Clinical trials: Coronary Embolism
Ischemic Stroke, Ischemia
Biomarkers of Acute Stroke in Clinic
The proposed study will investigate the clinical use of the ISCDX test that may differentiate between diverse stroke etiologies as listed below: Aim 1: Differentiate between cardioembolic and large artery atherosclerotic ischemic…
- Conditions
- Ischemic Stroke, Ischemia, Atrial Fibrillation, Transient Ischemic Attack
- Trial name
- BASIC (NCT03897478)
- Testing
- ISCDX blood test
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- Ischemia Care LLC
ST Elevation Myocardial Infarction, Thrombi
Quantitative Estimation of Thrombus Burden in Patients With STEMI Using Micro-Computed Tomography (QUEST-STEMI)
The study aims to assess for the first time, through the application of innovative technologies (micro-CT), important characteristics of aspirated thrombi (such as their volume and their density), which might be linked to certain…
- Trial name
- QUEST-STEMI (NCT03429608)
- Where
- Greece
- Volunteers
- 115 people
- Sponsor
- Aristotle University Of Thessaloniki
Thromboprophylaxis, Thromboembolism, Venous
Thromboembolic Risk Assessment in Patients Admitted With Acute Medical Diseases to Conventional and At Home Hospitalization
The thromboembolic disease is a common complication of patients admitted to conventional hospitalization units. To prevent such complications, thromboprophylaxis is indicated in high-risk patients identified with validated…
- Conditions
- Thromboprophylaxis, Thromboembolism, Venous, Atrial Fibrillation, Physical Inactivity
- Trial name
- TROMBODOM (NCT06110949)
- Testing
- Triaxial accelerometry
- Where
- Spain
- Volunteers
- 1,953 people
- Sponsor
- Universidad Pública de Navarra
Cardiogenic Shock, Malignant Arrhythmias
The Caribbean Registry of Extracorporeal Membrane Oxygenation (ECMO) From the University Hospital in Martinique
The project's main goal is to collect baseline clinical and procedural data as well as to assess clinical outcomes for all patients undergoing VV, VA or VAV ECMO implantation in the French West Indies and Guiana.
- Conditions
- Cardiogenic Shock, Malignant Arrhythmias, Ischemic or Valvular Heart Failure, Drepanocytosis and Thoracic Syndrome
- Trial name
- NCT07351435
- Volunteers
- 1,200 people
- Sponsor
- University of Genova
Atrial Fibrillation, Stroke, Ischemic
The Fourth Left Atrial Appendage Occlusion Study
LAAOS-4 aims to determine if catheter-based endovascular left atrial appendage occlusion prevents ischemic stroke or systemic embolism in participants with atrial fibrillation, who remain at high risk of stroke, despite receiving…
- Conditions
- Atrial Fibrillation, Stroke, Ischemic, Systemic Embolism
- Trial name
- LAAOS-4 (NCT05963698)
- Testing
- WATCHMAN device
- Where
- 150 sites in United States, Belgium and 10 more
- Volunteers
- 4,000 people
- Sponsor
- Hamilton Health Sciences Corporation
Coronary Embolism, Atrial Fibrillation (AF)
AF Coronary Embolism Long Term Outcomes
Introduction Coronary embolism (CE) is a relatively rare but significant cause of non-atherosclerotic acute myocardial infarction (AMI), representing about 3% of all AMI cases, though it is likely underdiagnosed.
- Trial name
- NCT06948240
- Testing
- AF related coronary embolism
- Where
- Spain
- Volunteers
- 400 people
- Sponsor
- Fundacion Miguel Servet
Thrombosis
STRATAGEM: Strategy for Managing Antiplatelet Therapy in the Perioperative Period of Non Coronary Surgery
The STRATAGEM trial is an investigator-driven French nationwide multicenter, randomized, double-blind, placebo-controlled trial comparing perioperative low-dose aspirin therapy versus placebo in the perioperative period in…
- Trial name
- STRATAGEM (NCT00190307)
- Testing
- aspirin 75 mg/day
- Where
- France
- Volunteers
- 293 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Acute Coronary Syndromes, Heart Failure
Registry Of Acute meDical Emergencies in Brazil
Critical patients in emergency room are seriously situations that need quickly diagnosis and treatment. Different predictors of prognosis can be related with mortality and morbidity in-hospital and in long-term.
