Clinical trials: Coronary Bypass
Systemic Inflammatory Response Syndrome, Postoperative Shock
The Effects of Gut Micribiota Disruption on the Immune Response After Open Heart Surgery
In this randomized, double-blind, placebo-controlled study, the investigators will assess whether preoperative disruption of the gut microbiota by a course of broad spectrum antibiotics will attenuate the postoperative systemic…
- Conditions
- Systemic Inflammatory Response Syndrome, Postoperative Shock, Coronary Artery Disease, Extracorporeal Circulation; Complications
- Trial name
- REMEDI (NCT03939273)
- Testing
- Vancomycin Oral, Metronidazole Oral, Ciprofloxacin Pill
- Where
- Netherlands
- Volunteers
- 80 people
- Sponsor
- Radboud University Medical Center
Coronary Artery Disease
Ticagrelor and Aspirin for the Prevention of Cardiovascular Events After Coronary Artery Bypass Surgery
Subjects will be consented to the study prior to Coronary Artery Bypass Graft (CABG) and randomly assigned to receive either ticagrelor 90 mg bid or placebo bid starting within 48 hours of surgery.
- Trial name
- TAP-CABG (NCT01373411)
- Testing
- ticagrelor
- Where
- Canada
- Volunteers
- 70 people
- Sponsor
- Cardiology Research UBC
Saphenous Vein Graft Disease
Aggressive Cholesterol Therapy to Inhibit Vein Graft Events After CABG (ACTIVE Trial)
During coronary artery bypass graft surgery (CABG), saphenous vein from the leg is used to bypass the atherosclerotic blockages in the arteries of the heart.
- Trial name
- ACTIVE (NCT01528709)
- Testing
- Atorvastatin 80 mg daily, Atorvastatin 10 mg daily
- Where
- 2 sites in United States, Canada
- Volunteers
- 173 people
- Sponsor
- Boca Raton Regional Hospital
Coronary Artery Bypass Graft Triple Vessel, Apoptotic DNA Damage
Remote Ischemic Preconditioning of Human Myocardium
The investigators aim to definitively show if human myocardium can be remotely preconditioned. In the writings there are no experiments that would prove that the remote preconditioning protocol effects on the higher protection of…
- Trial name
- NCT01994707
- Testing
- Remote ischemic preconditioning
- Where
- Poland
- Volunteers
- 134 people
- Sponsor
- Medical University of Silesia
Coronary Artery Bypass, Cardiac Surgical Procedures
Thiamine as an Adjunctive Therapy in Cardiac Surgery
The main purpose of this pilot study is to test the effects of thiamine (vitamin B1) administration before and after major cardiac surgery. Half of patients will receive thiamine and the other half will receive placebo.
- Trial name
- NCT02322892
- Testing
- Thiamine, Normal saline solution
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- Beth Israel Deaconess Medical Center
Coronary Artery Disease Amenable to Bypass Graft Surgery
Graft Patency in Beating Heart Vs. Conventional CABG Using Cardiac CT
The purpose of this study is to compare graft patency rates following coronary artery bypass graft surgery performed by beating heart vs. conventional techniques using cardiac CT scanning to evaluate the bypass grafts.
- Trial name
- NCT00259493
- Testing
- Off-Pump Coronary Artery Bypass Graft Surgery
- Where
- Canada
- Volunteers
- 350 people
- Sponsor
- Trillium Health Centre
Myocardial Revascularization, Spinal Anesthesia
Spinal Anesthesia Associated With General Anesthesia in Coronary Artery Bypass
CONTEXT: In patients eligible for coronary artery bypass surgery, anesthesia should provide a number of conditions that exceed the limits of cardiovascular stability, myocardial protection and other organs.
- Conditions
- Myocardial Revascularization, Spinal Anesthesia, Postoperative Care, Fentanyl
- Trial name
- NCT02840006
- Testing
- General anesthesia only, General anesthesia and Spinal anesthesia
- Where
- 2 sites in Brazil
- Volunteers
- 60 people
- Sponsor
- Daniel Gioielli de Castilho
Cardiac Surgery, Coronary Artery Bypass Grafting
Safety, Tolerability and Pharmacodynamics of AP214 Acetate in Patients Undergoing Cardiac Surgery
The purpose of the present research study is to investigate for the first time, the safety and tolerability of infusion doses of AP214 in subjects having heart surgery such as coronary bypass graft and/or valve repair or…
- Conditions
- Cardiac Surgery, Coronary Artery Bypass Grafting, Valve Surgery, Kidney Injury
- Trial name
- NCT00628264
- Testing
- AP214
- Where
- 2 sites in United States
- Volunteers
- 75 people
- Sponsor
- Action Pharma A/S
Coronary Artery Disease
VEST Venous Graft External Support Pivotal Study
Prospective, multi-center, randomized, within-subject-controlled , trial, enrolling patients with multi vessel atherosclerotic coronary artery disease, scheduled to undergo SVG CABG with arterial grafting of IMA to LAD and two or…
- Trial name
- VEST Pivotal (NCT03209609)
- Testing
- VEST, Coronary artery bypass vein grafts
- Where
- 17 sites in United States, Canada
- Volunteers
- 224 people
- Sponsor
- Vascular Graft Solutions Ltd.
