Clinical trials: Coronary Bypass
Diabetes, Coronary Artery Bypass Grafting
Vein-Coronary Atherosclerosis And Rosiglitazone After Bypass Surgery: The VICTORY Trial
HYPOTHESES Rosiglitazone in diabetic patients with previous coronary bypass surgery may prevent or slow the progression of atherosclerosis in SVGs and native coronary arteries.
- Trial name
- VICTORY (NCT00169832)
- Where
- 9 sites in Canada, Spain
- Volunteers
- 193 people
- Sponsor
- Laval University
Coronary Artery Bypass Surgery
Pre- and Postoperative Cardiopulmonary Rehabilitation Reduces Complications After Coronary Artery Bypass Surgery: A Randomized Trial
Pre- and postoperative cardiopulmonary rehabilitation reduces complications after coronary artery bypass surgery. This study was conducted as a randomized trial to verify this hypothesis in our institution. ICSC
- Trial name
- NCT00670176
- Testing
- REHAB (Pre- and postoperative cardiopulmonary rehabilitation)
- Volunteers
- 56 people
- Sponsor
- Universidade do Sul de Santa Catarina
Pleural Effusion, Coronary Artery Bypass
Pleural Effusion Following Cardiac Surgery: Prevalence, Risk Factors and Clinical Features
Pleural effusion is a common complication of cardiac surgery. The aim of this study was to determine the prevalence, characteristics and determinants of clinically significant pleural effusions, defined as those requiring…
- Trial name
- NCT00665015
- Where
- Canada
- Volunteers
- 2,892 people
- Sponsor
- Laval University
Coronary Artery Bypass Graft Surgery
Peri-Operative Morbidity and Quality of Life After Coronary Artery Bypass Graft (CABG)
It is the long term objective of this study to preserve or improve the quality of life and to prevent deterioration in physical and mental function following myocardial revascularization among bypass surgery patients.
- Trial name
- NCT00248885
- Testing
- Regulating Mean Arterial Pressure during cardiopulmonary bypass
- Where
- United States
- Volunteers
- 248 people
- Sponsor
- Weill Medical College of Cornell University
Coronary Artery Bypass Graft Surgery Patients
Improving Outcomes and Quality of Life After CABG
The principal objective to this randomized trial is to compare the efficacy of two strategies of intra-operative hemodynamic management during cardiopulmonary bypass among patients undergoing primary elective coronary artery…
- Trial name
- NCT00256620
- Testing
- Mean arterial pressure during cardiopulmonary bypass 80 mmHg vs. customized
- Where
- United States
- Volunteers
- 412 people
- Sponsor
- Weill Medical College of Cornell University
Coronary Artery Disease, Cardiopulmonary Bypass
Propofol Pharmacokinetics and Pharmacodynamics During Cardiopulmonary Bypass
Cardiopulmonary bypass (CPB) is known to alter pharmacokinetics (PK) and brain sensitivity to several drugs, including propofol.
- Conditions
- Coronary Artery Disease, Cardiopulmonary Bypass, Coronary Artery Bypass Graft
- Trial name
- NCT00622791
- Where
- Brazil
- Volunteers
- 20 people
- Sponsor
- University of Sao Paulo
Coronary Artery Bypass
Atorvastatin for Prevention of Postoperative Atrial Fibrillation After Off-Pump Coronary Artery Bypass Grafting Surgery
The purpose of this study is to determine whether pretreatment with atorvastatin protects against atrial fibrillation following off-pump coronary artery bypass graft surgery.
- Trial name
- NCT00611143
- Testing
- atorvastatin
- Where
- South Korea
- Volunteers
- 124 people
- Sponsor
- Samsung Medical Center
Patients Undergoing Elective Coronary Artery Bypass Graft
Lansoprazole Preventing Gastroduodenal Stress Ulcerations
The primary objective of this study is to determine whether lansoprazole, administered intravenously, can protect patients undergoing cardiac surgery from the development of and/or progression of previously undetected acid/peptic…
- Trial name
- NCT00220909
- Testing
- Lansoprazole
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Temple University
Coronary Artery Disease, Cardiopulmonary Bypass
Long-Term Cognitive Decline After Coronary Artery Bypass Grafting: is Off-Pump Surgery Beneficial?
Coronary artery bypass surgery is associated with postoperative cognitive decline, which has largely been attributed to the use of the heart lung machine.
- Conditions
- Coronary Artery Disease, Cardiopulmonary Bypass, Cognition Disorders
- Trial name
- NCT00189215
- Testing
- cardiac stabilizer instead of cardiopulmonary bypass
- Where
- Netherlands
- Volunteers
- 280 people
- Sponsor
- UMC Utrecht
Coronary Artery Bypass Graft Surgery, Myocardial Ischemia
A Safety and Efficacy Study to Confirm the Cardioprotective Effects of MC-1 in Patients Undergoing High-Risk CABG
The purpose of this study is to determine the effect of MC-1 on the combined incidence of cardiovascular death and nonfatal myocardial infarction (MI) up to and including 30 days following coronary artery bypass graft (CABG)…
- Conditions
- Coronary Artery Bypass Graft Surgery, Myocardial Ischemia, Reperfusion Injury
- Trial name
- NCT00402506
- Testing
- (MC-1) Pyridoxal 5'-phosphate
- Where
- 2 sites in United States, Canada
- Volunteers
- 3,000 people
- Sponsor
- Medicure
Coronary Artery Bypass Grafting Surgery
Study of the Therapeutic Effects of Intercessory Prayer (STEP)
Intercessory prayer is widely believed to influence recovery from illness, but claims of benefits are not supported by well-controlled clinical trials.
