Clinical trials: Coronary Bypass
Atrial Fibrillation
Fish Oil for Reduction of Atrial Fibrillation After Cardiac Surgery
The primary objective of this study is to determine if omega-3 polyunsaturated fatty acids reduce atrial fibrillation and other outcomes after cardiac surgery.
- Trial name
- FISH (NCT00446966)
- Testing
- Omega Three Polyunsaturated fatty acids
- Where
- United States
- Volunteers
- 260 people, healthy volunteers welcome
- Sponsor
- Chirag Sandesara
Subclinical Hypothyroidism
Thyroid Hormone Replacement After Coronary Artery Bypass Grafting for Patients With Subclinical Hypothyroidism
The goal of this clinical trial is to find out whether levothyroxine reduces complications and improves the prognosis of patients with subclinical hypothyroidism (SCH) undergoing coronary artery bypass grafting (CABG).
- Trial name
- RepleniSH (NCT07380854)
- Testing
- levothyroxine
- Where
- South Korea
- Volunteers
- 338 people
- Sponsor
- Seoul National University Bundang Hospital
Cardiac Surgery, Intraoperative Hemodynamic Instability
Impact of Intraoperative Hemodynamic Instability on Outcomes in Cardiac Surgery
Intraoperative hemodynamic instability (IOHI) is a common occurrence during cardiac surgery and is associated with organ hypoperfusion. However, the specific impact of IOHI on composite adverse outcomes remains unclear.
- Conditions
- Cardiac Surgery, Intraoperative Hemodynamic Instability, Postoperative Complication, Acute Kidney Injury
- Trial name
- NCT07324694
- Where
- Turkey (Türkiye)
- Volunteers
- 351 people
- Sponsor
- Saglik Bilimleri Universitesi Gazi Yasargil Training and Research Hospital
Coronary Disease, Coronary Artery Bypass
Integrated Assessment of Cervicocerebral Vessels to Improve the Brain Injury for CAGB Patients (IACV Study)
The goal of this study is to establish a prospective study to focus on the high-risk stroke population who require coronary artery bypass graft surgery.
- Conditions
- Coronary Disease, Coronary Artery Bypass, Strokes Thrombotic
- Trial name
- NCT06275139
- Testing
- Integrated Assessment of Cervicocerebral Vessels
- Where
- China
- Volunteers
- 348 people
- Sponsor
- China National Center for Cardiovascular Diseases
Carotid Artery Diseases, Peripheral Artery Disease
Assessment of Carotid Artery Stenosis and Lower Limb Peripheral Ischemia Prior to CABG
From our experience among Egyptian population in our institution, there is an increased prevalence of hidden subclinical peripheral artery disease along with carotid artery affection.
- Trial name
- NCT03516929
- Testing
- carotid duplex, both LL arterial duplex
- Where
- Egypt
- Volunteers
- 360 people
- Sponsor
- Mr Ihab Ali
Coronary Artery Bypass
Effect of Post-isometric Relaxation Technique and Static Stretching on Length of the Calf Muscles in Post-CABG Patients
Coronary artery bypass grafting (CABG) is one of the common procedure used in coronary artery disease patients which has significant impact on cardiopulmonary and musculoskeletal systems.
- Trial name
- NCT05503537
- Testing
- post-isometric relaxation technique, Static stretching, Basic Cardiac Rehabilitation Protocol
- Where
- Pakistan
- Volunteers
- 135 people
- Sponsor
- Foundation University Islamabad
Atrial Fibrillation
Homeopathy for Prevention of Atrial Fibrillation After Aortocoronary Bypass Surgery
After heart surgery, about 30% of patients suffer from atrial fibrillation. Patients are randomized into two groups receiving either potentized Strychnos Nux vomica or placebo under double blind conditions.
- Trial name
- NCT00861237
- Testing
- Nux vomica (active comparator)
- Where
- Austria
- Volunteers
- 12 people
- Sponsor
- Medical University of Vienna
Platelets, Bleeding
Delayed Cold-Stored Platelets -PLTS-1
PLTS-1 is a multicentre, randomized, controlled, pilot trial, using a conventional, parallel group, two-armed design at 2 cardiac surgery centres in Canada.
- Conditions
- Platelets, Bleeding, Cardiopulmonary Bypass, Cardiac Surgery
- Trial name
- PLTS-1 (NCT06147531)
- Testing
- Delayed Cold-Stored Buffy Coat Platelets, Room Temperature Buffy Coat Platelets
- Where
- 2 sites in Canada
- Volunteers
- 150 people
- Sponsor
- University Health Network, Toronto
Prehabilitation, Cardiac Surgery
Feasibility of Physical Prehabilitation for High-Risk Patients Undergoing Cardiac Surgery Via Sternotomy
Rationale Cardiac surgery via median sternotomy carries an elevated risk of postoperative complications and delayed functional recovery.
- Conditions
- Prehabilitation, Cardiac Surgery, Risk Assesment, Aortic Valve
- Trial name
- PREPA-STER (NCT07893184)
- Testing
- Physical Prehabilitation Intervention
- Where
- Netherlands
- Volunteers
- 24 people
- Sponsor
- Maastricht University Medical Center
Acute Kidney Injury, Neurological Injury
Mini Versus Conventional Cardiopulmonary Bypass In CABG in Asian Patients
Our intention is to perform a randomized controlled trial to compare the efficacy and safety of mini cardiopulmonary bypass system to a modified conventional bypass circuit in 80 Asian patients undergoing elective CABG.
