Clinical trials: Coronary Computed Tomography Angiography
Coronary Heart Disease, Coronary Artery Disease
Machine leArning Based CT angiograpHy derIved FFR: a Multi-ceNtEr, Registry
Demonstrate in a large multicenter population the diagnostic performance of a pre-commercial on-site, local, CT angiography derived FFR algorithm in comparison to invasive FFR.
- Trial name
- Machine (NCT02805621)
- Where
- Netherlands
- Volunteers
- 352 people
- Sponsor
- Erasmus Medical Center
Coronary Artery Disease
Diagnostic Performance of Noninvasive Fractional Flow Reserve From Computed Tomography
Fractional Flow Reserve derived from computed tomography(FFRCT) is a novel method for determining the physiologic significance of coronary artery disease (CAD), which will help physicians in clinical decision-making and decrease…
- Trial name
- PERFECT (NCT01747317)
- Testing
- FFR (PressureWire)
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Shanghai 10th People's Hospital
Microvascular Angina, Angina Pectoris
Changes in Ischemia and Angina Over 1 Year Among ISCHEMIA Trial Screen Failures With no Obstructive CAD on Coronary CT Angiography
Serial assessment of angina status and ischemia on stress echo over one year among patients with moderate ischemia on stress imaging and non-obstructive CAD on coronary CT angiography.
- Trial name
- CIAO (NCT02347215)
- Testing
- Quality of Life assessment, Stress imaging
- Where
- United States
- Volunteers
- 212 people
- Sponsor
- NYU Langone Health
Coronary Artery Disease, CT
Coronary Computed Tomography Angiography (CCTA) for the Pre-procedural Planning of Percutaneous Coronary Intervention
The CT-PLAN PCI trial will evaluate whether CCTA-guided PCI improves procedural efficiency compared with routine PCI (without pre-procedural CCTA-guidance for PCI planning) using procedural time as the primary endpoint.
- Trial name
- CT-PLAN-PCI (NCT07691502)
- Testing
- CT-guided PCI, Routine PCI
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Minneapolis Heart Institute Foundation
Type 2 Diabetes Mellitus, Coronary Atherosclerosis
Assessment With CCTA and MRI in Asymptomatic Patients With Type 2 Diabetes for Detection of Unrecognized Myocardial Scar in Subclinical Coronary Atherosclerosis
The study aimed to prospectively investigate the prevalence of myocardial scar on Dotarem-enhanced Cardiovascular Magnetic Resonance Imaging (MRI) in asymptomatic patients with type-2 Diabetes Mellitus and to assess its…
- Trial name
- ACCREDIT (NCT01254552)
- Testing
- iobitridol, gadoterate meglumine
- Where
- South Korea
- Volunteers
- 351 people
- Sponsor
- Guerbet
Evaluate the Relationship Between HIV Medications and Coronary Atherosclerosis
Utilizing Computed Tomographic Angiography to Evaluate Coronary Artery Disease in Patients on Long-Term Antiretroviral Therapy
Utilizing Computed Tomographic Angiography to Evaluate Coronary Artery Disease in Patients on Long-Term Antiretroviral Therapy Intro: It is well known that HIV treated with antiretroviral drugs increases the risk for coronary…
- Trial name
- NCT02191306
- Where
- 2 sites in United States
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Florida State University
Coronary Artery Disease
Evaluation of the CardioSond Electronic Stethoscope in the Detection of Coronary Artery Disease
The study is designed to evaluate the predictive accuracy of the CardioSond digital electronic stethoscope in the detection of coronary artery disease (CAD) in patients with and without known disease who are referred to cardiac…
- Trial name
- NCT01374555
- Where
- United States
- Volunteers
- 107 people, healthy volunteers welcome
- Sponsor
- SonoMedica, Inc.
Coronary Artery Disease
A Low-dose Radiation and Contrast Agent Exposure Protocol for Coronary CTA in Diabetic Patients
To assess diagnostic accuracy,image quality and renal safety of a double low-dose coronary CTA protocol at coronary artery evaluation in patients with diabetes by using invasive coronary angiography(ICA) as the reference method…
- Trial name
- NCT04342455
- Testing
- double-low scanning
- Where
- China
- Volunteers
- 400 people
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Calcific Coronary Arteriosclerosis, Coronary Stenosis
Whole Blood Transcriptomic Signal According to Coronary Atherosclerotic Plaque Burden Assessed by CT Angiography
The present clinical study aims to identify transcriptomic patterns derived from whole blood samples related to coronary atherotic burden.
- Conditions
- Calcific Coronary Arteriosclerosis, Coronary Stenosis, Coronary Plaque, Aortic Calcification
- Trial name
- CORPLAQ-TRAIT (NCT06194526)
- Where
- 2 sites in Argentina
- Volunteers
- 200 people
- Sponsor
- MultiplAI Health Limited
Coronary Artery Disease
Physicians International Coronary Computed Tomography Angiography (CCTA) Utilization Registry
This protocol describes an observational study whose goal is to collect de-identified Coronary CT Angiography (CCTA) acquisition factors and interpretations (findings) from several hundred U.S.
