Clinical trials: Coronary Bypass
Coronary Artery Disease
Quantitative Flow Ratio on Radial Artery Graft Outcome After Coronary Artery Bypass Grafting
In coronary artery bypass grafting (CABG), the use of radial artery (RA) is recommended by the guidelines only to significantly stenosed vessel, due to its high vulnerability to competitive flow.
- Trial name
- ASRAB-QUARGO (NCT05556590)
- Where
- China
- Volunteers
- 135 people
- Sponsor
- Ruijin Hospital
Coronary Artery Disease
PeRcutaneous cOronary Intervention of Native Coronary arTery Versus Venous Bypass Graft in Patients With Prior CABG
Multi-centre, randomised clinical trial with anticipated 17 European centres: in the Netherlands, Belgium, Germany and UK. Patients with a dysfunctional bypass graft with a clinical indication for revascularization will be…
- Trial name
- PROCTOR (NCT03805048)
- Testing
- Percutaneous coronary intervention
- Where
- 21 sites in Belgium, Germany and 3 more
- Volunteers
- 221 people
- Sponsor
- Amsterdam UMC, location VUmc
Thoracic Surgery
Albumin Administration and Outcomes in Cardiac Surgery
The invesitgators utilized the Cerner HealthFacts database (a large HIPAA-compliant clinical-administrative database maintained by Cerner Inc., USA) to identify a cohort of 6,249 adults that underwent on-pump cardiac surgery for…
- Trial name
- NCT02878733
- Testing
- Albumin
- Volunteers
- 6,249 people
- Sponsor
- Vanderbilt University
Erector Spinea Block in Open Heart Surgery
Continuous Erector Spinea Block Versus Intravenous Analgesia in Coronary Bypass Surgery
Adequate postoperative pain relief in patients in cardiac surgery is very essential. multimodal techniques for perioperative pain management post cardiac surgery include intravenous patient controlled analgesia, thoracic epidural…
- Trial name
- NCT03866733
- Testing
- continous erector spinea block, intravenous narcotics
- Where
- 2 sites in Egypt
- Volunteers
- 60 people
- Sponsor
- Ain Shams University
Intraoperative Hypotension, Postoperative Hypotension
Hypotension Prediction 2 Study in Cardiac Surgery and Postoperative ICU Admission
This trial registration serves as an amendment incorporating the IPD Sharing Statement. This study already has a trial registration (2021 April 30) in the Netherlands Trial Registry (Reference number NL9449…
- Conditions
- Intraoperative Hypotension, Postoperative Hypotension, Hypotension
- Trial name
- HYPE-2 (NCT05821647)
- Testing
- HPI guided treatment advice
- Where
- Netherlands
- Volunteers
- 130 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Coronary Artery Disease
Postoperative Respiratory Depression After Cardiac Surgery
Coronary artery bypass graft surgery (CABG) is associated with postoperative respiratory depression. In this study we aimed at investigating perioperative parameters that could predict the nadir of postoperative respiratory…
- Trial name
- CABG PRD (NCT02074371)
- Where
- Brazil
- Volunteers
- 44 people
- Sponsor
- Ovidiu Constantin Baltatu
Opioid Use, Unspecified
Methadone vs. Fentanyl Administration on Postoperative Pain Control in Pediatric Patients Undergoing Cardiac Surgery
The purpose of this study is to determine if methadone improves postoperative pain control in pediatric patient's undergoing cardiac surgery.
- Trial name
- CV_RCT_M_F (NCT02747875)
- Testing
- Methadone, Fentanyl
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Andrew Waberski
Vasodilation
Effects of Exercise Training on Vascular Endothelial Function of Patients Submitted to Coronary Artery Bypass Graft
Objective: To observe the effects of exercise training on vascular endothelial function in patients undergoing coronary artery bypass graft (CABG) alone in phase III after six months of Cardiac rehabilitation programs (CRP).
- Trial name
- NCT02265107
- Testing
- exercise training
- Where
- Brazil
- Volunteers
- 9 people
- Sponsor
- Universidade Federal do Rio Grande (FURG)
Pediatric, Cardiac Surgery
Cardiopulmonary Circuits in the Pediatric Population
During open-heart surgery, blood flow is supported by a heart-lung machine that both pumps the blood and gives it oxygen. A problem associated with a heart-lung machine is the damage to some of the blood caused by protein in the…
- Trial name
- NCT00208728
- Testing
- PC/SMART cardiopulmonary bypass circuit, PMEA modified cardiopulmonary bypass circuit, Standard of care uncoated cardiopulmonary bypass circuit
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Emory University
Ischemic Heart Disease, Bone Marrow Cells
Autologous Bone Marrow Mononuclear Cells in the Combined Treatment of Coronary Heart Disease
The purpose of this study evaluate the effect of the method of administration of autologous bone marrow mononuclear cells for the duration of of functioning aorto-coronary bypass grafts in the surgical treatment of coronary heart…
- Conditions
- Ischemic Heart Disease, Bone Marrow Cells, Coronary Artery Bypass Grafting (CABG), Heart Failure, Diastolic
- Trial name
- TAMIS (NCT02059512)
- Testing
- Group 1, Group 0, Group 2
- Where
- Russia
- Volunteers
- 117 people
- Sponsor
- St. Petersburg State Pavlov Medical University
Cardio-pulmonary Bypass, Cytokine
Compare the Impact of Hemofilters and Hemodialyzers on Cytokine Removal During Cardiopulmonary Bypass in Pediatric Cardiac Surgery
Cardiopulmonary bypass (CPB) allowed the correction of several congenital heart diseases such as intracardiac malformations, but it is well known that this is not a harmless procedure because it can lead to a systemic…
- Trial name
- NCT06792565
- Testing
- hemodializer, hemofilter
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Alnas Hospital
Platelet Function
Remote Ischemic Conditioning and Platelet Dysfunction
The purpose of this study is to evaluate the effects of remote ischemic conditioning on platelet function during off-pump coronary artery bypass surgery.