- Trial name
- MiniCPB (NCT03657225)
- Testing
- Utilization of the mini CPB circuit, Utilization of the conventional circuit
- Where
- Singapore
- Volunteers
- 80 people
- Sponsor
- National University Hospital, Singapore
Cardiovascular Diseases
Continuous Hemofiltration During Cardiopulmonary Bypass and Its Effect on Lactatemia
This study aims to analyze the impact of using polysulfone membranes on continuous ultrafiltration with volume replacement in patients undergoing cardiac surgery.
- Trial name
- CPB-LACTATE (NCT03412968)
- Testing
- Polysulfone Filter, Procedure/ Surgery: without Polysulfone Filter
- Where
- Spain
- Volunteers
- 76 people
- Sponsor
- University of Cadiz
Coronary Artery Disease
Effects of Conditioning Exercises and Resistance Interval Training on Post CABG Patients.
Coronary artery disease (CAD) is a global health challenge influenced by diabetes, hypertension, and psychosocial stress, with women having a higher prevalence of Coronary microvascular disease.
- Trial name
- NCT06844591
- Testing
- Conditioning Exercises/ Aerobic Interval Training, Resistance Interval Training
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- Riphah International University
Anemia, Coronary Disease
PBM as Strategy to CABG Anemic Patients Bypass Graft (CABG)
Anemia poses risks during coronary artery bypass grafting (CABG), increasing complications and mortality rates. Blood transfusions in cardiac surgery have negative outcomes, prompting the use of erythropoietin in Patient Blood…
- Conditions
- Anemia, Coronary Disease, Coronary Artery Disease, Coronary Stenosis
- Trial name
- NCT06542393
- Testing
- Erythropoietin, blood transfusion
- Where
- Brazil
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Federal University of São Paulo
Sleep Disorder, Coronary Artery Disease
Sleep Quality and Sleep-disordered Breathing in Bypass Surgery Patients
Patients undergoing non-emergency coronary artery bypass surgery (CABG) are included. All patients will be examined for transthoracic echo, blood samples will be collected, and an overnight sleep polygraph will be performed in a…
- Trial name
- UNI-CABG (NCT06453538)
- Where
- Finland
- Volunteers
- 54 people
- Sponsor
- Turku University Hospital
Coronary Artery Disease, Myocardial Infarction (MI)
Low-dose Interleukin-2 After Myocardial Infarction to Investigate Effects on Tissue-resident Regulatory T Cells
The primary goals of this study are to compare the differences in tissue-resident Treg gene signature for activation, proliferation, and suppressive function using single-cell/-nucleus RNA sequencing in patients treated with…
- Conditions
- Coronary Artery Disease, Myocardial Infarction (MI), CABG
- Trial name
- Leuk-ALIVE (NCT07610538)
- Testing
- Interleukin-2 (Aldesleukin), Standard care
- Where
- 2 sites in United Kingdom
- Volunteers
- 24 people
- Sponsor
- Cambridge University Hospitals NHS Foundation Trust
Ischemic Heart Disease, Coronary Artery Disease
ITA Vs LAD; Evaluation of Inflammatory Burden in OP-CABG Patients
Introduction. Ischemic cardiomyopathy is one of the death leading causes in industrialized countries. Up-to-date ESC guidelines recommend a surgical approach (coronary by pass graft) in patients with multivessel coronaropathy…
- Conditions
- Ischemic Heart Disease, Coronary Artery Disease, Atherosclerosis, Inflammation
- Trial name
- NCT05574621
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- Cardiochirurgia E.H.
Inflammatory Response, Chronic Renal Disease
Hemadsorption During and After Cardiopulmonary Bypass to Modulate the Inflammatory Response
Chronic kidney disease (CKD) is a risk factor for the development of cardiovascular disease, which increases the risk of death after cardiac surgery.
- Conditions
- Inflammatory Response, Chronic Renal Disease, Cardiac Surgery
- Trial name
- IMHeS (NCT04157647)
- Testing
- CytoSorb, Control
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- University Magna Graecia
Congenital Heart Defect, Blood Coagulation Disorder
Bedside Evaluation of Coagulation in Children With Congenital Heart Disease
The purpose of this study is to assess coagulation and platelet function in children with congenital heart disease, measured with a bedside device (thromboelastometry and impedance aggregometry).
- Trial name
- POCHEMO (NCT02387944)
- Where
- Switzerland
- Volunteers
- 200 people
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Cardiopulmonary Bypass
Prothrombin Complex Concentrate (PCC)
The overall objective of this study is to determine whether ROTEM (rotational thromboelastometry) guided dosing of four-factor prothrombin complex concentrate (4F-PCC) results in superior perioperative bleeding control compared…
- Trial name
- NCT07881393
- Testing
- Four Factor Prothrombin Complex Concentrate, ROTEM (Rotational Thromboelastometry) analyzer (TEM International GmbH)
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- University of Miami
Ischemic Coronary Artery Disease, Coronary Artery Bypass Surgery
Comparison of AQUAVAN® Injection to DISOPRIVAN® Injectable Emulsion for Anesthesia During Coronary Artery Surgery
This is an exploratory clinical trial designed to examine the efficacy, safety and tolerability of fospropofol (AQUAVAN) Injection compared to propofol (DISOPRIVAN) Injectable Emulsion when used to preoperatively sedate, induce…
- Trial name
- NCT00209521
- Testing
- fospropofol, propofol
- Volunteers
- 16 people
- Sponsor
- Eisai Inc.
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