- Trial name
- BIGPICTURE (NCT00932958)
- Where
- United States
- Volunteers
- 6,000 people
- Sponsor
- MDDX LLC
Chest Pain
Low-Dose Coronary Computed Tomographic Angiography for Early Triage of Acute Chest Pain
This study is to see whether the low-dose coronary computed tomographic angiography (CCTA) protocol is as safe and efficacious as conventional-dose protocol in early triage of acute chest pain.
- Trial name
- NCT01770444
- Testing
- Low-dose Cardiac CT protocol, Conventional cardiac CT protocol
- Where
- 3 sites in South Korea
- Volunteers
- 681 people
- Sponsor
- Seoul National University Hospital
Chest Pain, Coronary Artery Disease
Coronary Computed Tomographic Angiography Combined With CT-FFR in Intermediate-Risk Chest Pain Patients.
This study aims to investigate the guiding value of coronary CTA combined with CT-FFR in diagnostic and treatment decision-making for emergency chest pain patients at moderate risk, as well as its impact on clinical outcomes.
- Conditions
- Chest Pain, Coronary Artery Disease, Emergency Department
- Trial name
- E-CCTA (NCT07140419)
- Testing
- Coronary computed tomographic angiography with CT - derived fractional flow reserve
- Where
- China
- Volunteers
- 2,000 people
- Sponsor
- Qilu Hospital of Shandong University
Coronary Artery Disease
Myovista iECG for Detecting Ischemic Heart Disease: Comparison With Computed Tomography Coronary Angiography
Study evaluates the new technique MyoVista™ iECG sensitivity and ability to predict myocardial diseases, comparing iECG results with Computed Tomography Coronary Angiography findings
- Trial name
- NCT01562730
- Where
- Switzerland
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Cardiocentro Ticino
Acute Ischemic Stroke, Coronary Artery Disease
Cardiac CT Angiography in Patients With Acute Ischemic Stroke
Mortality rates after acute ischemic stroke remain high despite continuously improving treatment. In this context, it is important to note that a relevant portion of acute ischemic stroke patients die from adverse cardiovascular…
- Trial name
- ACUTE (NCT06176872)
- Testing
- Cardiac Computed Tomography Angiography
- Volunteers
- 165 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Non-ST Elevation Myocardial Infarction
Initial CT Perfusion-Guided Strategy for Suspected NSTEMI
Non-ST elevation myocardial infarction (NSTEMI) is a relatively complex type of myocardial infarction, characterized by chest pain symptoms and elevated troponin levels.
- Trial name
- SMART (NCT06689267)
- Testing
- computed tomography myocardial perfusion, Invasive Coronary Angiography
- Where
- China
- Volunteers
- 180 people
- Sponsor
- Shanghai Zhongshan Hospital
Out of Hospital Cardiac Arrest Without ST-segment Elevation
Performance of Coronary CT Angiography to Rule Out Coronary Artery Disease After Out-of-hospital Cardiac Arrest
Out-of-hospital cardiac arrest (OHCA) has multiple etiologies. In the absence of ST-elevation myocardial infarction, percutaneous coronary intervention (PCI) is delayed.
- Trial name
- PERFECCT (NCT05961488)
- Testing
- Coronary Calcium Score and Coronary CT angiogram
- Where
- France
- Volunteers
- 200 people
- Sponsor
- CHU de Reims
Coronary Disease
320 Multidetector Computed Tomography Prior to Coronary Artery Bypass Surgery
Recent advances in technology have resulted in the development of scanners that can n image the heart arteries within 10 to 20 minutes but without the need for admission to hospital or insertion of catheters.
- Trial name
- NCT01169948
- Testing
- Computed tomography scan
- Where
- United Kingdom
- Sponsor
- University of Edinburgh
Coronary Artery Disease
Computed Tomography Coronary Angiography (CTCA) and Coronary Flow in Stenosis Analysis
The investigators' rationale was to evaluate whether a 64-slice CT scanner allows accurate measurement of computed tomographic changes in coronary artery flow profiles and whether CT flow measurements are suitable for classifying…
- Trial name
- NCT00921440
- Volunteers
- 50 people
- Sponsor
- University of Cologne
Coronary Arterial Disease (CAD), Coronary Arteriosclerosis
PRogression of Atheroma Evaluated by CT Angiography and IntraCoronary Imaging tEchniques
This is a combined cohort study with retrospectively and prospectively enrolled coronary artery disease (CAD) patients. All the patients will undergo clinical follow-up for up to 5 years, and repeat coronary CTA will be conducted…
- Trial name
- PRACTICE (NCT06794684)
- Where
- 2 sites in China
- Volunteers
- 50,000 people
- Sponsor
- Ruijin Hospital
Coronary Artery Disease, In-stent Restenosis
CT-FFR-guided Strategy for In-stent Restenosis
This study will be a prospective, randomized clinical trial to compare standard practice guided by usual care testing to CT-FFR-guided management in patients with in-stent restenosis.
- Trial name
- NCT05611190
- Testing
- CT-FFR, Usual Care
- Volunteers
- 294 people
- Sponsor
- Yan'an Affiliated Hospital of Kunming Medical University