- Trial name
- NCT00179491
- Testing
- Intercessory Prayer
- Volunteers
- 1,802 people
- Sponsor
- Beth Israel Deaconess Medical Center
Coronary Artery Bypass, Epidural Anesthesia
Comparison of Ropivacaine and Levobupivacaine in High Thoracic Epidural Anesthesia
In High Thoracic Epidural Anesthesia (HTEA) the use of a local anesthetic (LA) with low cardiac toxicity is crucial as myocardial contractility is often already seriously impaired.
- Trial name
- NCT00552864
- Testing
- Ropivacaine, Levobupivacaine
- Where
- Italy
- Volunteers
- 61 people
- Sponsor
- Centro Cardiologico Monzino
Cardiopulmonary Bypass, Coronary Artery Disease
Cardiopulmonary Bypass (CPB) Pumps and Blood Activation
Blood activation induced by cardiopulmonary bypass may compromise the postoperative outcome. The goal of this study is to compare blood activation induced by cardiopulmonary bypass performed with centrifugal pump or roller pump…
- Trial name
- NCT00187967
- Testing
- pumps used for cardiopulmonary bypass
- Where
- France
- Sponsor
- University Hospital, Angers
Cardiac Pacing,Artificial, Coronary Artery Bypass
Biventricular Pacing After Coronary Artery Bypass Grafting (BIVAC)
The purpose of this study is to determine which pacing mode after coronary artery bypass grafting in patients with reduced left ventricular function is hemodynamically favorable.
- Conditions
- Cardiac Pacing,Artificial, Coronary Artery Bypass, Ventricular Function, Left
- Trial name
- NCT00417092
- Testing
- Postoperative Pacing
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- University Hospital Schleswig-Holstein
Coronary Bypass Graft Failure/Occlusion
Fondaparinux to Prevent Thrombotic Complications and Graft Failure in Patients Undergoing Coronary Artery Bypass Graft Surgery: The Fonda CABG Study
(i) Main Research Question(s): What is the effect of fondaparinux on coronary graft patency, heart attack, stroke, and death in patients who have undergone coronary artery bypass grafting (CABG)? To reliably answer this question…
- Trial name
- Fonda CABG (NCT00474591)
- Testing
- Fondaparinux
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- Hamilton Health Sciences Corporation
Coronary Artery Disease, Off Pump Coronary Artery Bypass Surgery
Early Cardioprotective Effect of Sevoflurane
In vitro studies and in vivo animal experiments have shown that halogenated volatile anesthetics have a protective effect on the ischemic myocardium.
- Trial name
- NCT00477737
- Testing
- Sevoflurane, propofol
- Where
- Croatia
- Volunteers
- 32 people
- Sponsor
- University Hospital Dubrava
Major Coronary Event, Cerebrovascular Accident
CARDS Is Designed To Show If Lowering Cholesterol With Atorvastatin In Type 2 Diabetics Without CV Disease Reduces The Risk Of CV Events
A study to assess the efficacy of once daily atorvastatin 10 mg versus placebo on cardiovascular endpoints in patients with non-insulin-dependent diabetes mellitus (NIDDM) who have a history of either hypertension, retinopathy…
- Conditions
- Major Coronary Event, Cerebrovascular Accident, Coronary Artery Bypass Graft, Angina, Unstable
- Trial name
- CARDS (NCT00327418)
- Testing
- Atorvastatin
- Where
- 135 sites in United Kingdom
- Volunteers
- 2,800 people
- Sponsor
- Pfizer
Postoperative Coronary Artery Bypass Grafting (CABG), Chronic Obstructive Pulmonary Disease (COPD)
The Effect of Neuromuscular Electrical Stimulation
The effect of neuromuscular electrical stimulation on muscle atrophy in sedated patients on intensive care was studied. The aim of this study was to explore if electrical stimulation could prevent muscle atrophy.
- Conditions
- Postoperative Coronary Artery Bypass Grafting (CABG), Chronic Obstructive Pulmonary Disease (COPD), Ventilatory Failure
- Trial name
- NCT00442728
- Testing
- ELECTRICAL STIMULATION
- Where
- Belgium
- Volunteers
- 21 people
- Sponsor
- Provinciale Hogeschool Limburg
Bleeding and Cardiac Surgery, Allogeneic Blood Transfusion
Comparison of Aprotinin and Tranexamic Acid in Routine Cardiac Surgery
The hypothesis of this study is that the antifibrinolytic drugs aprotinin and tranexamic acid equally influence bleeding tendency and transfusion requirement in patients undergoing first time cardiac procedures with a low risk of…
- Conditions
- Bleeding and Cardiac Surgery, Allogeneic Blood Transfusion, Aortic Valve Replacement, Coronary Artery Bypass Graft Surgery
- Trial name
- NCT00396760
- Testing
- aprotinin or tranexamic acid
- Where
- Germany
- Volunteers
- 220 people
- Sponsor
- German Heart Center
Coronary Artery Bypass Graft Surgery, Myocardial Ischemia
MEND-CABG (MC-1 to Eliminate Necrosis and Damage in Coronary Artery Bypass Graft Surgery)
The purpose of this study is to determine whether MC-1 is effective and safe in reducing cardiovascular and neurological events in patients undergoing high-risk coronary artery bypass surgery
- Conditions
- Coronary Artery Bypass Graft Surgery, Myocardial Ischemia, Reperfusion Injury, Myocardial Revascularization
- Trial name
- NCT00157716
- Testing
- (MC-1) Pyridoxal-5'-phosphate
- Where
- 2 sites in United States, Canada
- Volunteers
- 900 people
- Sponsor
- Medicure