Clinical trials: Coronary Bypass
Coronary Artery Disease
Dexmedetomidine in Off Pump Coronary Artery Bypass Grafting
the study will assess the impact of intraoperative dexmedetomidine infusion on myocardial performance by investigating the left ventricular (LV) systolic and diastolic function and right ventricular (RV) fraction area change…
- Trial name
- NCT05577871
- Testing
- Dexmedetomidine, normal saline
- Where
- Egypt
- Volunteers
- 36 people
- Sponsor
- Suez Canal University
Myocardial Ischemia, Coronary Artery Bypass Surgery
Humanin Isoforms in Cardiac Muscle and Blood Plasma and Major Complications After Cardiac Operation
Objective of the study is to clarify humanin-like peptide concentration in myocard tissue and in blood and to study if its concentration level is related to early complication occurrence and frequency after cardiac operation.
- Trial name
- NCT03431844
- Where
- 2 sites in Estonia
- Volunteers
- 106 people
- Sponsor
- University of Tartu
Morbid Obesity, Diabetes
Single-Anastomosis Duodeno-Ileal Bypass With Sleeve Gastrectomy (SADI-S) for the Treatment of Morbid Obesity and Its Metabolic Complications
Single-Anastomosis Duodeno-Ileal Bypass with Sleeve Gastrectomy is a modified and simplified duodenal switch. It is performed on morbid obese patients and severe T2DM patients with obesity, and a proper weight loss is expected as…
- Trial name
- SADI-S 250 (NCT01463904)
- Testing
- SADI-S 250
- Where
- Spain
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Hospital San Carlos, Madrid
Coronary Artery Disease
Tranexamic Acid in Clopidogrel Exposure to Decrease Hemorrhage and Transfusion
The use of platelet aggregation inhibitors, including aspirin and clopidogrel(CPDG), has become a standard management strategy for patients with acute coronary syndrome.
- Trial name
- TRACED (NCT01060163)
- Testing
- Tranexamic Acid, Saline
- Where
- 7 sites in China
- Volunteers
- 552 people
- Sponsor
- Chinese Academy of Medical Sciences, Fuwai Hospital
Anemia, Renal Impairment
Blood Products in Cardiac Surgery
Blood transfusion is a common procedure essential for the treatment of patients undergoing cardiac surgery. Inappropriate transfusions, however, not only incur needless healthcare costs, but increase unnecessary risks due to…
- Conditions
- Anemia, Renal Impairment, Thrombocytopenia
- Trial name
- BiCS (NCT02068755)
- Volunteers
- 31,000 people
- Sponsor
- University of Turku
Patients Undergoing Cardiac Surgery Using Cardiopulmonary Bypass
FiO2 and Outcomes After Cardiac Surgery With Cardiopulmonary Bypass
Conventionally, a relatively high level of fraction of inspired oxygen (FiO2) has been used for secure a margin of safety in patients undergoing cardiac surgery using cardiopulmonary bypass (CPB).
- Trial name
- NCT03939832
- Testing
- Fraction of inspired oxygen level
- Where
- South Korea
- Sponsor
- Seoul National University Hospital
Coronary Artery Disease of Significant Bypass Graft, Metabolic Dysfunction-associated Fatty Liver Disease
Positive Association of US-FLI With the Severity of CAD
As a multisystem disease, metabolic dysfunction-associated fatty liver disease (MAFLD) is closely linked to the onset and progression of coronary heart disease (CHD).
- Conditions
- Coronary Artery Disease of Significant Bypass Graft, Metabolic Dysfunction-associated Fatty Liver Disease, SYNTAX Score, Ultrasonography
- Trial name
- NCT06541132
- Testing
- Observational study without human intervention
- Where
- China
- Volunteers
- 190 people, healthy volunteers welcome
- Sponsor
- Chongqing Medical University
Elective Cardiac Surgery
Microcirculation of the Thenar Eminence
Microcirculatory disturbances following cardiac surgery with cardiopulmonary bypass (CPB) have been thought to be at the origin of organ dysfunction. Though, few studies correlated microvascular alterations with outcome.
- Trial name
- NCT01748266
- Testing
- microcirculatory reactivity
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Coagulation Changes During Coronary Artery Bypass Grafting
Coagulation Profiles in Conventional and Minimal Invasive Extracorporeal Circulation
The aim of this study is to compare the effects of conventional and minimally invasive extracorporeal circulation (MiECC) techniques, which are routinely used in open-heart surgery, on coagulation parameters.
- Trial name
- NCT07844031
- Testing
- Conventional extracorporeal circulation, Minimally invasive extracorporeal circulation
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Bursa Yuksek Ihtisas Training and Research Hospital
Cardiac Surgery, Intraoperative Hemodynamic Instability
Impact of Intraoperative Hemodynamic Instability on Outcomes in Cardiac Surgery
Intraoperative hemodynamic instability (IOHI) is a common occurrence during cardiac surgery and is associated with organ hypoperfusion. However, the specific impact of IOHI on composite adverse outcomes remains unclear.
- Conditions
- Cardiac Surgery, Intraoperative Hemodynamic Instability, Postoperative Complication, Acute Kidney Injury
- Trial name
- NCT07324694
- Where
- Turkey (Türkiye)
- Volunteers
- 351 people
- Sponsor
- Saglik Bilimleri Universitesi Gazi Yasargil Training and Research Hospital
Platelets, Bleeding
Delayed Cold-Stored Platelets -PLTS-1
PLTS-1 is a multicentre, randomized, controlled, pilot trial, using a conventional, parallel group, two-armed design at 2 cardiac surgery centres in Canada.