- Conditions
- Acute Coronary Syndromes, Heart Failure, Pulmonary Edema, Aortic Aneurysm, Familial Thoracic 1
- Trial name
- ROAD-Brazil (NCT02753023)
- Testing
- no intervention
- Where
- 6 sites in Brazil
- Volunteers
- 1,650 people
- Sponsor
- University of Sao Paulo General Hospital
Myocardial Infarction, Acute Coronary Syndrome
Diagnostic Accuracy of Electrocardiogram for Acute Coronary Occlusion Resulting in Myocardial Infarction
The decision of emergency reperfusion of a suspected acute coronary artery occlusion by means of percutaneous coronary intervention or intravenous thrombolytics depends on the presence of a certain amount of ST-segment elevation…
- Conditions
- Myocardial Infarction, Acute Coronary Syndrome, Coronary Artery Disease
- Trial name
- DIFOCCULT (NCT04022668)
- Testing
- Coronary angiogram
- Where
- Turkey (Türkiye)
- Volunteers
- 3,000 people
- Sponsor
- Yeditepe University
Mitral Regurgitation
STrategies for Antithrombotic tReatment Following Transcatheter Edge-to-Edge Repair in Patients Without an Indication for Oral Anticoagulant
Mitral regurgitation (MR) is the most common valvular heart disease, affecting approximately 24.2 million people worldwide (with a higher prevalence in older age groups).
- Trial name
- STAR-TEER Ⅱ (NCT07007143)
- Testing
- Experimental: Aspirin monotherapy, Active Comparator: Aspirin+Clopidogrel
- Where
- China
- Volunteers
- 1,032 people
- Sponsor
- Chinese Academy of Medical Sciences, Fuwai Hospital
Myocardial Infarction, Thrombosis
Non-invasive Coronary Thrombus Imaging to Define These Cause of Acute Myocardial Infarction
We now have very sensitive blood tests that can pick up damage to the heart and find patients who have had a heart attack. However, whilst this is welcome, it does not identify what causes the heart attack and can sometimes pick…
- Trial name
- NCT06113510
- Testing
- Hybrid 18F-GP1 positron emission tomography and coronary computed tomography coronary angiography
- Where
- United Kingdom
- Volunteers
- 80 people
- Sponsor
- University of Edinburgh
Myocardial Infarction
Anti-inflammatory Effects of Intracoronary and Intravenous Abciximab Administration During Primary Percutaneous Coronary Intervention
Intracoronary abciximab administration during primary percutaneous coronary intervention (pPCI) could offer clinical advantages over the intravenous route.
- Trial name
- NCT01757457
- Testing
- Intracoronary administration of an abciximab bolus during primary PCI, Intravenous administration of an abciximab bolus during primary PCI
- Where
- Italy
- Volunteers
- 89 people
- Sponsor
- Azienda Ospedaliero Universitaria Maggiore della Carita
Adrenal Gland Hyperfunction, Cardiovascular Disease
Heart Disease Risk Factors in Major Depression
A series of studies in patients with major depression have consistently demonstrated a doubling of the mortality rate at any age, independent of suicide.
- Conditions
- Adrenal Gland Hyperfunction, Cardiovascular Disease, Involutional Depression
- Trial name
- NCT00001969
- Where
- United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Atrial Fibrillation, Thromboembolism
Investigation on Appropriate Duration of Dabigatran Use After Catheter Ablation for Paroxysmal Atrial Fibrillation in Patients With Low Thromboembolic Risk
The purpose of this study is to investigate the appropriate duration of dabigatran use after radiofrequency catheter ablation for paroxysmal atrial fibrillation in patients with low thromboembolic risk.
