Clinical trials: Coronary Bypass
Postoperative Pain.
The Effects of Peri-operative Pregabalin Administration on Post-operative Analgesia in Patients Undergoing Coronary Bypass Grafting
We hypothesize that the perioperative administration of pregabalin will significantly decrease pain scores and post-operative opioid requirements for patients undergoing coronary artery bypass grafting, and reduces the incidence…
- Trial name
- NCT00623285
- Testing
- Pregabalin
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- University of Manitoba
Nerve Block, Coronary Artery Bypass
Comparison of Erector Spinae Plane Block and Transversus Thoracic Muscle Plane Block in Coronary Artery Surgery
The main objective of this study is to evaluate postoperative pain intensity comparatively between erector spinae plane block and transversus thoracic muscle plane block in patients undergoing open coronary artery surgery.
- Conditions
- Nerve Block, Coronary Artery Bypass, Anesthesia and Analgesia
- Trial name
- NCT06709625
- Testing
- Transversus thoracis plane block, Erector spina plane block (ESP)
- Where
- Turkey (Türkiye)
- Volunteers
- 92 people
- Sponsor
- Ankara City Hospital Bilkent
Cardiac Surgery, Aorta No-touch
Hemodynamic Changes During Displacement of the Heart in the Aorta No-touch Off-pump Coronary Artery Bypass Surgery
Introduction: Aorta no-touch off-pump coronary artery bypass surgery (OPCAB) has been the recommended technique for treatment of patients with high-risk of neurological damage or stroke.
- Trial name
- NCT03517189
- Testing
- Aorta no-touch
- Where
- Brazil
- Volunteers
- 40 people
- Sponsor
- Federal University of São Paulo
Coronary Artery Bypass Graft Surgery
Changes of Functional Status, Symptoms Distress and Quality of Life in Patients Undergoing Coronary Artery Bypass Graft (CABG) Surgery
The purpose of this study is to explore the changes of functional status, symptoms distress and quality of life in patients undergoing coronary artery bypass graft (CABG) surgery.
- Trial name
- NCT01127802
- Volunteers
- 50 people
- Sponsor
- National Taiwan University Hospital
Cardiopulmonary Bypass, Coronary Artery Disease
Cardiopulmonary Bypass (CPB) Pumps and Blood Activation
Blood activation induced by cardiopulmonary bypass may compromise the postoperative outcome. The goal of this study is to compare blood activation induced by cardiopulmonary bypass performed with centrifugal pump or roller pump…
- Trial name
- NCT00187967
- Testing
- pumps used for cardiopulmonary bypass
- Where
- France
- Sponsor
- University Hospital, Angers
Triple Vessel Disease, Unstable Angina
Comparison of Saphenous Vein Graft Harvested From Upper Versus Lower Leg in Coronary Artery Bypass Grafting
In coronary artery bypass grafting, saphenous veins are widely used as a composite grafts that are Y-anastomosed to in-situ left internal thoracic artery.
- Conditions
- Triple Vessel Disease, Unstable Angina, Stable Angina, Myocardial Infarction
- Trial name
- COSAVEGUL-1 (NCT01974492)
- Testing
- Upper leg vein harvesting, Lower leg vein harvesting
- Where
- South Korea
- Volunteers
- 26 people
- Sponsor
- Seoul National University Hospital
Myocardial Ischaemic Syndrome, Coronary Heart Disease
Protective Effect of PCSK9 Inhibitor Against Negative Inflammatory Response and Organ Dysfunction After Coronary Artery Bypass Grafting (PANDA VIII)
This is a multi-center, randomized controlled study to investigate whether early offering PCSK9 inhibitor can protect against negative inflammatory response and organ dysfunction after coronary artery bypass grafting (CABG).
- Trial name
- PANDA (NCT06730802)
- Testing
- PCSK9 inhibitor, Statin
- Where
- 2 sites in China
- Volunteers
- 400 people
- Sponsor
- Nanjing Medical University
Heart Diseases, Postoperative Complications
A Trial of INO-1001 in Patients Undergoing Heart Surgery That Involves Heart-lung Bypass
The purpose of this study is to assess the safety of INO-1001, an intravenous PARP (poly-[ADP ribose] polymerase) inhibitor, in patients undergoing heart surgery.
- Trial name
- NCT00271167
- Testing
- INO-1001
- Where
- 13 sites in United States, Australia and 2 more
- Volunteers
- 162 people
- Sponsor
- Inotek Pharmaceuticals Corporation
Cardiac Surgery, Cardiopulmonary Bypass
Sodium Bicarbonate in Cardiac Surgery Study
With over one million operations a year, cardiac surgery with cardiopulmonary bypass is one of the most common major surgical procedures worldwide (1).