- Trial name
- NCT03125681
- Testing
- Remote ischemic conditioning, Control
- Where
- South Korea
- Volunteers
- 58 people
- Sponsor
- Seoul National University Hospital
Congenital Heart Disease, Pulmonary Hypertension
A Comparative Study of Three Modes of Ventilation During CPB in Pediatrics With Pulmonary Hypertension Undergoing Congenital Heart Surgeries
Aim of Work: The aim of this randomized, double-blinded, study is to compare between three modes of ventilation during cardiopulmonary bypass in pediatric patients with pulmonary hypertension undergoing corrective cardiac…
- Trial name
- NCT04262037
- Testing
- lung ultrasound
- Where
- Egypt
- Volunteers
- 24 people
- Sponsor
- Cairo University
Congenital Heart Defects
Plasma Angiopoietin Levels in Children Following Cardiopulmonary Bypass
During cardiopulmonary bypass (CPB) after heart surgery, a child's blood is exposed to many foreign entities. These conditions trigger the body's inflammatory response which results in leaky capillaries, increased swelling and…
- Trial name
- NCT01489475
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Yale University
Cardiosurgery, Cardiopulmonary Bypass
Methadone in Adults Undergoing Cardiac Surgery
In cardiac surgery, the establishment of Cardiopulmonary bypass (CPB) involves profound changes that can alter the pharmacokinetics and clinical response to drugs.
- Conditions
- Cardiosurgery, Cardiopulmonary Bypass, Methadone
- Trial name
- NCT05075265
- Testing
- Methadone
- Where
- Chile
- Volunteers
- 29 people
- Sponsor
- Pontificia Universidad Catolica de Chile
Postoperative Acute Kidney Injury After Off-pump Coronary Artery Bypass Graft
Effect of N-acetylcysteine on Prevention of Acute Kidney Injury in High Risk Patients Undergoing Off-pump Coronary Artery Bypass Graft
N-acetylcysteine may prevent acute kidney injury in high risk patients undergoing off-pump coronary artery bypass graft.
- Trial name
- NCT01394419
- Testing
- N-acetylcysteine, Saline
- Where
- South Korea
- Volunteers
- 115 people
- Sponsor
- Yonsei University
Coronary Artery Bypass Graft Surgery, Spine Surgery
Does Pre-operative Carbohydrate Loading Reduce Insulin Resistance and Improve Outcomes in Elective Surgical Patients?
The recent development of an oral carbohydrate drink for consumption prior to elective surgical procedures has been shown to improve insulin sensitivity.
- Trial name
- Preop (NCT00618592)
- Testing
- PreOp carbohydrate drink
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- Unity Health Toronto
Postoperative Cognitive Complications, Open Heart Surgery
Effect of a Cooling Helmet on Postoperative Cognitive Dysfunction in Adults Undergoing Open-Heart Surgery
Postoperative cognitive dysfunction, or POCD, is a decline in thinking, memory, attention, or executive function that may occur after surgery and anesthesia.
- Trial name
- HELMET-POCD (NCT07689500)
- Testing
- Cooling Helmet With Cold Water Circulation, Cooling Helmet With Room-Temperature Water Circulation
- Where
- Indonesia
- Volunteers
- 153 people
- Sponsor
- Universitas Indonesia
Cardiac, Surgery (Cardiac)
AI-Generated Video Feedback to Improve Technical Skills in Coronary Artery Bypass Grafting
This study aims to evaluate whether targeted video feedback generated by an artificial intelligence (AI)-based surgical performance assessment model can support improvement in technical skills among cardiac surgeons performing…
- Conditions
- Cardiac, Surgery (Cardiac), Education, Artificial Intelligence (AI)
- Trial name
- NCT07400172
- Testing
- AI-Guided Video Feedback Intervention
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- China National Center for Cardiovascular Diseases
C.Surgical Procedure; Cardiac
Prospective Trial of Tranexamic Acid in Cardiac Surgery
Tranexamic acid, an antifibrinolytic drug, is wildly used in cardiac surgeries to decrease perioperative bleeding and allogenic transfusion. But the optimum dose of tranexamic acid is still unknown.
- Trial name
- NCT01998438
- Testing
- Tranexamic Acid
- Where
- China
- Volunteers
- 955 people
- Sponsor
- Hongwen Ji
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