- Trial name
- NCT02313584
- Testing
- dabigatran
- Volunteers
- 464 people
- Sponsor
- Korea University
Venous Thromboembolism (VTE), Atrial Fibrillation (AF)
EUropean Pharmacogenetics of AntiCoagulant Therapy - Phenprocoumon
Rationale: The narrow therapeutic range and wide inter-patient variability in dose requirement make anticoagulation response to coumarin derivatives unpredictable.
- Trial name
- EU-PACT (NCT01119274)
- Testing
- Genotype-guided dosing algorithm, Non-genotype-guided dosing algorithm
- Where
- 3 sites in Austria, Germany and 1 more
- Volunteers
- 970 people
- Sponsor
- Utrecht Institute for Pharmaceutical Sciences
Heart Defects, Congenital
Long Term Safety of Clopidogrel in Neonates/Infants With Systemic to Pulmonary Artery Shunt Palliation
This study is the extension of the CLARINET study [NCT00396877 -EFC5314] in neonates or infants with cyanotic congenital heart disease palliated with a systemic-to-pulmonary artery shunt.
- Trial name
- CLARINET LT (NCT00833703)
- Testing
- Clopidogrel
- Where
- 15 sites in United States, Brazil and 13 more
- Volunteers
- 49 people
- Sponsor
- Sanofi
Stroke, Cerebral Infarction
Platelet Hyperreactivity to Aspirin and Stroke
STUDY QUESTIONS What is the real prevalence of platelet "resistance" to aspirin during the acute phase of stroke and after 3 months, and 1 year, as measured using different platelet function tests? Do all methods measure similar…
- Conditions
- Stroke, Cerebral Infarction, Cardiovascular Diseases, Vascular Diseases
- Trial name
- PLARAS (NCT00766896)
- Testing
- Aspirin (platelet sensitive versus platelet hyperreactivity)
- Where
- Brazil
- Volunteers
- 203 people
- Sponsor
- University of Sao Paulo
Myocardial Infarction, Decompensated Chronic Heart Failure
Pre-discharge Influenza Vaccination in Patients Hospitalized for Acute Cardiac Conditions
Patients hospitalized for acute cardiac conditions-including acute myocardial infarction, acute heart failure, pulmonary embolism, arrhythmias, and hypertensive emergencies-represent a heterogeneous population at very high risk…
- Conditions
- Myocardial Infarction, Decompensated Chronic Heart Failure, Acute Heart Failure (AHF), Pulmonary Embolism Acute
- Trial name
- NCT07617376
- Testing
- Influenza vaccination
- Where
- Poland
- Volunteers
- 400 people
- Sponsor
- Wroclaw Medical University
Atrial Fibrillation, Venous Thromboembolism
Edoxaban Management in Diagnostic and Therapeutic Procedures
Patients receiving Novel Oral Anticoagulation (NOACs) undergo diagnostic and therapeutic procedures at a rate of 10% per year. Short half-lives and rapid onset of action allow for short periods of NOAC interruption without…
- Trial name
- EMIT-AF/VTE (NCT02950168)
- Testing
- Edoxaban
- Volunteers
- 1,197 people
- Sponsor
- Daiichi Sankyo
Atrial Fibrillation, Deep Vein Thrombosis
Genotype-Guided Warfarin Therapy Trial
The purpose of the investigators' study is to determine the clinical utility of a warfarin-dosing algorithm that incorporates genetic information (VKORC1 and CYP2C9 alleles) for adult patients initiating warfarin therapy.
- Conditions
- Atrial Fibrillation, Deep Vein Thrombosis, Pulmonary Embolism, Artificial Heart Valve
- Trial name
- WARFPGX (NCT00904293)
- Testing
- Genotype-guided dose determination, Non-genotype guided warfarin dosing
- Where
- United States
- Volunteers
- 109 people
- Sponsor
- University of North Carolina, Chapel Hill