- Trial name
- Bic-MC (NCT00672334)
- Testing
- Sodium Bicarbonate, Sodium Chloride
- Where
- 4 sites in Australia, Canada and 2 more
- Volunteers
- 350 people
- Sponsor
- Austin Health
Ischemic Heart Disease, Ischemic Heart Disease Chronic
DAN-RELEASE - Reconsidering Long-Term Aspirin in the Elderly Patients With Stable Ischemic Heart Disease
DAN-RELEASE is a national, randomized, registry-based trial including 7,000 participants in Denmark. The trial aims to determine whether discontinuation of long-term aspirin therapy is non-inferior to continued aspirin therapy in…
- Conditions
- Ischemic Heart Disease, Ischemic Heart Disease Chronic, Chronic Coronary Syndrome, Myocardial Infarction
- Trial name
- DAN-RELEASE (NCT07795398)
- Testing
- Continuation of daily low-dose Aspirin, Discontinuation of daily low-dose Aspirin
- Where
- 2 sites in Denmark
- Volunteers
- 7,000 people
- Sponsor
- Odense University Hospital
Coronary Artery Disease
Radial Artery Versus No-touch Saphenous Vein
This study evaluates the short-term and long-term patency of the radial artery and the No-touch vein in patients undergoing isolated on-pump/off-pump coronary artery bypass graft (CABG) surgery.
- Trial name
- NCT06014047
- Testing
- No-touch vein graft, Radial artery graft
- Where
- China
- Volunteers
- 774 people
- Sponsor
- China National Center for Cardiovascular Diseases
CAD - Coronary Artery Disease, CABG
A Randomized Controlled Trial: Fuzheng Yangxin Formula for ERAS After CABG
This study aims to evaluate the efficacy and safety of Fuzheng Yangxin Formula (FZYXF) in the treatment of qi-yin deficiency syndrome after coronary artery bypass grafting (CABG), formulate an integrated Chinese and Western…
- Conditions
- CAD - Coronary Artery Disease, CABG, ERAS, Medicine, Chinese Traditional
- Trial name
- FZYXF-RCT-CABG (NCT07781436)
- Testing
- FZYX
- Where
- China
- Volunteers
- 230 people
- Sponsor
- Peking University Third Hospital
Coronary Artery Disease, Atrial Fibrillation
Postoperative Lactate and Atrial Fibrillation After CABG
Postoperative atrial fibrillation (POAF) is associated with increased mortality and morbidity in patients undergoing isolated coronary artery bypass grafting (CABG).
- Trial name
- NCT05448521
- Where
- Turkey (Türkiye)
- Volunteers
- 250 people
- Sponsor
- Başakşehir Çam & Sakura City Hospital
Coronary Artery Disease, Ischemic Heart Disease (IHD)
Prognostic Value of Hyperpolarized 13C MRI for Clinical Myocardial Viability
Heart failure due to coronary artery disease represents a significant cause of mortality. The detection of patients eligible for bypass surgery is a pivotal concern.
- Conditions
- Coronary Artery Disease, Ischemic Heart Disease (IHD), Myocardial Viability
- Trial name
- NCT06047028
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Cardiovascular Diseases
Effects of the Low-level Laser Therapy on Inflammatory Profile of the Patients With Coronary Artery Bypass Surgery
Cardiovascular diseases are the leading causes of morbidity and mortality in Brazil and surgical procedures to treat these disorders have grown dramatically in recent years.
- Trial name
- NCT02709499
- Testing
- 0J LLLT, 6J LLLT
- Volunteers
- 38 people
- Sponsor
- Federal University of Health Science of Porto Alegre
Chronic Pain
Does the Speed of Sternal Retraction Affect Postoperative Pain Outcomes
In North America, almost ½ million people undergo coronary artery bypass graft surgery annually and over 1/3rd develop chronic chest pain.
- Trial name
- NCT02697812
- Testing
- slow sternal retraction
- Where
- Canada
- Volunteers
- 326 people
- Sponsor
- Dr. Tarit Saha
Coronary Artery Disease
Evaluation of Inspiratory Muscle Strength Early After Coronary Artery Bypass
The purpose of this study is to evaluate the effects of a 6-day postoperative in hospital cardiopulmonary rehabilitation program on inspiratory muscle strength and its potential association with improved functional capacity after…
- Trial name
- NCT00873028
- Testing
- In Hospital Cardiopulmonary Rehabilitation
- Where
- Brazil
- Volunteers
- 20 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Heart; Surgery, Heart, Functional Disturbance as Result
Evaluation of Damaging Factors to Endothelial Glycocalyx During Heart Surgery.
Evaluation of endothelial glycocalyx damage in on-pump conventional coronary artery bypass surgery using a syndecan-1 (CD138) blood test. The study will be carried out in two stages.
- Trial name
- NCT03491163
- Testing
- Syndecan-1 concentration evaluation
- Where
- Lithuania
- Volunteers
- 147 people
- Sponsor
- Lithuanian University of Health Sciences
Coronary Artery Bypass Graft Surgery
Effects of Massage Therapy on Sleep After Heart Surgery
The purpose of this study is to evaluate the effects of Massage Therapy for improving the quality of sleep in patients on postoperative period of coronary artery bypass graft surgery (CABG).
- Trial name
- MT and CABG (NCT01095419)
- Testing
- Massage Therapy, Control
- Where
- Brazil
- Volunteers
- 40 people
- Sponsor
- University of Sao Paulo
Coronary Artery Bypass Graft and/or Aortic Valve Replacement Surgery
Sugammadex and Decreased Time to Extubation
The purpose of this study is to demonstrate faster time to extubation after arrival in the cardiothoracic intensive care unit (ICU) in patients undergoing isolated coronary artery bypass grafting (CABG), AVR and AVR/CABG…
- Trial name
- NCT03196167
- Testing
- Sugammadex
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Yale University
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