative, Cognitive Dysfunction, Cardiac Surgery
- Trial name
- NCT07361068
- Where
- Turkey (Türkiye)
- Volunteers
- 102 people
- Sponsor
- Bursa Yuksek Ihtisas Training and Research Hospital
Myocardial Protection
Levosimendan and Myocardial Protection
The aim of this study is to investigate whether pharmacological pre-treatment with levosimendan reduces intensive care unit (ICU) length of stay in patients undergoing elective myocardial revascularization under cardiopulmonary…
- Trial name
- NCT00610350
- Testing
- levosimendan
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- University of Roma La Sapienza
Myocardial Reperfusion Injury
The Role of Pioglitazone in Vascular Transcriptional Remodeling
Acute myocardial infarction (AMI) remains the leading cause of death worldwide. In this scenario, early coronary reperfusion is the main therapeutic strategy as it substantially reduces mortality.
- Trial name
- PREVALENT (NCT05775380)
- Testing
- Pioglitazone 45 mg
- Where
- Brazil
- Volunteers
- 20 people
- Sponsor
- University of Campinas, Brazil
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