Atrial Fibrillation, Post-Op Complication
Prevention of Postoperative Atrial Fibrillation (POAF) Using Intra-Pericardial Amiodarone
The purpose of this study is to evaluate the combination of CardiaMend, with the addition of amiodarone in the prevention of postoperative atrial fibrillation (POAF) in patients undergoing cardiac arterial bypass grafting (CABG)…
- Trial name
- NCT06063538
- Testing
- CardiaMend in Combination with Amiodarone
- Where
- United States
- Volunteers
- 63 people
- Sponsor
- University of Chicago
Coronary Artery Disease, Myocardial Infarction
Outcome After Coronary Artery Bypass Grafting
The E-CABG registry is a multicenter, European registry collecting data on the preoperative characteristics, treatment strategies and outcome of patients undergoing isolated coronary artery bypass grafting (CABG).
- Conditions
- Coronary Artery Disease, Myocardial Infarction, Angina Pectoris
- Trial name
- E-CABG (NCT02319083)
- Testing
- Coronary artery bypass surgery
- Where
- Finland
- Volunteers
- 4,000 people
- Sponsor
- University of Oulu
Congenital Heart Defects
Plasma Angiopoietin Levels in Children Following Cardiopulmonary Bypass
During cardiopulmonary bypass (CPB) after heart surgery, a child's blood is exposed to many foreign entities. These conditions trigger the body's inflammatory response which results in leaky capillaries, increased swelling and…
- Trial name
- NCT01489475
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Yale University
Coronary Artery Bypass, Off-Pump, Intraoperative Hypotension
Intraoperative Hypotension and Acute Kidney Injury After Off-pump Coronary Artery Bypass Grafting Surgery
Acute renal injury (AKI) is a common complication after cardiac surgery and is associated with worse outcomes. Hypotension is an important risk factor for the development of AKI after noncardiac surgery.
- Conditions
- Coronary Artery Bypass, Off-Pump, Intraoperative Hypotension, Acute Kidney Injury
- Trial name
- NCT03889730
- Where
- China
- Volunteers
- 821 people
- Sponsor
- Peking University First Hospital
Coronary Artery Disease
Cost-effectiveness of EGDT Using FloTrac/EV1000
Coronary artery bypass graft (CABG) with cardiopulmonary bypass (CPB) is a high-risk surgery with significant morbidity that results in a prolonged stay in the intensive care unit (ICU) at an increased cost.
- Trial name
- NCT05826795
- Testing
- Early goal-directed therapy (EGDT)
- Where
- 2 sites in Thailand
- Volunteers
- 60 people
- Sponsor
- Khon Kaen University
Chronic Pain
Does the Speed of Sternal Retraction Affect Postoperative Pain Outcomes
In North America, almost ½ million people undergo coronary artery bypass graft surgery annually and over 1/3rd develop chronic chest pain.
- Trial name
- NCT02697812
- Testing
- slow sternal retraction
- Where
- Canada
- Volunteers
- 326 people
- Sponsor
- Dr. Tarit Saha
Peripheral Circulation During On-pump Cardiac Surgery
Assessment of Skin Perfusion Pressure as an Indicator of Tissue Oxygenation in Cardiac Surgery Patients Undergoing Cardiopulmonary Bypass
This study is aim to evaluate usefulness of the perioperative monitoring of skin perfusion pressure as an indicator of perpheral perfusion in patients undergoing on-pump cardiac surgery.
- Trial name
- NCT02329392
- Where
- South Korea
- Volunteers
- 72 people
- Sponsor
- Yonsei University
Bypass, Cardiopulmonary
Menthol Massage for Post-Bypass Pain & Anxiety
This randomized controlled trial aims to evaluate the effectiveness of mentholated ointment massage in reducing pain and anxiety levels in patients who have undergone coronary bypass surgery, volunteered to participate in the…
- Trial name
- Menthol Care (NCT07508371)
- Testing
- Menthol Massage, Massage
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people
- Sponsor
- Istanbul Medipol University Hospital
Coronary Artery Disease
Home-Based Versus Center-Based Cardiac Rehabilitation After CABG Surgery
This randomized controlled trial was designed to compare the efficacy of a 12-week home-based telerehabilitation (HBTCR) program against traditional center-based cardiac rehabilitation (CBCR) and usual care in patients who have…
- Trial name
- NCT07243444
- Testing
- Structured Exercise Program, Standard Health Education
- Where
- China
- Volunteers
- 110 people
- Sponsor
- The First Hospital of Hebei Medical University
Coronary Artery Disease
Endoscopic Saphenous Vein Harvest for Coronary Artery Bypass Grafting
Although the long saphenous vein remains the most commonly used conduit in coronary revascularization, traditional open vein harvest may lead to significantly impaired wound healing and post-operative pain.
- Trial name
- NCT00712192
- Testing
- coronary artery bypass grafting
- Volunteers
- 34 people
- Sponsor
- Far Eastern Memorial Hospital
Multivessel Coronary Artery Disease
Ten-Year Outcomes of Randomized Comparison of Coronary Artery Bypass Surgery and Everolimus-Eluting Stent Implantation in the Treatment of Patients With Multivessel Coronary Artery Disease
The primary objective of the BEST extended 10Y follow-up study is to compare the safety and effectiveness of coronary stent implantation using everolimus-eluting balloon-expandable stents with bypass grafting for the treatment of…
- Trial name
- BEST Extended (NCT05125367)
- Testing
- coronary stent implantation, bypass grafting
- Where
- 24 sites in China, Malaysia and 2 more
- Volunteers
- 880 people
- Sponsor
- Seung-Jung Park
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