- Conditions
- Platelets, Bleeding, Cardiopulmonary Bypass, Cardiac Surgery
- Trial name
- PLTS-1 (NCT06147531)
- Testing
- Delayed Cold-Stored Buffy Coat Platelets, Room Temperature Buffy Coat Platelets
- Where
- 2 sites in Canada
- Volunteers
- 150 people
- Sponsor
- University Health Network, Toronto
Pharmacological Action
Ulinastatin Improves and Prevents Cardiac Dysfunction Induced by Cardiopulmonary Bypass
This project explores the role and mechanism of ulinastatin in preventing cardiac dysfunction caused by cardiopulmonary bypass by reducing cardiac endothelial permeability through clinical research.
- Trial name
- NCT05534802
- Testing
- Ulinastatin, saline
- Where
- China
- Volunteers
- 236 people
- Sponsor
- Qin Zhang
Valve Surgery, Coronary Artery Bypass Grafting
Effect of Prime Solution on Fluid Balance After Open Heart Surgery
The use of Tetraspan® as prime solution can reduce fluid extravasation after perfusion versus Ringer acetate. Plasma-adapted HES-solutions produce also less acidosis.
- Trial name
- NCT00797589
- Testing
- HES, Ringer lactate
- Where
- Finland
- Volunteers
- 35 people
- Sponsor
- University of Helsinki
Coronary Artery Disease
Comparison of One-stop Hybrid Revascularization Versus Off-pump Coronary Artery Bypass for the Treatment of Multi-vessel Disease
The "one-stop" hybrid coronary revascularization combines minimally invasive direct coronary artery bypass (MIDCAB) and PCI to be performed in the hybrid operating suite, an enhanced operating room equipped with radiographic…
- Trial name
- NCT01034371
- Testing
- Minimally invasive direct coronary artery bypass, PCI-Drug eluting stents, Off-pump coronary artery bypass
- Where
- 2 sites in China
- Volunteers
- 400 people
- Sponsor
- China National Center for Cardiovascular Diseases
Heart Disease
Impact of Preoperative FFR on Arterial Bypass Graft Functionality
This study was designed to evaluate the correlation between pre-operative FFR and the functionality of arterial bypass grafts six months after coronary artery bypass grafting.
- Trial name
- IMPAG (NCT02527044)
- Testing
- Fractional Flow Reserve (FFR)
- Where
- 2 sites in Belgium, Canada
- Volunteers
- 120 people
- Sponsor
- Ottawa Heart Institute Research Corporation
CABG
Effect of a Preoperative Video Education Program on ICU Delirium After CABG (VIDEO-CABG Trial)
The goal of this clinical trial is to evaluate the effect of a preoperative video-based educational program on postoperative outcomes in adult patients undergoing coronary artery bypass graft (CABG) surgery.
- Trial name
- VIDEO-CABG (NCT07570420)
- Testing
- Video-Based Educational Program
- Where
- Jordan
- Volunteers
- 220 people
- Sponsor
- University of Jordan
Acute Kidney Injury, Coronary Artery Bypass
Effect of Remote Ischemic Preconditioning on the Incidence of Acute Kidney Injury in Patients Undergoing Coronary Artery Bypass Graft Surgery
Background: Acute kidney injury (AKI) following coronary artery bypass graft (CABG) surgery is a major complication occurring in 1% to 53% of patients (depending on how it is defined) with the pooled rate of 18.2% and…
- Conditions
- Acute Kidney Injury, Coronary Artery Bypass, Ischemic Preconditioning
- Trial name
- NCT02981680
- Testing
- Remote Ischemic Preconditioning (RIPC)
- Where
- Iran
- Volunteers
- 180 people
- Sponsor
- Shiraz University of Medical Sciences
Coronary Artery Bypass
A Retrospective Analysis of the Predictive Potential of Pre-operative
Roughly thirty percent of people that undergo open heart surgery get an abnormal heart beat afterwards known as atrial fibrillation (AF).
- Trial name
- NCT00321282
- Testing
- Atrial Fibrillation
- Where
- 3 sites in United States
- Volunteers
- 600 people
- Sponsor
- Emory University
Spine Erector, Cardiac Surgery
Comparison Erect Spine in Cardiac Surgery
Open cardiac surgeries are characterized by the increased use of opioids and longer extubation times, being post-sternotomy pain one of the causes of greater patient discomfort, plexus blockages have been used more frequently…
- Conditions
- Spine Erector, Cardiac Surgery, Acute Pain, Chronic Pain
- Trial name
- COESPINE (NCT04313959)
- Testing
- Ropivacaine 0.2% Injectable Solution, Ropivacaine 0.2% + Dexamethasone
- Where
- Brazil
- Volunteers
- 40 people
- Sponsor
- Instituto do Coracao
Patients Who Underwent CPB for MICS
EIT Based Regional Lung Ventilation in Minimally Invasive Cardiac Surgery
Electrical impedance tomography (EIT) is a non-invasive, radiation-free imaging technique that measures local pulmonary ventilation and ventilation distribution through potential changes on the skin surface of the chest wall…
- Trial name
- NCT04985513
- Testing
- Ventilation during cardiopulmonary bypass
- Where
- South Korea
- Volunteers
- 60 people
- Sponsor
- Pusan National University Yangsan Hospital
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